This paper describes the design and development of a novel electrochemical biosensor for measuring glycerol in wine. Our initial detailed studies were aimed at deducing the optimum conditions for biosensor operation by conducting hydrodynamic voltamm... Read More about Development of a disposable, amperometric glycerol biosensor based on a screen-printed carbon electrode, modified with the electrocatalyst meldolas blue, coated with glycerol dehydrogenase and NAD+: Application to the analysis of wine quality.
Outputs (92)
The manufacturing and characterisation of eugenol-enclosed liposomes produced by microfluidic method (2023)
Journal Article
In this study, liposomes enclosing eugenol were prepared using microfluidics. Two lipids—1,2-dimyristoyl-sn-glycero-3-phosphocholine, 18:0 (DSPC) and 2-dimyristoyl-sn-glycero-3-phosphocholine, 14:0 (DMPC)—and microfluidic chips with serpentine and Y-... Read More about The manufacturing and characterisation of eugenol-enclosed liposomes produced by microfluidic method.
Development of a novel dual-enzyme screen-printed amperometric biosensor for the analysis of esterified fatty acids (2023)
Journal Article
This paper describes, for the first time, the development of a novel trilinolein biosensor based on the immobilisation of lipase and lipoxygenase (LOX) onto a cobalt phthalocyanine screen-printed carbon electrode (CoPC-SPCE) in conjunction with amper... Read More about Development of a novel dual-enzyme screen-printed amperometric biosensor for the analysis of esterified fatty acids.
Development of geraniol-loaded liposomal nanoformulations against salmonella colonization in the pig gut (2022)
Journal Article
Salmonella is a global health threat, with pig production being one of the main sources of human salmonellosis. The current study investigated the antivirulence properties of geraniol for inhibiting the in vitro colonization of Salmonella. The minimu... Read More about Development of geraniol-loaded liposomal nanoformulations against salmonella colonization in the pig gut.
Inhibition of corrosion causing Pseudomonas aeruginosa using plasma-activated water (2021)
Journal Article
Aims: The cost of Microbiologically Influenced Corrosion (MIC) significantly affects a wide range of sectors. This study aims to assess the efficiency of a novel technology based on the use of plasma-activated water (PAW) in inhibiting corrosion caus... Read More about Inhibition of corrosion causing Pseudomonas aeruginosa using plasma-activated water.
The effect of cold atmospheric plasma and linalool nanoemulsions against Escherichia coli O157:H7 and Salmonella on ready-to-eat chicken meat (2021)
Journal Article
In this study, the antimicrobial efficiency of a novel low-voltage piezoelectric direct discharge generated cold plasma (CAP) and linalool-loaded nanoemulsion washing (LW) was assessed against Salmonella and Escherichia coli O157:H7 on ready-to-eat (... Read More about The effect of cold atmospheric plasma and linalool nanoemulsions against Escherichia coli O157:H7 and Salmonella on ready-to-eat chicken meat.
Studies towards the development of a novel, screen-printed carbon-based, biosensor for the measurement of polyunsaturated fatty acids (2020)
Journal Article
This paper describes the design, development and characterisation of an electrochemical biosensor for the measurement of linoleic and α-linolenic acid, as representative free polyunsaturated fatty acids (PUFAs), that may be implicated in food safety... Read More about Studies towards the development of a novel, screen-printed carbon-based, biosensor for the measurement of polyunsaturated fatty acids.
Screen-printed carbon based biosensors and their applications in agri-food safety (2020)
Journal Article
This review focuses on the ways in which screen-printed carbon electrodes have been tailored with different biorecognition elements, including enzymes, antibodies, and aptamers, often with other modifiers, such as mediators and nanoparticles, to prod... Read More about Screen-printed carbon based biosensors and their applications in agri-food safety.
© 2019 Elsevier B.V. This is the first report on the fabrication, characterisation and application of an electrochemical (bio)sensor system for the simultaneous measurement of skatole and androstenone. A biosensor for androstenone was fabricated usin... Read More about Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method.
