A novel electroanalytical approach to the measurement of B vitamins in food supplements based on screen-printed carbon sensors (2017)
Journal Article
Westmacott, K. L., Crew, A. P., Doran, O., & Hart, J. P. (2018). A novel electroanalytical approach to the measurement of B vitamins in food supplements based on screen-printed carbon sensors. Talanta, 181, 13-18. https://doi.org/10.1016/j.talanta.2017.12.074

© 2017 Elsevier B.V. This paper describes the development of a novel electrochemical assay for the measurement of water-soluble vitamins in food and pharmaceutical products. The optimum conditions for the determination of vitamin B1 (thiamine), B2 (r... Read More about A novel electroanalytical approach to the measurement of B vitamins in food supplements based on screen-printed carbon sensors.

Comparative analysis of 37 Acinetobacter bacteriophages (2017)
Journal Article
Reynolds, D. M., Kropinski, A. M., Turner, D., Ackermann, H. W., Kropinski, A., Lavigne, R., …Reynolds, D. M. (2018). Comparative analysis of 37 Acinetobacter bacteriophages. Viruses, 10(1), 5. https://doi.org/10.3390/v10010005

© 2017 by the authors. Licensee MDPI, Basel, Switzerland. Members of the genus Acinetobacter are ubiquitous in the environment and the multipledrug resistant species A. baumannii is of significant clinical concern. This clinical relevance is currentl... Read More about Comparative analysis of 37 Acinetobacter bacteriophages.

A study of the analysis of acidic solutes by hydrophilic interaction chromatography (2017)
Journal Article
McCalley, D. V. (2018). A study of the analysis of acidic solutes by hydrophilic interaction chromatography. Journal of Chromatography A, 1534, 64-74. https://doi.org/10.1016/j.chroma.2017.12.045

© 2017 Elsevier B.V. The analysis of acidic solutes was compared on a cross-linked bonded amino phase and a neutral hybrid inorganic-organic amide phase, previously shown to give reasonable retention of acidic solutes. The amino column gave strong se... Read More about A study of the analysis of acidic solutes by hydrophilic interaction chromatography.

Ecobat: An online resource to facilitate transparent, evidence-based interpretation of bat activity data (2017)
Journal Article
Lintott, P., Davison, S., van Breda, J., Kubasiewicz, L., Dowse, D., Daisley, J., …Mathews, F. (2018). Ecobat: An online resource to facilitate transparent, evidence-based interpretation of bat activity data. Ecology and Evolution, 8(2), 935-941. https://doi.org/10.1002/ece3.3692

© 2017 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. Acoustic surveys of bats are one of the techniques most commonly used by ecological practitioners. The results are used in Ecological Impact Assessments to assess the lik... Read More about Ecobat: An online resource to facilitate transparent, evidence-based interpretation of bat activity data.

Interaction of nitric oxide with auxin and ethylene signalling in Arabidopsis root gravitropism (2017)
Thesis
Vembu, K. Interaction of nitric oxide with auxin and ethylene signalling in Arabidopsis root gravitropism. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/877297

Gravitropism is required for the appropriate alignment of the plant root and shoot. According to the Cholodny-Went hypothesis, gravity induces asymmetric accumulation of auxin in the lower side of the root tissue. More recent studies on root gravitro... Read More about Interaction of nitric oxide with auxin and ethylene signalling in Arabidopsis root gravitropism.

Quantum pathogen evolution by integron-mediated effector capture (2017)
Thesis
Payne, J. D. Quantum pathogen evolution by integron-mediated effector capture. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/877432

Plant pathogenic Pseudomonads are responsible for the loss of millions of pounds in crop revenue each year. They export effector molecules via the type three secretion system into the plants’ cells in order to elicit disease. If the plant has the cor... Read More about Quantum pathogen evolution by integron-mediated effector capture.

Physical conditions regulate the fungal to bacterial ratios of a tropical suspended soil (2017)
Journal Article
Donald, J., Bonnett, S., Cutler, M., Majalap, N., Maxfield, P., & Ellwood, M. D. F. (2017). Physical conditions regulate the fungal to bacterial ratios of a tropical suspended soil. Forests, 8(12), Article 474. https://doi.org/10.3390/f8120474

As a source of ‘suspended soils’, epiphytes contribute large amounts of organic matter to the canopy of tropical rain forests. Microbes associated with epiphytes are responsible for much of the nutrient cycling taking place in rain forest canopies. H... Read More about Physical conditions regulate the fungal to bacterial ratios of a tropical suspended soil.

Chernobyl; The disaster zone becomes a laboratory (2017)
Journal Article
Willey, N. (2017). Chernobyl; The disaster zone becomes a laboratory

Zapping plants with radiation might not initially appear useful, however Prof Neil Willey from the University of the West of England monitors the responses of plants under conditions similar to those at the infamous Chernobyl site, and for good reaso... Read More about Chernobyl; The disaster zone becomes a laboratory.

A novel mechanism linking memory stem cells with innate immunity in protection against HIV-1 infection (2017)
Journal Article
O'Connell, R. J., Wang, Y., Whittall, T., Neil, S., Britton, G., Mistry, M., …Lehner, T. (2017). A novel mechanism linking memory stem cells with innate immunity in protection against HIV-1 infection. Scientific Reports, 7(1), https://doi.org/10.1038/s41598-017-01188-3

© 2017 The Author(s). HIV infection affects 37 million people and about 1.7 million are infected annually. Among the phase III clinical trials only the RV144 vaccine trial elicited significant protection against HIV-1 acquisition, but the efficacy an... Read More about A novel mechanism linking memory stem cells with innate immunity in protection against HIV-1 infection.

Hydrological legacy determines the type of enzyme inhibition in a peatlands chronosequence (2017)
Journal Article
Bonnett, S., Maltby, E., & Freeman, C. (2017). Hydrological legacy determines the type of enzyme inhibition in a peatlands chronosequence. Scientific Reports, 7(1), https://doi.org/10.1038/s41598-017-10430-x

© 2017 The Author(s). Peatland ecosystems contain one-third of the world's soil carbon store and many have been exposed to drought leading to a loss of carbon. Understanding biogeochemical mechanisms affecting decomposition in peatlands is essential... Read More about Hydrological legacy determines the type of enzyme inhibition in a peatlands chronosequence.

Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line (2017)
Journal Article
Daly, C. S., Flemban, A., Shafei, M., Conway, M. E., Qualtrough, D., & Dean, S. J. (2018). Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line. Oncology Reports, 39(2), 483-490. https://doi.org/10.3892/or.2017.6125

A common feature among pre-malignant lesions is the induction of hypoxia through increased cell propagation and reduced access to blood flow. Hypoxia in breast cancer has been associated with poor patient prognosis, resistance to chemotherapy and inc... Read More about Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line.

Temporal effects of disturbance on community composition in simulated stage-structured plant communities (2017)
Journal Article
Wang, Y., Wen, S., Farnon Ellwood, M. D., Miller, A. D., & Chu, C. (2018). Temporal effects of disturbance on community composition in simulated stage-structured plant communities. Ecology and Evolution, 8(1), 120-127. https://doi.org/10.1002/ece3.3660

© 2017 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. In an era of global environmental change, understanding how disturbance affects the dynamics of ecological communities is crucial. However, few studies have theoretically... Read More about Temporal effects of disturbance on community composition in simulated stage-structured plant communities.

Next generation sequencing elucidates cacao badnavirus diversity and reveals the existence of more than ten viral species (2017)
Journal Article
Muller, E., Ravel, S., Agret, C., Abrokwah, F., Dzahini-Obiatey, H., Galyuon, I., …Wetten, A. (2018). Next generation sequencing elucidates cacao badnavirus diversity and reveals the existence of more than ten viral species. Virus Research, 244, 235-251. https://doi.org/10.1016/j.virusres.2017.11.019

© 2017 Elsevier B.V. Cacao swollen shoot virus is a member of the family Caulimoviridae, genus Badnavirus and is naturally transmitted to Theobroma cacao (L.) by several mealybug species. CSSV populations in West African countries are highly variable... Read More about Next generation sequencing elucidates cacao badnavirus diversity and reveals the existence of more than ten viral species.

