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Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics

Baumann, Reinhard R.; Ahmadraji, Termeh; Gonzalez-Macia, Laura; Ritvonen, Tapio; Willert, Andreas; Ylimaula, Satu; Donaghy, David; Tuurala, Saara; Suhonen, Mika; Smart, Dave; Morrin, Aoife; Efremov, Vitaly; Raja, Munira; Kemppainen, Antti; Killard, Anthony

Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics Thumbnail


Reinhard R. Baumann

Termeh Ahmadraji

Laura Gonzalez-Macia

Tapio Ritvonen

Andreas Willert

Satu Ylimaula

David Donaghy

Saara Tuurala

Mika Suhonen

Dave Smart

Aoife Morrin

Vitaly Efremov

Munira Raja

Antti Kemppainen


© 2017 American Chemical Society. Organic and printed electronics integration has the potential to revolutionize many technologies, including biomedical diagnostics. This work demonstrates the successful integration of multiple printed electronic functionalities into a single device capable of the measurement of hydrogen peroxide and total cholesterol. The single-use device employed printed electrochemical sensors for hydrogen peroxide electroreduction integrated with printed electrochromic display and battery. The system was driven by a conventional electronic circuit designed to illustrate the complete integration of silicon integrated circuits via pick and place or using organic electronic circuits. The device was capable of measuring 8 μL samples of both hydrogen peroxide (0-5 mM, 2.72 × 10 -6 A·mM -1 ) and total cholesterol in serum from 0 to 9 mM (1.34 × 10 -8 A·mM -1 , r 2 = 0.99, RSD < 10%, n = 3), and the result was output on a semiquantitative linear bar display. The device could operate for 10 min via a printed battery, and display the result for many hours or days. A mobile phone "app" was also capable of reading the test result and transmitting this to a remote health care provider. Such a technology could allow improved management of conditions such as hypercholesterolemia.

Journal Article Type Article
Acceptance Date Jun 22, 2017
Online Publication Date Jun 22, 2017
Publication Date Jul 18, 2017
Deposit Date Jun 23, 2017
Publicly Available Date Jun 22, 2018
Journal Analytical Chemistry
Print ISSN 0003-2700
Electronic ISSN 1520-6882
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 89
Issue 14
Pages 7447-7454
Keywords organic electronics, printed electronics, integration, sensor, cholesterol, printed battery, printed display, printed sensor, electrochemical
Public URL
Publisher URL
Contract Date Jun 23, 2017


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