All Outputs (103)

Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: A model for neuronal and synaptic differentiation in neurodegeneration (2024)
Journal Article
Targett, I. L., Crompton, L. A., Conway, M. E., & Craig, T. J. (in press). Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: A model for neuronal and synaptic differentiation in neurodegeneration. In Vitro Cellular and Developmental Biology - Animal,

There has been much interest in the use of cell culture models of neurones, to avoid the animal welfare and cost issues of using primary and human-induced pluripotent stem cell (hiPSC)-derived neurones respectively. The human neuroblastoma cell line,... Read More about Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: A model for neuronal and synaptic differentiation in neurodegeneration.

IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome (2024)
Journal Article
Asurappulige, H. S. H., Ladomery, M. R., & Morse, H. R. (2024). IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome. Translational Oncology, 46, Article 102030. https://doi.org/10.1016/j.tranon.2024.102030

Following infection or exposure to therapeutic agents, an aggressive immune response may result, termed cytokine storm (CS) or cytokine release syndrome. Here the innate immune system becomes uncontrolled, leading to serious consequences including po... Read More about IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome.

SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression (2024)
Journal Article
Fletcher-Jones, A., Spackman, E., Craig, T. J., Nakamura, Y., Wilkinson, K. A., & Henley, J. M. (2024). SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression. Journal of Cell Science, 137(11), Article jcs261551. https://doi.org/10.1242/jcs.261551

Endocannabinoid signalling mediated by cannabinoid receptor 1 (CB1R, also known as CNR1) is critical for homeostatic neuromodulation of both excitatory and inhibitory synapses. This requires highly polarised axonal surface expression of CB1R, but how... Read More about SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression.

Effectiveness of infection prevention and control interventions in health care facilities in Africa: A systematic review (2024)
Journal Article
Igwe, U., Okolie, O., Ismail, S., & Adukwu, E. (in press). Effectiveness of infection prevention and control interventions in health care facilities in Africa: A systematic review. American Journal of Infection Control, https://doi.org/10.1016/j.ajic.2024.06.004

Background Healthcare associated infections (HAIs) are a major threat to patient safety and quality care. However, they are avoidable by implementing evidence-based infection prevention and control measures. This re... Read More about Effectiveness of infection prevention and control interventions in health care facilities in Africa: A systematic review.

Attenuated-total-reflection Fourier-transformed spectroscopy as a rapid tool to reveal the molecular structure of insect powders as ingredients for animal feeds (2024)
Journal Article
Robertson, K., Ortuño, J., Stratakos, A., Stergiadis, S., & Theodoridou, K. (in press). Attenuated-total-reflection Fourier-transformed spectroscopy as a rapid tool to reveal the molecular structure of insect powders as ingredients for animal feeds. Journal of Insects as Food and Feed, https://doi.org/10.1163/23524588-00001092

Unsustainable agriculture contributes to disastrous global effects – insect-based feed shows potential due to their sustainable, nutritional, and waste upcycling properties. Current EU legislation restricts insect-based meals to fish, pork, and poult... Read More about Attenuated-total-reflection Fourier-transformed spectroscopy as a rapid tool to reveal the molecular structure of insect powders as ingredients for animal feeds.

Coupling of cold atmospheric plasma treatment with ultrasound-assisted extraction for enhanced recovery of bioactive compounds from cornelian cherry pomace (2024)
Journal Article
Loukri, A., Kissas, T., Kyriakoudi, A., Zymvrakaki, E., Stratakos, A. C., & Mourtzinos, I. (2024). Coupling of cold atmospheric plasma treatment with ultrasound-assisted extraction for enhanced recovery of bioactive compounds from cornelian cherry pomace. Food Chemistry, 455, Article 139989. https://doi.org/10.1016/j.foodchem.2024.139989

Cornelian cherry pomace is produced during the production of juice from this traditional superfood. Due to its high nutritive value, the by-product can be utilized as a source of bioactive compounds. The present study aimed to develop a sustainable m... Read More about Coupling of cold atmospheric plasma treatment with ultrasound-assisted extraction for enhanced recovery of bioactive compounds from cornelian cherry pomace.

Impacts of COVID-19 on UK environmental science engagement projects (2024)
Journal Article
Hobbs, L., Stevens, C., & Fletcher-Wood, R. (in press). Impacts of COVID-19 on UK environmental science engagement projects. School Science Review,

In February-March 2020, ‘Investing in the Future of Science’ collected data on environmental science engagement with UK school-aged children. The UK then entered its first COVID-19 national lockdown. Larger or wider-reaching projects appeared more li... Read More about Impacts of COVID-19 on UK environmental science engagement projects.

