Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection (2018)
Journal Article
Lu, C., Janice, K., Martina, P., & Richard, L. (2018). Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection. Scientific Reports, 8(1), 122687. https://doi.org/10.1038/s41598-018-30793-z

© 2018, The Author(s). The paper reports a biosensor formed from antibody coated ZnO nano-crystals which has been prepared using a rapid and inexpensive fabrication method which utilises colloidal dispersion enhanced using sonication. This technique... Read More about Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection.

The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins (2013)
Journal Article
Luxton, R., Sharif, E., Syarif, E., Kiely, J., Wraith, P., & Luxton, R. W. (2013). The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins. IEEE Transactions on Biomedical Engineering, 60(5), 1209-1216. https://doi.org/10.1109/TBME.2012.2228642

A novel, integrated lysis and immunoassay methodology and system for intracellular protein measurement are described. The method uses paramagnetic particles both as a lysis agent and assay label resulting in a rapid test requiring minimal operator in... Read More about The dual role of paramagnetic particles for integrated lysis and measurement in a rapid immunoassay for intracellular proteins.

Novel immunoassay technique for rapid measurement of intracellular proteins using paramagnetic particles (2013)
Journal Article
Sharif, E., Kiely, J., & Luxton, R. (2013). Novel immunoassay technique for rapid measurement of intracellular proteins using paramagnetic particles. Journal of Immunological Methods, 388(1-2), 78-85. https://doi.org/10.1016/j.jim.2012.11.015

Magnetic immunoassays have been shown to have similar detection limits to conventional immunoassays, with the advantage of reduced total assay time. The aim of this study was to demonstrate that an integrated lysis and measurement system could be use... Read More about Novel immunoassay technique for rapid measurement of intracellular proteins using paramagnetic particles.

Robust feature extraction from impedimetric signals using wavelet packet decomposition with application to cytotoxicity testing (2012)
Journal Article
Luxton, R., Wraith, P., Nibouche, M., Kiely, J., Abdul Djawad, Y., Djawad, Y. A., …Luxton, R. W. (2012). Robust feature extraction from impedimetric signals using wavelet packet decomposition with application to cytotoxicity testing. IET Science Measurement and Technology, 6(6), 456-463. https://doi.org/10.1049/iet-smt.2012.0009

Impedance-based cytotoxicity testing provides a simple, real-time and non-invasive assay technique that interferes minimally with cell morphology and function. In this study, impedimetric measurements of ECV304 cells with increasing concentrations of... Read More about Robust feature extraction from impedimetric signals using wavelet packet decomposition with application to cytotoxicity testing.

Comparison of cytotoxic changes in ECV304 cell through exposure to DMSO and sodium butyrate using impedance spectroscopy (2012)
Journal Article
Wang, Z., Kiely, J., Vargas, A. M., & Luxton, R. W. (2012). Comparison of cytotoxic changes in ECV304 cell through exposure to DMSO and sodium butyrate using impedance spectroscopy. Procedia Chemistry, 6, 89-99. https://doi.org/10.1016/j.proche.2012.10.134

This paper decides an impedance spectroscopy measurement system for real-time monitoring of cellular toxicity. The system is used to compare the impedance response of ECV304 cells to two toxicants, dimethyl sulphoxide (DMSO) and sodium butyrate. The... Read More about Comparison of cytotoxic changes in ECV304 cell through exposure to DMSO and sodium butyrate using impedance spectroscopy.

Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay (2009)
Journal Article
Eveness, J., Kiely, J., Hawkins, P., Wraith, P., & Luxton, R. (2009). Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay. Sensors and Actuators B: Chemical, 139(2), 538-542. https://doi.org/10.1016/j.snb.2009.03.078

This paper describes work that formed a part of an investigation to increase the detection sensitivity of a magneto-immunoassay. The study involved the characterisation of paramagnetic particles (PMPs) from a range of manufacturers in order to determ... Read More about Evaluation of paramagnetic particles for use in a resonant coil magnetometer based magneto-immunoassay.

Spot test: new technologies bring point-of-care testing into the 21st century (2009)
Journal Article
Luxton, R. W., & Kiely, J. (2009). Spot test: new technologies bring point-of-care testing into the 21st century

Every new technology offers the potential to effect changes in practise; many developments driven by the world-wide demand for instant results. This is never as true as in the arena of diagnostic testing. Once the sole preserve of the hospital labo... Read More about Spot test: new technologies bring point-of-care testing into the 21st century.

Paramagnetic particle detection for use with an immunoassay based biosensor (2007)
Journal Article
Kiely, J., Hawkins, P., Wraith, P., & Luxton, R. (2007). Paramagnetic particle detection for use with an immunoassay based biosensor. IET Science Measurement and Technology, 1(5), 270-275. https://doi.org/10.1049/iet-smt%3A20060103

A biosensor and detection system that can provide measurement of analyte concentration within a test sample in four minutes is presented. The biosensor uses an immunoassay with micrometre-sized paramagnetic particle (PMP) labels for quantification. A... Read More about Paramagnetic particle detection for use with an immunoassay based biosensor.

Use of External Magnetic Fields to Reduce Reaction Times in an Immunoassay Using Micrometer-Sized Paramagnetic Particles as Labels (Magnetoimmunoassay) (2004)
Journal Article
Luxton, R., Badesha, J., Kiely, J., & Hawkins, P. (2004). Use of External Magnetic Fields to Reduce Reaction Times in an Immunoassay Using Micrometer-Sized Paramagnetic Particles as Labels (Magnetoimmunoassay). Analytical Chemistry, 76(6), 1715-1719. https://doi.org/10.1021/ac034906%2B

The paper presents a rapid immunoassay system capable of quantifying analyte in complex biological and environmental media. Antibody-coated micrometer-sized paramagnetic particles are used as labels in an assay in which they bind quantitatively with... Read More about Use of External Magnetic Fields to Reduce Reaction Times in an Immunoassay Using Micrometer-Sized Paramagnetic Particles as Labels (Magnetoimmunoassay).