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Electrochemical detection of benzodiazepines, following liquid chromatography, for applications in pharmaceutical, biomedical and forensic investigations (2014)
Journal Article
Honeychurch, K. C., & Hart, J. P. (2014). Electrochemical detection of benzodiazepines, following liquid chromatography, for applications in pharmaceutical, biomedical and forensic investigations. https://doi.org/10.5640/insc.040101

Benzodiazepines are an important class of drugs commonly administered with a potential for abuse and environmental pollution. This review focuses on the liquid chromatographic electrochemical detection of the benzodiazepine class of drugs. These are... Read More about Electrochemical detection of benzodiazepines, following liquid chromatography, for applications in pharmaceutical, biomedical and forensic investigations.

The redox behaviour of diazepam (valium) using a disposable screen-printed sensor and its determination in drinks using a novel adsorptive stripping voltammetric assay (2013)
Presentation / Conference
Honeychurch, K. C., Crew, A. P., Northall, H., Radbourne, S., Davies, O., Newman, S., & Hart, J. P. (2013, June). The redox behaviour of diazepam (valium) using a disposable screen-printed sensor and its determination in drinks using a novel adsorptive stripping voltammetric assay. Presented at ISE Satellite Student Regional Symposium: Great Western Electrochemistry Meeting, University of Bath, Bath, England

Use of whole blood for analysis of disease-associated biomarkers (2013)
Journal Article
McLeod, J., Pemberton, R. M., May, J. E., Pemberton, R., Hart, J. P., McLeod, J. D., …Doran, O. (2013). Use of whole blood for analysis of disease-associated biomarkers. Analytical Biochemistry, 437(1), 59-61. https://doi.org/10.1016/j.ab.2013.02.024

Analyses for diagnosis and monitoring of pathological conditions often rely on blood samples, partly due to relative ease of collection. However, many interfering substances largely preclude the use of whole blood itself, necessitating separation of... Read More about Use of whole blood for analysis of disease-associated biomarkers.

Microfabricated glucose biosensor for culture welloperation (2013)
Journal Article
Hart, J. P., Luxton, R., Xu, J., Griffiths, J., Sage, I., Tuffin, R., …Hart, J. P. (2013). Microfabricated glucose biosensor for culture welloperation. Biosensors and Bioelectronics, 42(1), 668-677. https://doi.org/10.1016/j.bios.2012.11.032

A water-based carbon screen-printing ink formulation, containing the redox mediator cobalt phthalocyanine (CoPC) and the enzyme glucose oxidase (GOx), was investigated for its suitability to fabricate glucose microbiosensors in a 96-well microplate f... Read More about Microfabricated glucose biosensor for culture welloperation.

Development of an amperometric screen-printed galactose biosensor for serum analysis (2013)
Journal Article
Pemberton, R. M., Kanyong, P., Pemberton, R., Jackson, S. K., & Hart, J. P. (2013). Development of an amperometric screen-printed galactose biosensor for serum analysis. Analytical Biochemistry, 435(2), 114-119. https://doi.org/10.1016/j.ab.2013.01.006

The development of a disposable amperometric biosensor for the measurement of circulating galactose in serum is described. The biosensor comprises a screen-printed carbon electrode (SPCE), incorporating the electrocatalyst cobalt phthalocyanine (CoPC... Read More about Development of an amperometric screen-printed galactose biosensor for serum analysis.

The redox behaviour of diazepam (Valium®) using a disposable screen-printed sensor and its determination in drinks using a novel adsorptive stripping voltammetric assay (2013)
Journal Article
Crew, A., Honeychurch, K. C., Crew, A. P., Northall, H., Radbourne, S., Davies, O., …Hart, J. P. (2013). The redox behaviour of diazepam (Valium®) using a disposable screen-printed sensor and its determination in drinks using a novel adsorptive stripping voltammetric assay. Talanta, 116, 300-307. https://doi.org/10.1016/j.talanta.2013.05.017

In this study we investigated the possibility of applying disposable electrochemical screen-printed carbon sensors for the rapid identification and quantitative determination of diazepam in beverages. This was achieved utilising a previously unreport... Read More about The redox behaviour of diazepam (Valium®) using a disposable screen-printed sensor and its determination in drinks using a novel adsorptive stripping voltammetric assay.

The chronoamperometric and voltammetric behaviour of glutathione at screen-printed carbon micro-band electrodes modified with cobalt phthalocyanine (2012)
Journal Article
Honeychurch, K. C., & Hart, J. P. (2012). The chronoamperometric and voltammetric behaviour of glutathione at screen-printed carbon micro-band electrodes modified with cobalt phthalocyanine. Advances in Analytical Chemistry, 2(5), 46-52. https://doi.org/10.5923/j.aac.20120205.01

Screen-printed carbon electrodes (SPCEs) incorporating the electrocatalyst cobalt phthalocyanine (CoPC) have been successfully used for the manufacture of microband electrodes for the determination of reduced glutathione (GSH). Initially investigati... Read More about The chronoamperometric and voltammetric behaviour of glutathione at screen-printed carbon micro-band electrodes modified with cobalt phthalocyanine.

