Morpholino Oligonucleotide Cross-Linked Hydrogels as Portable Optical Oligonucleotide Biosensors (2018)
Journal Article
Langford, G. J., Raeburn, J., Ferrier, D. C., Hands, P. J. W., & Shaver, M. P. (2019). Morpholino Oligonucleotide Cross-Linked Hydrogels as Portable Optical Oligonucleotide Biosensors. ACS Sensors, 4(1), 185-191. https://doi.org/10.1021/acssensors.8b01208

© 2018 American Chemical Society. Morpholino Oligonucleotides (MOs), an uncharged DNA analogue, are functionalized with an acrylamide moiety and incorporated into polymer hydrogels as responsive cross-links for microRNA sequence detection. The MO cro... Read More about Morpholino Oligonucleotide Cross-Linked Hydrogels as Portable Optical Oligonucleotide Biosensors.

Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection (2018)
Journal Article
Lu, C., Janice, K., Martina, P., & Richard, L. (2018). Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection. Scientific Reports, 8(1), 122687. https://doi.org/10.1038/s41598-018-30793-z

© 2018, The Author(s). The paper reports a biosensor formed from antibody coated ZnO nano-crystals which has been prepared using a rapid and inexpensive fabrication method which utilises colloidal dispersion enhanced using sonication. This technique... Read More about Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection.

Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells (2018)
Journal Article
Sharma, R., Williams, I. S., Linda, G., Sonawane, V. R., Chaudhuri, B., & Bharate, S. B. (2018). Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells. Bioorganic and Medicinal Chemistry, 26(23-24), 6076-6086. https://doi.org/10.1016/j.bmc.2018.11.013

© 2018 Elsevier Ltd Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast c... Read More about Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.

Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[ a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1 (2018)
Journal Article
Sharma, R., Williams, I. S., Gatchie, L., Sonawane, V. R., Chaudhuri, B., & Bharate, S. B. (2018). Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[ a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1. ACS Omega, 3(8), 8553-8566. https://doi.org/10.1021/acsomega.8b01088

Copyright © 2018 American Chemical Society. Cytochrome P450 family 1 (CYP1) enzymes catalyze the metabolic activation of environmental procarcinogens such as benzo[a]pyrene, B[a]P, into carcinogens, which initiates the process of carcinogenesis. Thus... Read More about Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[ a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1.

Nonantioxidant Tetramethoxystilbene Abrogates α-Synuclein-Induced Yeast Cell Death but Not That Triggered by the Bax or βa4 Peptide (2018)
Journal Article
Derf, A., Mudududdla, R., Akintade, D., Williams, I. S., Abdullaha, M., Chaudhuri, B., & Bharate, S. B. (2018). Nonantioxidant Tetramethoxystilbene Abrogates α-Synuclein-Induced Yeast Cell Death but Not That Triggered by the Bax or βa4 Peptide. ACS Omega, 3(8), 9513-9532. https://doi.org/10.1021/acsomega.8b01154

© 2018 American Chemical Society. The overexpression of α-synuclein (α-syn) and its aggregation is the hallmark of Parkinson's disease. The α-syn aggregation results in the formation of Lewy bodies that causes neuronal cell death. Therefore, the smal... Read More about Nonantioxidant Tetramethoxystilbene Abrogates α-Synuclein-Induced Yeast Cell Death but Not That Triggered by the Bax or βa4 Peptide.

Biotransformation, Using Recombinant CYP450-Expressing Baker's Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme (2018)
Journal Article
Williams, I. S., Gatchie, L., Bharate, S. B., & Chaudhuri, B. (2018). Biotransformation, Using Recombinant CYP450-Expressing Baker's Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme. ACS Omega, 3(8), 8903-8912. https://doi.org/10.1021/acsomega.8b00809

© Copyright 2018 American Chemical Society. CYP2D6, a cytochrome P450 (CYP) enzyme, metabolizes codeine to morphine. Within the human body, 0-15% of codeine undergoes O-demethylation by CYP2D6 to form morphine, a far stronger analgesic than codeine.... Read More about Biotransformation, Using Recombinant CYP450-Expressing Baker's Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme.

Conductive composites for oligonucleotide detection (2017)
Journal Article
Ferrier, D. C., Shaver, M. P., & Hands, P. J. (2018). Conductive composites for oligonucleotide detection. Sensing and Bio-Sensing Research, 17, 1-6. https://doi.org/10.1016/j.sbsr.2017.11.007

© 2017 The Authors A new method for oligonucleotide detection is presented based on oligonucleotide cross-linked polymer composites. Conductive carbon nanoparticles are incorporated into a DNA-functionalised polymer, containing partially complementar... Read More about Conductive composites for oligonucleotide detection.

Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme (2017)
Journal Article
Bharate, S. B., Chaudhuri, B., Vishwakarma, R. A., Jain, S. K., Sharma, R., Gatchie, L., & Williams, I. S. (2017). Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme. Bioorganic and Medicinal Chemistry Letters, 27(24), 5400-5403. https://doi.org/10.1016/j.bmcl.2017.11.013

© 2017 Elsevier Ltd The development of multi-drug resistance to existing anticancer drugs is one of the major challenges in cancer treatment. The over-expression of cytochrome P450 1B1 enzyme has been reported to cause resistance to cisplatin. With a... Read More about Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme.

(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent (2017)
Journal Article
Horley, N. J., Beresford, K. J., Kaduskar, S., Joshi, P., McCann, G. J., Ruparelia, K. C., …Chaudhuri, B. (2017). (E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent. Bioorganic and Medicinal Chemistry Letters, 27(24), 5409-5414. https://doi.org/10.1016/j.bmcl.2017.11.009

The overexpression of CYP1 family of enzymes is reported to be associated with development of human carcinomas. It has been well reported that CYP1A1 specific inhibitors prevents carcinogenesis. Herein, thirteen pyridine-4-yl series of chalcones were... Read More about (E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent.

Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme (2017)
Journal Article
Bharate, S. B., Nuthakki, V. K., Williams, I. S., Chib, S., Gatchie, L., Joshi, P., …Chaudhuri, B. (2017). Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme. Journal of Agricultural and Food Chemistry, 65(34), 7440-7446. https://doi.org/10.1021/acs.jafc.7b02690

© 2017 American Chemical Society. Naturally occurring polyphenolic compounds are of medicinal importance because of their unique antioxidant, anticancer, and chemopreventive properties. Baicalein, a naturally occurring polyhydroxy flavonoid possessin... Read More about Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme.

Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance (2017)
Journal Article
Satti, N. K., Williams, I. S., Joshi, P., Gatchie, L., Sharma, M., Vishwakarma, R. A., …Bharate, S. B. (2017). Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance. Bioorganic and Medicinal Chemistry Letters, 27(16), 3683-3687. https://doi.org/10.1016/j.bmcl.2017.07.010

© 2017 Elsevier Ltd Inhibitors of CYP1 enzymes may play vital roles in the prevention of cancer and overcoming chemo-resistance to anticancer drugs. In this letter, we report synthesis of twenty-three pyrrole based heterocyclic chalcones which were s... Read More about Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance.

Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines (2017)
Journal Article
Horley, N. J., Beresford, K. J., Chawla, T., McCann, G. J., Ruparelia, K. C., Gatchie, L., …Chaudhuri, B. (2017). Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. European Journal of Medicinal Chemistry, 129, 159-174. https://doi.org/10.1016/j.ejmech.2017.02.016

© 2017 Elsevier Masson SAS The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones. Two potent CYP1B1 inhibitors 7k (DMU2105) and 6j (DMU2139) have been identified from two series of syn... Read More about Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines.

Biphenyl urea derivatives as selective CYP1B1 inhibitors (2016)
Journal Article
Chaudhuri, B., Jayaprakash, V., Bharate, S. B., Joshi, P., Williams, I. S., Horley, N., …Sinha, B. N. (2016). Biphenyl urea derivatives as selective CYP1B1 inhibitors. Organic and Biomolecular Chemistry, 14(38), 8931-8936. https://doi.org/10.1039/c6ob01506a

© 2016 The Royal Society of Chemistry. Highly selective CYP1B1 inhibitors have potential in the treatment of hormone-induced breast and prostate cancers. Mimicry of potent and selective CYP1B1 inhibitors, α-naphthoflavone and stilbenes, revealed that... Read More about Biphenyl urea derivatives as selective CYP1B1 inhibitors.

Micro- and nano-structure based oligonucleotide sensors (2015)
Journal Article
Ferrier, D. C., Shaver, M. P., & Hands, P. J. (2015). Micro- and nano-structure based oligonucleotide sensors. Biosensors and Bioelectronics, 68, 798-810. https://doi.org/10.1016/j.bios.2015.01.031

© 2015 Elsevier B.V. This paper presents a review of micro- and nano-structure based oligonucleotide detection and quantification techniques. The characteristics of such devices make them very attractive for Point-of-Care or On-Site-Testing biosensin... Read More about Micro- and nano-structure based oligonucleotide sensors.

