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Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices

Donaghy, David; Gonzalez-Macia, Laura; Killard, Anthony; Raja, Munira

Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices Thumbnail


Authors

David Donaghy

Laura Gonzalez-Macia

Munira Raja



Abstract

© The Institution of Engineering and Technology. This paper presents circuit design and simulations of a high gain organic Op-Amp, for use in quantification of real cholesterol, in the range of 1-9 mM. A 7-stage inverter chain is added onto the design so as to enhance the amplifier gain. The circuit adapts p-channel transistors only (PMOS) design architecture with saturated loads, simulated on a conventional platform, using appropriate OTFT model and associated parameters. The effect of variation in threshold voltage on circuit operation is also examined. For a supply voltage of ±15 V, the DC output voltage is found to be within an acceptable range of -1 V to -12.5 V, with a highest open loop gain of 83 dB. The closed loop gain is also in agreement with theoretical values, in the range of 1.5 dB to 39 dB, with corresponding bandwidths of 770 Hz to 275 Hz respectively. The latter gain of 39 dB and/or gain-bandwidth product of 10.63 kHz is currently the highest reported in the literature, for this lower supply voltage. The amplifier offers adequate quantification factor, with linear sensitivity of -0.7 V/mM. This paper is the first to adapt organic circuit designs in quantification of cholesterol, with promising outputs, for implementation in low-cost sensor systems.

Journal Article Type Article
Acceptance Date Apr 5, 2017
Publication Date Sep 1, 2017
Deposit Date May 16, 2017
Publicly Available Date May 23, 2017
Journal IET Circuits, Devices and Systems
Print ISSN 1751-858X
Publisher Institution of Engineering and Technology (IET)
Peer Reviewed Peer Reviewed
Volume 11
Issue 5
Pages 504-511
DOI https://doi.org/10.1049/iet-cds.2016.0500
Keywords organic electronics, amplifier, diagnostics, cholesterol
Public URL https://uwe-repository.worktribe.com/output/880526
Publisher URL http://dx.doi.org/10.1049/iet-cds.2016.0500
Additional Information Additional Information : This is the author's accepted manuscript. The final version is available at http://dx.doi.org/10.1049/iet-cds.2016.0500.
Contract Date May 23, 2017

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