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Outputs (38)

Graphene-based electrodes for monitoring of Estradiol (2023)
Journal Article
Musa, A. M., Kiely, J., Luxton, R., & Honeychurch, K. C. (2023). Graphene-based electrodes for monitoring of Estradiol. Chemosensors, 11(6), 337. https://doi.org/10.3390/chemosensors11060337

This study explores the potential use of graphene-based electrodes in the electrochemical determination of estradiol using amperometric techniques as a simple, enzyme-free approach. Graphene, a carbon-based nanomaterial, has been extensively investig... Read More about Graphene-based electrodes for monitoring of Estradiol.

Rapid detection of tetracycline residues at clinically relevant levels via a novel, inexpensive and analytically-sensitive magneto-immunoassay – A feasibility study (2023)
Journal Article
Harrison, O. J., Monnier, B., Regan, E., West, D., Dykes, H. B., Davey, J. S., …Luxton, R. (2023). Rapid detection of tetracycline residues at clinically relevant levels via a novel, inexpensive and analytically-sensitive magneto-immunoassay – A feasibility study. Sensing and Bio-Sensing Research, 41, Article 100566. https://doi.org/10.1016/j.sbsr.2023.100566

Expensive, time-consuming and labour-intensive solvent-extraction and liquid-chromatography methods are the industry's current gold standard for antibiotic residue quantification. A novel immunoassay methodology and system for the rapid detection of... Read More about Rapid detection of tetracycline residues at clinically relevant levels via a novel, inexpensive and analytically-sensitive magneto-immunoassay – A feasibility study.

A non-faradaic impedimetric biosensor for monitoring of caspase 9 in mammalian cell culture (2023)
Journal Article
Chen, B., Kiely, J., Luxton, R., & Williams, I. (2023). A non-faradaic impedimetric biosensor for monitoring of caspase 9 in mammalian cell culture. Bioelectrochemistry, 153, Article 108456. https://doi.org/10.1016/j.bioelechem.2023.108456

Lower yields and poorer quality of biopharmaceutical products result from cell death in bioreactors. Such cell death is commonly associated with programmed cell death or apoptosis. During apoptosis, caspases are activated and cause a cascade of event... Read More about A non-faradaic impedimetric biosensor for monitoring of caspase 9 in mammalian cell culture.

An electrochemical screen-printed sensor based on gold-nanoparticle-decorated reduced graphene oxide–carbon nanotubes composites for the determination of 17-β estradiol (2023)
Journal Article
Musa, A., Kiely, J., Luxton, R., & Honeychurch, K. C. (2023). An electrochemical screen-printed sensor based on gold-nanoparticle-decorated reduced graphene oxide–carbon nanotubes composites for the determination of 17-β estradiol. Biosensors, 13(4), Article 491. https://doi.org/10.3390/bios13040491

In this study, a screen-printed electrode (SPE) modified with gold-nanoparticle-decorated reduced graphene oxide–carbon nanotubes (rGO-AuNPs/CNT/SPE) was used for the determination of estradiol (E2). The AuNPs were produced through an eco-friendly me... Read More about An electrochemical screen-printed sensor based on gold-nanoparticle-decorated reduced graphene oxide–carbon nanotubes composites for the determination of 17-β estradiol.

Metal oxide decorated carbon nanocomposite electrodes for propofol monitoring (2022)
Journal Article
Ferrier, D., Kiely, J., & Luxton, R. (2022). Metal oxide decorated carbon nanocomposite electrodes for propofol monitoring. Biosensors and Bioelectronics, 12, Article 100286. https://doi.org/10.1016/j.biosx.2022.100286

Despite the growing evidence of the benefits of total-intravenous anaesthesia using propofol compared to conventional volatile-based anaesthesia, both in terms of environmental impact and patient outcomes, the majority of administered general anaesth... Read More about Metal oxide decorated carbon nanocomposite electrodes for propofol monitoring.

Modeling peptide nucleic acid binding enthalpies using MM-GBSA (2022)
Journal Article
Goodman, J., Attwood, D., Kiely, J., Coladas Mato, P., & Luxton, R. (2022). Modeling peptide nucleic acid binding enthalpies using MM-GBSA. Journal of Physical Chemistry B, 126(46), 9528-9538. https://doi.org/10.1021/acs.jpcb.2c05547

The binding enthalpies of peptide nucleic acid (PNA) homoduplexes were predicted using a molecular mechanics generalized Born surface area approach. Using the nucleic acid nearest-neighbor model, these were decomposed into sequence parameters which c... Read More about Modeling peptide nucleic acid binding enthalpies using MM-GBSA.

Modelling a dynamic magneto-agglutination bioassay (2022)
Journal Article
Hughes, R., Fishman, A., Lamb-Riddell, K., Sleigh Muñoz, V., Champneys, A., Kiely, J., & Luxton, R. (2023). Modelling a dynamic magneto-agglutination bioassay. Biosensors and Bioelectronics, 222, 114745. https://doi.org/10.1016/j.bios.2022.114745

The process of developing an end-to-end model of a magneto-immunoassay is described, simulating the agglutination effect due to the specific binding of bacteria to paramagnetic particles. After establishing the properties of the dose-specific aggluti... Read More about Modelling a dynamic magneto-agglutination bioassay.

Equivalent circuit model of a non-faradaic impedimetric ZnO nano-crystal biosensor (2022)
Journal Article
Eveness, J., Cao, L., Kiely, J., & Luxton, R. (2022). Equivalent circuit model of a non-faradaic impedimetric ZnO nano-crystal biosensor. Journal of Electroanalytical Chemistry, 906, Article 116003. https://doi.org/10.1016/j.jelechem.2021.116003

This paper describes the development of an equivalent electrical circuit (EEC) model of a unique co-planar electrode PET-ZnO biosensor platform. This non-faradaic ZnO biosensor had a PET insulating layer between the electrodes and the active ZnO sens... Read More about Equivalent circuit model of a non-faradaic impedimetric ZnO nano-crystal biosensor.

Passive impedance sensing using a SAW resonator-coupled biosensor for zero-power wearable applications (2021)
Journal Article
Yue, X., Kiely, J., Luxton, R., Chen, B., McLeod, C. N., & Drakakis, E. M. (2022). Passive impedance sensing using a SAW resonator-coupled biosensor for zero-power wearable applications. IEEE Sensors Journal, 22(3), 2347-2357. https://doi.org/10.1109/JSEN.2021.3136705

A bio-sensing scheme, which acquires impedance information of a capacitive biosensor by using the reflected RF signal from a surface acoustic wave (SAW) resonator connected to the biosensor, is proposed. This technique requires no power to be supplie... Read More about Passive impedance sensing using a SAW resonator-coupled biosensor for zero-power wearable applications.

Cytochrome P450 2B6 amperometric biosensor for continuous monitoring of propofol (2021)
Journal Article
Ferrier, D., Kiely, J., & Luxton, R. (2021). Cytochrome P450 2B6 amperometric biosensor for continuous monitoring of propofol. IEEE Sensors Journal, 21(21), https://doi.org/10.1109/JSEN.2021.3112273

Despite the growing evidence of improved patient outcomes and of a substantially reduced environmental impact of propofol-based total intravenous anesthesia when compared to volatile-based techniques, the vast majority of general anesthetics still us... Read More about Cytochrome P450 2B6 amperometric biosensor for continuous monitoring of propofol.

Propofol detection for monitoring of intravenous anaesthesia: A review (2021)
Journal Article
Ferrier, D., Kiely, J., & Luxton, R. (2022). Propofol detection for monitoring of intravenous anaesthesia: A review. Journal of Clinical Monitoring and Computing, 36, 315-323. https://doi.org/10.1007/s10877-021-00738-5

This paper presents a review of established and emerging methods for detecting and quantifying the intravenous anaesthetic propofol in solution. There is growing evidence of numerous advantages of total intravenous anaesthesia using propofol compared... Read More about Propofol detection for monitoring of intravenous anaesthesia: A review.

Recent progress in screen-printed electrochemical sensors and biosensors for the detection of estrogens (2021)
Journal Article
Musa, A. M., Kiely, J., Luxton, R., & Honeychurch, K. C. (2021). Recent progress in screen-printed electrochemical sensors and biosensors for the detection of estrogens. Trends in Analytical Chemistry, 139, Article 116254. https://doi.org/10.1016/j.trac.2021.116254

Estrogens have become increasingly prevalent in environmental samples across the world, posing a serious threat to human health. They have received considerable public attention due to their harmful effect on the normal endocrine functions of humans... Read More about Recent progress in screen-printed electrochemical sensors and biosensors for the detection of estrogens.

Classification of the mechanism of toxicity as applied to human cell line ECV304 (2020)
Journal Article
Djawad, Y. A., Kiely, J., & Luxton, R. (2021). Classification of the mechanism of toxicity as applied to human cell line ECV304. Computer Methods in Biomechanics and Biomedical Engineering, 24(9), 933-944. https://doi.org/10.1080/10255842.2020.1861255

© 2020 Informa UK Limited, trading as Taylor & Francis Group. The objective of this study was to identify the pattern of cytotoxicity testing of the human cell line ECV304 using three techniques of an ensemble learning algorithm (bagging, boosting... Read More about Classification of the mechanism of toxicity as applied to human cell line ECV304.

Algorithms for U-model-based dynamic inversion (UM-dynamic inversion) for continuous time control systems (2020)
Journal Article
Li, R., Zhu, Q., Kiely, J., & Zhang, W. (2020). Algorithms for U-model-based dynamic inversion (UM-dynamic inversion) for continuous time control systems. Complexity, 2020, https://doi.org/10.1155/2020/3640210

To setup a universal proper user toolbox from previous individual research publications, this study generalises the algorithms for the U-model dynamic inversion based on the realisation of U-model from polynomial and state-space described continuous-... Read More about Algorithms for U-model-based dynamic inversion (UM-dynamic inversion) for continuous time control systems.

Sensor (2020)
Patent
Allainguillaume, J., Barnett, J., Luxton, R., & Kiely, J. Sensor. WO 2020/089607 A1

The present invention relates to detecting viral infections in plants, especially Cacao swollen-shoot virus (CSSV) infections. Recombinant viral coat protein antigens and binding reagents that specifically bind to thereto are provided together with a... Read More about Sensor.

A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing (2020)
Journal Article
Gasser, A., Eveness, J., Kiely, J., Attwood, D., & Luxton, R. (2020). A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing. Bioelectrochemistry, 133, 107448. https://doi.org/10.1016/j.bioelechem.2019.107448

© 2019 We report on a novel impedance spectroscopy measurement and data analysis technique for cytotoxicity testing. The technique combines non-contact measurement with real-time impedance data analysis based on the toxin dose dependency of the outpu... Read More about A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing.

Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection (2019)
Journal Article
Barnett, J. M., Monnier, B. M., Tyler, S., West, D., Ballantine-Dykes, H., Regan, E., …Luxton, R. (2020). Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection. Sensing and Bio-Sensing Research, 27, 100315. https://doi.org/10.1016/j.sbsr.2019.100315

© 2019 The resonant coil magnetometer quantifies paramagnetic particles (PMPs) and has been used to develop magneto-immunoassays in a range of formats. The advantage of magneto-immunoassays is that they are relatively inexpensive, portable, easy to p... Read More about Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection.

SAW based passively bioimpedance sensing for zero-power wearable applications of biosensors (2019)
Conference Proceeding
Yue, A., Kiely, J., McLeod, C., & Wraith, P. (in press). SAW based passively bioimpedance sensing for zero-power wearable applications of biosensors. In 2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)

A novel passive bio-sensing method, which electrically connects a conventional biosensor to a surface acoustic wave (SAW) device, is proposed for passively sensing bio-impedance for zero-power wearable applications. The biosensor attached to the SAW... Read More about SAW based passively bioimpedance sensing for zero-power wearable applications of biosensors.

CSSV biosensor (WO2020089607-PAMPH-20200507-8395) (2019)
Patent
Allainguillaume, J., Barnett, J. M., Kiely, J., & Luxton, R. (in press). CSSV biosensor (WO2020089607-PAMPH-20200507-8395). WO 2020/089607 A1

The present invention relates to detecting viral infections in plants, especially Cacao swollen-shoot virus (CSSV) infections. Recombinant viral coat protein antigens and binding reagents that specifically bind to thereto are provided together with a... Read More about CSSV biosensor (WO2020089607-PAMPH-20200507-8395).

