Research Repository

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A copper oxide/zinc oxide composite nano-surface for use in a biosensor (2019)
Journal Article
Kiely, J., Piano, M., & Cao, L. (2019). A copper oxide/zinc oxide composite nano-surface for use in a biosensor. Materials, 12(7), 1126. https://doi.org/10.3390/ma12071126

In this study biosensors based on zinc oxide-copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 and 2:1 ZnO:CuO were comp... Read More

Charge-based supercapacitor storage estimation for indoor sub-mW photovoltaic energy harvesting powered wireless sensor nodes (2019)
Journal Article
Yue, X., & Kiely, J. (in press). Charge-based supercapacitor storage estimation for indoor sub-mW photovoltaic energy harvesting powered wireless sensor nodes. IEEE Transactions on Industrial Electronics, https://doi.org/10.1109/TIE.2019.2896321

Supercapacitors offer an attractive energy storage solution for lifetime “fit and forget” photovoltaic (PV) energy harvesting powered wireless sensor nodes for internet of things (IoT) applications. Whilst their low storage capacity is not an issue f... Read More

The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges (2019)
Journal Article
Djawad, Y., Attwood, D., Kiely, J., & Luxton, R. (2019). The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges. Sensing and Bio-Sensing Research, 23, 100269. https://doi.org/10.1016/j.sbsr.2019.100269

In this paper we present a non-contact, impedance-based sensor system capable of characterizing the toxic response of cells to three different types of toxin. ECV304 cells were treated with 1mM Hydrogen peroxide,5% Dimethyl Sulfoxide,and 10μg/ml sap... Read More

CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity (2019)
Journal Article
Williams, I. S., Sonawane, V. R., Mohd Usman, M. S., Gatchie, L., .Bharate, S. B., Jayaprakash, V., …Chaudhuri, B. (2019). CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance. European Journal of Pharmaceutical Sciences, 131, 177-194. https://doi.org/10.1016/j.ejps.2019.02.016

Microsomal cytochrome P450 (CYP) enzymes, isolated from recombinant bacterial/insect/yeast cells, are extensively used for drug metabolism studies. However, they may not always portray how a developmental drug would behave in human cells with intact... Read More

Morpholino oligonucleotide cross-linked hydrogels as portable optical oligonucleotide biosensors (2018)
Journal Article
Langford, G. J., Raeburn, J., Ferrier, D. C., Hands, P. J. W., & Shaver, M. P. (2019). Morpholino oligonucleotide cross-linked hydrogels as portable optical oligonucleotide biosensors. ACS Sensors, 4(1), 185-191. https://doi.org/10.1021/acssensors.8b01208

Morpholino Oligonucleotides (MOs), an uncharged DNA analogue, are functionalized with an acrylamide moiety and incorporated into polymer hydrogels as responsive cross-links for microRNA sequence detection. The MO crosslinks can be selectively cleaved... Read More

Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells (2018)
Journal Article
Sharma, R., Williams, I. S., Linda, G., Sonawane, V. R., Chaudhuri, B., & Bharate, S. B. (2018). Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells. Bioorganic and Medicinal Chemistry, 26(23-24), 6076-6086. https://doi.org/10.1016/j.bmc.2018.11.013

Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs)which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast cancers. Hence, phytoc... Read More

Analyses of parasitic capacitance effects and flicker noise of the DAC capacitor array for high resolution SAR ADCs (2018)
Journal Article
Yue, X., Kiely, J., & Mcleod, C. (2018). Analyses of parasitic capacitance effects and flicker noise of the DAC capacitor array for high resolution SAR ADCs. International Journal of Computer Applications in Technology, 58(4), 259-266. https://doi.org/10.1504/IJCAT.2018.095934

With the increasing number of bits, parasitic effects and flicker noise of switching transistors in the DAC capacitor array of the SAR ADC are getting relatively bigger when compared to the exponentially decreasing error budget. This paper analyses t... Read More

Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection (2018)
Journal Article
Lu, C., Janice, K., Martina, P., & Richard, L. (2018). Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection. Scientific Reports, 8(1), 122687. https://doi.org/10.1038/s41598-018-30793-z

The paper reports a biosensor formed from antibody coated ZnO nano-crystals which has been prepared using a rapid and inexpensive fabrication method which utilises colloidal dispersion enhanced using sonication. This technique was used to prepare hig... Read More

A non-antioxidant tetramethoxystilbene abrogates α-synuclein-induced yeast cell death but not that triggered by Bax or βA4 peptide (2018)
Journal Article
Derf, A., Mudududdla, R., Akintade, D., Williams, I. S., Abdullaha, M., Chaudhuri, B., & Bharate, S. B. (2018). A non-antioxidant tetramethoxystilbene abrogates α-synuclein-induced yeast cell death but not that triggered by Bax or βA4 peptide. ACS Omega, 3(8), 9513-9532. https://doi.org/10.1021/acsomega.8b01154

The overexpression of α-synuclein (α-syn) and its aggregation is the hallmark of Parkinson’s disease. The α-syn aggregation results in the formation of Lewy bodies that causes neuronal cell death. Therefore, the small molecules that can protect neuro... Read More

Biotransformation, using recombinant CYP450-expressing baker’s yeast cells, identifies a novel CYP2D6.10A122V variant which is a superior metaboliser of codeine to morphine than the wild-type enzyme (2018)
Journal Article
Williams, I. S., Gatchie, L., Bharate, S. B., & Chaudhuri, B. (2018). Biotransformation, using recombinant CYP450-expressing baker’s yeast cells, identifies a novel CYP2D6.10A122V variant which is a superior metaboliser of codeine to morphine than the wild-type enzyme. ACS Omega, 3(8), 8903-8912. https://doi.org/10.1021/acsomega.8b00809

CYP2D6, a cytochrome P450 (CYP) enzyme, metabolises codeine to morphine. Within the human body, 0-15% of codeine undergoes O-demethylation by CYP2D6 to form morphine, a far stronger analgesic than codeine. Genetic polymorphisms in wild-type CYP2D6 (C... Read More

Khellinoflavanone, a semisynthetic derivative of khellin, overcomes benzo[a]pyrene toxicity in human normal and cancer cells that express CYP1A1 (2018)
Journal Article
Sharma, R., Williams, I. S., Gatchie, L., Sonawane, V. R., Chaudhuri, B., & Bharate, S. B. (2018). Khellinoflavanone, a semisynthetic derivative of khellin, overcomes benzo[a]pyrene toxicity in human normal and cancer cells that express CYP1A1. ACS Omega, 3(8), 8553-8566. https://doi.org/10.1021/acsomega.8b01088

Cytochrome P450 family 1 (CYP1) enzymes catalyze the metabolic activation of environmental procarcinogens such as benzo[a]pyrene, B[a]P, into carcinogens, which initiate the process of carcinogenesis. Thus, stopping the metabolic activation of procar... Read More

Evaluation of an intensive interdisciplinary pain treatment based on Acceptance and Commitment Therapy for adolescents with chronic pain and their parents: A non-randomized clinical trial (2018)
Journal Article
Kemani, M., Kanstrup, M., Jordan, A., Caes, L., & Gauntlett-Gilbert, J. (2018). Evaluation of an intensive interdisciplinary pain treatment based on Acceptance and Commitment Therapy for adolescents with chronic pain and their parents: A non-randomized clinical trial. Journal of Pediatric Psychology, 43(9), 981-994. https://doi.org/10.1093/jpepsy/jsy031

Objective Parental factors are central in the development and maintenance of chronic pain in youths. Only a handful of studies have investigated the impact of psychological treatments for pediatric chronic pain on parental factors, and the relations... Read More

Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity (2018)
Journal Article
Efremov, V., Lakshmanan, R., Byrne, B., & Killard, A. (2018). Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity. Sensors and Actuators B: Chemical, 266, 472-476. https://doi.org/10.1016/j.snb.2018.03.145

