All Outputs (138)

Nitric oxide, other reactive signalling compounds, redox, and reductive stress (2020)
Journal Article
Hancock, J., & Veal, D. (2021). Nitric oxide, other reactive signalling compounds, redox, and reductive stress. Journal of Experimental Botany, 72(3), 819-829. https://doi.org/10.1093/jxb/eraa331

Nitric oxide (NO) and other reactive nitrogen species (RNS) are key signalling molecules in plants, but they do not work in isolation. NO is produced in cells, often increased in response to stress conditions, but many other reactive compounds used i... Read More about Nitric oxide, other reactive signalling compounds, redox, and reductive stress.

Breath analysis for detection of viral infection, the current position of the field (2020)
Journal Article
Gould, O., Ratcliffe, N., Król, E., & de Lacy Costello, B. (2020). Breath analysis for detection of viral infection, the current position of the field. Journal of Breath Research, 14(4), https://doi.org/10.1088/1752-7163/ab9c32

The COVID-19 pandemic has highlighted the importance of rapid, cost effective, accurate, and non-invasive testing for viral infections. Volatile compounds (VCs) have been suggested for several decades as fulfilling these criteria. However currently v... Read More about Breath analysis for detection of viral infection, the current position of the field.

An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy (2020)
Journal Article
Russell, G., Rehman, M., LeBaron, T. W., Veal, D., Adukwu, E., & Hancock, J. (2020). An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy. Reactive Oxygen Species, 10(28), 150–165

SARS-CoV-2 is an emerging β-coronavirus that causes COVID-19 disease that manifests primarily as a pulmonary infection that can rapidly progress into severe and acute respiratory distress in susceptible patients. Initial reports of severe pulmonary i... Read More about An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy.

Regulating the regulator: nitric oxide control of post-translational modifications (2020)
Journal Article
Gupta, K. J., Kolbert, Z., Durner, J., Lindermayr, C., Corpas, F. J., Brouquisse, R., …Loake, G. J. (2020). Regulating the regulator: nitric oxide control of post-translational modifications. New Phytologist, 227(5), 1319-1325. https://doi.org/10.1111/nph.16622

Nitric oxide (NO) is perfectly suited for the role of a redox signalling molecule. A key route for NO bioactivity occurs via protein S-nitrosation, and involves the addition of a NO moiety to a protein cysteine (Cys) thiol (–SH) to form an S-nitrosot... Read More about Regulating the regulator: nitric oxide control of post-translational modifications.

Screen-printed carbon based biosensors and their applications in agri-food safety (2020)
Journal Article
Smart, A., Crew, A., Pemberton, R., Hughes, G., Doran, O., & Hart, J. P. (2020). Screen-printed carbon based biosensors and their applications in agri-food safety. Trends in Analytical Chemistry, 127, Article 115898. https://doi.org/10.1016/j.trac.2020.115898

This review focuses on the ways in which screen-printed carbon electrodes have been tailored with different biorecognition elements, including enzymes, antibodies, and aptamers, often with other modifiers, such as mediators and nanoparticles, to prod... Read More about Screen-printed carbon based biosensors and their applications in agri-food safety.

ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia? (2020)
Journal Article
Vahabi, B., Jabr, R., Fry, C., McCloskey, K., Everaert, K., Agudelo, C. W., …Weiss, J. P. (2020). ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia?. Neurourology and Urodynamics, 39(S3 Supplement: ICI‐RS 2019), S88-S95. https://doi.org/10.1002/nau.24274

Introduction: The following is a report on the proceedings of the 2019 International Consultation on Incontinence-Research Society nocturia think tank (NTT). Objectives: The objectives of the 2019 NTT were as follows: (a) to evaluate the role of urot... Read More about ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia?.

Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator? (2020)
Journal Article
Russell, G., Veal, D., & Hancock, J. T. (2020). Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator?. Reactive Oxygen Species, 9(26), 48-69

D-Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an immensely important enzyme carrying out a vital step in glycolysis and is found in all living organisms. Although there are several isoforms identified in many species, it is now recognized tha... Read More about Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator?.

