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Oxygen is instrumental for biological signalling: An overview (2021)
Journal Article
Hancock, J. (2021). Oxygen is instrumental for biological signalling: An overview. Oxygen, 1(1), 3-15. https://doi.org/10.3390/oxygen1010002

Control of cellular function is extremely complex, being reliant on a wide range of components. Several of these are small oxygen-based molecules. Although reactive compounds containing oxygen are usually harmful to cells when accumulated to relative... Read More about Oxygen is instrumental for biological signalling: An overview.

Broken chocolate: Biomarkers as a method for delivering cocoa supply chain visibility (2021)
Journal Article
Lafargue, P., Rogerson, M., Parry, G. C., & Allainguillaume, J. (2022). Broken chocolate: Biomarkers as a method for delivering cocoa supply chain visibility. Supply Chain Management, 27(6), 728-741. https://doi.org/10.1108/SCM-11-2020-0583

Purpose: This paper examines the potential of “biomarkers” to provide immutable identification for food products (chocolate), providing traceability and visibility in the supply chain from retail product back to farm. Design/methodology/approach: Thi... Read More about Broken chocolate: Biomarkers as a method for delivering cocoa supply chain visibility.

Bioscience laboratory practicals, projects and placements in a Covid-19 world (2021)
Journal Article
Rolfe, V., & Adukwu, E. (2023). Bioscience laboratory practicals, projects and placements in a Covid-19 world. Journal of Biological Education, 57(3), 668-677. https://doi.org/10.1080/00219266.2021.1941187

The aim of this review is to discuss alternatives to the traditional practicals, undergraduate projects and student placements that are presently being disrupted by Covid-19. We focus on bioscience higher education (biology, biomedical sciences) with... Read More about Bioscience laboratory practicals, projects and placements in a Covid-19 world.

Cell Signalling (2021)
Book
Hancock, J. (2021). Cell Signalling. Oxford: Oxford University Press

Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia (2021)
Thesis
Wodi, C. Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490771

This study was aimed at investigating the effect of inhibiting SRPK1 in leukaemic cells. It was also aimed at exploring the potential utility of combining conventional leukaemia chemotherapy (such as imatinib) with compounds that inhibit SRPK1. SR... Read More about Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia.

Molecular hydrogen: Redox reactions and possible biological interactions (2021)
Journal Article
Hancock, J. T., LeBaron, T. W., & Russell, G. (2021). Molecular hydrogen: Redox reactions and possible biological interactions. Reactive Oxygen Species, 11, m17–m25. https://doi.org/10.20455/ros.2021.m.803

Molecular hydrogen (H2), either as a gas or as hydrogen-rich water (HRW), is suggested to be a useful treatment for a range of human diseases and also to improve agricultural output. It is often posited that H2 accomplishes its biological action, in... Read More about Molecular hydrogen: Redox reactions and possible biological interactions.

Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases (2021)
Journal Article
Russell, G., Nenov, A., & Hancock, J. (2021). Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases. European Medical Journal, May 2021, https://doi.org/10.33590/emj/21-00027

Oxy-hydrogen gas (HHO) is a gaseous mixture of molecular hydrogen (H2) and molecular oxygen (O2) that is generated by the electrolysis of water and delivered in a 2:1 ratio (66% and 33%, respectively) through the use of non-invasive inhalation device... Read More about Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases.

Mapping scrub vegetation cover from photogrammetric point clouds: A useful tool in reserve management (2021)
Journal Article
Vafidis, J., Lucksted, I., Gall, M., Maxfield, P., Meakin, K., & Steer, M. (2021). Mapping scrub vegetation cover from photogrammetric point clouds: A useful tool in reserve management. Ecology and Evolution, 11(11), 6789-6797. https://doi.org/10.1002/ece3.7527

Scrub vegetation is a valuable habitat and resource for wildlife, but if unmanaged can encroach and dominate adjacent habitats, reducing biodiversity value. A primary task in the management of terrestrial nature reserves in the UK is monitoring and c... Read More about Mapping scrub vegetation cover from photogrammetric point clouds: A useful tool in reserve management.