An electrocatalytic screen-printed amperometric sensor for the selective measurement of thiamine (Vitamin B1) in food supplements (2019)
Journal Article
An electrocatalytic screen-printed sensor has been investigated for the measurement of the biologically important biomolecule vitamin B1 (thiamine) for the first time in food supplements. Under basic conditions, the vitamin was converted to its elect... Read More about An electrocatalytic screen-printed amperometric sensor for the selective measurement of thiamine (Vitamin B1) in food supplements.
Association of single nucleotide polymorphisms in leptin (LEP) and leptin receptor (LEPR) genes with backfat thickness and daily weight gain in Ukrainian Large White pigs (2018)
Journal Article
© 2018 Elsevier B.V. Leptin (LEP) and leptin receptor (LEPR) genes play an important role in the regulation of fat deposition and other commercially important traits in pigs and this regulation is known to be breed-specific. The aim of the present st... Read More about Association of single nucleotide polymorphisms in leptin (LEP) and leptin receptor (LEPR) genes with backfat thickness and daily weight gain in Ukrainian Large White pigs.
7-Hydroxylation of warfarin is strongly inhibited by sesamin, but not by episesamin, caffeic and ferulic acids in human hepatic microsomes (2018)
Journal Article
© 2018 Elsevier Ltd Warfarin is a commonly used anticoagulant drug and is a derivate of coumarin. Cytochrome P450 2C9 (CYP2C9) plays the key role in transformation of coumarin and thus, influences determination of warfarin dosage. A number of factors... Read More about 7-Hydroxylation of warfarin is strongly inhibited by sesamin, but not by episesamin, caffeic and ferulic acids in human hepatic microsomes.
A novel electroanalytical approach to the measurement of B vitamins in food supplements based on screen-printed carbon sensors (2017)
Journal Article
© 2017 Elsevier B.V. This paper describes the development of a novel electrochemical assay for the measurement of water-soluble vitamins in food and pharmaceutical products. The optimum conditions for the determination of vitamin B1 (thiamine), B2 (r... Read More about A novel electroanalytical approach to the measurement of B vitamins in food supplements based on screen-printed carbon sensors.
The reduction of starch in finishing diets supplemented with oil does not prevent the accumulation of trans-10 18:1 in lamb meat (2017)
Journal Article
© 2017 American Society of Animal Science. All rights reserved. The experiment was conducted to test the hypothesis that the replacement of cereal with low-starch feed ingredients in lambs’ finishing diets supplemented with oils could prevent the acc... Read More about The reduction of starch in finishing diets supplemented with oil does not prevent the accumulation of trans-10 18:1 in lamb meat.
Polymorphisms of the porcine cathepsins, growth hormone-releasing hormone and leptin receptor genes and their association with meat quality traits in Ukrainian Large White breed (2016)
Journal Article
© 2016, The Author(s). Cathepsins, growth hormone-releasing hormone (GHRH) and leptin receptor (LEPR) genes have been receiving increasing attention as potential markers for meat quality and pig performance traits. This study investigated the allele... Read More about Polymorphisms of the porcine cathepsins, growth hormone-releasing hormone and leptin receptor genes and their association with meat quality traits in Ukrainian Large White breed.
Influence of betaine and arginine supplementation of reduced protein diets on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of cross-bred pigs (2016)
Journal Article
© The Authors 2016. The isolated or combined effects of betaine and arginine supplementation of reduced protein diets (RPD) on fat content, fatty acid composition and mRNA levels of genes controlling lipid metabolism in pig m. longissimus lumborum an... Read More about Influence of betaine and arginine supplementation of reduced protein diets on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of cross-bred pigs.
Sensor and method for detecting androstenone or skatole in boar taint (2016)
Patent
The present application is concerned with a sensor system for and a method of detecting, and preferably quantifying, androstenone (CAS Reg.No. 18339-16-7) and/or skatole (CAS Reg. No. 83-34-1), the chemicals associated with boar taint. In a preferred... Read More about Sensor and method for detecting androstenone or skatole in boar taint.
Metabolism of androstenone, 17β-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3β-hydroxysteroid dehydrogenase in this process (2015)
Journal Article
© 2015 Chen et al. Steroids metabolism plays an important role in mammals and contributes to quality of pig meat. The main objective of this study was to identify metabolites of androstenone, 17β-estradiol and dihydrotestosterone using primary cultur... Read More about Metabolism of androstenone, 17β-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3β-hydroxysteroid dehydrogenase in this process.
