Janice Kiely's Outputs (54)

WATER'S SILENT HORMONE MONITORING: A novel electrochemical sensor for on-site detection of estradiol in water (2023)
Presentation / Conference Contribution

The supply of safe drinking water is paramount for the health and well-being of people across the globe. Environmental pollutants such as estradiol (E2) threaten water supplies. Estradiol contamination of water sources is a growing global concern tha... Read More about WATER'S SILENT HORMONE MONITORING: A novel electrochemical sensor for on-site detection of estradiol in water.

Graphene-based electrodes for monitoring of Estradiol (2023)
Journal Article

This study explores the potential use of graphene-based electrodes in the electrochemical determination of estradiol using amperometric techniques as a simple, enzyme-free approach. Graphene, a carbon-based nanomaterial, has been extensively investig... Read More about Graphene-based electrodes for monitoring of Estradiol.

Rapid detection of tetracycline residues at clinically relevant levels via a novel, inexpensive and analytically-sensitive magneto-immunoassay – A feasibility study (2023)
Journal Article

Expensive, time-consuming and labour-intensive solvent-extraction and liquid-chromatography methods are the industry's current gold standard for antibiotic residue quantification. A novel immunoassay methodology and system for the rapid detection of... Read More about Rapid detection of tetracycline residues at clinically relevant levels via a novel, inexpensive and analytically-sensitive magneto-immunoassay – A feasibility study.

A non-faradaic impedimetric biosensor for monitoring of caspase 9 in mammalian cell culture (2023)
Journal Article

Lower yields and poorer quality of biopharmaceutical products result from cell death in bioreactors. Such cell death is commonly associated with programmed cell death or apoptosis. During apoptosis, caspases are activated and cause a cascade of event... Read More about A non-faradaic impedimetric biosensor for monitoring of caspase 9 in mammalian cell culture.

An electrochemical screen-printed sensor based on gold-nanoparticle-decorated reduced graphene oxide–carbon nanotubes composites for the determination of 17-β estradiol (2023)
Journal Article

In this study, a screen-printed electrode (SPE) modified with gold-nanoparticle-decorated reduced graphene oxide–carbon nanotubes (rGO-AuNPs/CNT/SPE) was used for the determination of estradiol (E2). The AuNPs were produced through an eco-friendly me... Read More about An electrochemical screen-printed sensor based on gold-nanoparticle-decorated reduced graphene oxide–carbon nanotubes composites for the determination of 17-β estradiol.

Metal oxide decorated carbon nanocomposite electrodes for propofol monitoring (2022)
Journal Article

Despite the growing evidence of the benefits of total-intravenous anaesthesia using propofol compared to conventional volatile-based anaesthesia, both in terms of environmental impact and patient outcomes, the majority of administered general anaesth... Read More about Metal oxide decorated carbon nanocomposite electrodes for propofol monitoring.

Modeling peptide nucleic acid binding enthalpies using MM-GBSA (2022)
Journal Article

The binding enthalpies of peptide nucleic acid (PNA) homoduplexes were predicted using a molecular mechanics generalized Born surface area approach. Using the nucleic acid nearest-neighbor model, these were decomposed into sequence parameters which c... Read More about Modeling peptide nucleic acid binding enthalpies using MM-GBSA.

Modelling a dynamic magneto-agglutination bioassay (2022)
Journal Article

The process of developing an end-to-end model of a magneto-immunoassay is described, simulating the agglutination effect due to the specific binding of bacteria to paramagnetic particles. After establishing the properties of the dose-specific aggluti... Read More about Modelling a dynamic magneto-agglutination bioassay.

Equivalent circuit model of a non-faradaic impedimetric ZnO nano-crystal biosensor (2022)
Journal Article

This paper describes the development of an equivalent electrical circuit (EEC) model of a unique co-planar electrode PET-ZnO biosensor platform. This non-faradaic ZnO biosensor had a PET insulating layer between the electrodes and the active ZnO sens... Read More about Equivalent circuit model of a non-faradaic impedimetric ZnO nano-crystal biosensor.

