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Peoples’ experiences of painful diabetic neuropathy: A qualitative interview study (2021)
Journal Article
McCabe, C., Cramp, F., Gauntlett-Gilbert, J., & Davies, B. (2021). Peoples’ experiences of painful diabetic neuropathy: A qualitative interview study. Pain and Rehabilitation, 50, 14-21

Objective Painful diabetic neuropathy (PDN) is a common complication of diabetes. This study explored the experience and impact of living with PDN. Design People with PDN were recruited through local NHS clinics and by national advertisement in di... Read More about Peoples’ experiences of painful diabetic neuropathy: A qualitative interview study.

Alternative mobile phase additives for the characterization of protein biopharmaceuticals in liquid chromatography – mass spectrometry (2021)
Journal Article
Lardeux, H., Duivelshof, B. L., Colas, O., Beck, A., McCalley, D. V., Guillarme, D., & D’Atri, V. (in press). Alternative mobile phase additives for the characterization of protein biopharmaceuticals in liquid chromatography – mass spectrometry. Analytica Chimica Acta, https://doi.org/10.1016/j.aca.2021.338347

When analyzing large complex protein biopharmaceuticals, ion-pairing agents imparting low pH are widely used as mobile phase additives to improve the chromatographic performance. However, one of the most effective additives in RPLC and HILIC, trifluo... Read More about Alternative mobile phase additives for the characterization of protein biopharmaceuticals in liquid chromatography – mass spectrometry.

Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period (2021)
Journal Article
Silveira, N. M., Ribeiro, R. V., de Morais, S. F. N., de Souza, S. C. R., da Silva, S. F., Seabra, A. B., …Machado, E. C. (in press). Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period. Plant Physiology and Biochemistry,

Arginine (Arg) metabolism is associated with many cellular and developmental processes in plants. The products in this pathway, such as proline, nitric oxide (NO) and polyamines (PAs), have a wide range of physiological functions in plants, including... Read More about Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period.

Current provision of General Practitioner services in or alongside Emergency Departments in England (2021)
Journal Article
Brant, H., Voss, S., Morton, K., Cooper, A., Edwards, M., Price, D., …Benger, J. (in press). Current provision of General Practitioner services in or alongside Emergency Departments in England. Emergency Medicine Journal, https://doi.org/10.1136/emermed-2020-210539

Background In 2017 GPED, an approach that employs General Practitioners (GPs) in or alongside the Emergency Department (ED) to address increasing ED demand, was advocated by the National Health Service (NHS) in England and supported by capital fundi... Read More about Current provision of General Practitioner services in or alongside Emergency Departments in England.

Downstream signalling from molecular hydrogen (2021)
Journal Article
Hancock, J., & Russell, G. (2021). Downstream signalling from molecular hydrogen. Plants, 10(2), https://doi.org/10.3390/+plants10020367

Molecular hydrogen (H2) is now considered to be a part of the suite of small molecules which can control cellular activity. As such it has been suggested to be used in the therapy of diseases in humans but also to be used in plant science, to enhance... Read More about Downstream signalling from molecular hydrogen.

“We had to be very clear that they weren't going to try to break into any of the cases”: What potential do ‘escape rooms’ offer as a science communication technique? (2021)
Journal Article
Wilkinson, C., & Little, H. (2021). “We had to be very clear that they weren't going to try to break into any of the cases”: What potential do ‘escape rooms’ offer as a science communication technique?. JCOM: Journal of Science Communication, 20(1), https://doi.org/10.22323/2.20010307

‘Escape rooms’ are a recent cultural phenomena, whereby a group of ‘players’, often friends or colleagues, are ‘locked’ in a room and must solve a series of clues, puzzles, or mysteries in order to ‘escape’. Escape rooms are increasingly appearing in... Read More about “We had to be very clear that they weren't going to try to break into any of the cases”: What potential do ‘escape rooms’ offer as a science communication technique?.

Neglected spaces in science communication (2021)
Journal Article
Wilkinson, C. (2021). Neglected spaces in science communication. JCOM: Journal of Science Communication, 20(1), https://doi.org/10.22323/2.20010301

Many of the earliest drivers for improved scientific literacy and understanding were based on the assumption that science and technology is all around us, and yet there are some spaces and communities that are neglected in science communication conte... Read More about Neglected spaces in science communication.