Combined effects of dietary arginine, leucine and protein levels on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of crossbred pigs (2014)
Journal Article
The cumulative effects of dietary arginine, leucine and protein levels on fat content, fatty acid composition and mRNA levels of genes controlling lipid metabolism in pig longissimus lumborum muscle and subcutaneous adipose tissue (SAT) were investig... Read More about Combined effects of dietary arginine, leucine and protein levels on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of crossbred pigs.
Single nucleotide polymorphism (SNP) in CYP17A1 (rs743572) gene as a risk of prostate cancer development - a preliminary report in Caucasian group (2013)
Presentation / Conference Contribution
Effect of breed on fatty acid composition and lipogenic enzyme abundance in the subcutaneous adipose tissue of pigs (2013)
Journal Article
This study investigated the role of lipogenic enzyme expression in breed-specific fat deposition in pigs. Objectives: (i) determine effect of breed on the relative abundance of the key lipogenic enzymes stearoyl-CoA desaturase (SCD), delta-6 desatura... Read More about Effect of breed on fatty acid composition and lipogenic enzyme abundance in the subcutaneous adipose tissue of pigs.
The present study assessed the effect of pig genotype (fatty v. lean) and dietary protein and lysine (Lys) levels (normal v. reduced) on intramuscular fat (IMF) content, subcutaneous adipose tissue (SAT) deposition, fatty acid composition and mRNA le... Read More about Differential effects of reduced protein diets on fatty acid composition and gene expression in muscle and subcutaneous adipose tissue of Alentejana purebred and Large White ×â Landrace ×â Pietrain crossbred pigs.
Trpm8 agonists modulate contraction of the pig urinary bladder (2013)
Journal Article
The transient receptor potential melastin-8 (TRPM8) channel is activated by the "cooling" compounds menthol and icilin. Pathophysiologically, it is implicated in the overactive bladder and bladder cooling reflex, but the activity of TRPM8 in normal b... Read More about Trpm8 agonists modulate contraction of the pig urinary bladder.
Use of whole blood for analysis of disease-associated biomarkers (2013)
Journal Article
Analyses for diagnosis and monitoring of pathological conditions often rely on blood samples, partly due to relative ease of collection. However, many interfering substances largely preclude the use of whole blood itself, necessitating separation of... Read More about Use of whole blood for analysis of disease-associated biomarkers.
Boar taint: Challenges and opportunities (2013)
Presentation / Conference Contribution
Hepatic lipogenic enzyme expression in pigs is affected by selection for decreased backfat thickness at constant intramuscular fat content (2013)
Journal Article
This study investigated (i) whether genetic selection for decreased backfat thickness at constant intramuscular fat (IMF) affects the expression of lipogenic enzymes in pig liver and (ii) whether expression of the hepatic lipogenic enzymes is related... Read More about Hepatic lipogenic enzyme expression in pigs is affected by selection for decreased backfat thickness at constant intramuscular fat content.
Fatty acid composition and lipogenic enzyme protein expression in subcutaneous adipose tissue of male pigs vaccinated against boar taint, barrows, and entire boars (2013)
Journal Article
Objectives of this study were to compare fatty acid composition of subcutaneous adipose tissue of entire boars, barrows, and male pigs vaccinated against boar taint with a vaccine containing a GnRH analogue-protein conjugate (Improvac, Pfizer Animal... Read More about Fatty acid composition and lipogenic enzyme protein expression in subcutaneous adipose tissue of male pigs vaccinated against boar taint, barrows, and entire boars.
Effect of pig breed and dietary protein level on selected fatty acids and stearoylcoenzyme A desaturase protein expression in longissimus muscle and subcutaneous fat (2013)
Journal Article
The aims of the study were 1) to investigate effects of a low protein diet on fatty acids content and composition of the LM and subcutaneous adipose tissue in 3 genetically diverse breeds, Large White × Landrace, Alentejano, and Bizaro, and 2) to det... Read More about Effect of pig breed and dietary protein level on selected fatty acids and stearoylcoenzyme A desaturase protein expression in longissimus muscle and subcutaneous fat.