Passive impedance sensing using a SAW resonator-coupled biosensor for zero-power wearable applications (2021)
Journal Article

A bio-sensing scheme, which acquires impedance information of a capacitive biosensor by using the reflected RF signal from a surface acoustic wave (SAW) resonator connected to the biosensor, is proposed. This technique requires no power to be supplie... Read More about Passive impedance sensing using a SAW resonator-coupled biosensor for zero-power wearable applications.

Cytochrome P450 2B6 amperometric biosensor for continuous monitoring of propofol (2021)
Journal Article

Despite the growing evidence of improved patient outcomes and of a substantially reduced environmental impact of propofol-based total intravenous anesthesia when compared to volatile-based techniques, the vast majority of general anesthetics still us... Read More about Cytochrome P450 2B6 amperometric biosensor for continuous monitoring of propofol.

Propofol detection for monitoring of intravenous anaesthesia: A review (2021)
Journal Article

This paper presents a review of established and emerging methods for detecting and quantifying the intravenous anaesthetic propofol in solution. There is growing evidence of numerous advantages of total intravenous anaesthesia using propofol compared... Read More about Propofol detection for monitoring of intravenous anaesthesia: A review.

Low-power contactless physiological sensor (2021)
Patent

A system-on-chip contactless physiological sensor (10) is provided which comprises a capacitive-sensor electrode (14) having a first capacitance (C1) and an amplifier device (18) connected to the capacitive-sensor electrode (14), the capacitive-senso... Read More about Low-power contactless physiological sensor.

Recent progress in screen-printed electrochemical sensors and biosensors for the detection of estrogens (2021)
Journal Article

Estrogens have become increasingly prevalent in environmental samples across the world, posing a serious threat to human health. They have received considerable public attention due to their harmful effect on the normal endocrine functions of humans... Read More about Recent progress in screen-printed electrochemical sensors and biosensors for the detection of estrogens.

Classification of the mechanism of toxicity as applied to human cell line ECV304 (2020)
Journal Article

© 2020 Informa UK Limited, trading as Taylor & Francis Group. The objective of this study was to identify the pattern of cytotoxicity testing of the human cell line ECV304 using three techniques of an ensemble learning algorithm (bagging, boosting... Read More about Classification of the mechanism of toxicity as applied to human cell line ECV304.

Algorithms for U-model-based dynamic inversion (UM-dynamic inversion) for continuous time control systems (2020)
Journal Article

To setup a universal proper user toolbox from previous individual research publications, this study generalises the algorithms for the U-model dynamic inversion based on the realisation of U-model from polynomial and state-space described continuous-... Read More about Algorithms for U-model-based dynamic inversion (UM-dynamic inversion) for continuous time control systems.

Nanoparticle-based 3D membrane for impedimetric biosensor applications (2020)
Journal Article

This paper reports on a comparison between nano-ZnO/CuO and nano-ZnO nitrocellulose membrane biosensors, both of which were fabricated using a simple and inexpensive sonication technique. To produce the nano-ZnO/CuO membranes, the technique involved... Read More about Nanoparticle-based 3D membrane for impedimetric biosensor applications.

Sensor (2020)
Patent

The present invention relates to detecting viral infections in plants, especially Cacao swollen-shoot virus (CSSV) infections. Recombinant viral coat protein antigens and binding reagents that specifically bind to thereto are provided together with a... Read More about Sensor.

A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing (2020)
Journal Article

© 2019 We report on a novel impedance spectroscopy measurement and data analysis technique for cytotoxicity testing. The technique combines non-contact measurement with real-time impedance data analysis based on the toxin dose dependency of the outpu... Read More about A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing.

Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection (2019)
Journal Article

© 2019 The resonant coil magnetometer quantifies paramagnetic particles (PMPs) and has been used to develop magneto-immunoassays in a range of formats. The advantage of magneto-immunoassays is that they are relatively inexpensive, portable, easy to p... Read More about Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection.

Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films (2019)
Patent

The invention relates to the field of sensors for detecting volatile compounds. The sensor of the present invention for detecting volatile compounds comprises: a film of metal oxide; a heater configured to provide heat energy to the film of metal oxi... Read More about Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films.