Voltammetric behaviour of lead at a microband screen-printed carbon electrode and its trace determination in plants by stripping voltammetry (2012)
Presentation / Conference
Phillips, R., Honeychurch, K. C., Crew, A. P., Davies, R., Willey, N., & Hart, J. P. (2012, September). Voltammetric behaviour of lead at a microband screen-printed carbon electrode and its trace determination in plants by stripping voltammetry. Poster presented at Electrochem 2012: Electrochemical Horizons, Trinity College, Dublin

Redox mechanisms of rohypnol and mogadon and their exploitation in an assay using dual electrode ECD following HPLC (2012)
Presentation / Conference
Honeychurch, K. C., Li, H., Pericleous, S., Antoniou, M., Abed, A., & Hart, J. P. (2012, June). Redox mechanisms of rohypnol and mogadon and their exploitation in an assay using dual electrode ECD following HPLC. Presented at Great Western Electrochemistry Meeting, University of Bath

Importance of the 1,4-benzodiazepine class of drugs Cyclic voltammetric behaviour of Flunitrazepam (Rohypnol), and Nitrazepam (Mogadon) Possible mechanism for their voltammetric behaviour Optimisation of Liquid Chromatographic Separation and... Read More about Redox mechanisms of rohypnol and mogadon and their exploitation in an assay using dual electrode ECD following HPLC.

Novel electrode reactions of diazepam, flunitrazepam and lorazepam and their exploitation in a new redox mode LC-DED assay for serum (2012)
Journal Article
Honeychurch, K. C., Chong, A. T., Elamin, K., & Hart, J. P. (2012). Novel electrode reactions of diazepam, flunitrazepam and lorazepam and their exploitation in a new redox mode LC-DED assay for serum. Analytical Methods, 4(1), 132-140. https://doi.org/10.1039/c1ay05419h

Previously unreported voltammetric redox behaviour was identified for flunitrazepam, lorazepam and diazepam at a glassy carbon electrode. This was successfully exploited for their determination in serum by high performance liquid chromatography dual... Read More about Novel electrode reactions of diazepam, flunitrazepam and lorazepam and their exploitation in a new redox mode LC-DED assay for serum.

Determination of catecholamines in urine using hydrophilic interaction chromatography with electrochemical detection (2011)
Journal Article
Kumar, A., Hart, J. P., & McCalley, D. V. (2011). Determination of catecholamines in urine using hydrophilic interaction chromatography with electrochemical detection. Journal of Chromatography A, 1218(25), 3854-3861. https://doi.org/10.1016/j.chroma.2011.04.034

The determination of catecholamines in urine was investigated using hydrophilic interaction chromatography (HILIC) as an alternative to the commonly used reversed-phase (RP) method. A number of different approaches were explored, including per-aqueou... Read More about Determination of catecholamines in urine using hydrophilic interaction chromatography with electrochemical detection.

The voltammetric behaviour of lead at a microband screen-printed carbon electrode and its determination in acetate leachates from glazed ceramic plates (2011)
Journal Article
Honeychurch, K. C., Al-Berezanchi, S., & Hart, J. P. (2011). The voltammetric behaviour of lead at a microband screen-printed carbon electrode and its determination in acetate leachates from glazed ceramic plates. Talanta, 84(3), 717-723. https://doi.org/10.1016/j.talanta.2011.01.073

Microband screen-printed carbon electrodes (μBSPCEs) without further modification have been investigated as disposable sensors for the measurement of lead in acetate leachates from ceramic glazed plates. Cyclic voltammetry was employed to elucidate t... Read More about The voltammetric behaviour of lead at a microband screen-printed carbon electrode and its determination in acetate leachates from glazed ceramic plates.

A screen-printed, amperometric biosensor array incorporated into a novel automated system for the simultaneous determination of organophosphate pesticides (2011)
Journal Article
Crew, A. P., Lonsdale, D., Byrd, N., Pittson, R., & Hart, J. P. (2011). A screen-printed, amperometric biosensor array incorporated into a novel automated system for the simultaneous determination of organophosphate pesticides. Biosensors and Bioelectronics, 26(6), 2847-2851. https://doi.org/10.1016/j.bios.2010.11.018

Organophosphate pesticides present serious risks to human and environmental health. A rapid reliable, economical and portable analytical system will be of great benefit in the detection and prevention of contamination. A biosensor array based on six... Read More about A screen-printed, amperometric biosensor array incorporated into a novel automated system for the simultaneous determination of organophosphate pesticides.

