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Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects (2021)
Thesis
Ude, A. Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6971684

Advances in modern chemotherapeutic regimens have led to an increase in the overall survival of leukaemia patients in recent years. However, haematopoietic stem cell transplantation (HSCT) remains the curative option for these patients. In HSCT, high... Read More about Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects.

CDC2‑like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer (2021)
Journal Article
Uzor, S., Oltean, S., Ladomery, M., Alqasem, A., Perks, C., Wilson, I., …Iida, K. (2021). CDC2‑like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer. Scientific Reports, 11, https://doi.org/10.1038/s41598-021-86908-6

Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and o... Read More about CDC2‑like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer.

5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis (2021)
Journal Article
Dixon, S. W., Collard, T. J., Mortensson, E. M., Legge, D. N., Chambers, A. C., Greenhough, A., …Williams, A. C. (in press). 5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis. British Journal of Cancer, https://doi.org/10.1038/s41416-021-01354-5

Background: Most colorectal cancers (CRC) arise sporadically from precursor lesions: colonic polyps. Polyp resection prevents progression to CRC. Risk of future polyps is proportional to the number and size of polyps detected at screening, allowing i... Read More about 5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis.

Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases (2021)
Journal Article
Russell, G., Nenov, A., & Hancock, J. (in press). Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases. European Medical Journal,

Oxy-hydrogen gas (HHO) is a gaseous mixture of molecular hydrogen (H2) and molecular oxygen (O2) that is generated by the electrolysis of water and delivered in a 2:1 ratio (66% and 33%, respectively) through the use of non-invasive inhalation device... Read More about Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases.

Interacting proteins, polymorphisms and the susceptibility of animals to SARS-CoV-2 (2021)
Journal Article
Hancock, J., Rouse, R., Stone, E., & Greenhough, A. (2021). Interacting proteins, polymorphisms and the susceptibility of animals to SARS-CoV-2. Animals, 11(3), https://doi.org/10.3390/ani11030797

Abstract: COVID-19, caused by SARS-CoV-2, is a world-wide problem for the human population. It is known that some animal species, such as mink, can become infected and transmit the virus. However, the susceptibility of most animals is not known. Here... Read More about Interacting proteins, polymorphisms and the susceptibility of animals to SARS-CoV-2.

Epigenenetic regulation of alternative splicing: how lncRNAs tailor the message (2021)
Journal Article
Pisignano, G., & Ladomery, M. (2021). Epigenenetic regulation of alternative splicing: how lncRNAs tailor the message. Non-Coding RNA, 7(1), https://doi.org/10.3390/ncrna7010021

Alternative splicing is a highly fine-tuned regulated process and one of the main drivers of proteomic diversity across eukaryotes. The vast majority of human multi-exon genes is alternatively spliced in a cell type-and tissue-specific manner, and de... Read More about Epigenenetic regulation of alternative splicing: how lncRNAs tailor the message.

Downstream signalling from molecular hydrogen (2021)
Journal Article
Hancock, J., & Russell, G. (2021). Downstream signalling from molecular hydrogen. Plants, 10(2), https://doi.org/10.3390/+plants10020367

Molecular hydrogen (H2) is now considered to be a part of the suite of small molecules which can control cellular activity. As such it has been suggested to be used in the therapy of diseases in humans but also to be used in plant science, to enhance... Read More about Downstream signalling from molecular hydrogen.

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer (2020)
Journal Article
Nounu, A., Greenhough, A., Heesom, K. J., Richmond, R. C., Zheng, J., Weinstein, S. J., …Relton, C. L. (2021). A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer. Cancer Epidemiology, Biomarkers and Prevention, 30(3), 564-575. https://doi.org/10.1158/1055-9965.EPI-20-1176

Background: Evidence for aspirin’s chemopreventative properties on colorectal cancer (CRC) is substantial, but its mechanism of action is not well-understood. We combined a proteomic approach with Mendelian randomization (MR) to identify possible new... Read More about A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer.

Novel method for the measurement of erythrocyte acetylcholinesterase activity in the Yt blood group system using amperometry in conjunction with screen-printed carbon electrodes (2020)
Journal Article
Crew, A., Karamatic Crew, V., Bagelow, L., Walser, P., Thornton, N., & Hart, J. (2020). Novel method for the measurement of erythrocyte acetylcholinesterase activity in the Yt blood group system using amperometry in conjunction with screen-printed carbon electrodes. Vox Sanguinis, 115(S1), 271-271. https://doi.org/10.1111/vox.13031

Background: The five antigens of the Yt blood group system are located on the membrane GPI‐linked erythrocyte acetylcholinesterase (AChE‐E), which is implicated in a range of clinical issues, including sleep apnoea and neurotoxin poisoning. Conformat... Read More about Novel method for the measurement of erythrocyte acetylcholinesterase activity in the Yt blood group system using amperometry in conjunction with screen-printed carbon electrodes.

Investigation of the antifungal and anti-aflatoxigenic potential of plant-based essential oils against aspergillus flavus in peanuts (2020)
Journal Article
Sreenivasa, M. Y., Nagaraja, H., Quyen, P., Sharma, A., Msimanga, H. Z., Achar, P. N., & Adukwu, E. C. (2020). Investigation of the antifungal and anti-aflatoxigenic potential of plant-based essential oils against aspergillus flavus in peanuts. Journal of Fungi, 6(4), https://doi.org/10.3390/jof6040383

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Aspergillus species are known to cause damage to food crops and are associated with opportunistic infections in humans. In the United States, significant losses have been reported in peanut pr... Read More about Investigation of the antifungal and anti-aflatoxigenic potential of plant-based essential oils against aspergillus flavus in peanuts.