CSSV biosensor (WO2020089607-PAMPH-20200507-8395) (2019)
Patent

The present invention relates to detecting viral infections in plants, especially Cacao swollen-shoot virus (CSSV) infections. Recombinant viral coat protein antigens and binding reagents that specifically bind to thereto are provided together with a... Read More about CSSV biosensor (WO2020089607-PAMPH-20200507-8395).

C3bio Poster AM KH RL JK 2019 (2019)
Presentation / Conference Contribution

Bioinspired materials have emerged as alternatives to antibodies and enzymes in biosensor for environmental monitoring These are tailored made in order to mimics the molecular function of a natural receptors in
biosensor Aptamers and Molecularly imp... Read More about C3bio Poster AM KH RL JK 2019.

A copper oxide/zinc oxide composite nano-surface for use in a biosensor (2019)
Journal Article

© 2019 by the authors. In this study, biosensors based on zinc oxide-copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 a... Read More about A copper oxide/zinc oxide composite nano-surface for use in a biosensor.

Charge-based supercapacitor storage estimation for indoor sub-mW photovoltaic energy harvesting powered wireless sensor nodes (2019)
Journal Article

Supercapacitors offer an attractive energy storage solution for lifetime “fit and forget” photovoltaic (PV) energy harvesting powered wireless sensor nodes for internet of things (IoT) applications. Whilst their low storage capacity is not an issue f... Read More about Charge-based supercapacitor storage estimation for indoor sub-mW photovoltaic energy harvesting powered wireless sensor nodes.

The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges (2019)
Journal Article

© 2019 In this paper we present a non-contact, impedance-based sensor system capable of characterizing the toxic response of cells to three different types of toxin. ECV304 cells were treated with 1 mM Hydrogen peroxide, 5% Dimethyl Sulfoxide, and 10... Read More about The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges.

Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection (2018)
Journal Article

© 2018, The Author(s). The paper reports a biosensor formed from antibody coated ZnO nano-crystals which has been prepared using a rapid and inexpensive fabrication method which utilises colloidal dispersion enhanced using sonication. This technique... Read More about Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection.

Mathematical modelling of a magnetic immunoassay (2017)
Journal Article

© The authors 2017. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved. A mathematical model is developed to describe the action of a novel form of fluidic biosensor that uses para... Read More about Mathematical modelling of a magnetic immunoassay.

Particle facilitate testing (2017)
Patent

Magnetic particles are distributed across a fluid flow by applied magnetic field to interact with a test substance in fluid. Alternatively or additionally, particles, which may be magnetic, are combined with cells and energy, eg ultrasonic energy, is... Read More about Particle facilitate testing.

Enhanced output voltage generation via ZnO nanowires (50nm): Effect of diameter thinning on voltage enhancement (2017)
Journal Article

© 2017 Elsevier Ltd 50nm ZnO nanowires were grown on indium tin oxide (ITO) coated poly ethylene terephthalate (PET) substrates by adapting facile aqueous growth technique using low temperature and vacuum conditions. Prior to growth of ZnO nanowires,... Read More about Enhanced output voltage generation via ZnO nanowires (50nm): Effect of diameter thinning on voltage enhancement.

Facile aqueous growth of 150 nm ZnO nanowires for energy harvester: Enhanced output voltage using Pt sputtered electrode (2015)
Journal Article

© 2015. Facile aqueous growth technique was adopted to grow diameter controlled 150 nm ZnO nanowires on an ITO (indium tin oxide) coated PET (poly ethylene terephthalate) substrate. Prior to nanowire growth, a pure wurtazite structured ZnO seed layer... Read More about Facile aqueous growth of 150 nm ZnO nanowires for energy harvester: Enhanced output voltage using Pt sputtered electrode.

A new procedure for analysis and modelling of male urine flow rate (2015)
Presentation / Conference Contribution

In the first stage studies, this paper proposes a new piecewise linear discrete time dynamic model for describing global urine flow rate profiles against time sequence. The establishment of model has been guided by physician meaningful principles and... Read More about A new procedure for analysis and modelling of male urine flow rate.

