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Polydopamine-lysophosphatidate-functionalised titanium: A novel hybrid surface finish for bone regenerative applications

Baldwin, Fiona; Craig, Tim J.; Shiel, Anna I.; Cox, Timothy; Lee, Kyueui; Mansell, Jason P.

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Authors

Fiona Baldwin

Tim J. Craig

Anna I. Shiel

Kyueui Lee

Jason Mansell Jason.Mansell@uwe.ac.uk
Associate Professor in Biomedical Sciences



Contributors

Abstract

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Aseptic loosening of total joint replacements (TJRs) continues to be the main cause of implant failures. The socioeconomic impact of surgical revisions is hugely significant; in the United Kingdom alone, it is estimated that £135m is spent annually on revision arthroplasties. Enhancing the longevity of titanium implants will help reduce the incidence and overall cost of failed devices. In realising the development of a superior titanium (Ti) technology, we took inspiration from the growing interest in reactive polydopamine thin films for biomaterial surface functionalisations. Adopting a “one-pot” approach, we exposed medical-grade titanium to a mildly alkaline solution of dopamine hydrochloride (DHC) supplemented with (3S)1-fluoro-3-hydroxy-4-(oleoyloxy)butyl-1-phosphonate (FHBP), a phosphatase-resistant analogue of lysophosphatidic acid (LPA). Importantly, LPA and selected LPA analogues like FHBP synergistically cooperate with calcitriol to promote human osteoblast formation and maturation. Herein, we provide evidence that simply immersing Ti in aqueous solutions of DHC-FHBP afforded a surface that was superior to FHBP-Ti at enhancing osteoblast maturation. The facile step we have taken to modify Ti and the biological performance of the final surface finish are appealing properties that may attract the attention of implant manufacturers in the future.

Journal Article Type Article
Acceptance Date Mar 25, 2020
Online Publication Date Mar 30, 2020
Publication Date Jan 1, 2020
Deposit Date Aug 20, 2020
Publicly Available Date Aug 20, 2020
Journal Molecules
Electronic ISSN 1420-3049
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 25
Issue 7
Article Number 1583
DOI https://doi.org/10.3390/molecules25071583
Keywords polydopamine; lysophosphatidic acid; titanium; functionalisation; osteoblasts; differentiation
Public URL https://uwe-repository.worktribe.com/output/5919934
Publisher URL http://dx.doi.org/10.3390/molecules25071583

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