Comparison of MXene and SWCNTs effectiveness for osteoblast differentiation: A preliminary study with MG-63 cells (2024)
Journal Article
Elkodous, M. A., Elkhenany, H., & Mansell, J. P. (in press). Comparison of MXene and SWCNTs effectiveness for osteoblast differentiation: A preliminary study with MG-63 cells. NANO, https://doi.org/10.1142/S179329202450036X

The exceptional chemical and physical properties of nanomaterials have attracted growing interest in the field of bone tissue engineering. Single walled carbon nanotubes (SWCNTs) and MXenes are two types of unique nanomaterials that have shown promis... Read More about Comparison of MXene and SWCNTs effectiveness for osteoblast differentiation: A preliminary study with MG-63 cells.

Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3 (2024)
Journal Article
Williams, A., Cooper, E., Clark, B., Perry, L., Ponassi, M., Iervasi, E., …Ladomery, M. (2024). Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3. International Journal of Molecular Sciences, 25(10), Article 5380. https://doi.org/10.3390/ijms25105380

In a screen of over 200 novel pyrazole compounds, ethyl 1-(2-hydroxypentyl)-5-(3-(3-(trifluoromethyl) phenyl)ureido)-1H-pyrazole-4-carboxylate (named GeGe-3) has emerged as a potential anticancer compound. GeGe-3 displays potent anti-angiogenic prope... Read More about Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3.

Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii (2024)
Journal Article
Manley, R., Fitch, C., Francis, V., Temperton, I., Turner, D., Fletcher, J., …Temperton, B. (2024). Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii. Journal of Medical Microbiology, 73(5), Article 001829. https://doi.org/10.1099/jmm.0.001829

Introduction . Acinetobacter baumannii is a critical priority pathogen for novel antimicrobials (World Health Organization) because of the rise in nosocomial infections and its ability to evolve resistance to last resort antibiotics. A. baumannii is... Read More about Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii.

The effect of 3D printing speed and temperature on transferability of Staphylococcus aureus and Escherichia coli during 3D food printing (2024)
Journal Article
Εkonomou, S. Ι., Kageler, S., & Ch Stratakos, A. (2024). The effect of 3D printing speed and temperature on transferability of Staphylococcus aureus and Escherichia coli during 3D food printing. Food Microbiology, 122, Article 104561. https://doi.org/10.1016/j.fm.2024.104561

The current study aimed to determine if the 3D-printing speed and temperature would impact the transferability of foodborne pathogens from the stainless-steel (SS) food cartridge to the 3D-printed food ink. Staphylococcus aureus and Escherichia coli... Read More about The effect of 3D printing speed and temperature on transferability of Staphylococcus aureus and Escherichia coli during 3D food printing.

Two novel Raoultella species associated with bleeding cankers of broadleaf hosts, Raoultella scottia sp. nov. and Raoultella lignicola sp. nov. (2024)
Journal Article
Brady, C., Cramptom, B., Kaur, S., Maddock, D., Kile, H., Arnold, D., & Denman, S. (2024). Two novel Raoultella species associated with bleeding cankers of broadleaf hosts, Raoultella scottia sp. nov. and Raoultella lignicola sp. nov. Frontiers in Microbiology, 15, Article 1386923. https://doi.org/10.3389/fmicb.2024.1386923

Seventeen Gram-negative, facultatively anaerobic bacterial strains were isolated from bleeding cankers of various broadleaf hosts and oak rhizosphere soil in Great Britain. The strains were tentatively identified as belonging to the genus Raoultella... Read More about Two novel Raoultella species associated with bleeding cankers of broadleaf hosts, Raoultella scottia sp. nov. and Raoultella lignicola sp. nov..

A systematic review of the epidemiology and the public health implications of stroke in Sub-Saharan Africa (2024)
Journal Article
Abissegue, G., Yakubu, S. I., Ajay, A. S., & Niyi-Odumosu, F. (2024). A systematic review of the epidemiology and the public health implications of stroke in Sub-Saharan Africa. Journal of Stroke and Cerebrovascular Diseases, 33(8), Article 107733. https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.107733

Background: With approximately 11 million strokes occurring annually worldwide, and over 6.5 million deaths annually, stroke has made its place as one of the major killers in the world. Although developing countries make up more than 4/5 of the globa... Read More about A systematic review of the epidemiology and the public health implications of stroke in Sub-Saharan Africa.

Politicisation of science in COVID-19 editorial cartoons: A comparative study of cartoons in Australia, South Africa and the United Kingdom (2024)
Journal Article
Weitkamp, E., Milani, E., Joubert, M., & Riedlinger, M. (2024). Politicisation of science in COVID-19 editorial cartoons: A comparative study of cartoons in Australia, South Africa and the United Kingdom. Journalism Studies, 25(8), 813-836. https://doi.org/10.1080/1461670X.2024.2342416

This study explores the representation of scientists and politicians in editorial cartoons from three countries: Australia, South Africa and the United Kingdom. Of 466 cartoons collected from six Sunday newspapers (two from each country) over an 1... Read More about Politicisation of science in COVID-19 editorial cartoons: A comparative study of cartoons in Australia, South Africa and the United Kingdom.

