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Competition of reactive signals and thiol modifications of proteins

Hancock, John T; Craig, Tim J.; Whiteman, Matthew


Tim Craig
AHoD in Biological Sciences

Matthew Whiteman


It is clear that cells are constantly bombarded by multiple signals, often initiating similar, or even conflicting, responses. Important players in this suite of signals are the reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), the reactive nitrogen species (RNS), such as nitric oxide (NO) and sulfur-based molecules, such as hydrogen sulfide (H2S). These compounds are often involved in stress responses and dysfunction of these signaling systems is often involved in disease [1-3]. This commentary discusses the interactions of such signals, which was discussed in a previous paper [3]. It was argued that all these molecules are not acting in the same manner, and that H2S was acting in a role which moderated the effects of ROS and NO.


Hancock, J. T., Craig, T. J., & Whiteman, M. (2017). Competition of reactive signals and thiol modifications of proteins.

Journal Article Type Article
Acceptance Date Nov 2, 2017
Publication Date Jan 1, 2017
Journal Journal of Cell Signaling
Print ISSN 2576-1471
Peer Reviewed Peer Reviewed
Volume 2
Issue 4
Pages 170
Keywords cell signalling, reactive oxygen species, hydrogen sulphide, nitric oxide
Public URL
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