Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences (2023)
Journal Article
Zulfiqar, F., Moosa, A., Darras, A., Nafees, M., Ashraf, M., Al-Ashkar, I., …Hancock, J. T. (2024). Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences. Journal of Plant Growth Regulation, 43, 1153–1165. https://doi.org/10.1007/s00344-023-11173-y

Gladiolus is a well-known bulbous plant producing impressive cut spikes. Hydrogen sulfide and nitric oxide are vital signaling molecules for the proper functioning of plant metabolism. Preharvest applications of these molecules to crops have gained a... Read More about Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences.

Bacteria associated with acute oak decline: Where did they come from? We know where they go (2023)
Journal Article
Maddock, D., Brady, C., Denman, S., & Arnold, D. (2023). Bacteria associated with acute oak decline: Where did they come from? We know where they go. Microorganisms, 11(11), Article 2789. https://doi.org/10.3390/microorganisms11112789

Acute oak decline is a high-impact disease causing necrotic lesions on the trunk, crown thinning and the eventual death of oak. Four bacterial species are associated with the lesions—Brenneria goodwinii, Gibbsiella quercinecans, Rahnella victoriana a... Read More about Bacteria associated with acute oak decline: Where did they come from? We know where they go.

Promoting access to haemostasis testing in resource-scarce and emergency settings using paper-based lateral flow diagnostic screening assays for coagulation disorders (2023)
Thesis
Saidykhan, J. Promoting access to haemostasis testing in resource-scarce and emergency settings using paper-based lateral flow diagnostic screening assays for coagulation disorders. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/10774108

Haemostatic disorders cause excessive bleeding and clotting and result in high morbidity and mortality worldwide, but especially in low-income areas which often lack suitable facilities and expertise for affordable diagnosis and treatment. Simple and... Read More about Promoting access to haemostasis testing in resource-scarce and emergency settings using paper-based lateral flow diagnostic screening assays for coagulation disorders.

H2S priming and plant abiotic stress tolerance (2023)
Book Chapter
Silveira, N. M., Hancock, J., Machado, E. C., & Ribeiro, R. V. (2023). H2S priming and plant abiotic stress tolerance. In Plant Gasotransmiitters and Molecules with Hormonal Activity (245-262). Elsevier Academic Press. https://doi.org/10.1016/B978-0-323-99035-6.00008-7

Hydrogen sulfide (H2S) is an emerging multitasking signaling molecule involved in plant responses to many abiotic stresses, promoting tolerance and growth under limiting conditions. There is experimental evidence of cross talk between H2S and nitric... Read More about H2S priming and plant abiotic stress tolerance.

The effects of commercially available herbal teas on the human microbiota (2023)
Presentation / Conference
Okeyoyin, O. R., O, G., & E, A. (2023, November). The effects of commercially available herbal teas on the human microbiota. Presented at Annual Biomedical Research Conference for Minoritized Scientists (ABRCMS) conference, Phoenix, Arizona, USA

Background: For centuries, herbal teas have been consumed by people of all ages and has been used for therapy in different civilisations and medical systems such as the Chinese, Indian, indigenous, and African. The aphorism- ‘Nature is the best chemi... Read More about The effects of commercially available herbal teas on the human microbiota.

Reactive oxygen, nitrogen, and sulfur species cellular crosstalk (2023)
Book Chapter
Ziogas, V., Hancock, J. T., & Corpas, F. J. (2024). Reactive oxygen, nitrogen, and sulfur species cellular crosstalk. In Oxygen, nitrogen, and sulfur species in post-harvest physiology of horticultural crops (247-271). Elsevier Academic Press. https://doi.org/10.1016/B978-0-323-91798-8.00001-1

Accumulating data highlight the fact that nitric oxide (NO), hydrogen sulfide (H2S), and reactive oxygen species (ROS) act as intercellular key signaling molecules in plants. These molecules act in a well-orchestrated manner that regulates cells redo... Read More about Reactive oxygen, nitrogen, and sulfur species cellular crosstalk.

Molecular hydrogen as a beneficial postharvest treatment (2023)
Book Chapter
Hancock, J. T., LeBaron, T. W., May, J., Thomas, A., Zulfiqar, F., & Russell, G. (2024). Molecular hydrogen as a beneficial postharvest treatment. In V. Ziogas, & F. J. Corpas (Eds.), Oxygen, Nitrogen and Sulfur Species in Post-Harvest Physiology of Horticultural Crops (303-318). Elsevier. https://doi.org/10.1016/B978-0-323-91798-8.00011-4

Molecular hydrogen (H2) has been shown to have significant effects in plants, especially during stress responses. H2 treatment can be used as a gas or as an H2-enriched solution, often termed hydrogen-rich water (HRW). Cellular effects of H2 are ofte... Read More about Molecular hydrogen as a beneficial postharvest treatment.

The value of twinned pollinator-pollen metabarcoding: Bumblebee pollination service is weakly partitioned within a UK grassland community (2023)
Journal Article
Ronca, S., Ford, C. S., Allanguillame, J., Szabo, C., Kipling, R., & Wilkinson, M. J. (2023). The value of twinned pollinator-pollen metabarcoding: Bumblebee pollination service is weakly partitioned within a UK grassland community. Scientific Reports, 13(1), Article 18016. https://doi.org/10.1038/s41598-023-44822-z

Predicting ecological impact of declining bumblebee (Bombus) populations requires better understanding of interactions between pollinator partitioning of floral resources and plant partitioning of pollinator resources. Here, we combine Cytochrome Oxi... Read More about The value of twinned pollinator-pollen metabarcoding: Bumblebee pollination service is weakly partitioned within a UK grassland community.

Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells (2023)
Journal Article
Robson, J. L., Thorn, R. M. S., Williams, A. C., Collard, T. J., & Qualtrough, D. (2023). Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells. Scientific Reports, 13(1), Article 17291. https://doi.org/10.1038/s41598-023-44130-6

Colorectal cancer (CRC) is a significant global health burden with a rising incidence worldwide. Distinct bacterial populations are associated with CRC development and progression, and it is thought that the relationship between CRC and associated gu... Read More about Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells.

New applications of gas chromatography and gas chromatography-mass spectrometry for novel sample matrices in the forensic sciences: A literature review (2023)
Journal Article
Gould, O., Nguyen, N., & Honeychurch, K. C. (2023). New applications of gas chromatography and gas chromatography-mass spectrometry for novel sample matrices in the forensic sciences: A literature review. Chemosensors, 11(10), Article 527. https://doi.org/10.3390/chemosensors11100527

The investigation of novel sample matrices in the forensic sciences offers several possible advantages, such as allowing for results to be obtained in cases where common sample types are absent. This review focuses on the application of gas chromatog... Read More about New applications of gas chromatography and gas chromatography-mass spectrometry for novel sample matrices in the forensic sciences: A literature review.

The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells (2023)
Journal Article
Russell, G., Thomas, A. D., Nenov, A., Mannings, G., & Hancock, J. T. (2023). The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells. Hydrogen, 4(4), 746-759. https://doi.org/10.3390/hydrogen4040047

Cancer is a leading cause of mortality worldwide. B-cells are a keystone of the adaptive immune response and are essential for the presentation of tumor-associated antigens to various types of T-cells. Approximately 1.5% of global cancer cases, inclu... Read More about The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells.

Gamification in biomedical science education: The successful implementation of Resimion, a scenario-based learning tool (2023)
Journal Article
May, J. E., Anderson, E., Clark, D., & Hull, J. (2023). Gamification in biomedical science education: The successful implementation of Resimion, a scenario-based learning tool. British Journal of Biomedical Science, 80, Article 11756. https://doi.org/10.3389/bjbs.2023.11756

Introduction: Scenario-based learning and gamification have many advantages in comparison to traditional didactic teaching methods, including development of many higher-level skills such as analysis and evaluation. It is hoped that these simulations... Read More about Gamification in biomedical science education: The successful implementation of Resimion, a scenario-based learning tool.

Ternary nanocomposite potentiates the lysophosphatidic acid effect on human osteoblast (MG63) maturation (2023)
Journal Article
Elkhenany, H., Elkodous, M. A., & Mansell, J. (2023). Ternary nanocomposite potentiates the lysophosphatidic acid effect on human osteoblast (MG63) maturation. Nanomedicine, 18(21), 1459-1475. https://doi.org/10.2217/nnm-2023-0117

Aim: This study aimed to investigate the potential of ternary nanocomposite (TNC) to support MG63 osteoblast maturation to EB1089-(3S)1-fluoro-3-hydroxy-4-(oleoyloxy)butyl-1-phosphonate (FHBP) cotreatment. Materials & methods: Binary (P25/reduced gra... Read More about Ternary nanocomposite potentiates the lysophosphatidic acid effect on human osteoblast (MG63) maturation.