Use of machine learning-enabled scenario-based teaching in Haematology and Biomedical Science, as a replacement and supplement to traditional tools and in-person teaching during COVID-19 (2021)
Journal Article
May, J., Anderson, E., Clark, D., & Hull, J. (2021). Use of machine learning-enabled scenario-based teaching in Haematology and Biomedical Science, as a replacement and supplement to traditional tools and in-person teaching during COVID-19. British Journal of Haematology, 193(S1), 72

One of the biggest challenges during the COVID-19 pandemic has been maintaining student engagement and providing the best learning experience with limited face-to-face (FTF) contact, and social distancing requirements. Whilst multiple tools are avail... Read More about Use of machine learning-enabled scenario-based teaching in Haematology and Biomedical Science, as a replacement and supplement to traditional tools and in-person teaching during COVID-19.

Shedding smart light on the effectiveness of chemotherapy: using Raman spectroscopy and machine learning to differentiate the effects of Cytarabine toxicity and crosstalk of leukaemic and bone marrow stromal cells (2021)
Journal Article
Gynn, L., Lamb-Riddell, K., Cox, T., Hansen, M., Conway, M., & May, J. (2021). Shedding smart light on the effectiveness of chemotherapy: using Raman spectroscopy and machine learning to differentiate the effects of Cytarabine toxicity and crosstalk of leukaemic and bone marrow stromal cells. British Journal of Haematology, 193(S1), 46-47

Mesenchymal stromal cells (MSC) protect leukaemic cells from drug-induced toxicity within the bone marrow niche, with increasing evidence of leukaemic impact on supportive stroma. The nucleoside analogue, cytarabine (ara-C), is a front-line agent for... Read More about Shedding smart light on the effectiveness of chemotherapy: using Raman spectroscopy and machine learning to differentiate the effects of Cytarabine toxicity and crosstalk of leukaemic and bone marrow stromal cells.

Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry (2021)
Thesis
Lafargue, P. Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6642792

Theobroma cacao (cocoa) is one of the most studied commodities around the world and the source of one of the world’s most consumed and familiar products, chocolate. The multibillion-pound industry has changed to a higher demand for sustainably certif... Read More about Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry.

A literature survey of all volatiles from healthy human breath and bodily fluids: The human volatilome (2021)
Journal Article
Drabińska, N., Flynn, C., Ratcliffe, N., Belluomo, I., Myridakis, A., Gould, O., …Costello, B. D. L. (2021). A literature survey of all volatiles from healthy human breath and bodily fluids: The human volatilome. Journal of Breath Research, 15(3), 034001. https://doi.org/10.1088/1752-7163/abf1d0

This paper comprises an updated version of the 2014 review which reported 1846 volatile organic compounds (VOCs) identified from healthy humans. In total over 900 additional VOCs have been reported since the 2014 review and the VOCs from semen have b... Read More about A literature survey of all volatiles from healthy human breath and bodily fluids: The human volatilome.

A case study: The deployment of a novel in situ fluorimeter for monitoring biological contamination within the urban surface waters of Kolkata, India (2021)
Presentation / Conference
Fox, B., Thorn, R., Dutta, T., & Reynolds, D. (2021, April). A case study: The deployment of a novel in situ fluorimeter for monitoring biological contamination within the urban surface waters of Kolkata, India. Presented at EGU General Assembly 2021

With increasing pressures on water resources due to population, industrialization, agriculture, urbanization and climatic changes, improved temporal and spatial understanding of water quality is required. The development of new monitoring parameters,... Read More about A case study: The deployment of a novel in situ fluorimeter for monitoring biological contamination within the urban surface waters of Kolkata, India.

