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In vitro modelling of tongue derived microbial biofilms and their reponse to treatment (2020)
Thesis
Hewett, K. E. In vitro modelling of tongue derived microbial biofilms and their reponse to treatment. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/1491292

This work concerns the development of a flat plate perfusion model to study biofilms derived from human tongue biota. The model has been derived from a previous sorbarod model, via a flat plate model (used to study wound organisms), to the model desc... Read More about In vitro modelling of tongue derived microbial biofilms and their reponse to treatment.

Targeting the splice factor kinase CLK1 in prostate cancer cells (2020)
Thesis
Uzor, S. O. Targeting the splice factor kinase CLK1 in prostate cancer cells. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/1490733

Prostate cancer is the most rampant diagnosed cancer and the second leading cause of cancer related death in men between middle age and old age. There is a need to identify the molecular genetic processes that underpin prostate cancer and to search f... Read More about Targeting the splice factor kinase CLK1 in prostate cancer cells.

Antimicrobial activity of essential oils as liquid and vapour applications (2020)
Thesis
Elcocks, E. R. (2020). Antimicrobial activity of essential oils as liquid and vapour applications. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/1490727

Essential oils produced by plants have been used as antimicrobial agents historically, however, many essential oils remain under-exploited as alternatives to antimicrobials. Therefore, the aim of this thesis was to evaluate the antibacterial efficacy... Read More about Antimicrobial activity of essential oils as liquid and vapour applications.

BCAT-induced autophagy regulates Aβ load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease. (2020)
Journal Article
Harris, M., El Hindy, M., Usmari-Moraes, M., Hudd, F., Shafei, M., Dong, M., …Conway, M. E. (in press). BCAT-induced autophagy regulates Aβ load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease. Free Radical Biology and Medicine, https://doi.org/10.1016...eeradbiomed.2020.01.019

Leucine, nutrient signal and substrate for the branched chain aminotransferase (BCAT) activates the mechanistic target of rapamycin (mTORC1) and regulates autophagic flux, mechanisms implicated in the pathogenesis of neu... Read More about BCAT-induced autophagy regulates Aβ load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease..

A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing (2020)
Journal Article
Gasser, A., Eveness, J., Kiely, J., Attwood, D., & Luxton, R. (2020). A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing. Bioelectrochemistry, 133, 107448. https://doi.org/10.1016/j.bioelechem.2019.107448

© 2019 We report on a novel impedance spectroscopy measurement and data analysis technique for cytotoxicity testing. The technique combines non-contact measurement with real-time impedance data analysis based on the toxin dose dependency of the outpu... Read More about A non-contact impedimetric biosensing system for classification of toxins associated with cytotoxicity testing.

Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator? (2020)
Journal Article
Hancock, J. T., Russell, G., & Veal, D. (2020). Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator?. Reactive Oxygen Species, 9(26), 48-69

D-Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an immensely important enzyme carrying out a vital step in glycolysis and is found in all living organisms. Although there are several isoforms identified in many species, it is now recognized tha... Read More about Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator?.

Science communication and public relations: beyond borders (2019)
Book Chapter
Weitkamp, E., & Autzen, C. (in press). Science communication and public relations: beyond borders. In M. Dascal, T. Gloning, & A. Lessmollman (Eds.), Science Communication, (465-484). Berlin: De Gruyter

This chapter applies an overall communication constitute organizations (CCO) perspective to explore the relationships between science communication and public relations. In the context of increasing institutional interest in public relations and scie... Read More about Science communication and public relations: beyond borders.

An in vitro collagen perfusion wound biofilm model; with applications for antimicrobial studies and microbial metabolomics (2019)
Journal Article
Slade, E. A., Thorn, R. M. S., Young, A., & Reynolds, D. M. (2019). An in vitro collagen perfusion wound biofilm model; with applications for antimicrobial studies and microbial metabolomics. BMC Microbiology, 19(1), https://doi.org/10.1186/s12866-019-1682-5

Background The majority of in vitro studies of medically relevant biofilms involve the development of biofilm on an inanimate solid surface. However, infection in vivo consists of biofilm growth on, or suspended within, the semi-solid matrix of the... Read More about An in vitro collagen perfusion wound biofilm model; with applications for antimicrobial studies and microbial metabolomics.

Aluminium Induced DNA-damage and Oxidative Stress in Cultures of the Marine Sponge Hymeniacidon perlevis (2019)
Journal Article
Akpiri, R. U., Hodges, N. J., & Konya, R. S. (2020). Aluminium Induced DNA-damage and Oxidative Stress in Cultures of the Marine Sponge Hymeniacidon perlevis. Journal of Marine Science, 2(1), https://doi.org/10.30564/jms.v2i1.1070

Aluminium is the most abundant element in the earth crust, and has no known biological function. However, it is an established neurotoxicant in its trivalent oxidation state, with exposure resulting in neurodegenerative diseases like Parkinson’s dise... Read More about Aluminium Induced DNA-damage and Oxidative Stress in Cultures of the Marine Sponge Hymeniacidon perlevis.

Leukaemic and Bone Marrow Stromal Cells Alter Cytarabine Genotoxicity and Cytotoxicity in Favour of Disease (2019)
Journal Article
May, J., Gynn, L., Anderson, E., & Robinson, G. (2019). Leukaemic and Bone Marrow Stromal Cells Alter Cytarabine Genotoxicity and Cytotoxicity in Favour of Disease. Mutagenesis, 34(5/6), e5. https://doi.org/10.1093/mutage/gez025

Resistance to therapy remains one of the greatest challenges in the management of the blood and bone marrow (BM) disorder, acute myeloid leukaemia (AML). This study aimed to investigate how leukaemic and BM stromal cells contribute to altered chemo-s... Read More about Leukaemic and Bone Marrow Stromal Cells Alter Cytarabine Genotoxicity and Cytotoxicity in Favour of Disease.

Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection (2019)
Journal Article
Barnett, J. M., Monnier, B. M., Tyler, S., West, D., Ballantine-Dykes, H., Regan, E., …Luxton, R. (2020). Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection. Sensing and Bio-Sensing Research, 27, 100315. https://doi.org/10.1016/j.sbsr.2019.100315

© 2019 The resonant coil magnetometer quantifies paramagnetic particles (PMPs) and has been used to develop magneto-immunoassays in a range of formats. The advantage of magneto-immunoassays is that they are relatively inexpensive, portable, easy to p... Read More about Initial trail results of a magnetic biosensor for the rapid detection of Porcine Reproductive and Respiratory Virus (PRRSV) infection.

Narrative, drama and science communication (2019)
Book Chapter
Weitkamp, E. (2019). Narrative, drama and science communication. In L. Olman, & D. Gruber (Eds.), The Routledge Handbook of Language and Science(1). London: Taylor & Francis (Routledge)

This chapter considers the role that narrative, as a means of storytelling, could have in science communication, a practice which is often seen as translating information from the specialist language of science into words and concepts that can be und... Read More about Narrative, drama and science communication.

Science Hunters: Teaching science concepts in schools using Minecraft (2019)
Journal Article
Hobbs, L., Stevens, C., Hartley, J., Ashby, M., Jackson, B., Bowden, L., …Bentley, S. (2019). Science Hunters: Teaching science concepts in schools using Minecraft. Action Research and Innovation in Science Education, 2(2), 13-21

Background Science Hunters is an outreach project based at Lancaster University, UK. It uses the computer game Minecraft, alongside interactive discussion and hands-on demonstrations, to engage children with scientific research topics and science l... Read More about Science Hunters: Teaching science concepts in schools using Minecraft.

Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML). (2019)
Journal Article
Gynn, L. E., Anderson, E., Robinson, G. M., Wexler, S. A., Upstill-Goddard, G., Cox, C., …Morgan, R. G. (2019). Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML). Blood, 134(Supplement 1), 2492. https://doi.org/10.1182/blood-2019-122891

Mesenchymal stromal cells (MSC) are known to protect leukemic cells from drug-induced toxicity within the bone marrow (BM) niche, however, less is known about leukemic impact on supportive MSC. The nucleoside-analogue, cytarabine (Ara-C), is a front-... Read More about Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML)..

Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method (2019)
Journal Article
Westmacott, K. L., Crew, A. P., Doran, O., & Hart, J. P. (2020). Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method. Biosensors and Bioelectronics, 150, https://doi.org/10.1016/j.bios.2019.111837

© 2019 Elsevier B.V. This is the first report on the fabrication, characterisation and application of an electrochemical (bio)sensor system for the simultaneous measurement of skatole and androstenone. A biosensor for androstenone was fabricated usin... Read More about Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method.

The development of point-of-use treatment technologies for the production of drinking water (2019)
Thesis
Clayton, G. The development of point-of-use treatment technologies for the production of drinking water. (Thesis). University of the West of England. Retrieved from https://uwe-repository....ribe.com/output/1490721

An estimated 884 million people worldwide lack access to drinking water from improved water sources. With the global population expected to reach eleven billion by the end of the 21st Century, stress on water and energy resources will be exacerbated.... Read More about The development of point-of-use treatment technologies for the production of drinking water.

Review of electroanalytical-based approaches for the determination of benzodiazepines (2019)
Journal Article
Honeychurch, K. C. (2019). Review of electroanalytical-based approaches for the determination of benzodiazepines. Biosensors, 9(4), https://doi.org/10.3390/bios9040130

The benzodiazepine class of drugs are characterised by a readily electrochemically reducible azomethine group. A number are also substituted by other electrochemically active nitro, N-oxide, and carbonyl groups, making them readily accessible to elec... Read More about Review of electroanalytical-based approaches for the determination of benzodiazepines.