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Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay

Eveness, John; Kiely, Janice; Hawkins, Peter; Wraith, Patrick; Luxton, Richard

Authors

John Eveness John.Eveness@uwe.ac.uk
Research Fellow in Sensory Technology

Janice Kiely Janice.Kiely@uwe.ac.uk
Professor in Bio-electronics/Res In CoDi

Peter Hawkins

Patrick Wraith

Richard Luxton Richard.Luxton@uwe.ac.uk
Research Centre Director-IBST/Professor



Abstract

This paper describes work that formed a part of an investigation to increase the detection sensitivity of a magneto-immunoassay. The study involved the characterisation of paramagnetic particles (PMPs) from a range of manufacturers in order to determine parameters that influence the assay sensitivity. Magnetisation curves were produced for each PMP type using a vibrating sample magnetometer. A resonant coil magnetometer which incorporated of a planar, spiral coil integrated with a phase locked loop based detector was used to investigate the effect of PMP number and mass on the resonant frequency of the coil. In order to compare performance in an assay using a resonant coil magnetometer, the sensitivity for a monolayer of particles was evaluated. The results enabled the identification of parameters that were critical for achieving maximum sensitivity and, of the particles studied, the 0.75 μm diameter PMPs demonstrated the greatest sensitivity in the resonant coil magnetometer. © 2009 Elsevier B.V. All rights reserved.

Citation

Eveness, J., Kiely, J., Hawkins, P., Wraith, P., & Luxton, R. (2009). Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay. Sensors and Actuators B: Chemical, 139(2), 538-542. https://doi.org/10.1016/j.snb.2009.03.078

Journal Article Type Article
Publication Date Jun 4, 2009
Journal Sensors and Actuators, B: Chemical
Print ISSN 0925-4005
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 139
Issue 2
Pages 538-542
DOI https://doi.org/10.1016/j.snb.2009.03.078
Keywords magneto-immunoassay; paramagnetic particles; resonant coil magnetometer.
Public URL https://uwe-repository.worktribe.com/output/995236
Publisher URL http://dx.doi.org/10.1016/j.snb.2009.03.078

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