C3bio Poster AM KH RL JK 2019 (2019)
Presentation / Conference
Musa, A., Honeychurch, K., Kelly, J., & Luxton, R. (2019, September). C3bio Poster AM KH RL JK 2019

Bioinspired materials have emerged as alternatives to antibodies and enzymes in biosensor for environmental monitoring These are tailored made in order to mimics the molecular function of a natural receptors in biosensor Aptamers and Molecularly imp... Read More about C3bio Poster AM KH RL JK 2019.

A copper oxide/zinc oxide composite nano-surface for use in a biosensor (2019)
Journal Article
Cao, L., Kiely, J., Piano, M., & Luxton, R. (2019). A copper oxide/zinc oxide composite nano-surface for use in a biosensor. Materials, 12(7), 1126. https://doi.org/10.3390/ma12071126

© 2019 by the authors. In this study, biosensors based on zinc oxide-copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 a... Read More about A copper oxide/zinc oxide composite nano-surface for use in a biosensor.

Charge-based supercapacitor storage estimation for indoor sub-mW photovoltaic energy harvesting powered wireless sensor nodes (2019)
Journal Article
Yue, X., Kiely, J., Gibson, D., & Drakakis, E. M. (2020). Charge-based supercapacitor storage estimation for indoor sub-mW photovoltaic energy harvesting powered wireless sensor nodes. IEEE Transactions on Industrial Electronics, 67(3), 2411-2421. https://doi.org/10.1109/TIE.2019.2896321

Supercapacitors offer an attractive energy storage solution for lifetime “fit and forget” photovoltaic (PV) energy harvesting powered wireless sensor nodes for internet of things (IoT) applications. Whilst their low storage capacity is not an issue f... Read More about Charge-based supercapacitor storage estimation for indoor sub-mW photovoltaic energy harvesting powered wireless sensor nodes.

The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges (2019)
Journal Article
Djawad, Y. A., Attwood, D., Kiely, J., & Luxton, R. (2019). The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges. Sensing and Bio-Sensing Research, 23, Article 100269. https://doi.org/10.1016/j.sbsr.2019.100269

© 2019 In this paper we present a non-contact, impedance-based sensor system capable of characterizing the toxic response of cells to three different types of toxin. ECV304 cells were treated with 1 mM Hydrogen peroxide, 5% Dimethyl Sulfoxide, and 10... Read More about The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges.

Mathematical modelling of a magnetic immunoassay (2017)
Journal Article
Roberts, L., Griffith, T., Champneys, A., Piano, M., Kiely, J., & Luxton, R. W. (2017). Mathematical modelling of a magnetic immunoassay. IMA Journal of Applied Mathematics, 82(6), 1253-1282. https://doi.org/10.1093/imamat/hxx034

© The authors 2017. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved. A mathematical model is developed to describe the action of a novel form of fluidic biosensor that uses para... Read More about Mathematical modelling of a magnetic immunoassay.

Particle facilitate testing (2017)
Patent
Luxton, R. W., Kiely, J., & Wraith, P. (2017). Particle facilitate testing. 2017/0146525A1

Magnetic particles are distributed across a fluid flow by applied magnetic field to interact with a test substance in fluid. Alternatively or additionally, particles, which may be magnetic, are combined with cells and energy, eg ultrasonic energy, is... Read More about Particle facilitate testing.

A new procedure for analysis and modelling of male urine flow rate (2015)
Presentation / Conference
Li, R., Gammie, A., Zhu, Q., Nibouche, M., & Kiely, J. (2015, July). A new procedure for analysis and modelling of male urine flow rate

In the first stage studies, this paper proposes a new piecewise linear discrete time dynamic model for describing global urine flow rate profiles against time sequence. The establishment of model has been guided by physician meaningful principles and... Read More about A new procedure for analysis and modelling of male urine flow rate.

Low temperature hydrothermal synthesis of ZnO nanowires for nanogenerator: Effect of gold electrode on the output voltage of nanogenerator (2014)
Journal Article
Mansoor, A., Iqbal, M., Kiely, J., & Luxton, R. (2014). Low temperature hydrothermal synthesis of ZnO nanowires for nanogenerator: Effect of gold electrode on the output voltage of nanogenerator. Indian Journal of Engineering and Materials Sciences, 21(6), 672-676

A low temperature hydrothermal technique is developed to grow ZnO (diameter 100 nm) nanowires for high output nanogenerator. Vertically aligned ZnO nanowires are grown on indium tin oxide (ITO) coated poly ethylene terephthalate (PET) substrate. Morp... Read More about Low temperature hydrothermal synthesis of ZnO nanowires for nanogenerator: Effect of gold electrode on the output voltage of nanogenerator.

Lock-in amplifier as a sensitive instrument for biomedical measurement: Analysis and implementation (2014)
Journal Article
Abd Djawad, Y., Kiely, J., Luxton, R., & Wraith, P. (2014). Lock-in amplifier as a sensitive instrument for biomedical measurement: Analysis and implementation

A measuring instrument plays important role in the biomedical measurement since the biological process in living organism generates very weak signal. Therefore, a reliable and sensitive measuring instrument is needed. In this study, a lock-in amplifi... Read More about Lock-in amplifier as a sensitive instrument for biomedical measurement: Analysis and implementation.

Hilbert huang transform impedance measurement data for cellular toxicity monitoring (2009)
Conference Proceeding
Wang, Z., Zhu, Q., Kiely, J., & Luxton, R. W. (2009). Hilbert huang transform impedance measurement data for cellular toxicity monitoring. In N. NA (Ed.), International Conference on Networking, Sensing and Control (767-772). https://doi.org/10.1109/ICNSC.2009.4919375

This paper investigates the Hilbert-Huang transformation (HHT), which is adaptive analysis of nonlinear and non-stationary signals. The aim of this study is to apply HHT to impedance measurement data analysis in order to discriminate different types... Read More about Hilbert huang transform impedance measurement data for cellular toxicity monitoring.

Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay (2009)
Journal Article
Eveness, J., Kiely, J., Hawkins, P., Wraith, P., & Luxton, R. (2009). Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay. Sensors and Actuators B: Chemical, 139(2), 538-542. https://doi.org/10.1016/j.snb.2009.03.078

This paper describes work that formed a part of an investigation to increase the detection sensitivity of a magneto-immunoassay. The study involved the characterisation of paramagnetic particles (PMPs) from a range of manufacturers in order to determ... Read More about Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay.

Spot test: new technologies bring point-of-care testing into the 21st century (2009)
Journal Article
Luxton, R. W., & Kiely, J. (2009). Spot test: new technologies bring point-of-care testing into the 21st century

Every new technology offers the potential to effect changes in practise; many developments driven by the world-wide demand for instant results. This is never as true as in the arena of diagnostic testing. Once the sole preserve of the hospital labo... Read More about Spot test: new technologies bring point-of-care testing into the 21st century.

Spot test (2009)
Other
Kiely, J., & Luxton, R. W. (2009). Spot test

Paramagnetic particle detection for use with an immunoassay based biosensor (2007)
Journal Article
Kiely, J., Hawkins, P., Wraith, P., & Luxton, R. (2007). Paramagnetic particle detection for use with an immunoassay based biosensor. IET Science Measurement and Technology, 1(5), 270-275. https://doi.org/10.1049/iet-smt%3A20060103

A biosensor and detection system that can provide measurement of analyte concentration within a test sample in four minutes is presented. The biosensor uses an immunoassay with micrometre-sized paramagnetic particle (PMP) labels for quantification. A... Read More about Paramagnetic particle detection for use with an immunoassay based biosensor.

Use of External Magnetic Fields to Reduce Reaction Times in an Immunoassay Using Micrometer-Sized Paramagnetic Particles as Labels (Magnetoimmunoassay) (2004)
Journal Article
Luxton, R., Badesha, J., Kiely, J., & Hawkins, P. (2004). Use of External Magnetic Fields to Reduce Reaction Times in an Immunoassay Using Micrometer-Sized Paramagnetic Particles as Labels (Magnetoimmunoassay). Analytical Chemistry, 76(6), 1715-1719. https://doi.org/10.1021/ac034906%2B

The paper presents a rapid immunoassay system capable of quantifying analyte in complex biological and environmental media. Antibody-coated micrometer-sized paramagnetic particles are used as labels in an assay in which they bind quantitatively with... Read More about Use of External Magnetic Fields to Reduce Reaction Times in an Immunoassay Using Micrometer-Sized Paramagnetic Particles as Labels (Magnetoimmunoassay).