Fluorescence analysis of dissolved organic matter in natural, waste and polluted waters - A review (2007)
Journal Article
Hudson, N., Baker, A., & Reynolds, D. M. (2007). Fluorescence analysis of dissolved organic matter in natural, waste and polluted waters - A review. River Research and Applications, 23(6), 631-649. https://doi.org/10.1002/rra.1005

Dissolved organic matter (DOM) in aquatic systems originates from a range of sources. Some is allochthonous, transported from the surrounding landscape to the water body, and is derived from and influenced by the geology, land use and hydrology of it... Read More about Fluorescence analysis of dissolved organic matter in natural, waste and polluted waters - A review.

Thickness determination of thin and ultra-thin SiO 2 films by C-AFM IV-spectroscopy (2006)
Journal Article
Frammelsberger, W., Benstetter, G., Kiely, J., & Stamp, R. (2006). Thickness determination of thin and ultra-thin SiO 2 films by C-AFM IV-spectroscopy. Applied Surface Science, 252(6), 2375-2388. https://doi.org/10.1016/j.apsusc.2005.04.010

Conductive atomic force microscopy was used to determine the electrical oxide thickness for five different silicon dioxide layers with thickness in the order of 1.6-5.04 nm. The electrical thickness results were compared with values determined by ell... Read More about Thickness determination of thin and ultra-thin SiO 2 films by C-AFM IV-spectroscopy.

Simplified tunnelling current calculation for MOS structures with ultra-thin oxides for conductive atomic force microscopy investigations (2005)
Journal Article
Frammelsberger, W., Benstetter, G., Stamp, R., Kiely, J., & Schweinboeck, T. (2005). Simplified tunnelling current calculation for MOS structures with ultra-thin oxides for conductive atomic force microscopy investigations. Materials Science and Engineering: B, 116(2), 168-174. https://doi.org/10.1016/j.mseb.2004.09.027

As charge tunnelling through thin and ultra-thin silicon dioxide layers is regarded as the driving force for MOS device degradation the determination and characterisation of electrically week spots is of paramount importance for device reliability an... Read More about Simplified tunnelling current calculation for MOS structures with ultra-thin oxides for conductive atomic force microscopy investigations.

The rapid detection of methyl tert-butyl ether (MtBE) in water using a prototype gas sensor system (2005)
Journal Article
de Lacy Costello, B., Sivanand, P. S., Ratcliffe, N. M., & Reynolds, D. M. (2005). The rapid detection of methyl tert-butyl ether (MtBE) in water using a prototype gas sensor system. Water Science and Technology, 52(8), 117-123

Identification by gas chromatography-mass spectrometry of the volatile organic compounds emitted from the wood-rotting fungi Serpula lacrymans and Coniophora puteana, and from Pinus sylvestris timber (2004)
Journal Article
Ewen, R. J., Jones, P. R., Ratcliffe, N. M., & Spencer-Phillips, P. T. (2004). Identification by gas chromatography-mass spectrometry of the volatile organic compounds emitted from the wood-rotting fungi Serpula lacrymans and Coniophora puteana, and from Pinus sylvestris timber. Mycological Research, 108(7), 806-814. https://doi.org/10.1017/S095375620400022X

Volatile organic compounds (VOCs) emitted by two wood-rotting basidiomycete fungi, Serpula lacrymans (dry rot fungus) and Coniophora puteana (cellar fungus), and the timber of Pinus sylvestris (Scots pine), were identified. Several volatile collectio... Read More about Identification by gas chromatography-mass spectrometry of the volatile organic compounds emitted from the wood-rotting fungi Serpula lacrymans and Coniophora puteana, and from Pinus sylvestris timber.

A prototype sensor system for the early detection of microbially linked spoilage in stored wheat grain (2003)
Journal Article
de Lacy Costello, B., Ewen, R., Gunson, H., Ratcliffe, N. M., Sivanand, P., & Spencer-Phillips, P. T. (2003). A prototype sensor system for the early detection of microbially linked spoilage in stored wheat grain. Measurement Science and Technology, 14(4), 397-409. https://doi.org/10.1088/0957-0233/14/4/301

Spencer-Phillips was Co-Investigator, the lead biologist in this HGCA-funded multi-disciplinary work, and co-wrote the paper. The grant was based on his expertise in the microbiology of post-harvest spoilage.