Low temperature hydrothermal synthesis of ZnO nanowires for nanogenerator: Effect of gold electrode on the output voltage of nanogenerator (2014)
Journal Article

A low temperature hydrothermal technique is developed to grow ZnO (diameter 100 nm) nanowires for high output nanogenerator. Vertically aligned ZnO nanowires are grown on indium tin oxide (ITO) coated poly ethylene terephthalate (PET) substrate. Morp... Read More about Low temperature hydrothermal synthesis of ZnO nanowires for nanogenerator: Effect of gold electrode on the output voltage of nanogenerator.

Lock-in amplifier as a sensitive instrument for biomedical measurement: Analysis and implementation (2014)
Journal Article

A measuring instrument plays important role in the biomedical measurement since the biological process in living organism generates very weak signal. Therefore, a reliable and sensitive measuring instrument is needed. In this study, a lock-in amplifi... Read More about Lock-in amplifier as a sensitive instrument for biomedical measurement: Analysis and implementation.

An inexpensive, fast and sensitive quantitative lateral flow magneto-immunoassay for total prostate specific antigen (2014)
Journal Article

We describe the detection characteristics of a device the Resonant Coil Magnetometer (RCM) to quantify paramagnetic particles (PMPs) in immunochromatographic (lateral flow) assays. Lateral flow assays were developed using PMPs for the measurement of... Read More about An inexpensive, fast and sensitive quantitative lateral flow magneto-immunoassay for total prostate specific antigen.

The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins (2013)
Journal Article

A novel, integrated lysis and immunoassay methodology and system for intracellular protein measurement are described. The method uses paramagnetic particles both as a lysis agent and assay label resulting in a rapid test requiring minimal operator in... Read More about The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins.

Novel immunoassay technique for rapid measurement of intracellular proteins using paramagnetic particles (2013)
Journal Article

Magnetic immunoassays have been shown to have similar detection limits to conventional immunoassays, with the advantage of reduced total assay time. The aim of this study was to demonstrate that an integrated lysis and measurement system could be use... Read More about Novel immunoassay technique for rapid measurement of intracellular proteins using paramagnetic particles.

Robust feature extraction from impedimetric signals using wavelet packet decomposition with application to cytotoxicity testing (2012)
Journal Article

Impedance-based cytotoxicity testing provides a simple, real-time and non-invasive assay technique that interferes minimally with cell morphology and function. In this study, impedimetric measurements of ECV304 cells with increasing concentrations of... Read More about Robust feature extraction from impedimetric signals using wavelet packet decomposition with application to cytotoxicity testing.

Comparison of cytotoxic changes in ECV304 cell through exposure to DMSO and sodium butyrate using impedance spectroscopy (2012)
Journal Article

This paper decides an impedance spectroscopy measurement system for real-time monitoring of cellular toxicity. The system is used to compare the impedance response of ECV304 cells to two toxicants, dimethyl sulphoxide (DMSO) and sodium butyrate. The... Read More about Comparison of cytotoxic changes in ECV304 cell through exposure to DMSO and sodium butyrate using impedance spectroscopy.

Magnetic particle detector system (2010)
Patent

A magnetic particle detector system comprises a plurality of reaction surfaces; a corresponding plurality of electrical coils, each located adjacent a respective reaction surface; and a measuring system for measuring the effect of magnetic particles... Read More about Magnetic particle detector system.

Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay (2009)
Journal Article

This paper describes work that formed a part of an investigation to increase the detection sensitivity of a magneto-immunoassay. The study involved the characterisation of paramagnetic particles (PMPs) from a range of manufacturers in order to determ... Read More about Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay.

Spot test: new technologies bring point-of-care testing into the 21st century (2009)
Journal Article

Every new technology offers the potential to effect changes in practise; many developments driven by the world-wide demand for instant results. This is never as true as in the arena of diagnostic testing. Once the sole preserve of the hospital labo... Read More about Spot test: new technologies bring point-of-care testing into the 21st century.

Spot test (2009)
Other

Particle facilitated testing (2008)
Patent

Impedimetric discrimination of cell types for use in a whole cell biosensor (2008)
Presentation / Conference Contribution

Paramagnetic particle detection for use with an immunoassay based biosensor (2007)
Journal Article

A biosensor and detection system that can provide measurement of analyte concentration within a test sample in four minutes is presented. The biosensor uses an immunoassay with micrometre-sized paramagnetic particle (PMP) labels for quantification. A... Read More about Paramagnetic particle detection for use with an immunoassay based biosensor.

Thickness determination of thin and ultra-thin SiO 2 films by C-AFM IV-spectroscopy (2006)
Journal Article

Conductive atomic force microscopy was used to determine the electrical oxide thickness for five different silicon dioxide layers with thickness in the order of 1.6-5.04 nm. The electrical thickness results were compared with values determined by ell... Read More about Thickness determination of thin and ultra-thin SiO 2 films by C-AFM IV-spectroscopy.

Simplified tunnelling current calculation for MOS structures with ultra-thin oxides for conductive atomic force microscopy investigations (2005)
Journal Article

As charge tunnelling through thin and ultra-thin silicon dioxide layers is regarded as the driving force for MOS device degradation the determination and characterisation of electrically week spots is of paramount importance for device reliability an... Read More about Simplified tunnelling current calculation for MOS structures with ultra-thin oxides for conductive atomic force microscopy investigations.

Use of External Magnetic Fields to Reduce Reaction Times in an Immunoassay Using Micrometer-Sized Paramagnetic Particles as Labels (Magnetoimmunoassay) (2004)
Journal Article

The paper presents a rapid immunoassay system capable of quantifying analyte in complex biological and environmental media. Antibody-coated micrometer-sized paramagnetic particles are used as labels in an assay in which they bind quantitatively with... Read More about Use of External Magnetic Fields to Reduce Reaction Times in an Immunoassay Using Micrometer-Sized Paramagnetic Particles as Labels (Magnetoimmunoassay).

Magnetic field characteristics of a magneto-biosensor detection coil
Presentation / Conference Contribution

This study describes numerical modelling of a magneto-biosensor detection coil using a Boundary Element Method (BEM). The Z and X axis magnetic profiles of the coil have been analysed. The model was extended to incorporate paramagnetic particles to e... Read More about Magnetic field characteristics of a magneto-biosensor detection coil.

Non-linear data analysis of impedance spectroscopy as applied to cellular toxicity systems
Presentation / Conference Contribution

This paper introduces an impedance measurement system that can be performed non-destructively to detect cellular toxicity with a cell culture system. This study examines
ECV304 cells grown in culture well and exposed to toxicant
dimethyl sulphoxide... Read More about Non-linear data analysis of impedance spectroscopy as applied to cellular toxicity systems.

Hilbert huang transform impedance measurement data for cellular toxicity monitoring
Presentation / Conference Contribution

This paper investigates the Hilbert-Huang transformation (HHT), which is adaptive analysis of nonlinear and non-stationary signals. The aim of this study is to apply HHT to impedance measurement data analysis in order to discriminate different types... Read More about Hilbert huang transform impedance measurement data for cellular toxicity monitoring.

SAW based passively bioimpedance sensing for zero-power wearable applications of biosensors
Presentation / Conference Contribution

A novel passive bio-sensing method, which electrically connects a conventional biosensor to a surface acoustic wave (SAW) device, is proposed for passively sensing bio-impedance for zero-power wearable applications. The biosensor attached to the SAW... Read More about SAW based passively bioimpedance sensing for zero-power wearable applications of biosensors.

Speed settling of AC-coupled amplifier for active contactless ECG electrode
Presentation / Conference Contribution

Contactless electrodes have the ability of long- term wearable physiological recording to meet the massive data requirements in digital health. Active electrodes have been used to avoid noise induced by the high-impedance contactless electrodes for b... Read More about Speed settling of AC-coupled amplifier for active contactless ECG electrode.