Nanoparticle-based 3D membrane for impedimetric biosensor applications
Cao, Lu; Kiely, Janice; Piano, Martina; Luxton, Richard
Janice Kiely Janice.Kiely@uwe.ac.uk
Professor in Bio-electronics/Res In CoDi
Martina Piano Martina.Piano@uwe.ac.uk
Research Fellow Biosensor reproducibility testing
Richard Luxton Richard.Luxton@uwe.ac.uk
Research Centre Director-IBST/Professor
This paper reports on a comparison between nano-ZnO/CuO and nano-ZnO nitrocellulose membrane biosensors, both of which were fabricated using a simple and inexpensive sonication technique. To produce the nano-ZnO/CuO membranes, the technique involved sonication of 1% (w/v) ZnO and 1% (w/v) CuO nano-crystal colloidal suspensions, with a volume ratio of 1:2. The membranes were analysed by scanning electron microscopy and energy-dispersive spectroscopy, which showed the gradated distribution of nanoparticles in the membrane. Impedance spectroscopy demonstrated that the sonication resulted in a greater than two-fold enhancement of the output signal. Changes in impedance phase values, at a frequency of 100 Hz, were used to establish dose dependent responses for C-reactive protein (CRP). Limits of detection of 27 pg/mL for the 1% (w/v) nano-ZnO and 16 pg/mL for the 1% (w/v) nano-ZnO/CuO nitrocellulose membrane biosensors were demonstrated.
Cao, L., Kiely, J., Piano, M., & Luxton, R. (2020). Nanoparticle-based 3D membrane for impedimetric biosensor applications. Bioelectrochemistry, 136, https://doi.org/10.1016/j.bioelechem.2020.107593
|Journal Article Type||Article|
|Acceptance Date||Jun 28, 2020|
|Online Publication Date||Jul 3, 2020|
|Publication Date||Dec 1, 2020|
|Deposit Date||Sep 24, 2020|
|Publicly Available Date||Jul 4, 2022|
|Peer Reviewed||Peer Reviewed|
|Keywords||Physical and Theoretical Chemistry; Biophysics; Electrochemistry; General Medicine|
|Additional Information||This article is maintained by: Elsevier; Article Title: Nanoparticle-based 3D membrane for impedimetric biosensor applications; Journal Title: Bioelectrochemistry; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.bioelechem.2020.107593; Content Type: article; Copyright: © 2020 Elsevier B.V. All rights reserved.|
This file is under embargo until Jul 4, 2022 due to copyright reasons.
Contact Richard.Luxton@uwe.ac.uk to request a copy for personal use.
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