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Article a non-faradaic impedimetric biosensor for monitoring of Caspase 9 in Mammalian cell culture (2022)
Journal Article
Chen, B., Kiely, J., Luxton, R., & Williams, I. (in press). Article a non-faradaic impedimetric biosensor for monitoring of Caspase 9 in Mammalian cell culture. Bioelectrochemistry, https://doi.org/10.2139/ssrn.4070649

Lower yields and poorer quality of biopharmaceutical products result from cell death in biore-actors. Such cell death is commonly associated with programmed cell death or apoptosis. During apoptosis, caspases are activated and cause a cascade of even... Read More about Article a non-faradaic impedimetric biosensor for monitoring of Caspase 9 in Mammalian cell culture.

Modelling a dynamic magneto-agglutination bioassay (2022)
Journal Article
Hughes, R., Fishman, A., Lamb-Riddell, K., Muñoz, V. S., Champneys, A., Kiely, J., & Luxton, R. (in press). Modelling a dynamic magneto-agglutination bioassay. Biosensors and Bioelectronics, 114745. https://doi.org/10.1016/j.bios.2022.114745

The process of developing an end-to-end model of a magneto-immunoassay is described which models the agglutination effect due to specific binding of bacteria to paramagnetic particles. After establishing the properties of the dose-specific agglutinat... Read More about Modelling a dynamic magneto-agglutination bioassay.

Equivalent circuit model of a non-faradaic impedimetric ZnO nano-crystal biosensor (2022)
Journal Article
Eveness, J., Cao, L., Kiely, J., & Luxton, R. (2022). Equivalent circuit model of a non-faradaic impedimetric ZnO nano-crystal biosensor. Journal of Electroanalytical Chemistry, 906, Article 116003. https://doi.org/10.1016/j.jelechem.2021.116003

This paper describes the development of an equivalent electrical circuit (EEC) model of a unique co-planar electrode PET-ZnO biosensor platform. This non-faradaic ZnO biosensor had a PET insulating layer between the electrodes and the active ZnO sens... Read More about Equivalent circuit model of a non-faradaic impedimetric ZnO nano-crystal biosensor.

Passive impedance sensing using a SAW resonator-coupled biosensor for zero-power wearable applications (2021)
Journal Article
Yue, X., Kiely, J., Luxton, R., Chen, B., McLeod, C. N., & Drakakis, E. M. (2022). Passive impedance sensing using a SAW resonator-coupled biosensor for zero-power wearable applications. IEEE Sensors Journal, 22(3), 2347-2357. https://doi.org/10.1109/JSEN.2021.3136705

A bio-sensing scheme, which acquires impedance information of a capacitive biosensor by using the reflected RF signal from a surface acoustic wave (SAW) resonator connected to the biosensor, is proposed. This technique requires no power to be supplie... Read More about Passive impedance sensing using a SAW resonator-coupled biosensor for zero-power wearable applications.

Cytochrome P450 2B6 amperometric biosensor for continuous monitoring of propofol (2021)
Journal Article
Ferrier, D., Kiely, J., & Luxton, R. (2021). Cytochrome P450 2B6 amperometric biosensor for continuous monitoring of propofol. IEEE Sensors Journal, 21(21), https://doi.org/10.1109/JSEN.2021.3112273

Despite the growing evidence of improved patient outcomes and of a substantially reduced environmental impact of propofol-based total intravenous anesthesia when compared to volatile-based techniques, the vast majority of general anesthetics still us... Read More about Cytochrome P450 2B6 amperometric biosensor for continuous monitoring of propofol.

Propofol detection for monitoring of intravenous anaesthesia: A review (2021)
Journal Article
Ferrier, D., Kiely, J., & Luxton, R. (2022). Propofol detection for monitoring of intravenous anaesthesia: A review. Journal of Clinical Monitoring and Computing, 36, 315-323. https://doi.org/10.1007/s10877-021-00738-5

This paper presents a review of established and emerging methods for detecting and quantifying the intravenous anaesthetic propofol in solution. There is growing evidence of numerous advantages of total intravenous anaesthesia using propofol compared... Read More about Propofol detection for monitoring of intravenous anaesthesia: A review.

