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Biofilm management; Investigating the inhibitory effects of chlorine-based disinfectants on biofilms (2020)
Conference Proceeding
Clayton, G., Thorn, R., & Reynolds, D. (in press). Biofilm management; Investigating the inhibitory effects of chlorine-based disinfectants on biofilms

Summary of key findings Direct disinfection of established Pseudomonas aeruginosa biofilms by electrochemically activated solutions [ECAS] exhibited significantly greater anti-biofilm activity compared to NaOCl and HOCl at free chlorine concentratio... Read More about Biofilm management; Investigating the inhibitory effects of chlorine-based disinfectants on biofilms.

The effects of seed priming with NaHS on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth (2020)
Journal Article
Ocvirk, D., Špoljarević, M., Kristić, M., Hancock, J. T., Teklić, T., & Lisjak, M. (in press). The effects of seed priming with NaHS on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth. Annals of Applied Biology, https://doi.org/10.1111/aab.12658

Sunflower seeds (hybrid Luka) were primed with water (hydropriming) or sodium hydrosulfide (NaHS) solutions (0.1, 0.5, 1.0 and 1.5 mM NaHS) and subsequently dried to initial moisture content. Un-primed (control) and primed seeds were germinated in a... Read More about The effects of seed priming with NaHS on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth.

Laboratory evaluation of the Sigma Transwab® transport system for the recovery of Candida species using the Clinical and Laboratory Standards Institute (CLSI) document M40-A2 (2020)
Journal Article
Adukwu, E., & Elcocks, E. (in press). Laboratory evaluation of the Sigma Transwab® transport system for the recovery of Candida species using the Clinical and Laboratory Standards Institute (CLSI) document M40-A2. European Journal of Clinical Microbiology and Infectious Diseases, https://doi.org/10.1007/s10096-020-04062-9

Rising healthcare complications due to fungal infections increase the importance of efficient specimen collection and maintenance systems for correct identification and diagnosis. The CLSI M40-A2 protocol provides guidelines for laboratories assessin... Read More about Laboratory evaluation of the Sigma Transwab® transport system for the recovery of Candida species using the Clinical and Laboratory Standards Institute (CLSI) document M40-A2.

WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1 (2020)
Journal Article
Belali, T., Wodi, C., Clark, B., Cheung, M. K., Craig, T. J., Wheway, G., …Ladomery, M. (2020). WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1. BBA - Gene Regulatory Mechanisms, 1863(12), https://doi.org/10.1016/j.bbagrm.2020.194642

Dysregulated alternative splicing plays a prominent role in all hallmarks of cancer. The splice factor kinase SRPK1 drives the activity of oncogenic splice factors such as SRSF1. SRSF1 in turn promotes the expression of splice isoforms that favour tu... Read More about WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1.

From orphan phage to a proposed new family–the diversity of N4-like viruses (2020)
Journal Article
Wittmann, J., Turner, D., Millard, A., Mahadevan, P., Kropinski, A., & Adriaenssens, E. (2020). From orphan phage to a proposed new family–the diversity of N4-like viruses. Antibiotics, 9(10), 663. https://doi.org/10.3390/antibiotics9100663

Escherichia phage N4 was isolated in 1966 in Italy and has remained a genomic orphan for a long time. It encodes an extremely large virion-associated RNA polymerase unique for bacterial viruses that became characteristic for this group. In recent yea... Read More about From orphan phage to a proposed new family–the diversity of N4-like viruses.

The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades (2020)
Thesis
Shafei, M. The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/3429539

Introduction and Aims: Breast cancer remains the leading cause of cancer mortality in women globally, despite advances in the development of targeted therapies. Driven by oncogenic signals, cancer cells undergo metabolic reprogramming, upregulatin... Read More about The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades.

Hydrogen sulfide in horticulture: Emerging roles in the era of climate change (2020)
Journal Article
Hancock, J. T., Zulfiqar, F., & Hancock, J. (2020). Hydrogen sulfide in horticulture: Emerging roles in the era of climate change. Plant Physiology and Biochemistry, 155, 667-675. https://doi.org/10.1016/j.plaphy.2020.08.010

Future climate change will present many plants with environmental challenges, including extreme temperatures and drought. Hydrogen sulfide (H2S) has emerged as an important signal transmitting molecule in plants, especially important in many stress r... Read More about Hydrogen sulfide in horticulture: Emerging roles in the era of climate change.

Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways (2020)
Thesis
Okoro, G. U. Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/1491050

Introduction and aims: Alzheimer’s disease (AD) has for decades been associated with increased accumulation of brain amyloid β peptides (Aβ) and phosphorylated tau. Unfortunately, targeted therapy to Aβ in particular has not been successful resulting... Read More about Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways.

Nitric oxide, other reactive signalling compounds, redox and reductive stress (2020)
Journal Article
Hancock, J., & Veal, D. (in press). Nitric oxide, other reactive signalling compounds, redox and reductive stress. Journal of Experimental Botany, https://doi.org/10.1093/jxb/eraa331

Nitric oxide (NO) and other reactive nitrogen species (RNS) are key signalling molecules in plants, but they do not work in isolation. NO is produced in cells, often increased in response to stress conditions, but many other reactive compounds used i... Read More about Nitric oxide, other reactive signalling compounds, redox and reductive stress.

Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia (2020)
Thesis
Fombon, I. Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/3829730

Introduction and aims: Fenofibrate is the most widely used fibric acid derivative for managing mixed dyslipidaemia, characterised by elevated levels of cholesterol, triglycerides and LDL cholesterol and low levels of HDL cholesterol. Fenofibrate is a... Read More about Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia.

An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy (2020)
Journal Article
Russell, G., Rehman, M., LeBaron, T. W., Veal, D., Adukwu, E., & Hancock, J. (2020). An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy. Reactive Oxygen Species, 10(28), 150–165

SARS-CoV-2 is an emerging β-coronavirus that causes COVID-19 disease that manifests primarily as a pulmonary infection that can rapidly progress into severe and acute respiratory distress in susceptible patients. Initial reports of severe pulmonary i... Read More about An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy.

Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer (2020)
Journal Article
Li, L., Hobson, L., Perry, L., Clark, B., Heavey, S., Haider, A., …Ladomery, M. (2020). Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer. British Journal of Cancer, 123, 1024-1032. https://doi.org/10.1038/s41416-020-0951-2

Background: The ERG oncogene, a member of the ETS family of transcription factor encoding genes, is a genetic driver of prostate cancer. It is activated through a fusion with the androgen-responsive TMPRSS2 promoter in 50% of cases. There is therefor... Read More about Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer.

Chemotherapy induces a genotoxic bystander effect in cell lines from the human bone marrow; evaluation of the role of the redox microenvironment (2020)
Thesis
Okeke, K. Chemotherapy induces a genotoxic bystander effect in cell lines from the human bone marrow; evaluation of the role of the redox microenvironment. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/2812709

Modern chemotherapeutic regimens for adult and childhood leukaemia rely on the use of a combination of various cytotoxic agents. Unfortunately, haematopoietic stem cell transplant, a last resort treatment for haematologic malignancies requires high d... Read More about Chemotherapy induces a genotoxic bystander effect in cell lines from the human bone marrow; evaluation of the role of the redox microenvironment.

A comparison of European eel Anguilla anguilla eDNA concentrations to fyke net catches in five Irish lakes. (2020)
Journal Article
Weldon, L., O'Leary, C., Steer, M., Newton, L., Macdonald, H., & Sargeant, S. (2020). A comparison of European eel Anguilla anguilla eDNA concentrations to fyke net catches in five Irish lakes. Environmental DNA, 2(4), 587-600. https://doi.org/10.1002/edn3.91

The European eel, Anguilla anguilla, is classified as critically endangered by the IUCN. To protect what remains of the European eel population, accurate monitoring methods for this species are important. Environmental DNA (eDNA) techniques are gaini... Read More about A comparison of European eel Anguilla anguilla eDNA concentrations to fyke net catches in five Irish lakes..

Regulating the regulator: nitric oxide control of post-translational modifications (2020)
Journal Article
Gupta, K. J., Kolbert, Z., Durner, J., Lindermayr, C., Corpas, F. J., Brouquisse, R., …Loake, G. J. (2020). Regulating the regulator: nitric oxide control of post-translational modifications. New Phytologist, 227(5), 1319-1325. https://doi.org/10.1111/nph.16622

Nitric oxide (NO) is perfectly suited for the role of a redox signalling molecule. A key route for NO bioactivity occurs via protein S-nitrosation, and involves the addition of a NO moiety to a protein cysteine (Cys) thiol (–SH) to form an S-nitrosot... Read More about Regulating the regulator: nitric oxide control of post-translational modifications.

Screen-printed carbon based biosensors and their applications in agri-food safety (2020)
Journal Article
Smart, A., Crew, A., Pemberton, R., Hughes, G., Doran, O., & Hart, J. P. (2020). Screen-printed carbon based biosensors and their applications in agri-food safety. Trends in Analytical Chemistry, 127, https://doi.org/10.1016/j.trac.2020.115898

This review focuses on the ways in which screen-printed carbon electrodes have been tailored with different biorecognition elements, including enzymes, antibodies, and aptamers, often with other modifiers, such as mediators and nanoparticles, to prod... Read More about Screen-printed carbon based biosensors and their applications in agri-food safety.

In vitro modelling of tongue derived microbial biofilms and their reponse to treatment (2020)
Thesis
Hewett, K. E. In vitro modelling of tongue derived microbial biofilms and their reponse to treatment. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/1491292

This work concerns the development of a flat plate perfusion model to study biofilms derived from human tongue biota. The model has been derived from a previous sorbarod model, via a flat plate model (used to study wound organisms), to the model desc... Read More about In vitro modelling of tongue derived microbial biofilms and their reponse to treatment.