Skip to main content

Research Repository

Advanced Search

All Outputs (92)

Migration and niche partitioning simultaneously increase species richness and rarity (2013)
Journal Article
Ellwood, M. D., Ai, D., Chu, C., Ellwood, M. D. F., Hou, R., & Wang, G. (2013). Migration and niche partitioning simultaneously increase species richness and rarity. Ecological Modelling, 258, 33-39. https://doi.org/10.1016/j.ecolmodel.2013.03.001

To understand species abundance distributions effectively, it is essential to consider the forces which create the overwhelmingly long 'tail' of rare species. Both neutral and niche theory have been invoked to explain the rarity of certain species in... Read More about Migration and niche partitioning simultaneously increase species richness and rarity.

Use of whole blood for analysis of disease-associated biomarkers (2013)
Journal Article
McLeod, J., Pemberton, R. M., May, J. E., Pemberton, R., Hart, J. P., McLeod, J. D., …Doran, O. (2013). Use of whole blood for analysis of disease-associated biomarkers. Analytical Biochemistry, 437(1), 59-61. https://doi.org/10.1016/j.ab.2013.02.024

Analyses for diagnosis and monitoring of pathological conditions often rely on blood samples, partly due to relative ease of collection. However, many interfering substances largely preclude the use of whole blood itself, necessitating separation of... Read More about Use of whole blood for analysis of disease-associated biomarkers.

Smart integrated biosensor system (2013)
Journal Article
Killard, A. (2013). Smart integrated biosensor system. International innovation : disseminating science, research and technology, 22, 30-32

Professor Tony Killard from the University of the West of England is leading a collaborative project to develop and implement smart integrated miniturised sensor systems.

A novel bioluminescent bacterial biosensor for measurement of Ara-CTP and cytarabine potentiation by fludarabine in seven leukaemic cell lines (2013)
Journal Article
Conway, M., Anderson, E., Smith, M. A., Martin, A., Ruddock, M., Lamont, J., …Salisbury, V. (2013). A novel bioluminescent bacterial biosensor for measurement of Ara-CTP and cytarabine potentiation by fludarabine in seven leukaemic cell lines. Leukemia Research, 37(6), 690-696. https://doi.org/10.1016/j.leukres.2013.02.012

This study evaluates an in vitro biosensor assay capable of detecting the intracellular levels of the tri-phosphorylated form of cytarabine (Ara-CTP) within one working day. The biosensor predicted the response of seven leukaemic cell lines with vary... Read More about A novel bioluminescent bacterial biosensor for measurement of Ara-CTP and cytarabine potentiation by fludarabine in seven leukaemic cell lines.

The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium (2013)
Journal Article
Giles, R. H., Slaats, G. G., Van Dam, T. J., Huynen, M. A., van Dam, T. J., Wheway, G., …Giles, R. H. (2013). The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium. Cilia, 2(1), 7. https://doi.org/10.1186/2046-2530-2-7

The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive models of relationships between complex genotypes and variable phenotyp... Read More about The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium.

Direct measurement of ammonia in simulated human breath using an inkjet-printed polyaniline nanoparticle sensor (2013)
Journal Article
Killard, A. J., Killard, A., Hibbard, T., & Crowley, K. (2013). Direct measurement of ammonia in simulated human breath using an inkjet-printed polyaniline nanoparticle sensor. Analytica Chimica Acta, 779, 56-63. https://doi.org/10.1016/j.aca.2013.03.051

A sensor fabricated from the inkjet-printed deposition of polyaniline nanoparticles onto a screen-printed silver interdigitated electrode was developed for the detection of ammonia in simulated human breath samples. Impedance analysis showed that exp... Read More about Direct measurement of ammonia in simulated human breath using an inkjet-printed polyaniline nanoparticle sensor.

Taking a breath for better health (2013)
Journal Article
Killard, A. (2013). Taking a breath for better health

What does your breath say about you? It might tell the world (or at least anyone at close quarters) that you didn’t brush your teeth this morning, or that you ate garlic last night. But there might also be other, subtle and important clues in there a... Read More about Taking a breath for better health.

LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: Implications for targeting adenoma stem cells with nsaids (2013)
Journal Article
Williams, A. C., Emery, E. D., Collard, T. J., Smartt, H. J., Al-Kharusi, M. R., Al-Kharusi, M. H., …Paraskeva, C. (2013). LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: Implications for targeting adenoma stem cells with nsaids. Carcinogenesis, 34(5), 1150-1157. https://doi.org/10.1093/carcin/bgt020

Cyclooxygenase-2 is overexpressed in the majority of colorectal tumours leading to elevated levels of prostaglandin E2 (PGE2), promoting many hallmarks of cancer. Importantly, PGE2 is reported to enhance Wnt/β-catenin signalling in colorectal carcino... Read More about LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: Implications for targeting adenoma stem cells with nsaids.

Aberrant Wnt signalling and cellular over-proliferation in a novel mouse model of Meckel-Gruber syndrome (2013)
Journal Article
Wheway, G., Abdelhamed, Z., Natarajan, S., Toomes, C., Inglehearn, C., & Johnson, C. A. (2013). Aberrant Wnt signalling and cellular over-proliferation in a novel mouse model of Meckel-Gruber syndrome. Developmental Biology, 377(1), 55-66. https://doi.org/10.1016/j.ydbio.2013.02.015

Meckel-Gruber syndrome (MKS) is an embryonic lethal ciliopathy resulting from mutations in genes encoding proteins localising to the primary cilium. Mutations in the basal body protein MKS1 account for 7% of cases of MKS. The condition affects the de... Read More about Aberrant Wnt signalling and cellular over-proliferation in a novel mouse model of Meckel-Gruber syndrome.

Comparative antimicrobial activities of aerosolized sodium hypochlorite, chlorine dioxide, and electrochemically activated solutions evaluated using a novel standardized assay (2013)
Journal Article
Reynolds, D. M., Thorn, R. M., Thorn, R., Reynolds, D. M., & Robinson, G. M. (2013). Comparative antimicrobial activities of aerosolized sodium hypochlorite, chlorine dioxide, and electrochemically activated solutions evaluated using a novel standardized assay. Antimicrobial Agents and Chemotherapy, 57(5), 2216-2225. https://doi.org/10.1128/AAC.02589-12

The main aim of this study was to develop a standardized experimental assay to enable differential antimicrobial comparisons of test biocidal aerosols. This study represents the first chlorine-matched comparative assessment of the antimicrobial activ... Read More about Comparative antimicrobial activities of aerosolized sodium hypochlorite, chlorine dioxide, and electrochemically activated solutions evaluated using a novel standardized assay.

The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins (2013)
Journal Article
Luxton, R., Sharif, E., Syarif, E., Kiely, J., Wraith, P., & Luxton, R. W. (2013). The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins. IEEE Transactions on Biomedical Engineering, 60(5), 1209-1216. https://doi.org/10.1109/TBME.2012.2228642

A novel, integrated lysis and immunoassay methodology and system for intracellular protein measurement are described. The method uses paramagnetic particles both as a lysis agent and assay label resulting in a rapid test requiring minimal operator in... Read More about The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins.

Temperature response of denitrification rate and greenhouse gas production in agricultural river marginal wetland soils (2013)
Journal Article
Blackwell, M. S., Bonnett, S. A., Bonnett, S., Blackwell, M. S. A., Leah, R., Cook, V., …Maltby, E. (2013). Temperature response of denitrification rate and greenhouse gas production in agricultural river marginal wetland soils. Geobiology, 11(3), 252-267. https://doi.org/10.1111/gbi.12032

Soils are predicted to exhibit significant feedback to global warming via the temperature response of greenhouse gas (GHG) production. However, the temperature response of hydromorphic wetland soils is complicated by confounding factors such as oxyge... Read More about Temperature response of denitrification rate and greenhouse gas production in agricultural river marginal wetland soils.

CoreGenes3.5: A webserver for the determination of core genes from sets of viral and small bacterial genomes (2013)
Journal Article
Turner, D., Reynolds, D., Seto, D., & Mahadevan, P. (2013). CoreGenes3.5: A webserver for the determination of core genes from sets of viral and small bacterial genomes. BMC Research Notes, 6(1), 140. https://doi.org/10.1186/1756-0500-6-140

Background: CoreGenes3.5 is a webserver that determines sets of core genes from viral and small bacterial genomes as an automated batch process. Previous versions of CoreGenes have been used to classify bacteriophage genomes and mine data from pathog... Read More about CoreGenes3.5: A webserver for the determination of core genes from sets of viral and small bacterial genomes.

Microfabricated glucose biosensor for culture welloperation (2013)
Journal Article
Hart, J. P., Luxton, R., Xu, J., Griffiths, J., Sage, I., Tuffin, R., …Hart, J. P. (2013). Microfabricated glucose biosensor for culture welloperation. Biosensors and Bioelectronics, 42(1), 668-677. https://doi.org/10.1016/j.bios.2012.11.032

A water-based carbon screen-printing ink formulation, containing the redox mediator cobalt phthalocyanine (CoPC) and the enzyme glucose oxidase (GOx), was investigated for its suitability to fabricate glucose microbiosensors in a 96-well microplate f... Read More about Microfabricated glucose biosensor for culture welloperation.

Electrochemical detection of extracellular hydrogen peroxide in Arabidopsis thaliana: A real-time marker of oxidative stress (2013)
Journal Article
Killard, A. J., Hancock, J., Valero, E., Pérez-Prior, M. T., González-Macia, L., González-Sánchez, M. I., …Killard, A. (2013). Electrochemical detection of extracellular hydrogen peroxide in Arabidopsis thaliana: A real-time marker of oxidative stress. Plant, Cell and Environment, 36(4), 869-878. https://doi.org/10.1111/pce.12023

An electrochemical approach to directly measure the dynamic process of H2O2 release from cultures of Arabidopsis thaliana cells is reported. This approach is based on H2O2 oxidation on a Pt electrode in conjunction with continuous measurement of samp... Read More about Electrochemical detection of extracellular hydrogen peroxide in Arabidopsis thaliana: A real-time marker of oxidative stress.

Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel - Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and wnt signalling defects (2013)
Journal Article
Abdelhamed, Z. A., Wheway, G., Szymanska, K., Natarajan, S., Toomes, C., Inglehearn, C., & Johnson, C. A. (2013). Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel - Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and wnt signalling defects. Human Molecular Genetics, 22(7), 1358-1372. https://doi.org/10.1093/hmg/dds546

The ciliopathies are a group of heterogeneous diseases with considerable variations in phenotype for allelic conditions such as Meckel-Gruber syndrome (MKS) and Joubert syndrome (JBTS) even at the inter-individual level within families. In humans, mu... Read More about Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel - Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and wnt signalling defects.

Dendritic cell migration assay: A potential prediction model for identification of contact allergens (2013)
Journal Article
McLeod, J., Gibbs, S., Spiekstra, S., Corsini, E., & Reinders, J. (2013). Dendritic cell migration assay: A potential prediction model for identification of contact allergens. Toxicology in Vitro, 27(3), 1170-1179. https://doi.org/10.1016/j.tiv.2012.05.016

This manuscript describes methodology and a prediction model for the MUTZ-LC migration assay. The assay represents the physiological change in Langerhans cell (LC) behavior after exposure to a sensitizing chemical, resulting in LC migration from the... Read More about Dendritic cell migration assay: A potential prediction model for identification of contact allergens.

Investigation on Cacao swollen shoot virus (CSSV) pollen transmission through cross-pollination (2013)
Journal Article
Ameyaw, G. A., Wetten, A., Dzahini-Obiatey, H., Domfeh, O., & Allainguillaume, J. (2013). Investigation on Cacao swollen shoot virus (CSSV) pollen transmission through cross-pollination. Plant Pathology, 62(2), 421-427. https://doi.org/10.1111/j.1365-3059.2012.02640.x

DNA- and RNA-based polymerase chain reaction (PCR) systems were used with Cacao swollen shoot virus (CSSV) primers designed from conserved regions of the six published genomic sequences of CSSV to investigate whether the virus is transmissible from i... Read More about Investigation on Cacao swollen shoot virus (CSSV) pollen transmission through cross-pollination.

Recent developments in the stripping voltammetric determination of indium (2013)
Journal Article
Honeychurch, K. C. (2013). Recent developments in the stripping voltammetric determination of indium. World Journal of Analytical Chemistry, 1(1), 8-13. https://doi.org/10.12691/wjac-1-1-2

The determination of indium has become increasingly more important as the demand for this metal has greatly increased in recent years for the manufacture of touch screen devices, photovoltaic and semi-conductor devices. Concentrations of In generally... Read More about Recent developments in the stripping voltammetric determination of indium.