A screen-printed microband glucose biosensor system for real-time monitoring of toxicity in cell culture (2011)
Journal Article
Xu, J., Pemberton, R., Pittson, R., Drago, G. A., Griffiths, J., Jackson, S. K., & Hart, J. P. (2011). A screen-printed microband glucose biosensor system for real-time monitoring of toxicity in cell culture. Biosensors and Bioelectronics, 26(5), 2448-2453. https://doi.org/10.1016/j.bios.2010.10.030

Microband biosensors, screen-printed from a water-based carbon ink containing cobalt phthalocyanine redox mediator and glucose oxidase (GOD) enzyme, were used to monitor glucose levels continuously in buffer and culture medium. Five biosensors were o... Read More about A screen-printed microband glucose biosensor system for real-time monitoring of toxicity in cell culture.

Voltammetric behavior of DNA and its derivatives using screen printed carbon electrodes and its possible application in genotoxicity screening (2010)
Journal Article
Rawson, F. J., Jackson, S. K., & Hart, J. P. (2010). Voltammetric behavior of DNA and its derivatives using screen printed carbon electrodes and its possible application in genotoxicity screening. Analytical Letters, 43(10-11), 1790-1800. https://doi.org/10.1080/00032711003653908

The aim of the current work was to characterize the electrochemical behavior of DNA and its derivatives using screen printed carbon electrodes (SPCEs). Differential pulse voltammetry (DPV) was carried out on guanine, adenine, 8-oxyguanine, 8-deoxygau... Read More about Voltammetric behavior of DNA and its derivatives using screen printed carbon electrodes and its possible application in genotoxicity screening.

Amperometric lactate biosensor for flow injection analysis based on a screen-printed carbon electrode containing Meldola's Blue-Reinecke salt, coated with lactate dehydrogenase and NAD+ (2010)
Journal Article
Piano, M., Serban, S., Pittson, R., Drago, G. A., & Hart, J. P. (2010). Amperometric lactate biosensor for flow injection analysis based on a screen-printed carbon electrode containing Meldola's Blue-Reinecke salt, coated with lactate dehydrogenase and NAD+. Talanta, 82(1), 34-37. https://doi.org/10.1016/j.talanta.2010.03.051

A biosensor for the measurement of lactate in serum has been developed, which is based on a screen-printed carbon electrode, modified with Meldola's Blue-Reinecke Salt (MBRS-SPCE), coated with the enzyme lactate dehydrogenase NAD+ dependent (from Por... Read More about Amperometric lactate biosensor for flow injection analysis based on a screen-printed carbon electrode containing Meldola's Blue-Reinecke salt, coated with lactate dehydrogenase and NAD+.

Cyclic voltammetric behaviour of Rohypnol, Ativan and Valium and its exploitation for their determination in serum using a novel method involving liquid chromatography-dual electrode detection (2010)
Presentation / Conference
Honeychurch, K. C., Chong, A., Elamin, K., & Hart, J. P. (2010, June). Cyclic voltammetric behaviour of Rohypnol, Ativan and Valium and its exploitation for their determination in serum using a novel method involving liquid chromatography-dual electrode detection. Paper presented at Great Western Electrochemistry Meeting 2010, University of Bath, Bath, UK

Electrocatalytic behaviour of citric acid at a cobalt phthalocyanine- modified screen-printed carbon electrode and its application in pharmaceutical and food analysis (2010)
Journal Article
Honeychurch, K. C., Gilbert, L., & Hart, J. P. (2010). Electrocatalytic behaviour of citric acid at a cobalt phthalocyanine- modified screen-printed carbon electrode and its application in pharmaceutical and food analysis. Analytical and Bioanalytical Chemistry, 396(8), 3103-3111. https://doi.org/10.1007/s00216-010-3534-x

Cobalt phthalocyanine-modified screen-printed carbon electrodes (CoPC-SPCEs) have been investigated as disposable sensors for the measurement of citric acid. The analyte was found to undergo an electrocatalytic oxidation process involving the Co2+/Co... Read More about Electrocatalytic behaviour of citric acid at a cobalt phthalocyanine- modified screen-printed carbon electrode and its application in pharmaceutical and food analysis.

Application of screen-printed microband biosensors incorporated with cells to monitor metabolic effects of potential environmental toxins (2010)
Journal Article
Pemberton, R., Rawson, F. J., Xu, J., Pittson, R., Drago, G. A., Griffiths, J., …Hart, J. P. (2010). Application of screen-printed microband biosensors incorporated with cells to monitor metabolic effects of potential environmental toxins. Microchimica Acta, 170(3), 321-330. https://doi.org/10.1007/s00604-010-0326-0

Microband biosensors were fabricated from a screen-printed water-based carbon ink containing cobalt phthalocyanine redox mediator and glucose oxidase or lactate oxidase enzyme. The microbiosensors were characterised for their ability to monitor ferro... Read More about Application of screen-printed microband biosensors incorporated with cells to monitor metabolic effects of potential environmental toxins.