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Development and biological evaluation of fluorophosphonate-modified hydroxyapatite for orthopaedic applications

Neary, Gr�inne; Blom, Ashley W; Shiel, Anna I; Wheway, Gabrielle; Mansell, Jason P


Gr�inne Neary

Ashley W Blom

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Dr Anna Shiel
Bid Developer - Science and Health

Gabrielle Wheway
Occasional Associate Lecturer - CHSS - DAS

Jason Mansell
Associate Professor in Biomedical Sciences


© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Abstract: There is an incentive to functionalise hydroxyapatite (HA) for orthopaedic implant use with bioactive agents to encourage superior integration of the implants into host bone. One such agent is (3S) 1-fluoro-3-hydroxy-4-(oleoyloxy) butyl-1-phosphonate (FHBP), a phosphatase-resistant lysophosphatidic acid (LPA) analogue. We investigated the effect of an FHBP-HA coating on the maturation of human (MG63) osteoblast-like cells. Optimal coating conditions were identified and cell maturation on modified and unmodified, control HA surfaces was assessed. Stress tests were performed to evaluate coating survivorship after exposure to mechanical and thermal insults that are routinely encountered in the clinical environment. MG63 maturation was found to be three times greater on FHBP-modified HA compared to controls (p < 0.0001). There was no significant loss of coating bioactivity after autoclaving (P = 0.9813) although functionality declined by 67% after mechanical cleaning and reuse (p < 0.0001). The bioactivity of modified disks was significantly greater than that of controls following storage for up to six months (p < 0.001). Herein we demonstrate that HA can be functionalised with FHBP in a facile, scalable manner and that this novel surface has the capacity to enhance osteoblast maturation. Improving the biological performance of HA in a bone regenerative setting could be realised through the simple conjugation of bioactive LPA species in the future. [Figure not available: see fulltext.].


Neary, G., Blom, A. W., Shiel, A. I., Wheway, G., & Mansell, J. P. (2018). Development and biological evaluation of fluorophosphonate-modified hydroxyapatite for orthopaedic applications. Journal of Materials Science: Materials in Medicine, 29(8),

Journal Article Type Article
Acceptance Date Jul 9, 2018
Online Publication Date Jul 21, 2018
Publication Date Aug 1, 2018
Deposit Date Aug 7, 2018
Publicly Available Date Jul 21, 2019
Journal Journal of Materials Science: Materials in Medicine
Print ISSN 0957-4530
Electronic ISSN 1573-4838
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 29
Issue 8
Keywords fluorophosphonate, hydroxyapatite, orthopaedics, implants, coatings,
Public URL
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Additional Information Additional Information : The final publication is available at Springer via


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