Recent progress in screen-printed electrochemical sensors and biosensors for the detection of estrogens (2021)
Journal Article
Musa, A. M., Kiely, J., Luxton, R., & Honeychurch, K. C. (2021). Recent progress in screen-printed electrochemical sensors and biosensors for the detection of estrogens. Trends in Analytical Chemistry, 139, Article 116254. https://doi.org/10.1016/j.trac.2021.116254

Estrogens have become increasingly prevalent in environmental samples across the world, posing a serious threat to human health. They have received considerable public attention due to their harmful effect on the normal endocrine functions of humans... Read More about Recent progress in screen-printed electrochemical sensors and biosensors for the detection of estrogens.

Classification of the mechanism of toxicity as applied to human cell line ECV304 (2020)
Journal Article
Djawad, Y. A., Kiely, J., & Luxton, R. (2021). Classification of the mechanism of toxicity as applied to human cell line ECV304. Computer Methods in Biomechanics and Biomedical Engineering, 24(9), 933-944. https://doi.org/10.1080/10255842.2020.1861255

© 2020 Informa UK Limited, trading as Taylor & Francis Group. The objective of this study was to identify the pattern of cytotoxicity testing of the human cell line ECV304 using three techniques of an ensemble learning algorithm (bagging, boosting... Read More about Classification of the mechanism of toxicity as applied to human cell line ECV304.

Nanoparticle-based 3D membrane for impedimetric biosensor applications (2020)
Journal Article
Cao, L., Kiely, J., Piano, M., & Luxton, R. (2020). Nanoparticle-based 3D membrane for impedimetric biosensor applications. Bioelectrochemistry, 136, Article 107593. https://doi.org/10.1016/j.bioelechem.2020.107593

This paper reports on a comparison between nano-ZnO/CuO and nano-ZnO nitrocellulose membrane biosensors, both of which were fabricated using a simple and inexpensive sonication technique. To produce the nano-ZnO/CuO membranes, the technique involved... Read More about Nanoparticle-based 3D membrane for impedimetric biosensor applications.

Sensor (2020)
Patent
Allainguillaume, J., Barnett, J., Luxton, R., & Kiely, J. Sensor. WO 2020/089607 A1

The present invention relates to detecting viral infections in plants, especially Cacao swollen-shoot virus (CSSV) infections. Recombinant viral coat protein antigens and binding reagents that specifically bind to thereto are provided together with a... Read More about Sensor.

A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing (2020)
Journal Article
Gasser, A., Eveness, J., Kiely, J., Attwood, D., & Luxton, R. (2020). A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing. Bioelectrochemistry, 133, 107448. https://doi.org/10.1016/j.bioelechem.2019.107448

© 2019 We report on a novel impedance spectroscopy measurement and data analysis technique for cytotoxicity testing. The technique combines non-contact measurement with real-time impedance data analysis based on the toxin dose dependency of the outpu... Read More about A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing.

Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection (2019)
Journal Article
Barnett, J. M., Monnier, B. M., Tyler, S., West, D., Ballantine-Dykes, H., Regan, E., …Luxton, R. (2020). Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection. Sensing and Bio-Sensing Research, 27, 100315. https://doi.org/10.1016/j.sbsr.2019.100315

© 2019 The resonant coil magnetometer quantifies paramagnetic particles (PMPs) and has been used to develop magneto-immunoassays in a range of formats. The advantage of magneto-immunoassays is that they are relatively inexpensive, portable, easy to p... Read More about Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection.

Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films (2019)
Patent
Cox, T., Kiely, J., Ratcliffe, N., deLacy Costello, B., & Luxton, R. (2019). Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films

The invention relates to the field of sensors for detecting volatile compounds. The sensor of the present invention for detecting volatile compounds comprises: a film of metal oxide; a heater configured to provide heat energy to the film of metal oxi... Read More about Sensors for determining volatile compounds based on electrical conductivity and cataluminescence measurements of metal oxide films.

CSSV biosensor (WO2020089607-PAMPH-20200507-8395) (2019)
Patent
Allainguillaume, J., Barnett, J. M., Kiely, J., & Luxton, R. (in press). CSSV biosensor (WO2020089607-PAMPH-20200507-8395). WO 2020/089607 A1

The present invention relates to detecting viral infections in plants, especially Cacao swollen-shoot virus (CSSV) infections. Recombinant viral coat protein antigens and binding reagents that specifically bind to thereto are provided together with a... Read More about CSSV biosensor (WO2020089607-PAMPH-20200507-8395).

C3bio Poster AM KH RL JK 2019 (2019)
Presentation / Conference
Musa, A., Honeychurch, K., Kelly, J., & Luxton, R. (2019, September). C3bio Poster AM KH RL JK 2019

Bioinspired materials have emerged as alternatives to antibodies and enzymes in biosensor for environmental monitoring These are tailored made in order to mimics the molecular function of a natural receptors in biosensor Aptamers and Molecularly imp... Read More about C3bio Poster AM KH RL JK 2019.

A copper oxide/zinc oxide composite nano-surface for use in a biosensor (2019)
Journal Article
Cao, L., Kiely, J., Piano, M., & Luxton, R. (2019). A copper oxide/zinc oxide composite nano-surface for use in a biosensor. Materials, 12(7), 1126. https://doi.org/10.3390/ma12071126

© 2019 by the authors. In this study, biosensors based on zinc oxide-copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 a... Read More about A copper oxide/zinc oxide composite nano-surface for use in a biosensor.

The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges (2019)
Journal Article
Djawad, Y. A., Attwood, D., Kiely, J., & Luxton, R. (2019). The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges. Sensing and Bio-Sensing Research, 23, Article 100269. https://doi.org/10.1016/j.sbsr.2019.100269

© 2019 In this paper we present a non-contact, impedance-based sensor system capable of characterizing the toxic response of cells to three different types of toxin. ECV304 cells were treated with 1 mM Hydrogen peroxide, 5% Dimethyl Sulfoxide, and 10... Read More about The application of detrended fluctuation analysis to assess physical characteristics of the human cell line ECV304 following toxic challenges.

Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection (2018)
Journal Article
Lu, C., Janice, K., Martina, P., & Richard, L. (2018). Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection. Scientific Reports, 8(1), 122687. https://doi.org/10.1038/s41598-018-30793-z

© 2018, The Author(s). The paper reports a biosensor formed from antibody coated ZnO nano-crystals which has been prepared using a rapid and inexpensive fabrication method which utilises colloidal dispersion enhanced using sonication. This technique... Read More about Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection.

Mathematical modelling of a magnetic immunoassay (2017)
Journal Article
Luxton, R., Roberts, L., Griffith, T., Champneys, A., Piano, M., Kiely, J., & Luxton, R. W. (2017). Mathematical modelling of a magnetic immunoassay. IMA Journal of Applied Mathematics, 82(6), 1253-1282. https://doi.org/10.1093/imamat/hxx034

© The authors 2017. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved. A mathematical model is developed to describe the action of a novel form of fluidic biosensor that uses para... Read More about Mathematical modelling of a magnetic immunoassay.

Particle facilitate testing (2017)
Patent
Luxton, R. W., Kiely, J., & Wraith, P. (2017). Particle facilitate testing. 2017/0146525A1

Magnetic particles are distributed across a fluid flow by applied magnetic field to interact with a test substance in fluid. Alternatively or additionally, particles, which may be magnetic, are combined with cells and energy, eg ultrasonic energy, is... Read More about Particle facilitate testing.