Review of electroanalytical-based approaches for the determination of benzodiazepines (2019)
Journal Article
Honeychurch, K. C. (2019). Review of electroanalytical-based approaches for the determination of benzodiazepines. Biosensors, 9(4), Article 130. https://doi.org/10.3390/bios9040130

The benzodiazepine class of drugs are characterised by a readily electrochemically reducible azomethine group. A number are also substituted by other electrochemically active nitro, N-oxide, and carbonyl groups, making them readily accessible to elec... Read More about Review of electroanalytical-based approaches for the determination of benzodiazepines.

A forty year journey: The generation and roles of NO in plants (2019)
Journal Article
Kolbert, Z., Barroso, J. B., Brouquisse, R., Corpas, F. J., Gupta, K. J., Lindermayr, C., …Hancock, J. (2019). A forty year journey: The generation and roles of NO in plants. Nitric Oxide: Biology and Chemistry, 93, 53-70. https://doi.org/10.1016/j.niox.2019.09.006

In this year there is the 40th anniversary of the first publication of plant nitric oxide (NO) emission by Lowell Klepper. In the decades since then numerous milestone discoveries have revealed that NO is a multifunctional molecule in plant cells reg... Read More about A forty year journey: The generation and roles of NO in plants.

Recommendations on terminology and experimental best practice associated with plant nitric oxide research (2019)
Journal Article
Gupta, K. J., Hancock, J. T., Petrivalsky, M., Kolbert, Z. S., Lindermayr, C., Durner, J., …John Loake, G. (2020). Recommendations on terminology and experimental best practice associated with plant nitric oxide research. New Phytologist, 225(5), 1828-1834. https://doi.org/10.1111/nph.16157

© 2019 The Authors. New Phytologist © 2019 New Phytologist Trust Nitric oxide (NO) emerged as a key signal molecule in plants. During the last two decades impressive progress has been made in plant NO research. This small, redox-active molecule is no... Read More about Recommendations on terminology and experimental best practice associated with plant nitric oxide research.

Herbal teas and their health benefits: A scoping review (2019)
Journal Article
Poswal, F. S., Russell, G., Mackonochie, M., MacLennan, E., Adukwu, E. C., & Rolfe, V. (2019). Herbal teas and their health benefits: A scoping review. Plant Foods for Human Nutrition, 74(3), 266-276. https://doi.org/10.1007/s11130-019-00750-w

Herbal teas are used as therapeutic vehicles in many forms of traditional medicine and are a popular global beverage. The purpose of this scoping review was to examine the evidence relating to the clinical efficacy and safety of herbal teas, and to i... Read More about Herbal teas and their health benefits: A scoping review.

The 2013-2016 Ebola epidemic: Evaluating communication strategies between two affected countries in West Africa (2019)
Journal Article
Adukwu, E. C., & Walker, B. F. (2020). The 2013-2016 Ebola epidemic: Evaluating communication strategies between two affected countries in West Africa. European Journal of Public Health, 30(1), 118-124. https://doi.org/10.1093/eurpub/ckz104

Background: Ebola is a haemorrhagic disease with high fatality rates between 25 and 90%. The 2013-16 Ebola outbreak in West Africa was the largest to date with >28 000 cases and >11 000 fatalities. This outbreak exposed inadequacies in public health... Read More about The 2013-2016 Ebola epidemic: Evaluating communication strategies between two affected countries in West Africa.

From fast identification to resistance testing: Volatile compound profiling as a novel diagnostic tool for detection of antibiotic susceptibility (2019)
Journal Article
Smart, A., de Lacy Costello, B., Ratcliffe, N., Drabinksa, N., & Hewett, K. (2019). From fast identification to resistance testing: Volatile compound profiling as a novel diagnostic tool for detection of antibiotic susceptibility. Trends in Analytical Chemistry, 115, 1-12. https://doi.org/10.1016/j.trac.2019.03.019

Widespread use of antibiotics has led to the development of antibiotic resistance in many pathogenic bacteria. If effective methods of alleviating this crisis are not applied, a return to high mortality and morbidity of the pre-antibiotic era could o... Read More about From fast identification to resistance testing: Volatile compound profiling as a novel diagnostic tool for detection of antibiotic susceptibility.

Thermal and non-thermal processing technologies on intrinsic and extrinsic quality factors of tomato products: A review (2019)
Journal Article
Jayathunge, K. G., Stratakos, A. C., Delgado-Pando, G., & Koidis, A. (2019). Thermal and non-thermal processing technologies on intrinsic and extrinsic quality factors of tomato products: A review. Journal of Food Processing and Preservation, 43(3), https://doi.org/10.1111/jfpp.13901

Tomato and tomato-based products play a vital role in human diet due to the presence of bioactive compounds. The conventional heat treatment is designed as a current practice in tomato products industry to ensure food safety but it can lead to undesi... Read More about Thermal and non-thermal processing technologies on intrinsic and extrinsic quality factors of tomato products: A review.

Efficacy of psychosocial and physical activity-based interventions to improve body image among women treated for breast cancer: A systematic review (2018)
Journal Article
Lewis-Smith, H., Diedrichs, P. C., Rumsey, N., & Harcourt, D. (2018). Efficacy of psychosocial and physical activity-based interventions to improve body image among women treated for breast cancer: A systematic review. Psycho-Oncology, 27(12), 2687-2699. https://doi.org/10.1002/pon.4870

© 2018 John Wiley & Sons, Ltd. Objective: Body image concerns warrant attention among women who have undergone treatment for breast cancer, due to their significant consequences for psychological and physical health, and interpersonal relationships... Read More about Efficacy of psychosocial and physical activity-based interventions to improve body image among women treated for breast cancer: A systematic review.

Ionizing radiation, higher plants, and radioprotection: From acute high doses to chronic low doses (2018)
Journal Article
Willey, N., & Caplin, N. (2018). Ionizing radiation, higher plants, and radioprotection: From acute high doses to chronic low doses. Frontiers in Plant Science, 9, Article 847. https://doi.org/10.3389/fpls.2018.00847

© 2018 Caplin and Willey. Understanding the effects of ionizing radiation (IR) on plants is important for environmental protection, for agriculture and horticulture, and for space science but plants have significant biological differences to the anim... Read More about Ionizing radiation, higher plants, and radioprotection: From acute high doses to chronic low doses.

Assessing the effectiveness of interventions to support patient decision making about breast reconstruction: A systematic review (2018)
Journal Article
Paraskeva, N., Guest, E., Lewis-Smith, H., & Harcourt, D. (2018). Assessing the effectiveness of interventions to support patient decision making about breast reconstruction: A systematic review. Breast, 40, 97-105. https://doi.org/10.1016/j.breast.2018.04.020

© 2018 Elsevier Ltd Background: Decision making about breast reconstruction (BR) following a diagnosis of breast cancer, Ductal Carcinoma in Situ (DCIS), or to reduce future breast cancer risk, is difficult and complex. This paper systematically revi... Read More about Assessing the effectiveness of interventions to support patient decision making about breast reconstruction: A systematic review.

Targeting splicing in prostate cancer (2018)
Journal Article
Antonopoulou, E., & Ladomery, M. (2018). Targeting splicing in prostate cancer. International Journal of Molecular Sciences, 19(5), 1287. https://doi.org/10.3390/ijms19051287

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Over 95% of human genes are alternatively spliced, expressing splice isoforms that often exhibit antagonistic functions. We describe genes whose alternative splicing has been linked to prostat... Read More about Targeting splicing in prostate cancer.

Alternative splicing in the hippo pathway-implications for disease and potential therapeutic targets (2018)
Journal Article
Porazinski, S., & Ladomery, M. (2018). Alternative splicing in the hippo pathway-implications for disease and potential therapeutic targets. Genes, 9(3), 161. https://doi.org/10.3390/genes9030161

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement o... Read More about Alternative splicing in the hippo pathway-implications for disease and potential therapeutic targets.

Fungal wars: The underlying molecular repertoires of combating mycelia (2018)
Journal Article
Ujor, V. C., Adukwu, E. C., & Okonkwo, C. C. (2018). Fungal wars: The underlying molecular repertoires of combating mycelia. Fungal Biology, 122(4), 191-202. https://doi.org/10.1016/j.funbio.2018.01.001

© 2018 British Mycological Society Non-self contact between fungi elicits strong morphological and biochemical reactions in the mycelia of interacting species. Although these reactions appear to be species- and interaction-specific, some responses su... Read More about Fungal wars: The underlying molecular repertoires of combating mycelia.