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The Pre-BRA (Pre-pectoral Breast Reconstruction Evaluation) Feasibility Study: Protocol for a mixed-methods IDEAL 2a/2b prospective cohort study to determine the safety and effectiveness of pre-pectoral implant-based breast reconstruction (2019)
Journal Article
Harvey, K., Mills, N., White, P., Holcombe, C., Potter, S., & The Pre-BRA Feasibility Study Steering Group, . (in press). The Pre-BRA (Pre-pectoral Breast Reconstruction Evaluation) Feasibility Study: Protocol for a mixed-methods IDEAL 2a/2b prospective cohort study to determine the safety and effectiveness of pre-pectoral implant-based breast reconstruction. BMJ Open,

Live birth rates and perinatal outcomes when all embryos are frozen compared with conventional fresh and frozen embryo transfer: a cohort study of 337,148 in vitro fertilisation cycles (2019)
Journal Article
Smith, A., Tilling, K., Lawlor, D., & Nelson, S. (2019). Live birth rates and perinatal outcomes when all embryos are frozen compared with conventional fresh and frozen embryo transfer: a cohort study of 337,148 in vitro fertilisation cycles. BMC Medicine, 17(1), https://doi.org/10.1186/s12916-019-1429-z

BACKGROUND: It is not known whether segmentation of an in vitro fertilisation (IVF) cycle, with freezing of all embryos prior to transfer, increases the chance of a live birth after all embryos are transferred. METHODS: In a prospective study of UK H... Read More about Live birth rates and perinatal outcomes when all embryos are frozen compared with conventional fresh and frozen embryo transfer: a cohort study of 337,148 in vitro fertilisation cycles.

Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children (2019)
Journal Article
Marini, S., Davis, K. A., Soare, T. W., Zhu, Y., Suderman, M. J., Simpkin, A. J., …Dunn, E. C. (2020). Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children. Psychoneuroendocrinology, 113, https://doi.org/10.1016/j.psyneuen.2019.104484

Objectives: Exposure to adversity has been linked to accelerated biological aging, which in turn has been shown to predict numerous physical and mental health problems. In recent years, measures of DNA methylation-based epigenetic age––known as “epig... Read More about Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children.

Characterising recovery from renal transplantation and live-related donation using cardiopulmonary exercise testing (2019)
Journal Article
Angell, J., Dodds, N., Darweish-Mednuik, A. M., Lewis, S., Pyke, M., Mitchell, D. C., …Tolchard, S. (in press). Characterising recovery from renal transplantation and live-related donation using cardiopulmonary exercise testing. Disability and Rehabilitation, https://doi.org/10.1080/09638288.2019.1674387

© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Background: An association between end-stage renal failure and exercise intolerance exists. Whether live kidney donation impacts on exercise tolerance is unknown. Here recovery p... Read More about Characterising recovery from renal transplantation and live-related donation using cardiopulmonary exercise testing.

Preliminary testing: The devil of statistics? (2019)
Journal Article
Pearce, J., & Derrick, B. (2019). Preliminary testing: The devil of statistics?. https://doi.org/10.31273/reinvention.v12i2.339

In quantitative research, the selection of the most appropriate statistical test for the comparison of two-independent samples can be problematic. There is a lack of consensus in the Statistics community regarding the appropriate approach; particular... Read More about Preliminary testing: The devil of statistics?.

An example motivated discourse of the chi-squared test of association (2 by 2) (2019)
Other
White, P., Redford, P., & Macdonald, J. (2019). An example motivated discourse of the chi-squared test of association (2 by 2)

An example application of the chi-square test of association is given through a set of questions and answers. The emphasis is on methodological aspects and what can be legitimately inferred, if anything. It is strongly highlighted that statistical... Read More about An example motivated discourse of the chi-squared test of association (2 by 2).

A primer on validity and design terminology in comparative designs (2019)
Other
White, P., Redford, P., & Macdonald, J. (2019). A primer on validity and design terminology in comparative designs

An overview of terminology (independent and dependent designs, dependent and independent variables) and validity (internal, external, and measurement) is given using six different scenarios. For simplicity of exposition, all examples have factors at... Read More about A primer on validity and design terminology in comparative designs.

Adolescent body dissatisfaction and disordered eating: Predictors of later risky health behaviours (2019)
Journal Article
Bornioli, A., Lewis-Smith, H., Smith, A., Slater, A., & Bray, I. (2019). Adolescent body dissatisfaction and disordered eating: Predictors of later risky health behaviours. Social Science and Medicine, 238, https://doi.org/10.1016/j.socscimed.2019.112458

Rationale Body dissatisfaction is prevalent among teenagers, and may influence the uptake of risky health behaviours. Objective The study assessed the influence of body dissatisfaction on smoking, cannabis use, drug use, self-harm, gambling, and... Read More about Adolescent body dissatisfaction and disordered eating: Predictors of later risky health behaviours.

Young carers in England: Findings from the 2018 BBC survey on the prevalence and nature of caring among young people (2019)
Journal Article
Joseph, S., Kendall, C., Toher, D., Sempik, J., Holland, J., & Becker, S. (2019). Young carers in England: Findings from the 2018 BBC survey on the prevalence and nature of caring among young people. Child: Care, Health and Development, 45(4), 606-612. https://doi.org/10.1111/cch.12674

© 2019 John Wiley & Sons Ltd Background: Many young people are involved in caring for parents, siblings, or other relatives who have an illness or disability. The aim of this study was to estimate the prevalence of caring by young people in England... Read More about Young carers in England: Findings from the 2018 BBC survey on the prevalence and nature of caring among young people.

Digging the optimum pit: Antlions, spirals and spontaneous stratification (2019)
Journal Article
Franks, N., Worley, A., Falkenberg, M., Sendova-Franks, A., & Christensen, K. (2019). Digging the optimum pit: Antlions, spirals and spontaneous stratification. Proceedings of the Royal Society B: Biological Sciences, 286(1899), 20190365. https://doi.org/10.1098/rspb.2019.0365

Most animal traps are constructed from self-secreted silk, so antlions are rare among trap builders because they use only materials found in the environment. We show how antlions exploit the properties of the substrate to produce very effective struc... Read More about Digging the optimum pit: Antlions, spirals and spontaneous stratification.

Social flocculation in plant–animal worms (2019)
Journal Article
Worley, A., Sendova-Franks, A., & Franks, N. (in press). Social flocculation in plant–animal worms. Royal Society Open Science, 6(181626), https://doi.org/10.1098/rsos.181626

Individual animals can often move more safely or more efficiently as members of a group. This can be as simple as safety in numbers or as sophisticated as aerodynamic or hydrodynamic cooperation. Here, we show that individual plant–animal worms (Syms... Read More about Social flocculation in plant–animal worms.

Sensitive periods for the effect of childhood adversity on DNA methylation: Results from a prospective, longitudinal study (2019)
Journal Article
Dunn, E. C., Soare, T. W., Zhu, Y., Simpkin, A. J., Suderman, M. J., Klengel, T., …Relton, C. L. (2019). Sensitive periods for the effect of childhood adversity on DNA methylation: Results from a prospective, longitudinal study. Biological Psychiatry, 85(10), 838-849. https://doi.org/10.1016/j.biopsych.2018.12.023

Background: Exposure to "early life" adversity is known to predict DNA methylation (DNAm) patterns that may be related to psychiatric risk. However, few studies have investigated whether adversity has time-dependent effects based on the age at exposu... Read More about Sensitive periods for the effect of childhood adversity on DNA methylation: Results from a prospective, longitudinal study.

Asymmetric ommatidia count and behavioural lateralization in the ant Temnothorax albipennis (2018)
Journal Article
Hunt, E., Dornan, S., Sendova-Franks, A., & Franks, N. (2018). Asymmetric ommatidia count and behavioural lateralization in the ant Temnothorax albipennis. Scientific Reports, 8(1), 5825. https://doi.org/10.1038/s41598-018-23652-4

© 2018 The Author(s). Workers of the house-hunting ant Temnothorax albipennis rely on visual edge following and landmark recognition to navigate their rocky environment, and they also exhibit a leftward turning bias when exploring unknown nest sites.... Read More about Asymmetric ommatidia count and behavioural lateralization in the ant Temnothorax albipennis.

