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Conductive composites for oligonucleotide detection

Ferrier, David C.; Shaver, Michael P.; Hands, Philip J.W.


David Ferrier
Research Fellow- Biosensing/ Health Technology

Michael P. Shaver

Philip J.W. Hands


© 2017 The Authors A new method for oligonucleotide detection is presented based on oligonucleotide cross-linked polymer composites. Conductive carbon nanoparticles are incorporated into a DNA-functionalised polymer, containing partially complementary oligonucleotide cross-linkers, which is polymerised in situ upon interdigitated electrodes. In the presence of an aqueous solution of a specific analyte oligonucleotide sequence, the cross-linkers are cleaved, leading to increased swelling. As the polymer swells the relative density of the conductive particles decreases, leading to an easily measurable decrease in electrical conductivity. We demonstrate that such are capable of discriminating between analyte and control solutions, with single-base specificity, in under 3 min. The lower detection limit of these composites is of the order of 10 nM. The swelling characteristics of these composites is confirmed by optical imaging and the effects of varying temperature upon such composites are also reported.


Ferrier, D. C., Shaver, M. P., & Hands, P. J. (2018). Conductive composites for oligonucleotide detection. Sensing and Bio-Sensing Research, 17, 1-6.

Journal Article Type Article
Acceptance Date Nov 22, 2017
Online Publication Date Nov 24, 2017
Publication Date Feb 1, 2018
Journal Sensing and Bio-Sensing Research
Print ISSN 2214-1804
Electronic ISSN 2214-1804
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 17
Pages 1-6
Keywords oligonucleotide sensor, DNA sensor, bio-responsive, nanocomposite, hydrogel, smart material
Public URL
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