Investigation of Testosterone, Androstenone, and Estradiol Metabolism in HepG2 Cells and Primary Culture Pig Hepatocytes and Their Effects on 17βHSD7 Gene Expression (2012)
Journal Article
Steroid metabolism is important in various species. The accumulation of androgen metabolite, androstenone, in pig adipose tissue is negatively associated with pork flavor, odour and makes the meat unfit for human consumption. The 17β-hydroxysteroid d... Read More about Investigation of Testosterone, Androstenone, and Estradiol Metabolism in HepG2 Cells and Primary Culture Pig Hepatocytes and Their Effects on 17βHSD7 Gene Expression.
Influence of oilseed supplement ranging in n-6/n-3 ratio on fatty acid composition and δ5-, δ6-desaturase protein expression in steer muscles (2012)
Journal Article
This study investigated effects of roasted or extruded oilseed supplementation ranging in n-6/n-3 ratios from 0.3 to 5.0 on the fatty acid composition and expression of delta-5 desaturase (δ5d) and δ6-desaturase (δ6d) protein in commercial steer chee... Read More about Influence of oilseed supplement ranging in n-6/n-3 ratio on fatty acid composition and δ5-, δ6-desaturase protein expression in steer muscles.
Expression of the hepatic skatole- and androstenone-metabolising enzymes in entire male pigs of two live weights (2012)
Journal Article
The aim of the present study was to investigate an in vivo relationship between increased levels of testicular steroids and protein expression of the key enzymes involved in hepatic metabolism of skatole (cytochrome P4502E1 and CYP2E1 and CYP2A) and... Read More about Expression of the hepatic skatole- and androstenone-metabolising enzymes in entire male pigs of two live weights.
Role of lipogenic enzymes expression in breed-specific fatty acid composition in pigs (2011)
Presentation / Conference Contribution
Relationship between the hepatic SULT2A1 protein expression and backfat androstenone level in pigs of three breeds (2010)
Presentation / Conference Contribution
Excessive accumulation of androstenone in pig adipose tissue contributes to the phenomenon of boar taint, an off-odour of some cooked pork. One of the reasons for high androstenone accumulation is a low rate of androstenone metabolism in pig liver. T... Read More about Relationship between the hepatic SULT2A1 protein expression and backfat androstenone level in pigs of three breeds.
Effect of selection for decreased backfat thickness on expression of delta-6 desaturase and fatty acid synthase in pig liver (2010)
Presentation / Conference Contribution
Effect of dietary fatty acids on expression of lipogenic enzymes and fatty acid profile in tissues of bulls (2010)
Journal Article
This study investigated the effects of dietary linolenic acid (C18:3n-3) v. linoleic acid (C18:2n-6) on fatty acid composition and protein expression of key lipogenic enzymes, acetyl-CoA carboxylase (ACC), stearoyl-CoA desaturase (SCD) and delta 6 de... Read More about Effect of dietary fatty acids on expression of lipogenic enzymes and fatty acid profile in tissues of bulls.
Comparison of two derivatisation methods for conjugated linoleic acid isomer analysis by Ag+-HPLC/DAD in beef fat (2010)
Journal Article
Two different procedures for the methylation of conjugated linoleic acid isomers (CLA) were compared by silver ion (Ag+)-HPLC. The base-catalysed method followed by an acid-catalysed method (NaOCH3/ BF3), and base hydrolysis followed by methylation w... Read More about Comparison of two derivatisation methods for conjugated linoleic acid isomer analysis by Ag+-HPLC/DAD in beef fat.
Relationship between the expression of key lipogenic enzymes, fatty acid composition, and intramuscular fat content of Limousin and Aberdeen Angus cattle (2010)
Journal Article
The amount and fatty acid composition of intramuscular fat (IMF) are major factors in determining the nutritional value of beef. Understanding the mechanisms regulating IMF formation is important for designing strategies for manipulation of IMF quant... Read More about Relationship between the expression of key lipogenic enzymes, fatty acid composition, and intramuscular fat content of Limousin and Aberdeen Angus cattle.
