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Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection

Lu, Cao; Janice, Kiely; Martina, Piano; Richard, Luxton

Authors

Cao Lu lu.cao@uwe.ac.uk

Janice Kiely Janice.Kiely@uwe.ac.uk
Professor in Bio-electronics/Res In CoDi

Martina Piano Martina.Piano@uwe.ac.uk
Research Fellow Biosensor reproducibility testing

Richard Luxton Richard.Luxton@uwe.ac.uk
Research Centre Director-IBST/Professor



Abstract

© 2018, The Author(s). The paper reports a biosensor formed from antibody coated ZnO nano-crystals which has been prepared using a rapid and inexpensive fabrication method which utilises colloidal dispersion enhanced using sonication. This technique was used to prepare highly ordered and uniform nano-crystalline sensor surfaces on polyethylene terephthalate (PET) using 0.5%, 1% and 5% concentrations of zinc oxide nano-crystal suspensions. Impedance spectroscopy was employed to interrogate the sensor surfaces and confirmed high reproducibility of the fabrication process. Changes in impedance values, at a frequency of 138 Hz, were used to establish dose dependent responses for C-reactive protein (CRP) antigen. A limit of detection of less than 1 ng/ml was demonstrated fornano-surfaces fabricated from concentrations of 1% ZnO.

Citation

Lu, C., Janice, K., Martina, P., & Richard, L. (2018). Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection. Scientific Reports, 8(1), 122687. https://doi.org/10.1038/s41598-018-30793-z

Journal Article Type Article
Acceptance Date Aug 2, 2018
Publication Date Dec 1, 2018
Journal Scientific Reports
Electronic ISSN 2045-2322
Publisher Nature Research (part of Springer Nature)
Peer Reviewed Peer Reviewed
Volume 8
Issue 1
Pages 122687
DOI https://doi.org/10.1038/s41598-018-30793-z
Keywords biosenor, zinc oxide, rapid, nanomaterials,
Public URL https://uwe-repository.worktribe.com/output/862678
Publisher URL http://dx.doi.org/10.1038/s41598-018-30793-z

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