Kevin Honeychurch Kevin.Honeychurch@uwe.ac.uk
Senior Lecturer in Forensic Science
Electrochemical detection of benzodiazepines, following liquid chromatography, for applications in pharmaceutical, biomedical and forensic investigations
Honeychurch, Kevin C.; Hart, John P.
Authors
John Hart John.Hart@uwe.ac.uk
Professor
Abstract
Benzodiazepines are an important class of drugs commonly administered with a potential for abuse and environmental pollution. This review focuses on the liquid chromatographic electrochemical detection of the benzodiazepine class of drugs. These are characterised by a readily electrochemically reducible azomethine group, with a number also substituted by other electrochemically active groups. Liquid chromatography employing both single and dual electrode detection has been reported for a variety of benzodiazepines and their metabolites in biological, pharmaceutical, biomedical and forensic investigations. Recently, electrochemistry has been utilised to mimic biological oxidation processes and has been combined with liquid chromatography/mass spectroscopy for their identification and quantification of the products generated. The present review focuses on recent developments in liquid chromatographic- electrochemical determination of benzodiazepines reported since 2006, with earlier reports given in summary.
Citation
Honeychurch, K. C., & Hart, J. P. (2014). Electrochemical detection of benzodiazepines, following liquid chromatography, for applications in pharmaceutical, biomedical and forensic investigations. https://doi.org/10.5640/insc.040101
Journal Article Type | Article |
---|---|
Publication Date | Jan 23, 2014 |
Journal | Insciences Journal Sensors |
Print ISSN | 1664-171X |
Peer Reviewed | Peer Reviewed |
Volume | 4 |
Issue | 1 |
Pages | 1-18 |
DOI | https://doi.org/10.5640/insc.040101 |
Keywords | benzodiazepines, liquid chromatography, electrochemical detection, single and dual electrodes, review |
Publisher URL | http://dx.doi.org/10.5640/insc.040101 |
Related Public URLs | http://journal.insciences.org |
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