The effects of molecular hydrogen therapies on fertility (2023)
Journal Article
Russell, G., & Nenov, A. (2023). The effects of molecular hydrogen therapies on fertility. SciBase Clinical and Medical Case Reports, 1(1), 1001. https://doi.org/10.52768/casereports/1001

Human reproductive health is an integral part of personal well-being that can markedly impact upon individuals, couples, families and the wider society. It is estimated that infertility affects 13 to 15% of the world’s population and with parents oft... Read More about The effects of molecular hydrogen therapies on fertility.

Going circular: history, present, and future of circRNAs in cancer. (2023)
Journal Article
Pisignano, G., Michael, D. C., Pirlog, R., Visal, T. H., Ladomery, M., & Calin, G. A. (2023). Going circular: history, present, and future of circRNAs in cancer. Oncogene, 42, 2783–2800. https://doi.org/10.1038/s41388-023-02780-w

To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally a... Read More about Going circular: history, present, and future of circRNAs in cancer..

HOCl vs OCl−: clarification on chlorine-based disinfectants used within clinical settings (2023)
Journal Article
Mehendale, F. V., Mehendale, F., Homyer, K. M., Clayton, G., Reynolds, D. M., Homyer, K., & Reynolds, D. (2023). HOCl vs OCl−: clarification on chlorine-based disinfectants used within clinical settings. Journal of Global Health Reports, 7, Article e2023052. https://doi.org/10.29392/001c.84488

Disinfection is a mainstay of infection prevention, the importance of which was highlighted throughout the SARS-CoV-2 pandemic. There is frequent misuse of terminology surrounding chlorine solutions in the literature. This leads not only to confusion... Read More about HOCl vs OCl−: clarification on chlorine-based disinfectants used within clinical settings.

An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation (2023)
Journal Article
Mansell, J. P., Tanatani, A., & Kagechika, H. (2023). An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation. Biomolecules, 13(7), Article 1113. https://doi.org/10.3390/biom13071113

Less-calcaemic vitamin D receptor (VDR) agonists have the potential to promote osteoblast maturation in a bone regenerative setting. The emergence of lithocholic acid (LCA) as a bona fide VDR agonist holds promise as an adjunct for arthroplasty follo... Read More about An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation.

Nanotechnology improves disease resistance in plants for food security: Applications and challenges (2023)
Journal Article
Munir, N., Gulzar, W., Abideen, Z., Hancock, J. T., El-Keblawy, A., & Radicetti, E. (2023). Nanotechnology improves disease resistance in plants for food security: Applications and challenges. Biocatalysis and Agricultural Biotechnology, 51, Article 102781

Green synthesis of nano-fertilizers is emerging as a potential strategy and could play a crucial role in disease mitigation, diagnosis, or suppression. Different nanoscale devices (nanoparticles, NPs), biosensors, nano-diagnostic kits, nanofabricatio... Read More about Nanotechnology improves disease resistance in plants for food security: Applications and challenges.

Are protein cavities and pockets commonly used by redox active signalling molecules? (2023)
Journal Article
Hancock, J. T. (2023). Are protein cavities and pockets commonly used by redox active signalling molecules?. Plants, 12(14), 2594. https://doi.org/10.3390/plants12142594

It has been well known for a long time that inert gases, such as xenon (Xe), have significant biological effects. As these atoms are extremely unlikely to partake in direct chemical reactions with biomolecules such as proteins, lipids, and nucleic ac... Read More about Are protein cavities and pockets commonly used by redox active signalling molecules?.

Sex estimation from virtual models: Exploring the potential of stereolithic (STL) 3D crania models for morphoscopic trait scoring (2023)
Journal Article
Robles, M., Carew, R. M., Rando, C., Nakhaeizadeh, S., & Morgan, R. M. (2023). Sex estimation from virtual models: Exploring the potential of stereolithic (STL) 3D crania models for morphoscopic trait scoring. Forensic Sciences Research, 8(2), 123-132. https://doi.org/10.1093/fsr/owad017

Modern computed tomography (CT) databases are becoming an accepted resource for the practice and development of identification methods in forensic anthropology. However, the utility of 3D models created using free and open-source visualization softwa... Read More about Sex estimation from virtual models: Exploring the potential of stereolithic (STL) 3D crania models for morphoscopic trait scoring.