Transcriptomic analyses of MYCN-regulated genes in anaplastic Wilms' tumour cell lines reveals oncogenic pathways and potential therapeutic vulnerabilities (2021)
Journal Article
Szemes, M., Melegh, Z., Bellamy, J., Park, J. H., Chen, B., Greenhough, A., …Malik, K. (in press). Transcriptomic analyses of MYCN-regulated genes in anaplastic Wilms' tumour cell lines reveals oncogenic pathways and potential therapeutic vulnerabilities. Cancers, https://doi.org/10.3390/xxxxx

Simple Summary: Wilms' tumour (WT) is one of the most common solid pediatric malignancies and arises in the developing kidney. Treatment of most WTs is relatively successful, with the notable exception of tumours with anaplastic histology. Anaplastic... Read More about Transcriptomic analyses of MYCN-regulated genes in anaplastic Wilms' tumour cell lines reveals oncogenic pathways and potential therapeutic vulnerabilities.

Peoples’ experiences of painful diabetic neuropathy: Are pain management programmes appropriate? (2021)
Journal Article
Davies, B., Cramp, F., Gauntlett-Gilbert, J., & McCabe, C. S. (in press). Peoples’ experiences of painful diabetic neuropathy: Are pain management programmes appropriate?. British Journal of Pain, https://doi.org/10.1177/2049463721989753

Objective: Painful diabetic neuropathy (PDN) is a painful complication of diabetes. This study aimed to explore: (1) strategies used by participants to manage impacts of PDN and (2) their perspectives on whether strategies from pain management progra... Read More about Peoples’ experiences of painful diabetic neuropathy: Are pain management programmes appropriate?.

5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis (2021)
Journal Article
Dixon, S. W., Collard, T. J., Mortensson, E. M., Legge, D. N., Chambers, A. C., Greenhough, A., …Williams, A. C. (in press). 5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis. British Journal of Cancer,

Background: Most colorectal cancers (CRC) arise sporadically from precursor lesions: colonic polyps. Polyp resection prevents progression to CRC. Risk of future polyps is proportional to the number and size of polyps detected at screening, allowing i... Read More about 5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis.

Evaluation of a linear free energy relationship for the determination of the column void volume in hydrophilic interaction chromatography (2021)
Journal Article
McCalley, D. V. (2021). Evaluation of a linear free energy relationship for the determination of the column void volume in hydrophilic interaction chromatography. Journal of Chromatography A, 1638, https://doi.org/10.1016/j.chroma.2020.461849

The application of a linear free energy relationship (LFER) to a variety of hydrophilic interaction chromatography columns with different bonded ligands and pore sizes was studied in order to determine their void volume Vm. The method was based on th... Read More about Evaluation of a linear free energy relationship for the determination of the column void volume in hydrophilic interaction chromatography.

Classification of the mechanism of toxicity as applied to human cell line ECV304 (2020)
Journal Article
Djawad, Y. A., Kiely, J., & Luxton, R. (in press). Classification of the mechanism of toxicity as applied to human cell line ECV304. Computer Methods in Biomechanics and Biomedical Engineering, https://doi.org/10.1080/10255842.2020.1861255

© 2020 Informa UK Limited, trading as Taylor & Francis Group. The objective of this study was to identify the pattern of cytotoxicity testing of the human cell line ECV304 using three techniques of an ensemble learning algorithm (bagging, boosting... Read More about Classification of the mechanism of toxicity as applied to human cell line ECV304.

Differential expression of the BCAT isoforms between breast cancer subtypes (2020)
Journal Article
Shafei, M. A., Flemban, A., Daly, C., Kendrick, P., White, P., Dean, S., …Conway, M. E. (in press). Differential expression of the BCAT isoforms between breast cancer subtypes. Breast Cancer, https://doi.org/10.1007/s12282-020-01197-7

© 2020, The Author(s). Background: Biological characterisation of breast cancer subtypes is essential as it informs treatment regimens especially as different subtypes have distinct locoregional patterns. This is related to metabolic phenotype, where... Read More about Differential expression of the BCAT isoforms between breast cancer subtypes.

Interaction between GRP78 and IGFBP-3 affects tumourigenesis and prognosis in breast cancer patients (2020)
Journal Article
Zielinska, H. A., Daly, C. S., Alghamdi, A., Bahl, A., Sohail, M., White, P., …Perks, C. M. (2020). Interaction between GRP78 and IGFBP-3 affects tumourigenesis and prognosis in breast cancer patients. Cancers, 12(12), 1-13. https://doi.org/10.3390/cancers12123821

Insulin-like growth factor binding protein 3 (IGFBP-3) plays a key role in breast cancer progression and was recently shown to bind to the chaperone protein glucose-regulated protein 78 (GRP78); however, the clinical significance of this association... Read More about Interaction between GRP78 and IGFBP-3 affects tumourigenesis and prognosis in breast cancer patients.

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer (2020)
Journal Article
Nounu, A., Greenhough, A., Heesom, K. J., Richmond, R. C., Zheng, J., Weinstein, S. J., …Relton, C. L. (in press). A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer. Cancer Epidemiology, Biomarkers and Prevention, https://doi.org/10.1158/1055-9965.EPI-20-1176

Background: Evidence for aspirin's chemopreventative properties on colorectal cancer (CRC) is substantial, but its mechanism of action is not well-understood. We combined a proteomic approach with Mendelian randomization (MR) to identify possible new... Read More about A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer.

Novel method for the measurement of erythrocyte acetylcholinesterase activity in the Yt blood group system using amperometry in conjunction with screen-printed carbon electrodes (2020)
Journal Article
Crew, A., Karamatic Crew, V., Bagelow, L., Walser, P., Thornton, N., & Hart, J. (2020). Novel method for the measurement of erythrocyte acetylcholinesterase activity in the Yt blood group system using amperometry in conjunction with screen-printed carbon electrodes. Vox Sanguinis, 115(S1), 271-271. https://doi.org/10.1111/vox.13031

Background: The five antigens of the Yt blood group system are located on the membrane GPI‐linked erythrocyte acetylcholinesterase (AChE‐E), which is implicated in a range of clinical issues, including sleep apnoea and neurotoxin poisoning. Conformat... Read More about Novel method for the measurement of erythrocyte acetylcholinesterase activity in the Yt blood group system using amperometry in conjunction with screen-printed carbon electrodes.

Vaccine movements on social media: A visual and network analysis (2020)
Thesis
Milani, E. Vaccine movements on social media: A visual and network analysis. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/5936098

Vaccines are considered one of the most effective public health interventions, but they have been subject to opposition since they were first proposed. Anti-vaccine activists disseminate and sensationalise objections to vaccinations through various c... Read More about Vaccine movements on social media: A visual and network analysis.

The use of mechanical insufflation-exsufflation in invasively ventilated critically ill adults: A scoping review protocol (2020)
Journal Article
Swingwood, E., Stilma, W., Tume, L., Cramp, F., Paulus, F., Schultz, M., …Rose, L. (2020). The use of mechanical insufflation-exsufflation in invasively ventilated critically ill adults: A scoping review protocol. Systematic Reviews, 9(1), https://doi.org/10.1186/s13643-020-01547-8

© 2020, The Author(s). Background: Critically ill patients receiving invasive ventilation are at risk of sputum retention. Mechanical insufflation-exsufflation (MI-E) is a technique used to mobilise sputum and optimise airway clearance. Recently, int... Read More about The use of mechanical insufflation-exsufflation in invasively ventilated critically ill adults: A scoping review protocol.

Investigation of the antifungal and anti-aflatoxigenic potential of plant-based essential oils against aspergillus flavus in peanuts (2020)
Journal Article
Sreenivasa, M. Y., Nagaraja, H., Quyen, P., Sharma, A., Msimanga, H. Z., Achar, P. N., & Adukwu, E. C. (2020). Investigation of the antifungal and anti-aflatoxigenic potential of plant-based essential oils against aspergillus flavus in peanuts. Journal of Fungi, 6(4), https://doi.org/10.3390/jof6040383

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Aspergillus species are known to cause damage to food crops and are associated with opportunistic infections in humans. In the United States, significant losses have been reported in peanut pr... Read More about Investigation of the antifungal and anti-aflatoxigenic potential of plant-based essential oils against aspergillus flavus in peanuts.

Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs) (2020)
Journal Article
Fois, M., Cox, T., Ratcliffe, N., & de Lacy Costello, B. (2021). Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs). Sensors and Actuators B: Chemical, 330, https://doi.org/10.1016/j.snb.2020.129264

Heated metal oxide sensors have been widely studied for their ability to give a reversible change in the electrical resistance following the interaction with a volatile compound. Another feature is their inherent cataluminescence (CTL) properties whe... Read More about Rare earth doped metal oxide sensor for the multimodal detection of volatile organic compounds (VOCs).