It is well-established that alterations in cell morphology are regulated by cell signalling pathways, with the qualitative and quantitative monitoring of these intrinsic processes being of potential diagnostic value. Moreover, the deformability of re... Read More

An implantable mixed-Signal CMOS die for battery-powered in vivo blowfly neural recordings (2018)
Journal Article
Yue, X. (2018). An implantable mixed-Signal CMOS die for battery-powered in vivo blowfly neural recordings. Microelectronics Journal, 74, 34-42. https://doi.org/10.1016/j.mejo.2018.01.022

A mixed-signal die containing two differential input amplifiers, a multiplexer and a 50 KSPS, 10-bit SAR ADC, has been designed and fabricated in a 0.35 µm CMOS process for in vivo neural recording from freely moving blowflies where power supplied vo... Read More

Assessment of a combined gas chromatography mass spectrometer sensor (GC-MSS) system for detecting biologically relevant volatile compounds (VCs) (2017)
Journal Article
Gould, O., Ratcliffe, N. M., de Lacy Costello, B., Wieczorek, T., & Persad, R. (2018). Assessment of a combined gas chromatography mass spectrometer sensor (GC-MSS) system for detecting biologically relevant volatile compounds (VCs). Journal of Breath Research, 12(1), 016009. https://doi.org/10.1088/1752-7163/aa8efe

There have been a number of studies in which metal oxide sensors (MOS) have replaced conventional analytical detectors in gas chromatography systems. However, despite the use of these instruments in a range of applications including breath research t... Read More

Conductive composites for oligonucleotide detection (2017)
Journal Article
Ferrier, D. C., Shaver, M. P., & Hands, P. J. (2018). Conductive composites for oligonucleotide detection. Sensing and Bio-Sensing Research, 17, 1-6. https://doi.org/10.1016/j.sbsr.2017.11.007

A new method for oligonucleotide detection is presented based on oligonucleotide cross-linked polymer composites. Conductive carbon nanoparticles are incorporated into a DNA-functionalised polymer, containing partially complementary oligonucleotide c... Read More

( E )-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent (2017)
Journal Article
Horley, N. J., Beresford, K. J., Kaduskar, S., Joshi, P., McCann, G. J., Ruparelia, K. C., …Chaudhuri, B. (2017). ( E )-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent. Bioorganic and Medicinal Chemistry Letters, 27(24), 5409-5414. https://doi.org/10.1016/j.bmcl.2017.11.009

The overexpression of CYP1 family of enzymes is reported to be associated with development of human, carcinomas. It has been well reported that CYP1A1 specific inhibitors prevents carcinogenesis. Herein, thirteen pyridine-4-yl series of chalcones wer... Read More

Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme (2017)
Journal Article
Sharma, R., Gatchie, L., & Williams, I. S. (2017). Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme. Bioorganic and Medicinal Chemistry Letters, 5400-5403. https://doi.org/10.1016/j.bmcl.2017.11.013

The development of multi-drug resistance to existing anticancer drugs is one of the major challenges in cancer treatment. The over-expression of cytochrome P450 1B1 enzyme has been reported to cause resistance to cisplatin. With an objective to disco... Read More

Development of an indoor photovoltaic energy harvesting module for autonomous sensors in building air quality applications (2017)
Journal Article
Yue, X., Kauer, M., Bellanger, M., Beard, O., Brownlow, M., Gibson, D., …Song, S. (2017). Development of an indoor photovoltaic energy harvesting module for autonomous sensors in building air quality applications. IEEE Internet of Things, 4(6), 2092-2103. https://doi.org/10.1109/JIOT.2017.2754981

a 50 mm × 20 mm × 15 mm indoor photovoltaic (PV) energy harvesting power module (IPEHPM) has been developed for powering an IoT sensor node containing a low-power CO2 sensor for automatic building ventilation. It is composed of a high efficiency PV e... Read More