All Outputs (71)

Effect of sex steroids on expression of sulfotransferase 2B1 immunoreactive protein in primary cultured porcine hepatocytes (2008)
Journal Article
Panella-Riera, N., Moe, M., Grindflek, E., Oliver, M. A., Wood, J. D., & Doran, O. (2008). Effect of sex steroids on expression of sulfotransferase 2B1 immunoreactive protein in primary cultured porcine hepatocytes. Livestock Science, 118(3), 223-230. https://doi.org/10.1016/j.livsci.2008.01.021

An excessive accumulation of androstenone (5α-androst-16-en-3-one) in pig adipose tissue is one of the two major contributors to the phenomenon of boar taint. High levels of adipose tissue androstenone have been related to a low rate of hepatic andro... Read More about Effect of sex steroids on expression of sulfotransferase 2B1 immunoreactive protein in primary cultured porcine hepatocytes.

Effect of breed on expression of stearoyl-CoA desaturase protein in muscle and subcutaneous adipose tissue of beef cattle (2008)
Journal Article
Dance, L. J. E., & Doran, O. (2008). Effect of breed on expression of stearoyl-CoA desaturase protein in muscle and subcutaneous adipose tissue of beef cattle

Fatty acid composition and lipogenic enzyme expression in semimembranosus muscle of Limousin and Aberdeen Angus cattle (2008)
Journal Article
Ward, R. E., Woodward, B. W., Nkrumah, J. D., Otter, N., & Doran, O. (2008). Fatty acid composition and lipogenic enzyme expression in semimembranosus muscle of Limousin and Aberdeen Angus cattle

Effect of testosterone, estrone sulphate and androstenone on 3β-hydroxysteroid dehydrogenase protein expression in primary cultured hepatocytes (2008)
Journal Article
Nicolau-Solano, S. I., & Doran, O. (2008). Effect of testosterone, estrone sulphate and androstenone on 3β-hydroxysteroid dehydrogenase protein expression in primary cultured hepatocytes. Livestock Science, 114(2-3), 202-210. https://doi.org/10.1016/j.livsci.2007.05.001

Androstenone (5α-androst-16-en-3-one) is a steroid pheromone, excessive accumulation of which in pig adipose tissue contributes to the phenomenon of "boar taint". The incidence of boar taint increases with age and weight of entire male pigs. One of t... Read More about Effect of testosterone, estrone sulphate and androstenone on 3β-hydroxysteroid dehydrogenase protein expression in primary cultured hepatocytes.

Regulation of CYP2A6 protein expression by skatole, indole, and testicular steroids in primary cultured pig hepatocytes (2008)
Journal Article
Wood, J. D., Chen, G., Cue, R. A., Lundstrom, K., & Doran, O. (2008). Regulation of CYP2A6 protein expression by skatole, indole, and testicular steroids in primary cultured pig hepatocytes. Drug Metabolism and Disposition, 36(1), 56-60. https://doi.org/10.1124/dmd.107.017285

CYP2A6 is one of the enzymes involved in the hepatic metabolism of a naturally produced compound, skatole, in the pig. Low CYP2A6 activity has been linked to excessive accumulation of skatole in pig adipose tissue and development of the phenomenon "b... Read More about Regulation of CYP2A6 protein expression by skatole, indole, and testicular steroids in primary cultured pig hepatocytes.

Expression of 3β-hydroxysteroid dehydrogenase, cytochrome P450-c17, and sulfotransferase 2B1 proteins in liver and testis of pigs of two breeds: Relationship with adipose tissue androstenone concentration (2007)
Journal Article
Moe, M., Moe, E., Grindflek, E., & Doran (nee Udovikova), O. (2007). Expression of 3β-hydroxysteroid dehydrogenase, cytochrome P450-c17, and sulfotransferase 2B1 proteins in liver and testis of pigs of two breeds: Relationship with adipose tissue androstenone concentration. Journal of Animal Science, 85(11), 2924-2931. https://doi.org/10.2527/jas.2007-0283

An excessive accumulation of androstenone in pig adipose tissue is a major contributor to the phenomenon of boar taint. Androstenone deposition is dependent on the rate of androstenone biosynthesis in testis and androstenone degradation in liver. The... Read More about Expression of 3β-hydroxysteroid dehydrogenase, cytochrome P450-c17, and sulfotransferase 2B1 proteins in liver and testis of pigs of two breeds: Relationship with adipose tissue androstenone concentration.

Relationship between carcass weight, adipose tissue androstenone level and expression of the hepatic 3β-hydroxysteroid dehydrogenase in entire commercial pigs (2007)
Journal Article
Nicolau-Solano, S. I., Wittington, F. M., Wood, J. D., & Doran (nee Udovikova), O. (2007). Relationship between carcass weight, adipose tissue androstenone level and expression of the hepatic 3β-hydroxysteroid dehydrogenase in entire commercial pigs. animal, 1(7), 1053-1059. https://doi.org/10.1017/S1751731107000274

Boar taint is a major meat-quality defect in pigs and is due to excessive accumulation of skatole and androstenone in adipose tissue. The present work investigated the relationship between carcass weight, levels of skatole and androstenone in adipose... Read More about Relationship between carcass weight, adipose tissue androstenone level and expression of the hepatic 3β-hydroxysteroid dehydrogenase in entire commercial pigs.

Breed-specific differences in the expression of the hepatic and testicular 3beta-hydroxysteroid dehydrogenase (HSD3B) and sulfotransferase 2B1 (SULT2B1)in boars with high and low backfat androstenone levels (2007)
Journal Article
Moe, M., Grendflek, E., & Doran (nee Udovikova), O. (2007). Breed-specific differences in the expression of the hepatic and testicular 3beta-hydroxysteroid dehydrogenase (HSD3B) and sulfotransferase 2B1 (SULT2B1)in boars with high and low backfat androstenone levels

Breed-associated variations in the sequence of the pig 3β- hydroxysteroid dehydrogenase gene (2007)
Journal Article
Cue, R. A., Nicolau-Solano, S., McGivan, J. D., Wood, J. D., & Doran, O. (2007). Breed-associated variations in the sequence of the pig 3β- hydroxysteroid dehydrogenase gene. Journal of Animal Science, 85(3), 571-576. https://doi.org/10.2527/jas.2006-366

The entire sequence of the pig 3β-hydroxysteroid dehydrogenase (3β-HSD) gene has recently become known. This gene is deemed to be important in androstenone metabolism in pig liver, and its defective expression has been shown to be related to androste... Read More about Breed-associated variations in the sequence of the pig 3β- hydroxysteroid dehydrogenase gene.

The effect of low protein diets on fat deposition in pigs (2007)
Journal Article
Stenehouse, G. G., Whittington, F. M., Doran (nee Udovikova), O., Stewart, A. H., Hazzledine, M. J., & Wood, J. D. (2007). The effect of low protein diets on fat deposition in pigs

Relationship between the expression of hepatic but not testicular 3β-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue (2006)
Journal Article
Wood, J. D., Whittington, F. M., McGivan, J. D., Nicolau-Solano, S. I., Nieuwhof, G. J., & Doran (nee Udovikova), O. (2006). Relationship between the expression of hepatic but not testicular 3β-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue. Journal of Animal Science, 84(10), 2809-2817. https://doi.org/10.2527/jas.2005-595

This study investigated the relationship between expression of hepatic and testicular 3/3-hydroxysteroid dehydrogenase (3/3-HSD) and accumulation of androstenone in adipose tissue because of its relation to boar taint. The experiments were performed... Read More about Relationship between the expression of hepatic but not testicular 3β-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue.

A reduced protein diet induces stearoyl-CoA desaturase protein expression in pig muscle but not in subcutaneous adipose tissue: Relationship with intramuscular lipid formation (2006)
Journal Article
Doran (nee Udovikova), O., Moule, S. K., Teye, G. A., Whittington, F. M., Hallett, K. G., & Wood, J. D. (2006). A reduced protein diet induces stearoyl-CoA desaturase protein expression in pig muscle but not in subcutaneous adipose tissue: Relationship with intramuscular lipid formation. British Journal of Nutrition, 95(3), 609-617. https://doi.org/10.1079/BJN20051526

A reduced protein diet (RPD) is known to increase the level of intramuscular lipid in pig meat with a smaller effect on the amount of subcutaneous adipose tissue. This might be due to tissue-specific activation of the expression of lipogenic enzymes... Read More about A reduced protein diet induces stearoyl-CoA desaturase protein expression in pig muscle but not in subcutaneous adipose tissue: Relationship with intramuscular lipid formation.

Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig (2005)
Journal Article
McGivan, J. D., Skinner, T. M., Doran (nee Udovikova), O., Haley, C. S., & Archibald, A. L. (2005). Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig. Animal Genetics, 36(5), 417-422. https://doi.org/10.1111/j.1365-2052.2005.01342.x

The porcine cytochrome-p450 2E1 (CYP2E1) gene was isolated by screening a pig BAC library and partially sequenced. This sequence information was used to identify six single nucleotide polymorphisms (SNPs) within the CYP2E1 gene and its promoter. In a... Read More about Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig.

The molecular mechanisms of inhibitory effect of androstenone on hepatic skatole metabolism in relation to boar taint (2005)
Journal Article
Doran (nee Udovikova), O., McGivan, J. D., Whittington, F. M., & Wood, J. D. (2005). The molecular mechanisms of inhibitory effect of androstenone on hepatic skatole metabolism in relation to boar taint

Characterisation of 3-beta-hydroxysteroid dehydrogenase from pig liver and testis in relation to boar taint (2005)
Journal Article
Nicolau-Solano, S. I., Whittington, F. M., Wood, J. D., & Doran (nee Udovikova), O. (2005). Characterisation of 3-beta-hydroxysteroid dehydrogenase from pig liver and testis in relation to boar taint

The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone (2004)
Journal Article
Doran, E., Tambyrajah, W. S., Doran (nee Udovikova), O., Wood, J. D., & McGivan, J. D. (2004). The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone. Archives of Biochemistry and Biophysics, 431(2), 252-260. https://doi.org/10.1016/j.abb.2004.08.016

Functional analysis of the pig cytochrome P4502E1 (CYP2E1) promoter identified two major activating elements. One corresponded to the hepatic nuclear factor 1 (HNF-1) consensus binding sequence at nucleotides -128/-98 and the other was located in the... Read More about The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone.

Characterisation of androstenone metabolism in pig liver microsomes (2004)
Journal Article
Doran (nee Udovikova), O., Whittington, F. M., Wood, J. D., & McGivan, J. D. (2004). Characterisation of androstenone metabolism in pig liver microsomes. Chemico-Biological Interactions, 147(2), 141-149. https://doi.org/10.1016/j.cbi.2003.12.002

Androstenone (5α-androst-16-en-3-one) is a steroid pheromone produced in the testis. Excessive accumulation of androstenone together with skatole (3-methyl-indole) in the adipose tissue of some male pigs leads to "boar taint". In isolated pig hepatoc... Read More about Characterisation of androstenone metabolism in pig liver microsomes.

The effect of age on the level of lipogenic enzymes in subcutaneouse fat and muscle of pigs (2004)
Journal Article
Doran (nee Udovikova), O., Moule, S. K., & Wood, J. D. (2004). The effect of age on the level of lipogenic enzymes in subcutaneouse fat and muscle of pigs

Relationship between skatole and androstenone accumulation in Meishan pigs - the role of cytochrome P450IIE! expression (2004)
Journal Article
Whittington, F. M., Nute, G. R., Hughes, S. I., McGivan, J. D., Lean, I. J., Wood, J. D., & Doran (nee Udovikova), O. (2004). Relationship between skatole and androstenone accumulation in Meishan pigs - the role of cytochrome P450IIE! expression. Meat Science, 67(4), 569-576

Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes (2002)
Journal Article
Wood, J. D., Doran (nee Udovikova), O., Whittington, F., & McGivan, J. D. (2002). Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes. Chemico-Biological Interactions, 140(1), 81-92. https://doi.org/10.1016/S0009-2797%2802%2900015-7

Skatole, a derivative of tryptophan, is produced in the hind-gut of pigs and is metabolised via hepatic cytochrome P4502E1 (CYP2E1). Excessive accumulation of skatole together with androstenone, a metabolite of testosterone, in adipose tissue in some... Read More about Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes.