Establishing the usefulness of the GO-QOL in a UK hospital-treated population with thyroid eye disease in the CIRTED trial

Jackson, Sue; Dietrich, Alina; Taylor, Peter; White, Paul; Wilson, Victoria; Uddin, Jimmy; Lee, Richard William John; Dayan, Colin

Abstract

© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Thyroid eye disease (TED) is a potentially sight-threatening and cosmetically disfiguring condition arising in 25–50% of patients with Graves’ hyperthyroidism. CIRTED is the first study to evaluate the long-term role of radiotherapy and prolonged immunosuppression with azathioprine in treating TED, one aim of which was to validate the use of the English version of GO-QOL in an UK population with TED. In a three stage design over a 48week period, the GO-QOL was tested and compared to a general measure of quality of life (WHOQOL-Bref). In stage 1 utilising a standard 14 day test-retest design both GO-QOL subscales achieved Cronbach’s alphas demonstrating excellent validity and internal reliability (Visual Function 0.929 and 0.931; Appearance 0.888 and 0.906). In stage 2, Repeated Measures ANOVA demonstrated longitudinal validity, with both subscales of the GO-QOL showing significant change over time (Visual Function, η 2 =0.114, p

• Journal Article Type: Article
• Acceptance Date: Jul 17, 2018
• Online Publication Date: Aug 9, 2018
• Publication Date: Dec 14, 2018
• Deposit Date: Jul 18, 2018
• Publicly Available Date: Aug 21, 2019
• Journal: Psychology, Health and Medicine
• Print ISSN: 1354-8506
• Publisher: Taylor & Francis (Routledge)
• Peer Reviewed: Peer Reviewed
• Volume: 23
• Issue: sup1
• Pages: 1341-1355
• DOI: https://doi.org/10.1080/13548506.2018.1503693
• Public URL: https://uwe-repository.worktribe.com/output/864402
• Publisher URL: https://doi.org/10.1080/13548506.2018.1503693
• Additional Information: Additional Information : This is an Accepted Manuscript of an article published by Taylor & Francis in Psychology, Health & Medicine on 9th August 2018, available online: https://doi.org/10.1080/13548506.2018.1503693.
• Contract Date: Jul 18, 2018