A systematic review of the epidemiology and the public health implications of stroke in Sub-Saharan Africa

Abissegue, Gisele; Yakubu, Seidina Iliasu; Ajay, Aiswarya Seema; Niyi-Odumosu, Faatihah

Abstract

Background: With approximately 11 million strokes occurring annually worldwide, and over 6.5 million deaths annually, stroke has made its place as one of the major killers in the world. Although developing countries make up more than 4/5 of the global stroke burden, well-grounded information on stroke epidemiology remains lacking there. Aims: This systematic review study aimed to provide a synthesis of studies on the incidence and prevalence of stroke among adults in sub-Saharan Africa (SSA), subsequently deduce the associated risk factors and public health implications (mortality rates and economic costs) of the disease on the population of this region. Methods: A systematic review of studies carried out in the region and published on PUBMED. Eligibility criteria were established using the PEO (Population/Patient, Exposure, Outcome) format. Research articles investigating either (or all) of the following: ischemic or haemorrhagic stroke, incidence, prevalence, and risk factors of stroke in adults (≥ 18 years old), in at least one region of SSA were included. Exclusion criteria comprised studies involving populations younger than 18 years old, research conducted outside the designated research region, and articles inaccessible in full text. The PRISMA guidelines were used for the search strategy. Results: Fifty-two studies were included review. Among them, over 11 studies investigated the prevalence of the disease. Some older studies within the continent (Nigeria, 2011) showed a prevalence of 1.3 per 100 while more recent studies (Zambia, 2021) showed a prevalence of 4.3 per 1000. The highest prevalence noted in this region was in Madagascar (2017) with 48.17 per 100, while the lowest was recorded in (Zimbabwe, 2017) with 0.61 per 100. The study in Tanzania showed a crude incidence of 94·5 per 100 000 (76·0–115·0) while the study in Ghana in 2018 showed an incidence of 14.19 events per 1000 person-years [10.77–18.38]. The identified risk factors included hypertension, diabetes, smoking, alcohol consumption, physical inactivity, poor diets (more salt, less vegetables), dyslipidaemia, HIV/AIDS co-infection, heart disease (cardiomyopathies, cardiac arrhythmias), obesity, previous stroke and/or family history of stroke. Over 21 studies investigated the mortality rates due to stroke in SSA, with most of the studies being in West Africa. These studies revealed mortality rates as high as 43.3% in Ghana, and as low as 10.9% in Cameroon. Few studies reported on the economic costs of stroke in the region; two in Benin, two in Nigeria and one in Tanzania. Conclusion: The increasing incidence/prevalence, lifestyle factors and interactions with other diseases, including major communicable diseases, stroke is becoming a pressing public health problem for SSA. Reducing the incidence of stroke in Africa will surely lower mortality, morbidity, disability, and the neurological as well as cognitive aftereffects of stroke, as is clear from the experience of higher-income nations. We recommend a collective intervention involving the governments of nations, international organizations, civil society, and the private sector for greater impact and sustainable outcomes reducing the epidemiology and implications of stroke in SSA.

Citation

Abissegue, G., Yakubu, S. I., Ajay, A. S., & Niyi-Odumosu, F. (2024). A systematic review of the epidemiology and the public health implications of stroke in Sub-Saharan Africa. Journal of Stroke and Cerebrovascular Diseases, 33(8), Article 107733. https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.107733

• Journal Article Type: Article
• Acceptance Date: Apr 22, 2024
• Online Publication Date: Apr 24, 2024
• Publication Date: Aug 31, 2024
• Deposit Date: May 3, 2024
• Publicly Available Date: May 23, 2024
• Journal: Journal of Stroke and Cerebrovascular Diseases
• Print ISSN: 1052-3057
• Electronic ISSN: 1532-8511
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 33
• Issue: 8
• Article Number: 107733
• DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.107733
• Public URL: https://uwe-repository.worktribe.com/output/11975584
• Additional Information: This article is maintained by: Elsevier; Article Title: A Systematic Review of the Epidemiology and The Public Health Implications of Stroke in Sub-Saharan Africa; Journal Title: Journal of Stroke and Cerebrovascular Diseases; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.107733; Content Type: article; Copyright: © 2024 The Author(s). Published by Elsevier Inc.