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Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment

May, J E; Morse, H R; Page, K; Soh, M; Wexler, S; Cox, C; Xu, J; Donaldson, C

Authors

Jennifer May Jennifer2.May@uwe.ac.uk
Senior Lecturer in Biomedical Science

K Page

M Soh

S Wexler

C Cox

J Xu

C Donaldson



Abstract

The bone marrow (BM) microenvironment is largely com- prised of mesenchymal stromal cells (MSCs) and is vital in supporting haematopoiesis. Limited studies have indicated that the BM microenvironment is damaged by chemotherapy; however the extent and long-term effects of this are unknown. This may be particularly critical in stem cell transplant patients who receive high-dose chemotherapy prior to transplant, and whilst the incoming graft replaces haematopoietic cells, the microenvironment remains of host origin. Consequently, dam- age caused by chemotherapy may be permanent and possibly implicated in graft failure if haematopoietic support is com- promised. MSCs were isolated from BM samples from patients undergoing chemotherapy for haematological malignancies as well as untreated control BM obtained as a waste product dur- ing total hip replacements. Following chemotherapy, MSCs have reduced proliferative capacity and survival (p

Journal Article Type Article
Publication Date Jan 31, 2014
Journal Mutagenesis
Print ISSN 0267-8357
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 29
Issue 1
Pages 79
APA6 Citation May, J. E., Morse, H. R., Page, K., Soh, M., Wexler, S., Cox, C., …Donaldson, C. (2014). Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment. Mutagenesis, 29(1), 79. https://doi.org/10.1093/mutage/get060
DOI https://doi.org/10.1093/mutage/get060
Keywords mutation, cancer, chemotherapy regimen, carcinogens, cell line, dna, dna damage, dna repair, genome, mammals, micronucleus, mutagens, pyrenes, bone marrow, mice, nanoparticles
Publisher URL http://dx.doi.org/10.1093/mutage/get060
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