Acetyl-CoA carboxylase and stearoyl-CoA desaturase protein expression in subcutaneous adipose tissue is reduced in pigs selected for decreased backfat thickness at constant intramuscular fat content (2009)
Journal Article
The objectives of this study were 1) to determine whether selection toward less subcutaneous fat thickness at constant intramuscular fat content in pigs is related to tissue-specific changes in the expression of lipogenic enzymes acetyl-CoA carboxyla... Read More about Acetyl-CoA carboxylase and stearoyl-CoA desaturase protein expression in subcutaneous adipose tissue is reduced in pigs selected for decreased backfat thickness at constant intramuscular fat content.
Effect of breed on fatty acid composition and stearoyl-CoA desaturase protein expression in the Semimembranosus muscle and subcutaneous adipose tissue of cattle (2009)
Journal Article
The present study investigated (i) the effect of breed on the expression of stearoyl-CoA desaturase (SCD) protein and fatty acid composition in Semimembranosus muscle and subcutaneous adipose tissue of beef cattle and (ii) the relationship between SC... Read More about Effect of breed on fatty acid composition and stearoyl-CoA desaturase protein expression in the Semimembranosus muscle and subcutaneous adipose tissue of cattle.
The ALCASDE project and WP1 tasks (2009)
Presentation / Conference Contribution
Effect of supplementation of the maternal diet with fish oil or linseed oil on fatty-acid composition and expression of δ5- and δ6-desaturase in tissues of female piglets (2009)
Journal Article
The present study investigated whether enrichment of the pig maternal diet with n-3 polyunsaturated fatty acids (PUFA) affects the fatty-acid composition of female piglets via enhancing of expression of the lipogenic enzymes 5-desaturase (5d) and 6-d... Read More about Effect of supplementation of the maternal diet with fish oil or linseed oil on fatty-acid composition and expression of δ5- and δ6-desaturase in tissues of female piglets.
Δ 9 desaturase protein expression and fatty acid composition of longissimus dorsi muscle in lambs fed green herbage or concentrate with or without added tannins (2009)
Journal Article
The aims of this study were to investigate the effect of feeding system and of supplementation of tannins (8.93% DM) on the relationship between intramuscular fat content, fatty acid composition and Δ 9 desaturase (Δ 9 d) protein expression in longis... Read More about Δ 9 desaturase protein expression and fatty acid composition of longissimus dorsi muscle in lambs fed green herbage or concentrate with or without added tannins.
Genetic test for food quality (2009)
Presentation / Conference Contribution
Breed-specific mechanisms of fat partitioning in pigs (2009)
Journal Article
Effect of sex steroids on expression of sulfotransferase 2B1 immunoreactive protein in primary cultured porcine hepatocytes (2008)
Journal Article
An excessive accumulation of androstenone (5α-androst-16-en-3-one) in pig adipose tissue is one of the two major contributors to the phenomenon of boar taint. High levels of adipose tissue androstenone have been related to a low rate of hepatic andro... Read More about Effect of sex steroids on expression of sulfotransferase 2B1 immunoreactive protein in primary cultured porcine hepatocytes.
ALCASDE project: Study on the improved methods for animal-friendly production, in particular on alternatives to the castration of pigs and on alternatives to the dehorming of cattle (2008)
Presentation / Conference Contribution
Effect of dietary protein concentration on performance of group-fed pigs (2008)
Presentation / Conference Contribution
Effect of testosterone, estrone sulphate and androstenone on 3β-hydroxysteroid dehydrogenase protein expression in primary cultured hepatocytes (2008)
Journal Article
Androstenone (5α-androst-16-en-3-one) is a steroid pheromone, excessive accumulation of which in pig adipose tissue contributes to the phenomenon of "boar taint". The incidence of boar taint increases with age and weight of entire male pigs. One of t... Read More about Effect of testosterone, estrone sulphate and androstenone on 3β-hydroxysteroid dehydrogenase protein expression in primary cultured hepatocytes.
Regulation of CYP2A6 protein expression by skatole, indole, and testicular steroids in primary cultured pig hepatocytes (2008)
Journal Article
CYP2A6 is one of the enzymes involved in the hepatic metabolism of a naturally produced compound, skatole, in the pig. Low CYP2A6 activity has been linked to excessive accumulation of skatole in pig adipose tissue and development of the phenomenon "b... Read More about Regulation of CYP2A6 protein expression by skatole, indole, and testicular steroids in primary cultured pig hepatocytes.
