IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome (2024)
Journal Article
Asurappulige, H. S. H., Ladomery, M. R., & Morse, H. R. (2024). IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome. Translational Oncology, 46, Article 102030. https://doi.org/10.1016/j.tranon.2024.102030

Following infection or exposure to therapeutic agents, an aggressive immune response may result, termed cytokine storm (CS) or cytokine release syndrome. Here the innate immune system becomes uncontrolled, leading to serious consequences including po... Read More about IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome.

Healthcare professionals' knowledge, understanding and confidence to manage chronic pain after cancer treatment: A UK survey (2024)
Journal Article
Armoogum, J., Harcourt, D., Foster, C., Llewellyn, A., Hepburn, J., Prior, M., & McCabe, C. (2024). Healthcare professionals' knowledge, understanding and confidence to manage chronic pain after cancer treatment: A UK survey. European Journal of Oncology Nursing, 71, Article 102610. https://doi.org/10.1016/j.ejon.2024.102610

Introduction: Healthcare professionals are vital in preparing people living with and beyond cancer about the risks of chronic pain after cancer treatment. To do so, healthcare professionals need to be knowledgeable and confident about chronic pain af... Read More about Healthcare professionals' knowledge, understanding and confidence to manage chronic pain after cancer treatment: A UK survey.

Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3 (2024)
Journal Article
Williams, A., Cooper, E., Clark, B., Perry, L., Ponassi, M., Iervasi, E., …Ladomery, M. (2024). Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3. International Journal of Molecular Sciences, 25(10), Article 5380. https://doi.org/10.3390/ijms25105380

In a screen of over 200 novel pyrazole compounds, ethyl 1-(2-hydroxypentyl)-5-(3-(3-(trifluoromethyl) phenyl)ureido)-1H-pyrazole-4-carboxylate (named GeGe-3) has emerged as a potential anticancer compound. GeGe-3 displays potent anti-angiogenic prope... Read More about Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3.

Patient experiences of brachytherapy for locally advanced cervical cancer: hearing the patient voice through qualitative interviews (2023)
Journal Article
Humphrey, P., Dures, E., Hoskin, P., & Cramp, F. (2024). Patient experiences of brachytherapy for locally advanced cervical cancer: hearing the patient voice through qualitative interviews. International Journal of Radiation Oncology - Biology - Physics, 119(3), 902-911. https://doi.org/10.1016/j.ijrobp.2023.12.016

Purpose: Brachytherapy for gynecological cancer is reported to cause pain, anxiety, and distress with no clear guidance for optimizing patient experiences. The aim of this study was to explore patient experiences of brachytherapy and views on improve... Read More about Patient experiences of brachytherapy for locally advanced cervical cancer: hearing the patient voice through qualitative interviews.

Evaluation of a live educational webinar on ‘Managing Chronic Pain’ (2023)
Presentation / Conference
Armoogum, J., Galligan, M., Cook, J., Mills, E., Munro, D., Wicke, K., & Wilson, T. (2023, November). Evaluation of a live educational webinar on ‘Managing Chronic Pain’. Poster presented at UKONS, Cardiff, Wales

1: Background Chronic cancer-related pain (CRP) is frequently reported, yet poorly understood. It is essential healthcare professionals have knowledge and skills to support those impacted with chronic and late effect CRP. However, literature shows t... Read More about Evaluation of a live educational webinar on ‘Managing Chronic Pain’.

Evaluation of the impacts of patient and public involvement on cancer nursing doctoral study exploring cancer survivors’ experiences of living with chronic post cancer treatment pain (2023)
Presentation / Conference
Armoogum, J., Hepburn, J., Prior, M., McCabe, C., Harcourt, D., Llewellyn, A., …Gibson, A. (2023, November). Evaluation of the impacts of patient and public involvement on cancer nursing doctoral study exploring cancer survivors’ experiences of living with chronic post cancer treatment pain. Poster presented at UKONS, Cardiff, Wales

Background. Patient and Public Involvement (PPI) can help shape research. It is important to capture the impacts that PPI have on cancer nursing doctoral research. Methods: Two Public Contributors, who were cancer survivors living with chronic post... Read More about Evaluation of the impacts of patient and public involvement on cancer nursing doctoral study exploring cancer survivors’ experiences of living with chronic post cancer treatment pain.

Chronic post cancer treatment pain – how can we increase unity across pathways? (2023)
Presentation / Conference
Armoogum, J., Llewellyn, A., Harcourt, D., Foster, C., & McCabe, C. (2023, November). Chronic post cancer treatment pain – how can we increase unity across pathways?. Poster presented at UKONS, Cardiff, Wales

Background: Chronic post cancer treatment pain is pain that persists or recurs for longer than three months and is caused by surgery, chemotherapy and/or radiotherapy . It can occur months or years after cancer treatment has finished. Limited knowl... Read More about Chronic post cancer treatment pain – how can we increase unity across pathways?.

Using the 'Evidencing Work Based Learning' module to improve the experience of people with cancer (2023)
Presentation / Conference
Bruce, L., Hamilton, L., & Armoogum, J. (2023, November). Using the 'Evidencing Work Based Learning' module to improve the experience of people with cancer. Poster presented at Macmillan Professionals Conference, Glasgow

Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells (2023)
Journal Article
Robson, J. L., Thorn, R. M. S., Williams, A. C., Collard, T. J., & Qualtrough, D. (2023). Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells. Scientific Reports, 13(1), Article 17291. https://doi.org/10.1038/s41598-023-44130-6

Colorectal cancer (CRC) is a significant global health burden with a rising incidence worldwide. Distinct bacterial populations are associated with CRC development and progression, and it is thought that the relationship between CRC and associated gu... Read More about Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells.

