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Oxygen is instrumental for biological signalling: An overview (2021)
Journal Article
Hancock, J. (in press). Oxygen is instrumental for biological signalling: An overview. Oxygen,

Control of cellular function is extremely complex, being reliant on a wide range of components. Several of these are small oxygen-based molecules. Although reactive compounds containing oxygen are usually harmful to cells when accumulated to relative... Read More about Oxygen is instrumental for biological signalling: An overview.

Cell Signalling (2021)
Book
Hancock, J. (2021). Cell Signalling. Oxford: Oxford University Press

Public engagement promotes consumer choice in favour of sustainable palm oil (2021)
Journal Article
Hobbs, L., Phillips, J., Staff, A., Goss, A., Fogg-Rogers, L., & Ellwood, F. (in press). Public engagement promotes consumer choice in favour of sustainable palm oil. Journal of Oil Palm Research,

Despite the superior productivity, utility and economic benefits of palm oil compared with other oil crops, the palm oil industry often receives negative publicity for its environmental impact. As such, there is widespread confusion over the percepti... Read More about Public engagement promotes consumer choice in favour of sustainable palm oil.

Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia (2021)
Thesis
Wodi, C. Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490771

This study was aimed at investigating the effect of inhibiting SRPK1 in leukaemic cells. It was also aimed at exploring the potential utility of combining conventional leukaemia chemotherapy (such as imatinib) with compounds that inhibit SRPK1. SR... Read More about Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia.

Molecular hydrogen: Redox reactions and possible biological interactions (2021)
Journal Article
Hancock, J. T., LeBaron, T. W., & Russell, G. (2021). Molecular hydrogen: Redox reactions and possible biological interactions. Reactive Oxygen Species, 11, m17–m25. https://doi.org/10.20455/ros.2021.m.803

Molecular hydrogen (H2), either as a gas or as hydrogen-rich water (HRW), is suggested to be a useful treatment for a range of human diseases and also to improve agricultural output. It is often posited that H2 accomplishes its biological action, in... Read More about Molecular hydrogen: Redox reactions and possible biological interactions.

Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases (2021)
Journal Article
Russell, G., Nenov, A., & Hancock, J. (2021). Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases. European Medical Journal, May 2021, https://doi.org/10.33590/emj/21-00027

Oxy-hydrogen gas (HHO) is a gaseous mixture of molecular hydrogen (H2) and molecular oxygen (O2) that is generated by the electrolysis of water and delivered in a 2:1 ratio (66% and 33%, respectively) through the use of non-invasive inhalation device... Read More about Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases.

Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry (2021)
Thesis
Lafargue, P. Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6642792

Theobroma cacao (cocoa) is one of the most studied commodities around the world and the source of one of the world’s most consumed and familiar products, chocolate. The multibillion-pound industry has changed to a higher demand for sustainably certif... Read More about Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry.

Inactivation of Listeria monocytogenes and Salmonella on stainless steel by a piezoelectric cold atmospheric plasma generator (2021)
Journal Article
Gonzalez-Gonzalez, C. R., Hindle, B. J., Saad, S., & Stratakos, A. C. (2021). Inactivation of Listeria monocytogenes and Salmonella on stainless steel by a piezoelectric cold atmospheric plasma generator. Applied Sciences, 11(8), https://doi.org/10.3390/app11083567

Cold atmospheric pressure plasma (CAP) is a novel non‐thermal technology that is gain-ing increasing importance as a decontamination method. Stainless steel is a widespread food contact surface used in food‐processing environments. In this study, for... Read More about Inactivation of Listeria monocytogenes and Salmonella on stainless steel by a piezoelectric cold atmospheric plasma generator.

Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects (2021)
Thesis
Ude, A. Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6971684

Advances in modern chemotherapeutic regimens have led to an increase in the overall survival of leukaemia patients in recent years. However, haematopoietic stem cell transplantation (HSCT) remains the curative option for these patients. In HSCT, high... Read More about Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects.

