Cytochrome P450 2B6 amperometric biosensor for continuous monitoring of propofol (2021)
Journal Article
Ferrier, D., Kiely, J., & Luxton, R. (2021). Cytochrome P450 2B6 amperometric biosensor for continuous monitoring of propofol. IEEE Sensors Journal, 21(21), https://doi.org/10.1109/JSEN.2021.3112273

Despite the growing evidence of improved patient outcomes and of a substantially reduced environmental impact of propofol-based total intravenous anesthesia when compared to volatile-based techniques, the vast majority of general anesthetics still us... Read More about Cytochrome P450 2B6 amperometric biosensor for continuous monitoring of propofol.

Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs) (2020)
Journal Article
Fois, M., Cox, T., Ratcliffe, N., & de Lacy Costello, B. (2021). Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs). Sensors and Actuators B: Chemical, 330, https://doi.org/10.1016/j.snb.2020.129264

Heated metal oxide sensors have been widely studied for their ability to give a reversible change in the electrical resistance following the interaction with a volatile compound. Another feature is their inherent cataluminescence (CTL) properties whe... Read More about Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs).

Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection (2019)
Journal Article
Barnett, J. M., Monnier, B. M., Tyler, S., West, D., Ballantine-Dykes, H., Regan, E., …Luxton, R. (2020). Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection. Sensing and Bio-Sensing Research, 27, 100315. https://doi.org/10.1016/j.sbsr.2019.100315

© 2019 The resonant coil magnetometer quantifies paramagnetic particles (PMPs) and has been used to develop magneto-immunoassays in a range of formats. The advantage of magneto-immunoassays is that they are relatively inexpensive, portable, easy to p... Read More about Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection.

A corroborative approach to verification and validation of human–robot teams (2019)
Journal Article
Webster, M., Western, D., Araiza-Illan, D., Dixon, C., Eder, K., Fisher, M., & Pipe, A. G. (2020). A corroborative approach to verification and validation of human–robot teams. International Journal of Robotics Research, 39(1), 73-99. https://doi.org/10.1177/0278364919883338

© The Author(s) 2019. We present an approach for the verification and validation (V&V) of robot assistants in the context of human–robot interactions, to demonstrate their trustworthiness through corroborative evidence of their safety and functional... Read More about A corroborative approach to verification and validation of human–robot teams.

Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films (2019)
Patent
Cox, T., Kiely, J., Ratcliffe, N., deLacy Costello, B., & Luxton, R. (2019). Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films

The invention relates to the field of sensors for detecting volatile compounds. The sensor of the present invention for detecting volatile compounds comprises: a film of metal oxide; a heater configured to provide heat energy to the film of metal oxi... Read More about Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films.

A copper oxide/zinc oxide composite nano-surface for use in a biosensor (2019)
Journal Article
Cao, L., Kiely, J., Piano, M., & Luxton, R. (2019). A copper oxide/zinc oxide composite nano-surface for use in a biosensor. Materials, 12(7), 1126. https://doi.org/10.3390/ma12071126

© 2019 by the authors. In this study, biosensors based on zinc oxide-copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 a... Read More about A copper oxide/zinc oxide composite nano-surface for use in a biosensor.

Charge-based supercapacitor storage estimation for indoor sub-mW photovoltaic energy harvesting powered wireless sensor nodes (2019)
Journal Article
Yue, X., Kiely, J., Gibson, D., & Drakakis, E. M. (2020). Charge-based supercapacitor storage estimation for indoor sub-mW photovoltaic energy harvesting powered wireless sensor nodes. IEEE Transactions on Industrial Electronics, 67(3), 2411-2421. https://doi.org/10.1109/TIE.2019.2896321

Supercapacitors offer an attractive energy storage solution for lifetime “fit and forget” photovoltaic (PV) energy harvesting powered wireless sensor nodes for internet of things (IoT) applications. Whilst their low storage capacity is not an issue f... Read More about Charge-based supercapacitor storage estimation for indoor sub-mW photovoltaic energy harvesting powered wireless sensor nodes.

The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges (2019)
Journal Article
Djawad, Y. A., Attwood, D., Kiely, J., & Luxton, R. (2019). The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges. Sensing and Bio-Sensing Research, 23, https://doi.org/10.1016/j.sbsr.2019.100269

© 2019 In this paper we present a non-contact, impedance-based sensor system capable of characterizing the toxic response of cells to three different types of toxin. ECV304 cells were treated with 1 mM Hydrogen peroxide, 5% Dimethyl Sulfoxide, and 10... Read More about The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges.

CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity (2019)
Journal Article
Williams, I. S., Sonawane, V. R., Mohd Usman, M. S., Gatchie, L., .Bharate, S. B., Jayaprakash, V., …Chaudhuri, B. (2019). CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance. European Journal of Pharmaceutical Sciences, 131, 177-194. https://doi.org/10.1016/j.ejps.2019.02.016

Microsomal cytochrome P450 (CYP) enzymes, isolated from recombinant bacterial/insect/yeast cells, are extensively used for drug metabolism studies. However, they may not always portray how a developmental drug would behave in human cells with intact... Read More about CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity .

Morpholino Oligonucleotide Cross-Linked Hydrogels as Portable Optical Oligonucleotide Biosensors (2018)
Journal Article
Langford, G. J., Raeburn, J., Ferrier, D. C., Hands, P. J. W., & Shaver, M. P. (2019). Morpholino Oligonucleotide Cross-Linked Hydrogels as Portable Optical Oligonucleotide Biosensors. ACS Sensors, 4(1), 185-191. https://doi.org/10.1021/acssensors.8b01208

© 2018 American Chemical Society. Morpholino Oligonucleotides (MOs), an uncharged DNA analogue, are functionalized with an acrylamide moiety and incorporated into polymer hydrogels as responsive cross-links for microRNA sequence detection. The MO cro... Read More about Morpholino Oligonucleotide Cross-Linked Hydrogels as Portable Optical Oligonucleotide Biosensors.

Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection (2018)
Journal Article
Lu, C., Janice, K., Martina, P., & Richard, L. (2018). Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection. Scientific Reports, 8(1), 122687. https://doi.org/10.1038/s41598-018-30793-z

© 2018, The Author(s). The paper reports a biosensor formed from antibody coated ZnO nano-crystals which has been prepared using a rapid and inexpensive fabrication method which utilises colloidal dispersion enhanced using sonication. This technique... Read More about Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection.

Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells (2018)
Journal Article
Sharma, R., Williams, I. S., Linda, G., Sonawane, V. R., Chaudhuri, B., & Bharate, S. B. (2018). Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells. Bioorganic and Medicinal Chemistry, 26(23-24), 6076-6086. https://doi.org/10.1016/j.bmc.2018.11.013

© 2018 Elsevier Ltd Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast c... Read More about Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.

Analyses of parasitic capacitance effects and flicker noise of the DAC capacitor array for high resolution SAR ADCs (2018)
Journal Article
Yue, X., Kiely, J., & McLeod, C. (2018). Analyses of parasitic capacitance effects and flicker noise of the DAC capacitor array for high resolution SAR ADCs. International Journal of Computer Applications in Technology, 58(4), 259-266. https://doi.org/10.1504/IJCAT.2018.095934

Copyright © 2018 Inderscience Enterprises Ltd. This paper analyses the effects of parasitic capacitances of unit capacitors on the accuracy and the noise performance of the DAC capacitor array in a SAR ADC, showing that thermal noise of the array dec... Read More about Analyses of parasitic capacitance effects and flicker noise of the DAC capacitor array for high resolution SAR ADCs.

Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[ a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1 (2018)
Journal Article
Sharma, R., Williams, I. S., Gatchie, L., Sonawane, V. R., Chaudhuri, B., & Bharate, S. B. (2018). Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[ a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1. ACS Omega, 3(8), 8553-8566. https://doi.org/10.1021/acsomega.8b01088

Copyright © 2018 American Chemical Society. Cytochrome P450 family 1 (CYP1) enzymes catalyze the metabolic activation of environmental procarcinogens such as benzo[a]pyrene, B[a]P, into carcinogens, which initiates the process of carcinogenesis. Thus... Read More about Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[ a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1.

Nonantioxidant Tetramethoxystilbene Abrogates α-Synuclein-Induced Yeast Cell Death but Not That Triggered by the Bax or βa4 Peptide (2018)
Journal Article
Derf, A., Mudududdla, R., Akintade, D., Williams, I. S., Abdullaha, M., Chaudhuri, B., & Bharate, S. B. (2018). Nonantioxidant Tetramethoxystilbene Abrogates α-Synuclein-Induced Yeast Cell Death but Not That Triggered by the Bax or βa4 Peptide. ACS Omega, 3(8), 9513-9532. https://doi.org/10.1021/acsomega.8b01154

© 2018 American Chemical Society. The overexpression of α-synuclein (α-syn) and its aggregation is the hallmark of Parkinson's disease. The α-syn aggregation results in the formation of Lewy bodies that causes neuronal cell death. Therefore, the smal... Read More about Nonantioxidant Tetramethoxystilbene Abrogates α-Synuclein-Induced Yeast Cell Death but Not That Triggered by the Bax or βa4 Peptide.

Biotransformation, Using Recombinant CYP450-Expressing Baker's Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme (2018)
Journal Article
Williams, I. S., Gatchie, L., Bharate, S. B., & Chaudhuri, B. (2018). Biotransformation, Using Recombinant CYP450-Expressing Baker's Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme. ACS Omega, 3(8), 8903-8912. https://doi.org/10.1021/acsomega.8b00809

© Copyright 2018 American Chemical Society. CYP2D6, a cytochrome P450 (CYP) enzyme, metabolizes codeine to morphine. Within the human body, 0-15% of codeine undergoes O-demethylation by CYP2D6 to form morphine, a far stronger analgesic than codeine.... Read More about Biotransformation, Using Recombinant CYP450-Expressing Baker's Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme.

An implantable mixed-signal CMOS die for battery-powered in vivo blowfly neural recordings (2018)
Journal Article
Drakakis, E. M., Krapp, H. G., Huang, J. V., & Yue, X. (2018). An implantable mixed-signal CMOS die for battery-powered in vivo blowfly neural recordings. Microelectronics Journal, 74, 34-42. https://doi.org/10.1016/j.mejo.2018.01.022

© 2018 A mixed-signal die containing two differential input amplifiers, a multiplexer and a 50 KSPS, 10-bit SAR ADC, has been designed and fabricated in a 0.35 μm CMOS process for in vivo neural recording from freely moving blowflies where power supp... Read More about An implantable mixed-signal CMOS die for battery-powered in vivo blowfly neural recordings.

Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity (2018)
Journal Article
Efremov, V., Lakshmanan, R., Byrne, B., & Killard, A. (2018). Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity. Sensors and Actuators B: Chemical, 266, 472-476. https://doi.org/10.1016/j.snb.2018.03.145

© 2018 Elsevier B.V. It is well-established that alterations in cell morphology are regulated by cell signalling pathways, with the qualitative and quantitative monitoring of these intrinsic processes being of potential diagnostic value. Moreover, th... Read More about Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity.

Estimation of the dynamic leakage current of a supercapacitor in energy harvesting powered autonomous wireless sensor nodes (2017)
Journal Article
Yue, X., Kiely, J., Farooq, A., & Champneys, A. (2017). Estimation of the dynamic leakage current of a supercapacitor in energy harvesting powered autonomous wireless sensor nodes. Intelec, 2017-October, 278-281. https://doi.org/10.1109/INTLEC.2017.8214147

© 2017 IEEE. The supercapacitor is a candidate energy storage component for energy harvesting powered autonomous wireless sensor node aiming to achieve battery replacement-free, 'fit and forget' sensor node in low-power IoT applications. The leakage... Read More about Estimation of the dynamic leakage current of a supercapacitor in energy harvesting powered autonomous wireless sensor nodes.

Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds (2017)
Journal Article
Gould, O., Ratcliffe, N. M., De Lacy Costello, B., Wieczorek, T., & Persad, R. (2018). Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds. Journal of Breath Research, 12(1), 016009. https://doi.org/10.1088/1752-7163/aa8efe

© 2017 IOP Publishing Ltd. There have been a number of studies in which metal oxide sensors (MOS) have replaced conventional analytical detectors in gas chromatography systems. However, despite the use of these instruments in a range of applications... Read More about Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds.