Electrochemical detection of benzodiazepines, following liquid chromatography, for applications in pharmaceutical, biomedical and forensic investigations

Honeychurch, Kevin C.; Hart, John P.

Abstract

Benzodiazepines are an important class of drugs commonly administered with a potential for abuse and environmental pollution. This review focuses on the liquid chromatographic electrochemical detection of the benzodiazepine class of drugs. These are characterised by a readily electrochemically reducible azomethine group, with a number also substituted by other electrochemically active groups. Liquid chromatography employing both single and dual electrode detection has been reported for a variety of benzodiazepines and their metabolites in biological, pharmaceutical, biomedical and forensic investigations. Recently, electrochemistry has been utilised to mimic biological oxidation processes and has been combined with liquid chromatography/mass spectroscopy for their identification and quantification of the products generated. The present review focuses on recent developments in liquid chromatographic- electrochemical determination of benzodiazepines reported since 2006, with earlier reports given in summary.

• Journal Article Type: Article
• Publication Date: Jan 23, 2014
• Publicly Available Date: Jun 6, 2019
• Journal: Insciences Journal Sensors
• Print ISSN: 1664-171X
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 1
• Pages: 1-18
• DOI: https://doi.org/10.5640/insc.040101
• Keywords: benzodiazepines, liquid chromatography, electrochemical detection, single and dual electrodes, review
• Public URL: https://uwe-repository.worktribe.com/output/821900
• Publisher URL: http://dx.doi.org/10.5640/insc.040101
• Related Public URLs: http://journal.insciences.org