Skip to main content

Research Repository

Advanced Search

Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons (2024)
Journal Article
Bridge, L., Chen, S., & Jones, B. (2024). Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons. Cellular Signalling, Article 111153. https://doi.org/10.1016/j.cellsig.2024.111153

The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) which plays important physiological roles in insulin release and promoting fullness. GLP-1R agonists initiate cellular responses by cyclic AMP (cAMP) pathway... Read More about Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons.

In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy (2024)
Journal Article
Manohar, P., Loh, B., Turner, D., Tamizhselvi, R., Mathankumar, M., Elangovan, N., …Leptihn, S. (2024). In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy. Frontiers in Microbiology, 15, Article 1344962. https://doi.org/10.3389/fmicb.2024.1344962

Infections caused by Pseudomonas aeruginosa are becoming increasingly difficult to treat due to the emergence of strains that have acquired multidrug resistance. Therefore, phage therapy has gained attention as an alternative to the treatment of pseu... Read More about In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy.

Determination of the relative sensitivity of polyaniline inks and films to deprotonation by ammonia using UV–Vis spectroscopy (2023)
Journal Article
Udum, Y. A., Killard, A. J., & Wagner, M. (2024). Determination of the relative sensitivity of polyaniline inks and films to deprotonation by ammonia using UV–Vis spectroscopy. European Polymer Journal, 205, Article 112709. https://doi.org/10.1016/j.eurpolymj.2023.112709

The deprotonation behavior of conducting polymers such as polyaniline (PANI) is an important functional parameter in the design of novel printed electronic devices, particularly for sensors and energy storage. PANI can be fabricated into films from p... Read More about Determination of the relative sensitivity of polyaniline inks and films to deprotonation by ammonia using UV–Vis spectroscopy.

Bacteriophage taxonomy: A continually evolving discipline (2023)
Book Chapter
Adriaenssens, E. M., Turner, D., Lehman, S. M., Adriaenssens, E. M., Lehman, S. M., Kropinski, A. M., …Kropinski, A. M. (2023). Bacteriophage taxonomy: A continually evolving discipline. In J. Azeredo, & S. Sillankorva (Eds.), In Bacteriophage Therapy: From Lab to Clinical Practice (27-45). Humana Press. https://doi.org/10.1007/978-1-0716-3523-0_3

While taxonomy is an often underappreciated branch of science, it serves very important roles. Bacteriophage taxonomy has evolved from a discipline based mainly on morphology, characterized by the work of David Bradley and Hans-Wolfgang Ackermann, to... Read More about Bacteriophage taxonomy: A continually evolving discipline.

Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells (2023)
Journal Article
Robson, J. L., Thorn, R. M. S., Williams, A. C., Collard, T. J., & Qualtrough, D. (2023). Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells. Scientific Reports, 13(1), Article 17291. https://doi.org/10.1038/s41598-023-44130-6

Colorectal cancer (CRC) is a significant global health burden with a rising incidence worldwide. Distinct bacterial populations are associated with CRC development and progression, and it is thought that the relationship between CRC and associated gu... Read More about Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells.

Diversity and inclusion: Creating a culture of equity in the biosciences (2023)
Presentation / Conference
Adukwu, E. (2023, September). Diversity and inclusion: Creating a culture of equity in the biosciences. Presented at Bioscience Education Summit 2023, University of Liverpool, Liverpool, UK

Abstract: Globally, science remains exclusive and inequalities continue for minoritised communities in the UK, US and across the world. Access to learning resources, quality of learning experiences and graduate outcomes continues to impact minoritise... Read More about Diversity and inclusion: Creating a culture of equity in the biosciences.

A non-faradaic impedimetric biosensor for monitoring of caspase 9 in mammalian cell culture (2023)
Journal Article
Chen, B., Kiely, J., Luxton, R., & Williams, I. (2023). A non-faradaic impedimetric biosensor for monitoring of caspase 9 in mammalian cell culture. Bioelectrochemistry, 153, Article 108456. https://doi.org/10.1016/j.bioelechem.2023.108456

Lower yields and poorer quality of biopharmaceutical products result from cell death in bioreactors. Such cell death is commonly associated with programmed cell death or apoptosis. During apoptosis, caspases are activated and cause a cascade of event... Read More about A non-faradaic impedimetric biosensor for monitoring of caspase 9 in mammalian cell culture.

NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model (2023)
Journal Article
Grätz, L., Sajkowska-Kozielewicz, J. J., Wesslowski, J., Kinsolving, J., Bridge, L. J., Petzold, K., …Kozielewicz, P. (in press). NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model. British Journal of Pharmacology, https://doi.org/10.1111/bph.16090

Background and Purpose: Wnt binding to Frizzleds (FZD) is a crucial step that leads to the initiation of signalling cascades governing multiple processes during embryonic development, stem cell regulation and adult tissue homeostasis. Recent efforts... Read More about NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model.

Slow Violence (2023)
Book
Fahy, N., & Clayton, G. (2023). Slow Violence. UWE, Bristol, UK: Impact Press

This publication details research conversation between researchers Niamh Fahy and Dr. Gillian Clayton which took place in December 2022 Gillian and Niamh have been collaborating on a project at Honeygar farm in Somerset,UK, from which Niamh is using... Read More about Slow Violence.

Workshop on viral genomics and taxonomy (2022)
Presentation / Conference
Turner, D., Adriaenssens, E. M., & Kropinski, A. M. (2022, June). Workshop on viral genomics and taxonomy. Presented at Viruses of Microbes 2022, Guimaraes, Portugal

How many of us have isolated and sequenced a phage, gotten reads back from the sequencing facility and thought "What now?" How can I assemble the data, and should I use an automated pipeline (DFAST, RASTtk, PHANOTATE) to annotate the genome, or shall... Read More about Workshop on viral genomics and taxonomy.

The in situ production of aquatic fluorescent organic matter in a simulated freshwater laboratory model (2022)
Journal Article
Perrin, E. M., Thorn, R. M., Sargeant, S. L., Attridge, J. W., & Reynolds, D. M. (2022). The in situ production of aquatic fluorescent organic matter in a simulated freshwater laboratory model. Frontiers in Microbiology, 13, Article 817976. https://doi.org/10.3389/fmicb.2022.817976

Dissolved organic matter (DOM) is ubiquitous throughout aquatic systems. Fluorescence techniques can be used to characterize the fluorescing proportion of DOM, aquatic fluorescent organic matter (AFOM). AFOM is conventionally named in association wit... Read More about The in situ production of aquatic fluorescent organic matter in a simulated freshwater laboratory model.

Herbal teas and their health benefits: A scoping review (2019)
Presentation / Conference
Poswal, F., Russell, G., Mackonochie, M., MacLennan, E., Adukwu, E., & Rolfe, V. (2019, April). Herbal teas and their health benefits: A scoping review. Poster presented at UWE Bristol Student Conference, Exhibition & Conference Centre, UWE Bristol

The effect of Chlorhexidine on bacterial strains (2019)
Presentation / Conference
Rashid, H., & Adukwu, E. (2019, April). The effect of Chlorhexidine on bacterial strains. Poster presented at UWE Bristol Student Conference, Conference Centre

An evaluation of faecal transport swabs using the swab elution method in accordance with approved standard CLSI M40-A2 (2017)
Presentation / Conference
Elcocks, E., Spencer-Phillips, P., & Adukwu, E. (2017, April). An evaluation of faecal transport swabs using the swab elution method in accordance with approved standard CLSI M40-A2. Poster presented at Scientific Spring Meeting KNVM & NVMM 2017, Papendal, Netherlands

Introduction Efficient absorption, transportation and release of specimens from faecal transport swabs are characteristics that commercial swabs must possess to be compliant with the M40-A2 criteria. The aim of this study was to evaluate and compare... Read More about An evaluation of faecal transport swabs using the swab elution method in accordance with approved standard CLSI M40-A2.