Biofilm management; Investigating the inhibitory effects of chlorine-based disinfectants on biofilms (2020)
Conference Proceeding
Clayton, G., Thorn, R., & Reynolds, D. (in press). Biofilm management; Investigating the inhibitory effects of chlorine-based disinfectants on biofilms

Summary of key findings Direct disinfection of established Pseudomonas aeruginosa biofilms by electrochemically activated solutions [ECAS] exhibited significantly greater anti-biofilm activity compared to NaOCl and HOCl at free chlorine concentratio... Read More about Biofilm management; Investigating the inhibitory effects of chlorine-based disinfectants on biofilms.

Studies towards the development of a novel, screen-printed carbon-based, biosensor for the measurement of polyunsaturated fatty acids (2020)
Journal Article
Smart, A., Hart, J., Crew, A., & Doran, O. (2020). Studies towards the development of a novel, screen-printed carbon-based, biosensor for the measurement of polyunsaturated fatty acids. Applied Sciences, 10(21), 1-13. https://doi.org/10.3390/app10217779

This paper describes the design, development and characterisation of an electrochemical biosensor for the measurement of linoleic and α-linolenic acid, as representative free polyunsaturated fatty acids (PUFAs), that may be implicated in food safety... Read More about Studies towards the development of a novel, screen-printed carbon-based, biosensor for the measurement of polyunsaturated fatty acids.

The effects of seed priming with sodium hydrosulphide on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth (2020)
Journal Article
Ocvirk, D., Špoljarević, M., Kristić, M., Hancock, J. T., Teklić, T., & Lisjak, M. (2021). The effects of seed priming with sodium hydrosulphide on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth. Annals of Applied Biology, 178(2), 400-413. https://doi.org/10.1111/aab.12658

© 2020 Association of Applied Biologists Sunflower seeds (hybrid Luka) were primed with water (hydropriming) or sodium hydrosulphide (NaHS) solutions (0.1, 0.5, 1.0 and 1.5 mM NaHS) and subsequently dried to initial moisture content. Unprimed (contro... Read More about The effects of seed priming with sodium hydrosulphide on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth.

Laboratory evaluation of the Sigma Transwab® transport system for the recovery of Candida species using the Clinical and Laboratory Standards Institute (CLSI) document M40-A2 (2020)
Journal Article
Adukwu, E., & Elcocks, E. (2021). Laboratory evaluation of the Sigma Transwab® transport system for the recovery of Candida species using the Clinical and Laboratory Standards Institute (CLSI) document M40-A2. European Journal of Clinical Microbiology and Infectious Diseases, 40, 735-738. https://doi.org/10.1007/s10096-020-04062-9

Rising healthcare complications due to fungal infections increase the importance of efficient specimen collection and maintenance systems for correct identification and diagnosis. The CLSI M40-A2 protocol provides guidelines for laboratories assessin... Read More about Laboratory evaluation of the Sigma Transwab® transport system for the recovery of Candida species using the Clinical and Laboratory Standards Institute (CLSI) document M40-A2.

WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1 (2020)
Journal Article
Belali, T., Wodi, C., Clark, B., Cheung, M. K., Craig, T. J., Wheway, G., …Ladomery, M. (2020). WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1. BBA - Gene Regulatory Mechanisms, 1863(12), https://doi.org/10.1016/j.bbagrm.2020.194642

Dysregulated alternative splicing plays a prominent role in all hallmarks of cancer. The splice factor kinase SRPK1 drives the activity of oncogenic splice factors such as SRSF1. SRSF1 in turn promotes the expression of splice isoforms that favour tu... Read More about WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1.

From orphan phage to a proposed new family–the diversity of N4-like viruses (2020)
Journal Article
Wittmann, J., Turner, D., Millard, A., Mahadevan, P., Kropinski, A., & Adriaenssens, E. (2020). From orphan phage to a proposed new family–the diversity of N4-like viruses. Antibiotics, 9(10), 663. https://doi.org/10.3390/antibiotics9100663

Escherichia phage N4 was isolated in 1966 in Italy and has remained a genomic orphan for a long time. It encodes an extremely large virion-associated RNA polymerase unique for bacterial viruses that became characteristic for this group. In recent yea... Read More about From orphan phage to a proposed new family–the diversity of N4-like viruses.

The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades (2020)
Thesis
Shafei, M. The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/3429539

Introduction and Aims: Breast cancer remains the leading cause of cancer mortality in women globally, despite advances in the development of targeted therapies. Driven by oncogenic signals, cancer cells undergo metabolic reprogramming, upregulatin... Read More about The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades.

Hydrogen sulfide in horticulture: Emerging roles in the era of climate change (2020)
Journal Article
Hancock, J. T., Zulfiqar, F., & Hancock, J. (2020). Hydrogen sulfide in horticulture: Emerging roles in the era of climate change. Plant Physiology and Biochemistry, 155, 667-675. https://doi.org/10.1016/j.plaphy.2020.08.010

Future climate change will present many plants with environmental challenges, including extreme temperatures and drought. Hydrogen sulfide (H2S) has emerged as an important signal transmitting molecule in plants, especially important in many stress r... Read More about Hydrogen sulfide in horticulture: Emerging roles in the era of climate change.