Expression of 3β-hydroxysteroid dehydrogenase, cytochrome P450-c17, and sulfotransferase 2B1 proteins in liver and testis of pigs of two breeds: Relationship with adipose tissue androstenone concentration (2007)
Journal Article
An excessive accumulation of androstenone in pig adipose tissue is a major contributor to the phenomenon of boar taint. Androstenone deposition is dependent on the rate of androstenone biosynthesis in testis and androstenone degradation in liver. The... Read More about Expression of 3β-hydroxysteroid dehydrogenase, cytochrome P450-c17, and sulfotransferase 2B1 proteins in liver and testis of pigs of two breeds: Relationship with adipose tissue androstenone concentration.
Relationship between carcass weight, adipose tissue androstenone level and expression of the hepatic 3β-hydroxysteroid dehydrogenase in entire commercial pigs (2007)
Journal Article
Boar taint is a major meat-quality defect in pigs and is due to excessive accumulation of skatole and androstenone in adipose tissue. The present work investigated the relationship between carcass weight, levels of skatole and androstenone in adipose... Read More about Relationship between carcass weight, adipose tissue androstenone level and expression of the hepatic 3β-hydroxysteroid dehydrogenase in entire commercial pigs.
Breed-associated variations in the sequence of the pig 3β- hydroxysteroid dehydrogenase gene (2007)
Journal Article
The entire sequence of the pig 3β-hydroxysteroid dehydrogenase (3β-HSD) gene has recently become known. This gene is deemed to be important in androstenone metabolism in pig liver, and its defective expression has been shown to be related to androste... Read More about Breed-associated variations in the sequence of the pig 3β- hydroxysteroid dehydrogenase gene.
The effect of low protein diets on fat deposition in pigs (2007)
Journal Article
Relationship between the expression of hepatic but not testicular 3β-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue (2006)
Journal Article
This study investigated the relationship between expression of hepatic and testicular 3/3-hydroxysteroid dehydrogenase (3/3-HSD) and accumulation of androstenone in adipose tissue because of its relation to boar taint. The experiments were performed... Read More about Relationship between the expression of hepatic but not testicular 3β-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue.
A reduced protein diet induces stearoyl-CoA desaturase protein expression in pig muscle but not in subcutaneous adipose tissue: Relationship with intramuscular lipid formation (2006)
Journal Article
A reduced protein diet (RPD) is known to increase the level of intramuscular lipid in pig meat with a smaller effect on the amount of subcutaneous adipose tissue. This might be due to tissue-specific activation of the expression of lipogenic enzymes... Read More about A reduced protein diet induces stearoyl-CoA desaturase protein expression in pig muscle but not in subcutaneous adipose tissue: Relationship with intramuscular lipid formation.
Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig (2005)
Journal Article
The porcine cytochrome-p450 2E1 (CYP2E1) gene was isolated by screening a pig BAC library and partially sequenced. This sequence information was used to identify six single nucleotide polymorphisms (SNPs) within the CYP2E1 gene and its promoter. In a... Read More about Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig.
Inhibition of CYP2E1 expression by androstenone: Relation to boar taint (2005)
Book Chapter
The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone (2004)
Journal Article
Functional analysis of the pig cytochrome P4502E1 (CYP2E1) promoter identified two major activating elements. One corresponded to the hepatic nuclear factor 1 (HNF-1) consensus binding sequence at nucleotides -128/-98 and the other was located in the... Read More about The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone.
Characterisation of androstenone metabolism in pig liver microsomes (2004)
Journal Article
Androstenone (5α-androst-16-en-3-one) is a steroid pheromone produced in the testis. Excessive accumulation of androstenone together with skatole (3-methyl-indole) in the adipose tissue of some male pigs leads to "boar taint". In isolated pig hepatoc... Read More about Characterisation of androstenone metabolism in pig liver microsomes.
The effect of age on the level of lipogenic enzymes in subcutaneouse fat and muscle of pigs (2004)
Journal Article
Liver androstenone metabolism in relation to boar taint (2003)
Book Chapter
Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes (2002)
Journal Article
Skatole, a derivative of tryptophan, is produced in the hind-gut of pigs and is metabolised via hepatic cytochrome P4502E1 (CYP2E1). Excessive accumulation of skatole together with androstenone, a metabolite of testosterone, in adipose tissue in some... Read More about Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes.
Diagnostic assay for boar taint (2002)
Patent
(EN) The present invention discloses a link between the level of cytochrome P450 isoform P4502E1 and the level of skatole. A polynucleotide encoding the sequence for P4502E1 and a polynucleotide encoding the sequence for P4502E1 and a polynucleotide... Read More about Diagnostic assay for boar taint.
The relationship between adipose tissue skatole levels, rates of hepatic microsomal skatole metabolism and hepatic cytochrome P450IIE1 expression in two breeds of pig (2002)
Journal Article
The relationships between the level of skatole in backfat, the rate of skatole metabolism in isolated liver microsomes, hepatic cytochrome P450IIE1 content and mRNA levels were investigated in Large White ✕ Landrace (LW) and the Meishan ✕ Landrace... Read More about The relationship between adipose tissue skatole levels, rates of hepatic microsomal skatole metabolism and hepatic cytochrome P450IIE1 expression in two breeds of pig.
Relationship between skatole and androstenone in Large White and Meishan pigs (2002)
Journal Article
The role of P450IIE! protein and mRAN expression in determining adipose tissue skatole level (2001)
Journal Article
Mitochondria and cell death: a pore way to die? (2000)
Journal Article
Cytochrome c release from isolated rat liver mitochondria can occur independently of outer-membrane rupture: possible role of contact sites (2000)
Journal Article
Percoll-purified rat liver mitochondria were shown to contain BAX dimer and rapidly (
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain (2000)
Journal Article
Although metformin is widely used for the treatment of non-insulin-dependent diabetes, its mode of action remains unclear. Here we provide evidence that its primary site of action is through a direct inhibition of complex 1 of the respiratory chain.... Read More about Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.
Mitochondria and cell death (2000)
Presentation / Conference Contribution
Mitochondria play a central role in both apoptosis and necrosis through the opening of the mitochondrial permeability transition pore (MPTP). This is thought to be formed through a Ca2+-triggered conformational change of the adenine nucleotide transl... Read More about Mitochondria and cell death.
Mitochondrial aldehyde reductase: Identification and characterization in rat liver and kidney cortex (1998)
Journal Article
Aldehyde reductase (EC 1.1.1.2) has been regarded so far as an exclusively cytosolic enzyme. The present investigation shows that mitochondria of rat liver, kidney cortex and, tentatively, heart also contain an enzyme catalyzing oxidation of NADPH by... Read More about Mitochondrial aldehyde reductase: Identification and characterization in rat liver and kidney cortex.
Effect of paracetamol on the microsomal oxidation, oxidative phosphorylation and liver mitochondria swelling in rats of various ages (1996)
Journal Article
The effect of hepatotoxic dose of paracetamol (800 mg per kg, intraperitoneally, once a day during two days) on the system of microsomal oxidation, respiration, oxidative phosphorylation and high amplitude swelling of liver mitochondria was studied o... Read More about Effect of paracetamol on the microsomal oxidation, oxidative phosphorylation and liver mitochondria swelling in rats of various ages.
The effect of osmotic pressure on oligomycin-sensitive ATPase activity and the liberation of Mg2+ from liver mitochondria of rats of various ages (1992)
Journal Article
The influence of osmotic pressure of the incubating medium (25-500 mM sucrose) on oligomycin--sensitive, 2,4-dinitrophenyl-stimulated ATP-ase-activity, Mg2+ release and swelling of the liver mitochondria in 1-, 3-, 12-, 24-months Wistar rats is, inve... Read More about The effect of osmotic pressure on oligomycin-sensitive ATPase activity and the liberation of Mg2+ from liver mitochondria of rats of various ages.
Age-related differences in the effect of osmotic pressure on liver mitochondrial respiration in rats (1991)
Journal Article
The subject under investigation is the influence of osmotic pressure of incubation medium (25-500 mM of sucrose) upon the respiration and the respiration control (RC) of mitochondria of the liver of rats aged 1, 3, 12 and 24 months when oxidizing suc... Read More about Age-related differences in the effect of osmotic pressure on liver mitochondrial respiration in rats.