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Establishing the usefulness of the GO-QOL in a UK hospital-treated population with thyroid eye disease in the CIRTED trial

Jackson, Sue; Dietrich, Alina; Taylor, Peter; White, Paul; Wilson, Victoria; Uddin, Jimmy; Lee, Richard William John; Dayan, Colin

Authors

Sue Jackson susan4.jackson@uwe.ac.uk

Alina Dietrich

Peter Taylor

Paul White Paul.White@uwe.ac.uk
Associate Professor in Applied Statistics

Victoria Wilson

Jimmy Uddin

Richard William John Lee

Colin Dayan



Abstract

© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Thyroid eye disease (TED) is a potentially sight-threatening and cosmetically disfiguring condition arising in 25–50% of patients with Graves’ hyperthyroidism. CIRTED is the first study to evaluate the long-term role of radiotherapy and prolonged immunosuppression with azathioprine in treating TED, one aim of which was to validate the use of the English version of GO-QOL in an UK population with TED. In a three stage design over a 48week period, the GO-QOL was tested and compared to a general measure of quality of life (WHOQOL-Bref). In stage 1 utilising a standard 14 day test-retest design both GO-QOL subscales achieved Cronbach’s alphas demonstrating excellent validity and internal reliability (Visual Function 0.929 and 0.931; Appearance 0.888 and 0.906). In stage 2, Repeated Measures ANOVA demonstrated longitudinal validity, with both subscales of the GO-QOL showing significant change over time (Visual Function, η 2 =0.114, p

Journal Article Type Article
Publication Date Dec 14, 2018
Journal Psychology, Health and Medicine
Print ISSN 1354-8506
Publisher Taylor & Francis (Routledge)
Peer Reviewed Peer Reviewed
Volume 23
Issue sup1
Pages 1341-1355
APA6 Citation Jackson, S., Dietrich, A., Taylor, P., White, P., Wilson, V., Uddin, J., …Dayan, C. (2018). Establishing the usefulness of the GO-QOL in a UK hospital-treated population with thyroid eye disease in the CIRTED trial. Psychology, Health and Medicine, 23(sup1), 1341-1355. https://doi.org/10.1080/13548506.2018.1503693
DOI https://doi.org/10.1080/13548506.2018.1503693
Publisher URL https://doi.org/10.1080/13548506.2018.1503693
Additional Information Additional Information : This is an Accepted Manuscript of an article published by Taylor & Francis in Psychology, Health & Medicine on 9th August 2018, available online: https://doi.org/10.1080/13548506.2018.1503693.

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