Feeding tube securement in critical illness: Implications for safety (2018)
Journal Article
Taylor, S. J., Allan, K., Clemente, R., Marsh, A., & Toher, D. (2018). Feeding tube securement in critical illness: Implications for safety. British Journal of Nursing, 27(18), 1036-1041. https://doi.org/10.12968/bjon.2018.27.18.1036

© 2018 MA Healthcare Ltd Over 50% of tape-secured feeding tubes are inadvertently lost. The impact of nasal bridle securement on nasogastric (NG) and nasointestinal (NI) tube loss, outcome and duration of use was determined from 1 October 2014 (NG) a... Read More about Feeding tube securement in critical illness: Implications for safety.

Genomic profiling of IDH-wildtype and IDH-mutant initial and matched recurrent glioblastomas reveals clinically actionable mutations (e.g. BRCA1/2) and resistance signatures (2018)
Journal Article
McInerney, C. E., Ellis, H. P., Schrimpf, D., Sahm, F., Stupnikov, A., Wadsley, M., …Kurian, K. M. (2018). Genomic profiling of IDH-wildtype and IDH-mutant initial and matched recurrent glioblastomas reveals clinically actionable mutations (e.g. BRCA1/2) and resistance signatures. Neuro-Oncology, 20(3), iii215-iii216. https://doi.org/10.1093/neuonc/noy139.003

Abstract: Background: Glioblastomas account for 90% of all adult brain tumours. Patient survival remains low because treatments are ineffective against this lethal disease. Understanding the genes and pathways altered in subtypes is necessary for th... Read More about Genomic profiling of IDH-wildtype and IDH-mutant initial and matched recurrent glioblastomas reveals clinically actionable mutations (e.g. BRCA1/2) and resistance signatures.

An outlier in an independent samples design (2018)
Presentation / Conference
Derrick, B. (2018, September). An outlier in an independent samples design. Paper presented at Royal Statistical Society Conference

There is a flaw with some of the most commonly performed statistical tests. A paradox of the one sample t-test is the contrariwise decrease in the p-value as the value of an outlier increases in the direction of the overall effect. Demonstration of t... Read More about An outlier in an independent samples design.

Establishing the usefulness of the GO-QOL in a UK hospital-treated population with thyroid eye disease in the CIRTED trial (2018)
Journal Article
Jackson, S., Dietrich, A., Taylor, P., White, P., Wilson, V., Uddin, J., …Dayan, C. (2018). Establishing the usefulness of the GO-QOL in a UK hospital-treated population with thyroid eye disease in the CIRTED trial. Psychology, Health and Medicine, 23(sup1), 1341-1355. https://doi.org/10.1080/13548506.2018.1503693

© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Thyroid eye disease (TED) is a potentially sight-threatening and cosmetically disfiguring condition arising in 25–50% of patients with Graves’ hyperthyroidism. CIRTED is the fir... Read More about Establishing the usefulness of the GO-QOL in a UK hospital-treated population with thyroid eye disease in the CIRTED trial.

Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of Nocturia in adults with multiple sclerosis (MeNiMS) (2018)
Journal Article
Drake, M., Canham, L., Cotterill, N., Delgado, D., Homewood, J., Inglis, K., …Cottrell, D. (2018). Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of Nocturia in adults with multiple sclerosis (MeNiMS). BMC Neurology, 18(1), https://doi.org/10.1186/s12883-018-1114-4

© 2018 The Author(s). Background: Nocturia is a common urinary symptom of multiple sclerosis (MS) which can affect quality of life (QoL) adversely. Melatonin is a hormone known to regulate circadian rhythm and reduce smooth muscle activity such as in... Read More about Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of Nocturia in adults with multiple sclerosis (MeNiMS).