All Outputs (11)

Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily (2022)
Journal Article
Hancock, J. T., Russell, G., Craig, T. J., May, J., Morse, H. R., & Stamler, J. S. (2022). Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily. Oxygen, 2(4), 578-590. https://doi.org/10.3390/oxygen2040038

Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported to have similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe),... Read More about Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily.

WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1 (2020)
Journal Article
Belali, T., Wodi, C., Clark, B., Cheung, M. K., Craig, T. J., Wheway, G., …Ladomery, M. (2020). WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1. BBA - Gene Regulatory Mechanisms, 1863(12), Article 194642. https://doi.org/10.1016/j.bbagrm.2020.194642

Dysregulated alternative splicing plays a prominent role in all hallmarks of cancer. The splice factor kinase SRPK1 drives the activity of oncogenic splice factors such as SRSF1. SRSF1 in turn promotes the expression of splice isoforms that favour tu... Read More about WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1.

Phosphorylation of Syntaxin‐1a by casein kinase 2α (CK2α) regulates presynaptic vesicle exocytosis from the reserve pool (2020)
Journal Article
Shi, V. (., Craig, T. J., Bishop, P., Nakamura, Y., Rocca, D., Wilkinson, K. A., & Henley, J. M. (2021). Phosphorylation of Syntaxin‐1a by casein kinase 2α (CK2α) regulates presynaptic vesicle exocytosis from the reserve pool. Journal of Neurochemistry, 156(5), 614-623. https://doi.org/10.1111/jnc.15161

The t-soluble NSF-attachment protein receptor protein Syntaxin-1a (Stx-1a) is abundantly expressed at pre-synaptic terminals where it plays a critical role in the exocytosis of neurotransmitter-containing synaptic vesicles. Stx-1a is phosphorylated... Read More about Phosphorylation of Syntaxin‐1a by casein kinase 2α (CK2α) regulates presynaptic vesicle exocytosis from the reserve pool.

Polydopamine-lysophosphatidate-functionalised titanium: A novel hybrid surface finish for bone regenerative applications (2020)
Journal Article
Baldwin, F., Craig, T. J., Shiel, A. I., Cox, T., Lee, K., & Mansell, J. P. (2020). Polydopamine-lysophosphatidate-functionalised titanium: A novel hybrid surface finish for bone regenerative applications. Molecules, 25(7), Article 1583. https://doi.org/10.3390/molecules25071583

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Aseptic loo... Read More about Polydopamine-lysophosphatidate-functionalised titanium: A novel hybrid surface finish for bone regenerative applications.

Insulin-dependent GLUT4 trafficking is not regulated by protein SUMOylation in L6 myocytes (2019)
Journal Article
Carmichael, R. E., Wilkinson, K. A., & Craig, T. J. (2019). Insulin-dependent GLUT4 trafficking is not regulated by protein SUMOylation in L6 myocytes. Scientific Reports, 9(1), Article 6477. https://doi.org/10.1038/s41598-019-42574-3

Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues today, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. One of the key pathological traits of this disease is insulin resistan... Read More about Insulin-dependent GLUT4 trafficking is not regulated by protein SUMOylation in L6 myocytes.

Protein SUMOylation regulates insulin secretion at multiple stages (2019)
Journal Article
Davey, J. S., Carmichael, R. E., & Craig, T. J. (2019). Protein SUMOylation regulates insulin secretion at multiple stages. Scientific Reports, 9, Article 2895. https://doi.org/10.1038/s41598-019-39681-6

Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues of modern times, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. A key pathological trait associated with this disease is the... Read More about Protein SUMOylation regulates insulin secretion at multiple stages.

MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1 (2018)
Journal Article
Carmichael, R. E., Wilkinson, K. A., Craig, T. J., Ashby, M. C., & Henley, J. M. (2018). MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1. Scientific Reports, 8(1), 5263. https://doi.org/10.1038/s41598-018-23440-0

© 2018 The Author(s). Differential trafficking of AMPA receptors (AMPARs) to and from the postsynaptic membrane is a key determinant of the strength of excitatory neurotransmission, and is thought to underlie learning and memory. The transcription fa... Read More about MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1.

Competition of reactive signals and thiol modifications of proteins (2017)
Journal Article
Hancock, J. T., Craig, T. J., & Whiteman, M. (2017). Competition of reactive signals and thiol modifications of proteins. https://doi.org/10.4172/2576-1471.1000170

It is clear that cells are constantly bombarded by multiple signals, often initiating similar, or even conflicting, responses. Important players in this suite of signals are the reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), the rea... Read More about Competition of reactive signals and thiol modifications of proteins.

SUMOylation of Syntaxin1A regulates presynaptic endocytosis (2015)
Journal Article
Henley, J. M., Craig, T. J., Anderson, D., Evans, A. J., & Girach, F. (2015). SUMOylation of Syntaxin1A regulates presynaptic endocytosis. Scientific Reports, 5, 17669. https://doi.org/10.1038/srep17669

Neurotransmitter release from the presynaptic terminal is under very precise spatial and temporal control. Following neurotransmitter release, synaptic vesicles are recycled by endocytosis and refilled with neurotransmitter. During the exocytosis eve... Read More about SUMOylation of Syntaxin1A regulates presynaptic endocytosis.

SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation (2015)
Journal Article
Henley, J. M., Tang, L. T., & Craig, T. J. (2015). SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation. Nature Communications, 6, 7728. https://doi.org/10.1038/ncomms8728

© 2015 Macmillan Publishers Limited. All rights reserved. Synapsins are key components of the presynaptic neurotransmitter release machinery. Their main role is to cluster synaptic vesicles (SVs) to each other and anchor them to the actin cytoskeleto... Read More about SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation.

RIM1α SUMOylation is required for fast synaptic vesicle exocytosis (2013)
Journal Article
Rocca, D. L., Henley, J. M., Girach, F., Craig, T. J., Rocca, D. L., & Henley, J. M. (2013). RIM1α SUMOylation is required for fast synaptic vesicle exocytosis. Cell Reports, 5(5), 1294-1301. https://doi.org/10.1016/j.celrep.2013.10.039

The rapid, activity-dependent quantal presynaptic release of neurotransmitter is vital for brain function. The complex process of vesicle priming, fusion, and retrieval is very precisely controlled and requires thespatiotemporal coordination of multi... Read More about RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.