Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment

May, J E; Morse, H R; Page, K; Soh, M; Wexler, S; Cox, C; Xu, J; Donaldson, C

Abstract

The bone marrow (BM) microenvironment is largely com- prised of mesenchymal stromal cells (MSCs) and is vital in supporting haematopoiesis. Limited studies have indicated that the BM microenvironment is damaged by chemotherapy; however the extent and long-term effects of this are unknown. This may be particularly critical in stem cell transplant patients who receive high-dose chemotherapy prior to transplant, and whilst the incoming graft replaces haematopoietic cells, the microenvironment remains of host origin. Consequently, dam- age caused by chemotherapy may be permanent and possibly implicated in graft failure if haematopoietic support is com- promised. MSCs were isolated from BM samples from patients undergoing chemotherapy for haematological malignancies as well as untreated control BM obtained as a waste product dur- ing total hip replacements. Following chemotherapy, MSCs have reduced proliferative capacity and survival (p

Citation

May, J. E., Morse, H. R., Page, K., Soh, M., Wexler, S., Cox, C., …Donaldson, C. (2014). Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment. Mutagenesis, 29(1), 79. https://doi.org/10.1093/mutage/get060

• Journal Article Type: Article
• Acceptance Date: Jul 15, 2013
• Online Publication Date: Dec 18, 2013
• Publication Date: Jan 31, 2014
• Journal: Mutagenesis
• Print ISSN: 0267-8357
• Publisher: Oxford University Press (OUP)
• Peer Reviewed: Peer Reviewed
• Volume: 29
• Issue: 1
• Pages: 79
• DOI: https://doi.org/10.1093/mutage/get060
• Keywords: mutation, cancer, chemotherapy regimen, carcinogens, cell line, dna, dna damage, dna repair, genome, mammals, micronucleus, mutagens, pyrenes, bone marrow, mice, nanoparticles
• Publisher URL: http://dx.doi.org/10.1093/mutage/get060