Estimation of the dynamic leakage current of a supercapacitor in energy harvesting powered autonomous wireless sensor nodes (2017)
Journal Article
Yue, X., Kiely, J., Farooq, A., & Champneys, A. (2017). Estimation of the dynamic leakage current of a supercapacitor in energy harvesting powered autonomous wireless sensor nodes. Intelec, 2017-October, 278-281. https://doi.org/10.1109/INTLEC.2017.8214147

© 2017 IEEE. The supercapacitor is a candidate energy storage component for energy harvesting powered autonomous wireless sensor node aiming to achieve battery replacement-free, 'fit and forget' sensor node in low-power IoT applications. The leakage... Read More about Estimation of the dynamic leakage current of a supercapacitor in energy harvesting powered autonomous wireless sensor nodes.

Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds (2017)
Journal Article
Gould, O., Ratcliffe, N. M., De Lacy Costello, B., Wieczorek, T., & Persad, R. (2018). Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds. Journal of Breath Research, 12(1), 016009. https://doi.org/10.1088/1752-7163/aa8efe

© 2017 IOP Publishing Ltd. There have been a number of studies in which metal oxide sensors (MOS) have replaced conventional analytical detectors in gas chromatography systems. However, despite the use of these instruments in a range of applications... Read More about Assessment of a combined gas chromatography mass spectrometer sensor system for detecting biologically relevant volatile compounds.

Development of an Indoor Photovoltaic Energy Harvesting Module for Autonomous Sensors in Building Air Quality Applications (2017)
Journal Article
Yue, X., Kauer, M., Bellanger, M., Beard, O., Brownlow, M., Gibson, D., …Song, S. (2017). Development of an Indoor Photovoltaic Energy Harvesting Module for Autonomous Sensors in Building Air Quality Applications. IEEE Internet of Things, 4(6), 2092-2103. https://doi.org/10.1109/JIOT.2017.2754981

© 2017 IEEE. A 50 mm × 20 mm × 15 mm indoor photovoltaic (PV) energy harvesting power module (IPEHPM) has been developed for powering an Internet of Things (IoT) sensor node containing a low-power CO 2 sensor for automatic building ventilation. It i... Read More about Development of an Indoor Photovoltaic Energy Harvesting Module for Autonomous Sensors in Building Air Quality Applications.

Conductive composites for oligonucleotide detection (2017)
Journal Article
Ferrier, D. C., Shaver, M. P., & Hands, P. J. (2018). Conductive composites for oligonucleotide detection. Sensing and Bio-Sensing Research, 17, 1-6. https://doi.org/10.1016/j.sbsr.2017.11.007

© 2017 The Authors A new method for oligonucleotide detection is presented based on oligonucleotide cross-linked polymer composites. Conductive carbon nanoparticles are incorporated into a DNA-functionalised polymer, containing partially complementar... Read More about Conductive composites for oligonucleotide detection.

Mathematical modelling of a magnetic immunoassay (2017)
Journal Article
Roberts, L., Griffith, T., Champneys, A., Piano, M., Kiely, J., & Luxton, R. W. (2017). Mathematical modelling of a magnetic immunoassay. IMA Journal of Applied Mathematics, 82(6), 1253-1282. https://doi.org/10.1093/imamat/hxx034

© The authors 2017. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved. A mathematical model is developed to describe the action of a novel form of fluidic biosensor that uses para... Read More about Mathematical modelling of a magnetic immunoassay.

Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme (2017)
Journal Article
Bharate, S. B., Chaudhuri, B., Vishwakarma, R. A., Jain, S. K., Sharma, R., Gatchie, L., & Williams, I. S. (2017). Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme. Bioorganic and Medicinal Chemistry Letters, 27(24), 5400-5403. https://doi.org/10.1016/j.bmcl.2017.11.013

© 2017 Elsevier Ltd The development of multi-drug resistance to existing anticancer drugs is one of the major challenges in cancer treatment. The over-expression of cytochrome P450 1B1 enzyme has been reported to cause resistance to cisplatin. With a... Read More about Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme.

(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent (2017)
Journal Article
Horley, N. J., Beresford, K. J., Kaduskar, S., Joshi, P., McCann, G. J., Ruparelia, K. C., …Chaudhuri, B. (2017). (E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent. Bioorganic and Medicinal Chemistry Letters, 27(24), 5409-5414. https://doi.org/10.1016/j.bmcl.2017.11.009

The overexpression of CYP1 family of enzymes is reported to be associated with development of human carcinomas. It has been well reported that CYP1A1 specific inhibitors prevents carcinogenesis. Herein, thirteen pyridine-4-yl series of chalcones were... Read More about (E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent.

A successive approximation method to precisely measure leakage current of the rechargeable Lithium coin battery (2017)
Journal Article
Yue, X., Kiely, J., Ghauri, S., Kauer, M., Bellanger, M., & Gibson, D. (2017). A successive approximation method to precisely measure leakage current of the rechargeable Lithium coin battery. Journal of Energy Storage, 13, 442-446. https://doi.org/10.1016/j.est.2017.08.006

© 2017 Elsevier Ltd When the rechargeable Lithium coin battery is employed as the storage component for indoor energy harvesting, the leakage current of the battery cannot be ignored, especially in ultra-low-power applications. The leakage current of... Read More about A successive approximation method to precisely measure leakage current of the rechargeable Lithium coin battery.

Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices (2017)
Journal Article
Donaghy, D., Gonzalez-Macia, L., Killard, A., & Raja, M. (2017). Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices. IET Circuits, Devices and Systems, 11(5), 504-511. https://doi.org/10.1049/iet-cds.2016.0500

© The Institution of Engineering and Technology. This paper presents circuit design and simulations of a high gain organic Op-Amp, for use in quantification of real cholesterol, in the range of 1-9 mM. A 7-stage inverter chain is added onto the desig... Read More about Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices.

Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme (2017)
Journal Article
Bharate, S. B., Nuthakki, V. K., Williams, I. S., Chib, S., Gatchie, L., Joshi, P., …Chaudhuri, B. (2017). Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme. Journal of Agricultural and Food Chemistry, 65(34), 7440-7446. https://doi.org/10.1021/acs.jafc.7b02690

© 2017 American Chemical Society. Naturally occurring polyphenolic compounds are of medicinal importance because of their unique antioxidant, anticancer, and chemopreventive properties. Baicalein, a naturally occurring polyhydroxy flavonoid possessin... Read More about Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme.

Disposable sensors (2017)
Journal Article
Killard, A. (2017). Disposable sensors. Current Opinion in Electrochemistry, 3(1), 57-62. https://doi.org/10.1016/j.coelec.2017.06.013

© 2017 Elsevier B.V. Device disposability is a critical feature of electrochemical sensor production, allowing complex measurements to be carried out in a low cost and efficient manner. Disposable sensors are increasing rapidly in their level of soph... Read More about Disposable sensors.

Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics (2017)
Journal Article
Baumann, R. R., Ahmadraji, T., Gonzalez-Macia, L., Ritvonen, T., Willert, A., Ylimaula, S., …Killard, A. (2017). Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics. Analytical Chemistry, 89(14), 7447-7454. https://doi.org/10.1021/acs.analchem.7b01012

© 2017 American Chemical Society. Organic and printed electronics integration has the potential to revolutionize many technologies, including biomedical diagnostics. This work demonstrates the successful integration of multiple printed electronic fu... Read More about Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics.

Particle facilitate testing (2017)
Patent
Luxton, R. W., Kiely, J., & Wraith, P. (2017). Particle facilitate testing. 2017/0146525A1

Magnetic particles are distributed across a fluid flow by applied magnetic field to interact with a test substance in fluid. Alternatively or additionally, particles, which may be magnetic, are combined with cells and energy, eg ultrasonic energy, is... Read More about Particle facilitate testing.

An electrochemical sensor device for measuring blood ammonia at the point of care (2017)
Journal Article
Brannelly, N. T., & Killard, A. (2017). An electrochemical sensor device for measuring blood ammonia at the point of care. Talanta, 167, 296-301. https://doi.org/10.1016/j.talanta.2017.02.025

The level of ammonia in blood is relevant in a number of medical conditions. While ammonia is a marker of dysfunction, elevated ammonia is itself a serious medical emergency and can lead to significant and permanent neurological impairment if not add... Read More about An electrochemical sensor device for measuring blood ammonia at the point of care.

Enhanced output voltage generation via ZnO nanowires (50nm): Effect of diameter thinning on voltage enhancement (2017)
Journal Article
Ahmad, M., Iqbal, M. A., Kiely, J., Luxton, R. W., & Jabeen, M. (2017). Enhanced output voltage generation via ZnO nanowires (50nm): Effect of diameter thinning on voltage enhancement. Journal of Physics and Chemistry of Solids, 104, 281-285. https://doi.org/10.1016/j.jpcs.2017.01.006

© 2017 Elsevier Ltd 50nm ZnO nanowires were grown on indium tin oxide (ITO) coated poly ethylene terephthalate (PET) substrates by adapting facile aqueous growth technique using low temperature and vacuum conditions. Prior to growth of ZnO nanowires,... Read More about Enhanced output voltage generation via ZnO nanowires (50nm): Effect of diameter thinning on voltage enhancement.

Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines (2017)
Journal Article
Horley, N. J., Beresford, K. J., Chawla, T., McCann, G. J., Ruparelia, K. C., Gatchie, L., …Chaudhuri, B. (2017). Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. European Journal of Medicinal Chemistry, 129, 159-174. https://doi.org/10.1016/j.ejmech.2017.02.016

© 2017 Elsevier Masson SAS The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones. Two potent CYP1B1 inhibitors 7k (DMU2105) and 6j (DMU2139) have been identified from two series of syn... Read More about Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines.

Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance (2017)
Journal Article
Satti, N. K., Williams, I. S., Joshi, P., Gatchie, L., Sharma, M., Vishwakarma, R. A., …Bharate, S. B. (2017). Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance. Bioorganic and Medicinal Chemistry Letters, 27(16), 3683-3687. https://doi.org/10.1016/j.bmcl.2017.07.010

© 2017 Elsevier Ltd Inhibitors of CYP1 enzymes may play vital roles in the prevention of cancer and overcoming chemo-resistance to anticancer drugs. In this letter, we report synthesis of twenty-three pyrrole based heterocyclic chalcones which were s... Read More about Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance.