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Electrochemical detection of benzodiazepines, following liquid chromatography, for applications in pharmaceutical, biomedical and forensic investigations

Honeychurch, Kevin C.; Hart, John P.

Authors



Abstract

Benzodiazepines are an important class of drugs commonly administered with a potential for abuse and environmental pollution. This review focuses on the liquid chromatographic electrochemical detection of the benzodiazepine class of drugs. These are characterised by a readily electrochemically reducible azomethine group, with a number also substituted by other electrochemically active groups. Liquid chromatography employing both single and dual electrode detection has been reported for a variety of benzodiazepines and their metabolites in biological, pharmaceutical, biomedical and forensic investigations. Recently, electrochemistry has been utilised to mimic biological oxidation processes and has been combined with liquid chromatography/mass spectroscopy for their identification and quantification of the products generated. The present review focuses on recent developments in liquid chromatographic- electrochemical determination of benzodiazepines reported since 2006, with earlier reports given in summary.

Journal Article Type Article
Publication Date Jan 23, 2014
Journal Insciences Journal Sensors
Print ISSN 1664-171X
Peer Reviewed Peer Reviewed
Volume 4
Issue 1
Pages 1-18
APA6 Citation Honeychurch, K. C., & Hart, J. P. (2014). Electrochemical detection of benzodiazepines, following liquid chromatography, for applications in pharmaceutical, biomedical and forensic investigations. https://doi.org/10.5640/insc.040101
DOI https://doi.org/10.5640/insc.040101
Keywords benzodiazepines, liquid chromatography, electrochemical detection, single and dual electrodes, review
Publisher URL http://dx.doi.org/10.5640/insc.040101
Related Public URLs http://journal.insciences.org
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