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Robust feature extraction from impedimetric signals using wavelet packet decomposition with application to cytotoxicity testing (2012)
Journal Article
Luxton, R., Wraith, P., Nibouche, M., Kiely, J., Abdul Djawad, Y., Djawad, Y. A., …Luxton, R. W. (2012). Robust feature extraction from impedimetric signals using wavelet packet decomposition with application to cytotoxicity testing. IET Science Measurement and Technology, 6(6), 456-463. https://doi.org/10.1049/iet-smt.2012.0009

Impedance-based cytotoxicity testing provides a simple, real-time and non-invasive assay technique that interferes minimally with cell morphology and function. In this study, impedimetric measurements of ECV304 cells with increasing concentrations of... Read More about Robust feature extraction from impedimetric signals using wavelet packet decomposition with application to cytotoxicity testing.

Non-linear data analysis of impedance spectroscopy as applied to cellular toxicity systems (2012)
Presentation / Conference
Wang, Z., Kiely, J., & Luxton, R. W. (2012, June). Non-linear data analysis of impedance spectroscopy as applied to cellular toxicity systems. Paper presented at International Conference on Modelling, Identification & Control (ICMIC), 2012

This paper introduces an impedance measurement system that can be performed non-destructively to detect cellular toxicity with a cell culture system. This study examines ECV304 cells grown in culture well and exposed to toxicant dimethyl sulphoxide... Read More about Non-linear data analysis of impedance spectroscopy as applied to cellular toxicity systems.

Comparison of cytotoxic changes in ECV304 cell through exposure to DMSO and sodium butyrate using impedance spectroscopy (2012)
Journal Article
Wang, Z., Kiely, J., Vargas, A. M., & Luxton, R. W. (2012). Comparison of cytotoxic changes in ECV304 cell through exposure to DMSO and sodium butyrate using impedance spectroscopy. Procedia Chemistry, 6, 89-99. https://doi.org/10.1016/j.proche.2012.10.134

This paper decides an impedance spectroscopy measurement system for real-time monitoring of cellular toxicity. The system is used to compare the impedance response of ECV304 cells to two toxicants, dimethyl sulphoxide (DMSO) and sodium butyrate. The... Read More about Comparison of cytotoxic changes in ECV304 cell through exposure to DMSO and sodium butyrate using impedance spectroscopy.

Magnetic particle detector system (2010)
Patent
Kiely, J., Luxton, R. W., & Hawkins, P. (2010). Magnetic particle detector system. EP20050744998 20050517

A magnetic particle detector system comprises a plurality of reaction surfaces; a corresponding plurality of electrical coils, each located adjacent a respective reaction surface; and a measuring system for measuring the effect of magnetic particles... Read More about Magnetic particle detector system.

Magnetizable antibody-like proteins (2010)
Journal Article
Luxton, R., Dehal, P. K., Livingston, C. F., Dunn, C. G., Buick, R., Luxton, R. W., & Pritchard, D. J. (2010). Magnetizable antibody-like proteins. Biotechnology Journal, 5(6), 596-604. https://doi.org/10.1002/biot.200900273

Use of paramagnetic particles to isolate molecules or cells from complex media is well established. Typically, particles are manufactured and coated with a biological molecule that confers specific biorecognition. Incubation of particles with sample... Read More about Magnetizable antibody-like proteins.

Hilbert huang transform impedance measurement data for cellular toxicity monitoring (2009)
Conference Proceeding
Luxton, R., Zhu, Q., Wang, Z., Zhu, Q., Kiely, J., & Luxton, R. W. (2009). Hilbert huang transform impedance measurement data for cellular toxicity monitoring. In N. NA (Ed.), International Conference on Networking, Sensing and Control, (767-772). https://doi.org/10.1109/ICNSC.2009.4919375

This paper investigates the Hilbert-Huang transformation (HHT), which is adaptive analysis of nonlinear and non-stationary signals. The aim of this study is to apply HHT to impedance measurement data analysis in order to discriminate different types... Read More about Hilbert huang transform impedance measurement data for cellular toxicity monitoring.

Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay (2009)
Journal Article
Eveness, J., Kiely, J., Hawkins, P., Wraith, P., & Luxton, R. (2009). Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay. Sensors and Actuators B: Chemical, 139(2), 538-542. https://doi.org/10.1016/j.snb.2009.03.078

This paper describes work that formed a part of an investigation to increase the detection sensitivity of a magneto-immunoassay. The study involved the characterisation of paramagnetic particles (PMPs) from a range of manufacturers in order to determ... Read More about Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay.

Spot test: new technologies bring point-of-care testing into the 21st century (2009)
Journal Article
Luxton, R. W., & Kiely, J. (2009). Spot test: new technologies bring point-of-care testing into the 21st century

Every new technology offers the potential to effect changes in practise; many developments driven by the world-wide demand for instant results. This is never as true as in the arena of diagnostic testing. Once the sole preserve of the hospital labo... Read More about Spot test: new technologies bring point-of-care testing into the 21st century.

Spot test (2009)
Other
Kiely, J., & Luxton, R. W. (2009). Spot test

Paramagnetic particle detection for use with an immunoassay based biosensor (2007)
Journal Article
Wraith, P., Hawkins, P., Kiely, J., Hawkins, P., Wraith, P., & Luxton, R. (2007). Paramagnetic particle detection for use with an immunoassay based biosensor. IET Science Measurement and Technology, 1(5), 270-275. https://doi.org/10.1049/iet-smt%3A20060103

A biosensor and detection system that can provide measurement of analyte concentration within a test sample in four minutes is presented. The biosensor uses an immunoassay with micrometre-sized paramagnetic particle (PMP) labels for quantification. A... Read More about Paramagnetic particle detection for use with an immunoassay based biosensor.

Use of External Magnetic Fields to Reduce Reaction Times in an Immunoassay Using Micrometer-Sized Paramagnetic Particles as Labels (Magnetoimmunoassay) (2004)
Journal Article
Luxton, R., Badesha, J., Kiely, J., & Hawkins, P. (2004). Use of External Magnetic Fields to Reduce Reaction Times in an Immunoassay Using Micrometer-Sized Paramagnetic Particles as Labels (Magnetoimmunoassay). Analytical Chemistry, 76(6), 1715-1719. https://doi.org/10.1021/ac034906%2B

The paper presents a rapid immunoassay system capable of quantifying analyte in complex biological and environmental media. Antibody-coated micrometer-sized paramagnetic particles are used as labels in an assay in which they bind quantitatively with... Read More about Use of External Magnetic Fields to Reduce Reaction Times in an Immunoassay Using Micrometer-Sized Paramagnetic Particles as Labels (Magnetoimmunoassay).

Rapid electrochemical detection and identification of catalase positive micro-organisms (2003)
Journal Article
Lewis, R. J., Luxton, R., Sippy, N., Luxton, R. W., Lewis, R., & Cowell, D. C. (2003). Rapid electrochemical detection and identification of catalase positive micro-organisms. Biosensors and Bioelectronics, 18(5-6), 741-749. https://doi.org/10.1016/S0956-5663%2803%2900023-X

The rapid detection and identification of bacteria has application in a number of fields, e.g. the food industry, environmental monitoring and biomedicine. While in biomedicine the number of organisms present during infection is multiples of millions... Read More about Rapid electrochemical detection and identification of catalase positive micro-organisms.

Towards the development of molecularly imprinted polymer based screen-printed sensors for metabolites of PAHs (2001)
Journal Article
McCalley, D. V., Luxton, R. W., Bird, D. J., Hart, J. P., Kirsch, N., Kirsch, N., …McCalley, D. V. (2001). Towards the development of molecularly imprinted polymer based screen-printed sensors for metabolites of PAHs. Analyst, 126(11), 1936-1941. https://doi.org/10.1039/b108008n

This paper describes the fabrication of a sensor for 1-hydroxypyrene (1-OHP) based on a screen-printed carbon electrode (SPCE) modified with a molecularly imprinted polymer (MIP); 1-OHP was chosen as a model metabolite of polyaromatic hydrocarbons (P... Read More about Towards the development of molecularly imprinted polymer based screen-printed sensors for metabolites of PAHs.

The use of coated paramagnetic particles as a physical label in a magneto-immunoassay (2001)
Journal Article
Luxton, R., Hawkins, P., & Richardson, J. (2001). The use of coated paramagnetic particles as a physical label in a magneto-immunoassay. Biosensors and Bioelectronics, 16(9-12), 989-993. https://doi.org/10.1016/S0956-5663%2801%2900201-9

An ideal label for use in an immunoassay would require no further chemical or electromagnetic stimulation prior to its detection and would be free from interference from the sample matrix. Micron sized paramagnetic particles are able to perturb magne... Read More about The use of coated paramagnetic particles as a physical label in a magneto-immunoassay.