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All Outputs (134)

Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment (2013)
Journal Article
May, J. E., Morse, H. R., Page, K., Soh, M., Wexler, S., Cox, C., …Donaldson, C. (2014). Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment. Mutagenesis, 29(1), 79. https://doi.org/10.1093/mutage/get060

The bone marrow (BM) microenvironment is largely com- prised of mesenchymal stromal cells (MSCs) and is vital in supporting haematopoiesis. Limited studies have indicated that the BM microenvironment is damaged by chemotherapy; however the extent and... Read More about Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment.

Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy (2013)
Journal Article
Page, K., Anderson, E., Smith, A., Reid, C., Salisbury, V., Donaldson, C., & May, J. E. (2014). Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy. Mutagenesis, 29(1), 92. https://doi.org/10.1093/mutage/get060

Cytosine arabinoside (ara-C) is a key chemotherapy drug used to treat acute myeloid leukaemia (AML), however, ap- proximately 30% of patients do not respond to this therapy. 92 An evaluative assay to determine resistance/sensitivity to ara- C prior... Read More about Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy.

Point of care monitoring of hemodialysis patients with a breath ammonia measurement device based on printed polyaniline nanoparticle sensors (2013)
Journal Article
Killard, A. J., Hibbard, T., Crowley, K., Kelly, F., Ward, F., Holian, J., …Killard, A. (2013). Point of care monitoring of hemodialysis patients with a breath ammonia measurement device based on printed polyaniline nanoparticle sensors. Analytical Chemistry, 85(24), 12158-12165. https://doi.org/10.1021/ac403472d

A device for measuring human breath ammonia was developed based on a single use, disposable, inkjet printed ammonia sensor fabricated using polyaniline nanoparticles. The device was optimized for sampling ammonia in human breath samples by addressing... Read More about Point of care monitoring of hemodialysis patients with a breath ammonia measurement device based on printed polyaniline nanoparticle sensors.

A case study in serendipity: Environmental researchers use of traditional and social media for dissemination (2013)
Journal Article
Wilkinson, C., & Weitkamp, E. (2013). A case study in serendipity: Environmental researchers use of traditional and social media for dissemination. PLoS ONE, 8(12), https://doi.org/10.1371/journal.pone.0084339

In the face of demands for researchers to engage more actively with a wider range of publics and to capture different kinds of research impacts and engagements, we explored the ways a small number of environmental researchers use traditional and soci... Read More about A case study in serendipity: Environmental researchers use of traditional and social media for dissemination.

RIM1α SUMOylation is required for fast synaptic vesicle exocytosis (2013)
Journal Article
Rocca, D. L., Henley, J. M., Girach, F., Craig, T. J., Rocca, D. L., & Henley, J. M. (2013). RIM1α SUMOylation is required for fast synaptic vesicle exocytosis. Cell Reports, 5(5), 1294-1301. https://doi.org/10.1016/j.celrep.2013.10.039

The rapid, activity-dependent quantal presynaptic release of neurotransmitter is vital for brain function. The complex process of vesicle priming, fusion, and retrieval is very precisely controlled and requires thespatiotemporal coordination of multi... Read More about RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.

Values associated with public involvement in health and social care research: A narrative review (2013)
Journal Article
Gradinger, F., Britten, N., Wyatt, K., Froggatt, K., Gibson, A., Jacoby, A., …Popay, J. (2015). Values associated with public involvement in health and social care research: A narrative review. Health Expectations, 18(5), 661-675. https://doi.org/10.1111/hex.12158

© 2015 John Wiley & Sons Ltd. Background: Much has been written about public involvement (PI) in health and social care research, but underpinning values are rarely made explicit despite the potential for these to have significant influence on the... Read More about Values associated with public involvement in health and social care research: A narrative review.

Connecting spiking neurons to a spiking memristor network changes the memristor dynamics (2013)
Presentation / Conference
Gater, D., Iqbal, A., Davey, J. S., & Gale, E. (2013, December). Connecting spiking neurons to a spiking memristor network changes the memristor dynamics. Paper presented at Proceedings of the International Conference on Electronics, Circuits and Systems (ICECS) 2013, Abu Dhabi, UAE

Memristors have been suggested as neuromorphic computing elements. Spike-time dependent plasticity and the Hodgkin-Huxley model of the neuron have both been modelled effectively by memristor theory. The d.c. response of the memristor is a current... Read More about Connecting spiking neurons to a spiking memristor network changes the memristor dynamics.