Water quality across the River Ganga basin in India: Trends, dominant geochemical processes and impacts (2021)
Presentation / Conference
Richards, L. A., Fox, B., Reynolds, D., Thorn, R., Clayton, G., Perrin, E., …Magnone, D. (2021, April). Water quality across the River Ganga basin in India: Trends, dominant geochemical processes and impacts. Presented at EGU General Assembly 2021

In a basin-wide survey of the River Ganga and key tributaries, from the Himalayan source to the Bay of Bengal in India, we aim to improve the conceptual understanding of downstream water quality trends along > 2000 km. Here we explore the spatial di... Read More about Water quality across the River Ganga basin in India: Trends, dominant geochemical processes and impacts.

Using in-situ sensors to quantify spatial variability in nutrient concentrations across the Ganges river basin (2021)
Presentation / Conference
Khamis, K., Fox, B., Reynolds, D., Thorn, R., Clayton, G., Perrin, E., …Magnone, D. (2021, April). Using in-situ sensors to quantify spatial variability in nutrient concentrations across the Ganges river basin. Presented at EGU General Assembly 2021

There is increasing interest in monitoring spatial variability in biogeochemical processes using field deployable sensors. Despite this, rigorous assessments of accuracy and optimal sensor configurations remain limited for such applications. We under... Read More about Using in-situ sensors to quantify spatial variability in nutrient concentrations across the Ganges river basin.

Taking the pulse of Mother Ganga - Revealing the visible and invisible water pollution crisis along the Ganges River (2021)
Presentation / Conference
Krause, S., Fox, B., Reynolds, D., Thorn, R., Clayton, G., Perrin, E., …Magnone, D. (2021, April). Taking the pulse of Mother Ganga - Revealing the visible and invisible water pollution crisis along the Ganges River. Presented at EGU General Assembly 2021

It is probably hard to overestimate the significance of the River Ganges for its spiritual, cultural and religious importance. As the worlds’ most populated river basin and a major water resource for the 400 million people inhabiting its catchment, t... Read More about Taking the pulse of Mother Ganga - Revealing the visible and invisible water pollution crisis along the Ganges River.

Sediment and surface water microplastic contamination along the Ganges River, from the Himalayan foothills to the tidal reach downstream of Kolkata, India (2021)
Presentation / Conference
Nel, H., Fox, B., Reynolds, D., Thorn, R., Clayton, G., Perrin, E., …Magnone, D. (2021, April). Sediment and surface water microplastic contamination along the Ganges River, from the Himalayan foothills to the tidal reach downstream of Kolkata, India. Presented at EGU General Assembly 2021

Twenty rivers have been estimated previously to account for almost 70% of global plastic emissions to the marine environment. Of these, the Ganges River was second only to the Yangtze River. Yet, scale and complexity of the Ganges River network make... Read More about Sediment and surface water microplastic contamination along the Ganges River, from the Himalayan foothills to the tidal reach downstream of Kolkata, India.

Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects (2021)
Thesis
Ude, A. Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6971684

Advances in modern chemotherapeutic regimens have led to an increase in the overall survival of leukaemia patients in recent years. However, haematopoietic stem cell transplantation (HSCT) remains the curative option for these patients. In HSCT, high... Read More about Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects.

Identification and distribution of novel badnaviral sequences integrated in the genome of cacao (Theobroma cacao) (2021)
Journal Article
Muller, E., Ullah, I., Dunwell, J. M., Daymond, A. J., Richardson, M., Allainguillaume, J., & Wetten, A. (2021). Identification and distribution of novel badnaviral sequences integrated in the genome of cacao (Theobroma cacao). Scientific Reports, 11(1), Article 8270. https://doi.org/10.1038/s41598-021-87690-1

Theobroma cacao is one of the most economically important tropical trees, being the source of chocolate. As part of an ongoing study to understand the diversity of the badnavirus complex, responsible for the cacao swollen shoot virus disease in West... Read More about Identification and distribution of novel badnaviral sequences integrated in the genome of cacao (Theobroma cacao).