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Nitric oxide, other reactive signalling compounds, redox and reductive stress (2020)
Journal Article
Hancock, J., & Veal, D. (in press). Nitric oxide, other reactive signalling compounds, redox and reductive stress. Journal of Experimental Botany,

Nitric oxide (NO) and other reactive nitrogen species (RNS) are key signalling molecules in plants, but they do not work in isolation. NO is produced in cells, often increased in response to stress conditions, but many other reactive compounds used i... Read More about Nitric oxide, other reactive signalling compounds, redox and reductive stress.

Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer (2020)
Journal Article
Li, L., Hobson, L., Perry, L., Clark, B., Heavey, S., Haider, A., …Ladomery, M. (in press). Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer. British Journal of Cancer, https://doi.org/10.1038/s41416-020-0951-2

Background: The ERG oncogene, a member of the ETS family of transcription factor encoding genes, is a genetic driver of prostate cancer. It is activated through a fusion with the androgen-responsive TMPRSS2 promoter in 50% of cases. There is therefor... Read More about Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer.

An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy (2020)
Journal Article
Russell, G., Rehman, M., LeBaron, T. W., Veal, D., Adukwu, E., & Hancock, J. (in press). An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy. Reactive Oxygen Species,

SARS-CoV-2 is an emerging β-coronavirus that causes COVID-19 disease that manifests primarily as a pulmonary infection that can rapidly progress into severe and acute respiratory distress in susceptible patients. Initial reports of severe pulmonary i... Read More about An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy.

Chemotherapy induces a genotoxic bystander effect in cell lines from the human bone marrow; evaluation of the role of the redox microenvironment (2020)
Thesis
Okeke, K. Chemotherapy induces a genotoxic bystander effect in cell lines from the human bone marrow; evaluation of the role of the redox microenvironment. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/2812709

Modern chemotherapeutic regimens for adult and childhood leukaemia rely on the use of a combination of various cytotoxic agents. Unfortunately, haematopoietic stem cell transplant, a last resort treatment for haematologic malignancies requires high d... Read More about Chemotherapy induces a genotoxic bystander effect in cell lines from the human bone marrow; evaluation of the role of the redox microenvironment.

A comparison of European eel Anguilla anguilla eDNA concentrations to fyke net catches in five Irish lakes. (2020)
Journal Article
Weldon, L., O'Leary, C., Steer, M., Newton, L., Macdonald, H., & Sargeant, S. (in press). A comparison of European eel Anguilla anguilla eDNA concentrations to fyke net catches in five Irish lakes. Environmental DNA, https://doi.org/10.1002/edn3.91

The European eel, Anguilla anguilla, is classified as critically endangered by the IUCN. To protect what remains of the European eel population, accurate monitoring methods for this species are important. Environmental DNA (eDNA) techniques are gaini... Read More about A comparison of European eel Anguilla anguilla eDNA concentrations to fyke net catches in five Irish lakes..

Regulating the regulator: nitric oxide control of post-translational modifications (2020)
Journal Article
Gupta, K. J., Kolbert, Z., Durner, J., Lindermayr, C., Corpas, F. J., Brouquisse, R., …Loake, G. J. (in press). Regulating the regulator: nitric oxide control of post-translational modifications. New Phytologist, https://doi.org/10.1111/nph.16622

Nitric oxide (NO) is perfectly suited for the role of a redox signalling molecule. A key route for NO bioactivity occurs via protein S-nitrosation, and involves the addition of a NO moiety to a protein cysteine (Cys) thiol (–SH) to form an S-nitrosot... Read More about Regulating the regulator: nitric oxide control of post-translational modifications.

Screen-printed carbon based biosensors and their applications in agri-food safety (2020)
Journal Article
Smart, A., Crew, A., Pemberton, R., Hughes, G., Doran, O., & Hart, J. P. (2020). Screen-printed carbon based biosensors and their applications in agri-food safety. Trends in Analytical Chemistry, 127, https://doi.org/10.1016/j.trac.2020.115898

This review focuses on the ways in which screen-printed carbon electrodes have been tailored with different biorecognition elements, including enzymes, antibodies, and aptamers, often with other modifiers, such as mediators and nanoparticles, to prod... Read More about Screen-printed carbon based biosensors and their applications in agri-food safety.

In vitro modelling of tongue derived microbial biofilms and their reponse to treatment (2020)
Thesis
Hewett, K. E. In vitro modelling of tongue derived microbial biofilms and their reponse to treatment. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/1491292

This work concerns the development of a flat plate perfusion model to study biofilms derived from human tongue biota. The model has been derived from a previous sorbarod model, via a flat plate model (used to study wound organisms), to the model desc... Read More about In vitro modelling of tongue derived microbial biofilms and their reponse to treatment.

Targeting the splice factor kinase CLK1 in prostate cancer cells (2020)
Thesis
Uzor, S. O. Targeting the splice factor kinase CLK1 in prostate cancer cells. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/1490733

Prostate cancer is the most rampant diagnosed cancer and the second leading cause of cancer related death in men between middle age and old age. There is a need to identify the molecular genetic processes that underpin prostate cancer and to search f... Read More about Targeting the splice factor kinase CLK1 in prostate cancer cells.

Antimicrobial activity of essential oils as liquid and vapour applications (2020)
Thesis
Elcocks, E. R. (2020). Antimicrobial activity of essential oils as liquid and vapour applications. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/1490727

Essential oils produced by plants have been used as antimicrobial agents historically, however, many essential oils remain under-exploited as alternatives to antimicrobials. Therefore, the aim of this thesis was to evaluate the antibacterial efficacy... Read More about Antimicrobial activity of essential oils as liquid and vapour applications.

ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia? (2020)
Journal Article
Vahabi, B., Jabr, R., Fry, C., McCloskey, K., Everaert, K., Agudelo, C. W., …Weiss, J. P. (in press). ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia?. Neurourology and Urodynamics, https://doi.org/10.1002/nau.24274

© 2020 Wiley Periodicals, Inc. Introduction: The following is a report on the proceedings of the 2019 International Consultation on Incontinence-Research Society nocturia think tank (NTT). Objectives: The objectives of the 2019 NTT were as follows: (... Read More about ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia?.

Sensitivity to experiencing alcohol hangovers: Reconsideration of the 0.11% Blood Alcohol Concentration (BAC) threshold for having a hangover (2020)
Journal Article
Verster, J. C., Kruisselbrink, L. D., Slot, K. A., Anogeianaki, A., Adams, S., Alford, C., …Stock, A. (2020). Sensitivity to experiencing alcohol hangovers: Reconsideration of the 0.11% Blood Alcohol Concentration (BAC) threshold for having a hangover. Journal of Clinical Medicine, 9(1), https://doi.org/10.3390/jcm9010179

The 2010 Alcohol Hangover Research Group consensus paper defined a cutoff blood alcohol concentration (BAC) of 0.11% as a toxicological threshold indicating that sufficient alcohol had been consumed to develop a hangover. The cutoff was based on prev... Read More about Sensitivity to experiencing alcohol hangovers: Reconsideration of the 0.11% Blood Alcohol Concentration (BAC) threshold for having a hangover.

Relationship between alcohol hangover and physical endurance performance: Walking the Samaria Gorge (2019)
Journal Article
Verster, J. C., Anogeianaki, A., Kruisselbrink, D., Alford, C., & Stock, A. (2020). Relationship between alcohol hangover and physical endurance performance: Walking the Samaria Gorge. Journal of Clinical Medicine, 9(1), https://doi.org/10.3390/jcm9010114

Alcohol hangover is a potentially debilitating state. Several studies have demonstrated that it does not seem to impair strength or short-term endurance, but its effects on continuous exercise performance/long-term endurance have never been investiga... Read More about Relationship between alcohol hangover and physical endurance performance: Walking the Samaria Gorge.

Leukaemic and bone marrow stromal cells alter cytarabine genotoxicity and cytotoxicity in favour of disease (2019)
Journal Article
May, J., Gynn, L., Anderson, E., & Robinson, G. (2019). Leukaemic and bone marrow stromal cells alter cytarabine genotoxicity and cytotoxicity in favour of disease. Mutagenesis, 34(5/6), e5. https://doi.org/10.1093/mutage/gez025

Resistance to therapy remains one of the greatest challenges in the management of the blood and bone marrow (BM) disorder, acute myeloid leukaemia (AML). This study aimed to investigate how leukaemic and BM stromal cells contribute to altered chemo-s... Read More about Leukaemic and bone marrow stromal cells alter cytarabine genotoxicity and cytotoxicity in favour of disease.

