Skip to main content

Research Repository

See what's under the surface

Browse


Leukaemic and Bone Marrow Stromal Cells Alter Cytarabine Genotoxicity and Cytotoxicity in Favour of Disease (2019)
Journal Article
May, J., Gynn, L., Anderson, E., & Robinson, G. (2019). Leukaemic and Bone Marrow Stromal Cells Alter Cytarabine Genotoxicity and Cytotoxicity in Favour of Disease. Mutagenesis, 34(5/6), e5. https://doi.org/10.1093/mutage/gez025

Resistance to therapy remains one of the greatest challenges in the management of the blood and bone marrow (BM) disorder, acute myeloid leukaemia (AML). This study aimed to investigate how leukaemic and BM stromal cells contribute to altered chemo-s... Read More about Leukaemic and Bone Marrow Stromal Cells Alter Cytarabine Genotoxicity and Cytotoxicity in Favour of Disease.

Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML). (2019)
Journal Article
Gynn, L. E., Anderson, E., Robinson, G. M., Wexler, S. A., Upstill-Goddard, G., Cox, C., …Morgan, R. G. (2019). Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML). Blood, 134(Supplement 1), 2492. https://doi.org/10.1182/blood-2019-122891

Mesenchymal stromal cells (MSC) are known to protect leukemic cells from drug-induced toxicity within the bone marrow (BM) niche, however, less is known about leukemic impact on supportive MSC. The nucleoside-analogue, cytarabine (Ara-C), is a front-... Read More about Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML)..

Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method (2019)
Journal Article
Westmacott, K. L., Crew, A. P., Doran, O., & Hart, J. P. (in press). Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method. Biosensors and Bioelectronics, https://doi.org/10.1016/j.bios.2019.111837

© 2019 Elsevier B.V. This is the first report on the fabrication, characterisation and application of an electrochemical (bio)sensor system for the simultaneous measurement of skatole and androstenone. A biosensor for androstenone was fabricated usin... Read More about Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method.

The development of point-of-use treatment technologies for the production of drinking water (2019)
Thesis
Clayton, G. The development of point-of-use treatment technologies for the production of drinking water. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/1490721

An estimated 884 million people worldwide lack access to drinking water from improved water sources. With the global population expected to reach eleven billion by the end of the 21st Century, stress on water and energy resources will be exacerbated.... Read More about The development of point-of-use treatment technologies for the production of drinking water.

Pseudomonas daroniae sp. nov. and Pseudomonas dryadis sp. nov., isolated from pedunculate oak affected by acute oak decline in the UK (2019)
Journal Article
Bueno-Gonzalez, V., Brady, C., Denman, S., Plummer, S., Allainguillaume, J., & Arnold, D. (2019). Pseudomonas daroniae sp. nov. and Pseudomonas dryadis sp. nov., isolated from pedunculate oak affected by acute oak decline in the UK. International Journal of Systematic and Evolutionary Microbiology, 69(11), 3368-3376. https://doi.org/10.1099/ijsem.0.003615

Twenty-two cream-coloured bacterial strains were isolated from oak trees affected by acute oak decline (AOD) in Southern England. Isolates were Gram-negative, motile, slightly curved rods, aerobic, non-spore-forming, catalase positive and oxidase pos... Read More about Pseudomonas daroniae sp. nov. and Pseudomonas dryadis sp. nov., isolated from pedunculate oak affected by acute oak decline in the UK.

Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films (2019)
Patent
Cox, T., Kiely, J., Ratcliffe, N., deLacy Costello, B., & Luxton, R. (2019). Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films

The invention relates to the field of sensors for detecting volatile compounds. The sensor of the present invention for detecting volatile compounds comprises: a film of metal oxide; a heater configured to provide heat energy to the film of metal oxi... Read More about Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films.

New approaches to the detection of echinocandin resistance in Candida glabrata in clinical diagnostic laboratories (2019)
Thesis
Fraser, M. A. New approaches to the detection of echinocandin resistance in Candida glabrata in clinical diagnostic laboratories. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/1490747

Candidaemia is widely reported as the fourth most common form of bloodstream infection worldwide. Reports of cases of candidaemia whilst patients are in receipt of antifungal therapy are increasing, and this is especially relevant as prescribing prac... Read More about New approaches to the detection of echinocandin resistance in Candida glabrata in clinical diagnostic laboratories.

Developmental, morphological and physiological effects of chronic low doses of ionising radiation on plants on earth and in space (2019)
Thesis
Caplin, N. M. Developmental, morphological and physiological effects of chronic low doses of ionising radiation on plants on earth and in space. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/1491172

Conclusions in the current literature are essentially unanimous regarding what is known about the effects of ionising radiation on plants. It is agreed that acute high-dose effects (primarily from laboratory tests) are well-documented and understood... Read More about Developmental, morphological and physiological effects of chronic low doses of ionising radiation on plants on earth and in space.

Prevalence of Carbapenemase Producing Organisms in East London, UK. (2019)
Presentation / Conference
Henderson, J., Ciesielczuk, H., & Nelson, S. (2019, September). Prevalence of Carbapenemase Producing Organisms in East London, UK. Poster presented at IBMS Congress 2019, Birmingham

Carbapenemases are enzymes, produced by an array of common Gram-negative organisms, which hydrolyse the carbapenem antibiotics, conferring resistance [1]. The main protagonists are the “big five” carbapenemases, KPC, OXA-48, IMP, VIM and NDM, which h... Read More about Prevalence of Carbapenemase Producing Organisms in East London, UK..

Evaluation of additives on reversed-phase chromatography of monoclonal antibodies using a 1000 Å stationary phase (2019)
Journal Article
McCalley, D. V., & Guillarme, D. (2020). Evaluation of additives on reversed-phase chromatography of monoclonal antibodies using a 1000 Å stationary phase. Journal of Chromatography A, 1610, https://doi.org/10.1016/j.chroma.2019.460562

© 2019 Elsevier B.V. A wide pore (1000 Å) diphenyl stationary phase was evaluated for the analysis of monoclonal antibodies (mAbs), comparing a conventional mobile phase of acetonitrile-water containing overall 0.1% trifluoracetic acid (TFA) with a s... Read More about Evaluation of additives on reversed-phase chromatography of monoclonal antibodies using a 1000 Å stationary phase.

Recommendations on terminology and experimental best practice associated with plant nitric oxide research (2019)
Journal Article
Gupta, K. J., Hancock, J. T., Petrivalsky, M., Kolbert, Z. S., Lindermayr, C., Durner, J., …John Loake, G. (in press). Recommendations on terminology and experimental best practice associated with plant nitric oxide research. New Phytologist, https://doi.org/10.1111/nph.16157

© 2019 The Authors. New Phytologist © 2019 New Phytologist Trust Nitric oxide (NO) emerged as a key signal molecule in plants. During the last two decades impressive progress has been made in plant NO research. This small, redox-active molecule is no... Read More about Recommendations on terminology and experimental best practice associated with plant nitric oxide research.

An investigation into the regulation of transcription of the splice factor kinase gene SRPK1 in prostate and leukaemia cancer cell lines (2019)
Thesis
Belali, T. An investigation into the regulation of transcription of the splice factor kinase gene SRPK1 in prostate and leukaemia cancer cell lines. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/1490649

The SRPK1 gene encodes a protein kinase that phosphorylates a class of splice factors called serine/arginine-rich proteins (SR proteins) modifying their ability to regulate alternative pre-mRNA splicing. Studies have linked high SRPK1 levels to tumou... Read More about An investigation into the regulation of transcription of the splice factor kinase gene SRPK1 in prostate and leukaemia cancer cell lines.

Network theory and the resilience of redox signaling (2019)
Journal Article
Hancock, J. T., Veal, D., & Hancock, A. L. (2019). Network theory and the resilience of redox signaling. Reactive Oxygen Species, 8(23), 245-257

The redox status inside and around cells is critically important to control, being used to maintain reduced compounds in the correct state and for cell signaling mechanisms. A myriad of compounds and proteins are involved in a vast network system to... Read More about Network theory and the resilience of redox signaling.

Lemurs in Cacao: Presence and Abundance within the Shade Plantations of Northern Madagascar (2019)
Journal Article
Webber, A. D., Solofondranohatra, J. S., Razafindramoana, S., Fernandez, D., Parker, C. A., Steer, M., …Allainguillaume, J. (in press). Lemurs in Cacao: Presence and Abundance within the Shade Plantations of Northern Madagascar. Folia Primatologica, https://doi.org/10.1159/000501987

© 2019 S. Karger AG, Basel. The recognition that much biodiversity exists outside protected areas is driving research to understand how animals survive in anthropogenic landscapes. In Madagascar, cacao (Theobroma cacao) is grown under a mix of native... Read More about Lemurs in Cacao: Presence and Abundance within the Shade Plantations of Northern Madagascar.

Abscisic acid induced a negative geotropic response in dark-incubated Chlamydomonas reinhardtii (2019)
Journal Article
Wilson, I., Ladomery, M., Macdonald, H., Al-Hijab, L., Gregg, A., & Davies, R. (2019). Abscisic acid induced a negative geotropic response in dark-incubated Chlamydomonas reinhardtii. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-48632-0

The phytohormone abscisic acid (ABA) plays a role in stresses that alter plant water status and may also regulate root gravitropism and hydrotropism. ABA also exists in the aquatic algal progenitors of land plants, but other than its involvement in s... Read More about Abscisic acid induced a negative geotropic response in dark-incubated Chlamydomonas reinhardtii.

An electrocatalytic screen-printed amperometric sensor for the selective measurement of thiamine (Vitamin B1) in food supplements (2019)
Journal Article
Smart, A., Westmacott, K. L., Crew, A., Doran, O., & Hart, J. P. (2019). An electrocatalytic screen-printed amperometric sensor for the selective measurement of thiamine (Vitamin B1) in food supplements. Biosensors, 9(3), 98. https://doi.org/10.3390/bios9030098

An electrocatalytic screen-printed sensor has been investigated for the measurement of the biologically important biomolecule vitamin B1 (thiamine) for the first time in food supplements. Under basic conditions, the vitamin was converted to its elect... Read More about An electrocatalytic screen-printed amperometric sensor for the selective measurement of thiamine (Vitamin B1) in food supplements.

Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment (2019)
Journal Article
Ladomery, M., Koschorke, A., Faraci, S., Giani, D., Iorio, E., Canese, R., …Chiodoni, C. (2019). Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment. Cellular Oncology, 42(6), 815-828. https://doi.org/10.1007/s13402-019-00464-w

© 2019, International Society for Cellular Oncology. Purpose: Isothiocyanates elicit anticancer effects by targeting cancer stem cells (CSCs). Here, we tested the antitumor activity of phenethyl-isothiocyanate (PEITC), either alone or in combination... Read More about Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment.

Herbal teas and their health benefits: A scoping review (2019)
Journal Article
Poswal, F. S., Russell, G., Mackonochie, M., MacLennan, E., Adukwu, E. C., & Rolfe, V. (2019). Herbal teas and their health benefits: A scoping review. Plant Foods for Human Nutrition, 74(3), 266-276. https://doi.org/10.1007/s11130-019-00750-w

Herbal teas are used as therapeutic vehicles in many forms of traditional medicine and are a popular global beverage. The purpose of this scoping review was to examine the evidence relating to the clinical efficacy and safety of herbal teas, and to i... Read More about Herbal teas and their health benefits: A scoping review.

Cumulative weather effects can impact across the whole life cycle (2019)
Journal Article
Hindle, B. J., Pilkington, J. G., Pemberton, J. M., & Childs, D. Z. (2019). Cumulative weather effects can impact across the whole life cycle. Global Change Biology, 25(10), 3282-3293. https://doi.org/10.1111/gcb.14742

Predicting how species will be affected by future climatic change requires the underlying environmental drivers to be identified. As vital rates vary over the lifecycle, structured population models derived from statistical environment-demography rel... Read More about Cumulative weather effects can impact across the whole life cycle.