Long-term patient-reported outcomes of immediate breast reconstruction after mastectomy for breast cancer: Population-based cohort study (2023)
Journal Article
Johnson, L., White, P., Jeevan, R., Browne, J., Gulliver-Clarke, C., O’Donoghue, J., …Potter, S. (2023). Long-term patient-reported outcomes of immediate breast reconstruction after mastectomy for breast cancer: Population-based cohort study. British Journal of Surgery, 110(12), 1815-1823. https://doi.org/10.1093/bjs/znad276

BACKGROUND: Breast reconstruction is offered to improve quality of life for women after mastectomy for breast cancer, but information regarding the long-term patient-reported outcomes of different reconstruction procedures is currently lacking. The B... Read More about Long-term patient-reported outcomes of immediate breast reconstruction after mastectomy for breast cancer: Population-based cohort study.

Development of online cancer resources to support pre-registration nurses and allied health professionals to increase their knowledge and understanding of cancer care (2023)
Journal Article
Armoogum, J., Taylor, V., Cruickshank, S., Donaldson, J., Wyatt, D., Tanay, M., …Potter, L. (2023). Development of online cancer resources to support pre-registration nurses and allied health professionals to increase their knowledge and understanding of cancer care. British Journal of Nursing, 32(17),

Cancer rates are increasing, and more people are living with cancer and its consequences. Healthcare students will be caring for people affected by cancer in all clinical contexts. However, pre-registration programmes can include limited cancer edu... Read More about Development of online cancer resources to support pre-registration nurses and allied health professionals to increase their knowledge and understanding of cancer care.

'I think it affects every aspect of my life, really': Cancer survivors' experience of living with chronic pain after curative cancer treatment in England, UK (2023)
Journal Article
Armoogum, J., Foster, C., Llewellyn, A., Harcourt, D., & McCabe, C. (2023). 'I think it affects every aspect of my life, really': Cancer survivors' experience of living with chronic pain after curative cancer treatment in England, UK. PLoS ONE, 18(9), Article e0290967. https://doi.org/10.1371/journal.pone.0290967

Aim: To explore cancer survivors’ experiences of living with chronic pain after curative cancer treatment in England, UK. Methods: A qualitative study using telephone interviews with adult cancer survivors experiencing chronic pain after curative can... Read More about 'I think it affects every aspect of my life, really': Cancer survivors' experience of living with chronic pain after curative cancer treatment in England, UK.

Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients (2023)
Journal Article
Harland, A. J., Perks, C. M., White, P., Kurian, K. M., & Barber, H. R. (2023). Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients. Cancer Medicine, 12(13), 14426-14439. https://doi.org/10.1002/cam4.6071

Background: The overall survival of IDH-wildtype glioblastoma patients is poor despite best available treatments. There is an urgent need for new biomarkers to inform more precise disease stratification. Previous studies have identified insulin-like... Read More about Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients.

Fluorescence-activated cell sorting and quantitative real-time PCR to reveal VEGF-expressing macrophage populations in the Zebrafish larvae (2022)
Book Chapter
Herman, A., Greenhough, A., & Gurevich, D. B. (2022). Fluorescence-activated cell sorting and quantitative real-time PCR to reveal VEGF-expressing macrophage populations in the Zebrafish larvae. In VEGF Signaling (325-337). Humana Press. https://doi.org/10.1007/978-1-0716-2217-9_24

The transparent, genetically tractable zebrafish is increasingly recognized as a useful model to both live image and uncover mechanistic insight into cell interactions governing tissue homeostasis, pathology, and regeneration. Here, we describe a pro... Read More about Fluorescence-activated cell sorting and quantitative real-time PCR to reveal VEGF-expressing macrophage populations in the Zebrafish larvae.

Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected (2021)
Journal Article
Gynn, L. E., Anderson, E., Robinson, G., Wexler, S. A., Upstill-Goddard, G., Cox, C., & May, J. E. (2021). Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected. Mutagenesis, 36(6), 419-428. https://doi.org/10.1093/mutage/geab033

Tumour microenvironments are hallmarked in many cancer types. In haematological malignancies, bone marrow (BM) mesenchymal stromal cells (MSC) protect malignant cells from drug-induced cytotoxicity. However, less is known about malignant impact on su... Read More about Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected.

Analysing cancer care informatics through the lens of the United Nations Sustainable Development Goals - A review and assessment (2019)
Conference Proceeding
Brooks, I., Longhurst, J., Kossmann, M., Mansour, A., Odeh, M., & Tbakhi, A. (2019). Analysing cancer care informatics through the lens of the United Nations Sustainable Development Goals - A review and assessment. . https://doi.org/10.1109/CANCERCARE.2018.8618264

© 2018 IEEE. Cancer Care Informatics (CCI) and its impacts are assessed using the United Nations Sustainable Development Goals (SDGs). The positive and negative impacts of CCI on the SDGs are considered through a literature review and expert assessme... Read More about Analysing cancer care informatics through the lens of the United Nations Sustainable Development Goals - A review and assessment.