Meckel-Gruber syndrome: An update on diagnosis, clinical management, and research advances (2017)
Journal Article
Hartill, V., Szymanska, K., Sharif, S. M., Wheway, G., & Johnson, C. A. (2017). Meckel-Gruber syndrome: An update on diagnosis, clinical management, and research advances. Frontiers in Pediatrics, 5(244), 1-9. https://doi.org/10.3389/fped.2017.00244

© 2017 Hartill, Szymanska, Sharif, Wheway and Johnson. Meckel-Gruber syndrome (MKS) is a lethal autosomal recessive congenital anomaly syndrome caused by mutations in genes encoding proteins that are structural or functional components of the primary... Read More about Meckel-Gruber syndrome: An update on diagnosis, clinical management, and research advances.

LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity (2017)
Journal Article
Morgan, R. G., Mortensson, E., Legge, D. N., Gupta, B., Collard, T. J., Greenhough, A., & Williams, A. C. (2018). LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity. British Journal of Cancer, 118(4), 558-565. https://doi.org/10.1038/bjc.2017.412

© The Author(s) named above 2018. Background:LGR5 serves as a co-receptor for Wnt/β-catenin signalling and marks normal intestinal stem cells; however, its role in colorectal cancer (CRC) remains controversial. LGR5 + cells are known to exist outside... Read More about LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity.

Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism (2017)
Journal Article
Hull, J., Usmari Moraes, M., Brookes, E., Love, S., & Conway, M. E. (2018). Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism. Neurochemistry International, 112, 49-58. https://doi.org/10.1016/j.neuint.2017.10.014

© 2017 Glutamate is the major excitatory neurotransmitter of the central nervous system, with the branched-chain amino acids (BCAAs) acting as key nitrogen donors for de novo glutamate synthesis. Despite the importance of these major metabolites, the... Read More about Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism.

Rapid in vitro testing and characterization of resistance to chemotherapeutic agents daunorubicin and cytarabine in acute myeloid leukaemia (2017)
Journal Article
May, J., Steven, J., Taylor, A., Dean, S., & Anderson, E. (2017). Rapid in vitro testing and characterization of resistance to chemotherapeutic agents daunorubicin and cytarabine in acute myeloid leukaemia. Mutagenesis, 32(6), 627. https://doi.org/10.1093/mutage/gex033

Treatment success in leukaemia is impacted by patient resistance to chemotherapy including cytarabine (ara-C) and the anthracycline daunorubicin (DNR) requiring rapid pre-screening testing. DNR is converted to daunorubicinol (DNRol) by carbonyl reduc... Read More about Rapid in vitro testing and characterization of resistance to chemotherapeutic agents daunorubicin and cytarabine in acute myeloid leukaemia.

Development of a 2D leukaemia-stroma model for analyses of chemo-toxicity protection using a novel bacterial bioluminescent biosensor (2017)
Journal Article
Gynn, L., May, J., Anderson, E., & Robinson, G. (2017). Development of a 2D leukaemia-stroma model for analyses of chemo-toxicity protection using a novel bacterial bioluminescent biosensor. Mutagenesis, 32(6), 619. https://doi.org/10.1093/mutage/gex033

This study aimed to develop a 2D leukaemia-stroma model of the bone marrow for analysis of stromal-mediated chemo-protection; known to contribute to chemotherapy resistance. The model must facilitate integration of a bioluminescent biosensor HA1 for... Read More about Development of a 2D leukaemia-stroma model for analyses of chemo-toxicity protection using a novel bacterial bioluminescent biosensor.

Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS) (2017)
Journal Article
May, J., Robinson, G., Thorn, R., & Reynolds, D. (2017). Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS). Mutagenesis, 32(6), 622-623. https://doi.org/10.1093/mutage/gex033

Electrochemically activated solutions (ECAS) are of interest as potential disinfectants due to high biocidal activity against many microorganisms. They are widely used clinically in some countries (decontamination of surgical instruments and wounds),... Read More about Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS).

Hydrogen gas and its role in cell signaling (2017)
Journal Article
Wilson, H. R., Veal, D., Whiteman, M., & Hancock, J. T. (2017). Hydrogen gas and its role in cell signaling. CABI Reviews, 12, 2-3

Hydrogen gas (H2) was once thought to be inert in biological systems but it has now become apparent that exposure of a wide range of organisms, including animals and plants, to H2 or hydrogen-rich water (HRW) has beneficial effects. It is involved in... Read More about Hydrogen gas and its role in cell signaling.