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Micro- and nano-structure based oligonucleotide sensors

Ferrier, David C.; Shaver, Michael P.; Hands, Philip J.W.


David Ferrier
Research Fellow- Biosensing/ Health Technology

Michael P. Shaver

Philip J.W. Hands


© 2015 Elsevier B.V. This paper presents a review of micro- and nano-structure based oligonucleotide detection and quantification techniques. The characteristics of such devices make them very attractive for Point-of-Care or On-Site-Testing biosensing applications. Their small scale means that they can be robust and portable, their compatibility with modern CMOS electronics means that they can easily be incorporated into hand-held devices and their suitability for mass production means that, out of the different approaches to oligonucleotide detection, they are the most suitable for commercialisation. This review discusses the advantages of micro- and nano-structure based sensors and covers the various oligonucleotide detection techniques that have been developed to date. These include: Bulk Acoustic Wave and Surface Acoustic Wave devices, micro- and nano-cantilever sensors, gene Field Effect Transistors, and nanowire and nanopore based sensors. Oligonucleotide immobilisation techniques are also discussed.


Ferrier, D. C., Shaver, M. P., & Hands, P. J. (2015). Micro- and nano-structure based oligonucleotide sensors. Biosensors and Bioelectronics, 68, 798-810.

Journal Article Type Review
Acceptance Date Jan 13, 2015
Online Publication Date Jan 13, 2015
Publication Date Jun 5, 2015
Deposit Date Jan 25, 2019
Journal Biosensors and Bioelectronics
Print ISSN 0956-5663
Electronic ISSN 1873-4235
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 68
Pages 798-810
Keywords biosensor, DNA, oligonucleotide, detection, MEMS, NEMS
Public URL
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