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Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment

May, J E; Morse, H R; Page, K; Soh, M; Wexler, S; Cox, C; Xu, J; Donaldson, C

Authors

Dr Ruth Morse Ruth.Morse@uwe.ac.uk
Associate Professor in Biomedical Sciences

K Page

M Soh

S Wexler

C Cox

J Xu

C Donaldson



Abstract

The bone marrow (BM) microenvironment is largely com- prised of mesenchymal stromal cells (MSCs) and is vital in supporting haematopoiesis. Limited studies have indicated that the BM microenvironment is damaged by chemotherapy; however the extent and long-term effects of this are unknown. This may be particularly critical in stem cell transplant patients who receive high-dose chemotherapy prior to transplant, and whilst the incoming graft replaces haematopoietic cells, the microenvironment remains of host origin. Consequently, dam- age caused by chemotherapy may be permanent and possibly implicated in graft failure if haematopoietic support is com- promised. MSCs were isolated from BM samples from patients undergoing chemotherapy for haematological malignancies as well as untreated control BM obtained as a waste product dur- ing total hip replacements. Following chemotherapy, MSCs have reduced proliferative capacity and survival (p

Citation

May, J. E., Morse, H. R., Page, K., Soh, M., Wexler, S., Cox, C., …Donaldson, C. (2014). Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment. Mutagenesis, 29(1), 79. https://doi.org/10.1093/mutage/get060

Journal Article Type Article
Acceptance Date Jul 15, 2013
Online Publication Date Dec 18, 2013
Publication Date Jan 31, 2014
Journal Mutagenesis
Print ISSN 0267-8357
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 29
Issue 1
Pages 79
DOI https://doi.org/10.1093/mutage/get060
Keywords mutation, cancer, chemotherapy regimen, carcinogens, cell line, dna, dna damage, dna repair, genome, mammals, micronucleus, mutagens, pyrenes, bone marrow, mice, nanoparticles
Public URL https://uwe-repository.worktribe.com/output/821744
Publisher URL http://dx.doi.org/10.1093/mutage/get060