Rapid bactericidal effect of cinnamon bark essential oil against Pseudomonas aeruginosa (2019)
Journal Article
Elcocks, E., Spencer‐Phillips, P., & Adukwu, E. (2020). Rapid bactericidal effect of cinnamon bark essential oil against Pseudomonas aeruginosa. Journal of Applied Microbiology, 128(4), 1025-1037. https://doi.org/10.1111/jam.14538

AIMS: This study aimed to identify the most effective antimicrobial from a selection of essential oils and investigate its bactericidal properties against Ps. aeruginosa. METHODS AND RESULTS: The disc diffusion assay and minimal inhibitory/bacte... Read More about Rapid bactericidal effect of cinnamon bark essential oil against Pseudomonas aeruginosa.

Advantages and limitations of naturalistic study designs and their implementation in alcohol hangover research (2019)
Journal Article
Verster, J. C., van de Loo, A. J. A. E., Adams, S., Stock, A., Benson, S., Scholey, A., …Bruce, G. (2019). Advantages and limitations of naturalistic study designs and their implementation in alcohol hangover research. Journal of Clinical Medicine, 8(12), https://doi.org/10.3390/jcm8122160

In alcohol hangover research, both naturalistic designs and randomized controlled trials (RCTs) are successfully employed to study the causes, consequences, and treatments of hangovers. Although increasingly applied in both social sciences and medica... Read More about Advantages and limitations of naturalistic study designs and their implementation in alcohol hangover research.

Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML). (2019)
Journal Article
Gynn, L. E., Anderson, E., Robinson, G. M., Wexler, S. A., Upstill-Goddard, G., Cox, C., …Morgan, R. G. (2019). Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML). Blood, 134(Supplement 1), 2492. https://doi.org/10.1182/blood-2019-122891

Mesenchymal stromal cells (MSC) are known to protect leukemic cells from drug-induced toxicity within the bone marrow (BM) niche, however, less is known about leukemic impact on supportive MSC. The nucleoside-analogue, cytarabine (Ara-C), is a front-... Read More about Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML)..

Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method (2019)
Journal Article
Westmacott, K. L., Crew, A. P., Doran, O., & Hart, J. P. (2020). Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method. Biosensors and Bioelectronics, 150, https://doi.org/10.1016/j.bios.2019.111837

© 2019 Elsevier B.V. This is the first report on the fabrication, characterisation and application of an electrochemical (bio)sensor system for the simultaneous measurement of skatole and androstenone. A biosensor for androstenone was fabricated usin... Read More about Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method.

The development of point-of-use treatment technologies for the production of drinking water (2019)
Thesis
Clayton, G. The development of point-of-use treatment technologies for the production of drinking water. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/1490721

An estimated 884 million people worldwide lack access to drinking water from improved water sources. With the global population expected to reach eleven billion by the end of the 21st Century, stress on water and energy resources will be exacerbated.... Read More about The development of point-of-use treatment technologies for the production of drinking water.

Pseudomonas daroniae sp. nov. and Pseudomonas dryadis sp. nov., isolated from pedunculate oak affected by acute oak decline in the UK (2019)
Journal Article
Bueno-Gonzalez, V., Brady, C., Denman, S., Plummer, S., Allainguillaume, J., & Arnold, D. (2019). Pseudomonas daroniae sp. nov. and Pseudomonas dryadis sp. nov., isolated from pedunculate oak affected by acute oak decline in the UK. International Journal of Systematic and Evolutionary Microbiology, 69(11), 3368-3376. https://doi.org/10.1099/ijsem.0.003615

Twenty-two cream-coloured bacterial strains were isolated from oak trees affected by acute oak decline (AOD) in Southern England. Isolates were Gram-negative, motile, slightly curved rods, aerobic, non-spore-forming, catalase positive and oxidase pos... Read More about Pseudomonas daroniae sp. nov. and Pseudomonas dryadis sp. nov., isolated from pedunculate oak affected by acute oak decline in the UK.



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