Voltammetric behaviour of hydrogen peroxide at a silver electrode fabricated from a rewritable digital versatile disc (DVD) and its determination in water samples (2013)
Journal Article
Shafei, M., & Honeychurch, K. C. (2013). Voltammetric behaviour of hydrogen peroxide at a silver electrode fabricated from a rewritable digital versatile disc (DVD) and its determination in water samples. Analytical Methods, 5(23), 6631-6636. https://doi.org/10.1039/c3ay41557k

In this study we investigated the possibility of applying Ag electrodes manufactured from recordable rewritable digital versatile discs (DVD-RW) for the voltammetric determination of hydrogen peroxide. The calibration plot was linear from 0.087 mM to... Read More about Voltammetric behaviour of hydrogen peroxide at a silver electrode fabricated from a rewritable digital versatile disc (DVD) and its determination in water samples.

Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice (2013)
Journal Article
Becker, K., Thomas, A. D., & Kaina, B. (2014). Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice. Environmental and Molecular Mutagenesis, 55(2), 145-150. https://doi.org/10.1002/em.21834

Several genotoxicity endpoints have been evaluated to define nonlinear dose-responses for S N 1 and S N 2 alkylating genotoxicants. Dose-response studies acknowledging the process of multistage tumorigenesis are important; however, data pertaining no... Read More about Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice.

The rulB gene of plasmid pWW0 is a hotspot for the site-specific insertion of integron-like elements found in the chromosomes of environmental Pseudomonas fluorescens group bacteria (2013)
Journal Article
Pickup, R. W., Jackson, R. W., Rhodes, G., Bosma, H., Studholme, D., & Arnold, D. L. (2014). The rulB gene of plasmid pWW0 is a hotspot for the site-specific insertion of integron-like elements found in the chromosomes of environmental Pseudomonas fluorescens group bacteria. Environmental Microbiology, 16(8), 2374-2388. https://doi.org/10.1111/1462-2920.12345

Summary: The rulAB operon of Pseudomonas spp. confers fitness traits on the host and has been suggested to be a hotspot for insertion of mobile elements that carry avirulence genes. Here, for the first time, we show that rulB on plasmid pWW0 is a hot... Read More about The rulB gene of plasmid pWW0 is a hotspot for the site-specific insertion of integron-like elements found in the chromosomes of environmental Pseudomonas fluorescens group bacteria.

A smart integrated biosensor system (2013)
Presentation / Conference
Killard, A. (2013, November). A smart integrated biosensor system. Paper presented at Printed Electronics USA, Santa Clara, USA

Online courses and social responsibility toward learners (2013)
Presentation / Conference
Rolfe, V. (2013, November). Online courses and social responsibility toward learners. Paper presented at Open Education Conference 2013, Park City, Utah, USA

When we develop and validate traditional degree programmes great emphasis is placed on ensuring that applicants meet entry criteria for enrolment, and that students gain a quality experience to reach their academic and employment potential. If a stud... Read More about Online courses and social responsibility toward learners.

Inkjet printing at the heart of sensors and diagnostics (2013)
Presentation / Conference
Gonzalez-Macia, L., & Killard, A. (2013, November). Inkjet printing at the heart of sensors and diagnostics. Paper presented at Science of inkjet and printed drops, Institute of Physics, London

A Pseudomonas syringae diversity survey reveals a differentiated phylotype of the pathovar syringae associated with the mango host and mangotoxin production (2013)
Journal Article
De Vicente, A., Cazorla, F. M., Arrebola, E., Murillo, J., Carrión, V. J., Gutiérrez-Barranquero, J. A., …Arnold, D. L. (2013). A Pseudomonas syringae diversity survey reveals a differentiated phylotype of the pathovar syringae associated with the mango host and mangotoxin production. Phytopathology, 103(11), 1115-1129. https://doi.org/10.1094/PHYTO-04-13-0093-R

Pseudomonas syringae pv. syringae, the causal agent of bacterial apical necrosis (BAN) in mango crops, has been isolated in different mango-producing areas worldwide. An extensive collection of 87 P. syringae pv. syringae strains isolated from mango... Read More about A Pseudomonas syringae diversity survey reveals a differentiated phylotype of the pathovar syringae associated with the mango host and mangotoxin production.