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer (2021)
Journal Article
Uzor, S., Oltean, S., Ladomery, M., Alqasem, A., Perks, C., Wilson, I. D., …Iida, K. (2021). CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer. Scientific Reports, 11(1), https://doi.org/10.1038/s41598-021-86908-6

Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and o... Read More about CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer.

5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis (2021)
Journal Article
Dixon, S. W., Collard, T. J., Mortensson, E. M. H., Legge, D. N., Chambers, A. C., Greenhough, A., …Williams, A. C. (2021). 5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis. British Journal of Cancer, 124, 1959–1969. https://doi.org/10.1038/s41416-021-01354-5

Background: Most colorectal cancers (CRC) arise sporadically from precursor lesions: colonic polyps. Polyp resection prevents progression to CRC. Risk of future polyps is proportional to the number and size of polyps detected at screening, allowing i... Read More about 5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis.

A roadmap for genome-based phage taxonomy (2021)
Journal Article
Turner, D., Kropinski, A. M., & Adriaenssens, E. M. (2021). A roadmap for genome-based phage taxonomy. Viruses, 13(3), https://doi.org/10.3390/v13030506

Bacteriophage (phage) taxonomy has been in flux since its inception over four decades ago. Genome sequencing has put pressure on the classification system and recent years have seen significant changes to phage taxonomy. Here, we reflect on the state... Read More about A roadmap for genome-based phage taxonomy.

Formation of furan in baby food products: Identification and technical challenges (2021)
Journal Article
Javed, F., Shahbaz, H. M., Nawaz, A., Olaimat, A. N., Stratakos, A. C., Wahyono, A., …Park, J. (2021). Formation of furan in baby food products: Identification and technical challenges. Comprehensive Reviews in Food Science and Food Safety, 20(3), 2699-2715. https://doi.org/10.1111/1541-4337.12732

Furan is generally produced during thermal processing of various foods including baked, fried, and roasted food items such as cereal products, coffee, canned, and jarred prepared foods as well as in baby foods. Furan is a toxic and carcinogenic compo... Read More about Formation of furan in baby food products: Identification and technical challenges.

Interacting proteins, polymorphisms and the susceptibility of animals to SARS-CoV-2 (2021)
Journal Article
Hancock, J., Rouse, R., Stone, E., & Greenhough, A. (2021). Interacting proteins, polymorphisms and the susceptibility of animals to SARS-CoV-2. Animals, 11(3), https://doi.org/10.3390/ani11030797

Abstract: COVID-19, caused by SARS-CoV-2, is a world-wide problem for the human population. It is known that some animal species, such as mink, can become infected and transmit the virus. However, the susceptibility of most animals is not known. Here... Read More about Interacting proteins, polymorphisms and the susceptibility of animals to SARS-CoV-2.

Epigenenetic regulation of alternative splicing: How lncRNAs tailor the message (2021)
Journal Article
Pisignano, G., & Ladomery, M. (2021). Epigenenetic regulation of alternative splicing: How lncRNAs tailor the message. Non-Coding RNA, 7(1), https://doi.org/10.3390/ncrna7010021

Alternative splicing is a highly fine-tuned regulated process and one of the main drivers of proteomic diversity across eukaryotes. The vast majority of human multi-exon genes is alternatively spliced in a cell type-and tissue-specific manner, and de... Read More about Epigenenetic regulation of alternative splicing: How lncRNAs tailor the message.

Downstream signalling from molecular hydrogen (2021)
Journal Article
Hancock, J., & Russell, G. (2021). Downstream signalling from molecular hydrogen. Plants, 10(2), https://doi.org/10.3390/plants10020367

Molecular hydrogen (H2) is now considered to be a part of the suite of small molecules which can control cellular activity. As such it has been suggested to be used in the therapy of diseases in humans but also to be used in plant science, to enhance... Read More about Downstream signalling from molecular hydrogen.