Public involvement and public engagement: An example of convergent evolution? Findings from a conceptual qualitative review of patient and public involvement, and public engagement, in health and scientific research. (2024)
Journal Article
Wilkinson, C., Gibson, A., Biddle, M., & Hobbs, L. (2024). Public involvement and public engagement: An example of convergent evolution? Findings from a conceptual qualitative review of patient and public involvement, and public engagement, in health and scientific research. PEC Innovation, 4, Article 100281. https://doi.org/10.1016/j.pecinn.2024.100281

Patient and public involvement (PPI) in health research is now well-established, whilst science, technology, engineering and mathematics (STEM) research has shifted from a focus on science communication alone to public engagement (PE) within its rese... Read More about Public involvement and public engagement: An example of convergent evolution? Findings from a conceptual qualitative review of patient and public involvement, and public engagement, in health and scientific research..

First report of Brenneria goodwinii, Gibbsiella quercinecans and Rahnella victoriana in declining oaks in France (2024)
Journal Article
Eichenlaub, L., Eichenlaub, L., Denman, S., Denman, S., Brady, C., Maddock, D., …Robin, C. (2024). First report of Brenneria goodwinii, Gibbsiella quercinecans and Rahnella victoriana in declining oaks in France. New Disease Reports, 49(2), Article e12264. https://doi.org/10.1002/ndr2.12264

Acute Oak Decline, Quercus petraea, Quercus robur Acute Oak Decline (AOD) is mediated by abiotic factors (temperature and precipitation) and triggered by insects (mainly the bark-boring beetle Agrilus biguttatus) and a complex of bacterial species (m... Read More about First report of Brenneria goodwinii, Gibbsiella quercinecans and Rahnella victoriana in declining oaks in France.

Assessing the effects of cold atmospheric plasma on the natural microbiota and quality of pork during storage (2024)
Journal Article
Oliinychenko, Y. K., Ekonomou, S. I., Tiwari, B. K., & Stratakos, A. C. (2024). Assessing the effects of cold atmospheric plasma on the natural microbiota and quality of pork during storage. Foods, 13(7), Article 1015. https://doi.org/10.3390/foods13071015

Cold atmospheric plasma (CAP) is a novel non-thermal technology with significant potential for use in meat processing to prolong shelf life. The objective of the study was to evaluate the efficiency of CAP treatment on the natural microbiota and qual... Read More about Assessing the effects of cold atmospheric plasma on the natural microbiota and quality of pork during storage.

IT-assisted comprehensive geriatric assessment for residents in care homes: Quasiexperimental longitudinal study (2024)
Journal Article
Attwood, D., Vafidis, J., Boorer, J., Long, S., Ellis, W., Earley, M., …Hope, S. (2024). IT-assisted comprehensive geriatric assessment for residents in care homes: Quasiexperimental longitudinal study. BMC Geriatrics, 24(1), 269. https://doi.org/10.1186/s12877-024-04824-6

Background: Frailty interventions such as Comprehensive Geriatric Assessment (CGA) can provide significant benefits for older adults living with frailty. However, incorporating such proactive interventions into primary care remains a challenge. We de... Read More about IT-assisted comprehensive geriatric assessment for residents in care homes: Quasiexperimental longitudinal study.

In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy (2024)
Journal Article
Manohar, P., Loh, B., Turner, D., Tamizhselvi, R., Mathankumar, M., Elangovan, N., …Leptihn, S. (2024). In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy. Frontiers in Microbiology, 15, Article 1344962. https://doi.org/10.3389/fmicb.2024.1344962

Infections caused by Pseudomonas aeruginosa are becoming increasingly difficult to treat due to the emergence of strains that have acquired multidrug resistance. Therefore, phage therapy has gained attention as an alternative to the treatment of pseu... Read More about In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy.

Cyclic voltammetric behaviour and high-performance liquid chromatography amperometric determination of levamisole (2024)
Journal Article
Chan, T. Y. J., & Honeychurch, K. C. (2024). Cyclic voltammetric behaviour and high-performance liquid chromatography amperometric determination of levamisole. Sci, 6(1), Article 15. https://doi.org/10.3390/sci6010015

The electrochemical oxidation of levamisole, a glassy carbon electrode, was investigated over the pH range 2.0–10.0. Cyclic voltammetric investigations showed a single oxidation process was recorded, with a peak potential (Ep) shown to be pH-dependen... Read More about Cyclic voltammetric behaviour and high-performance liquid chromatography amperometric determination of levamisole.