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Alternative splicing in the hippo pathway-implications for disease and potential therapeutic targets

Porazinski, Sean; Ladomery, Michael

Authors

Sean Porazinski Sean.Porazinski@uwe.ac.uk



Abstract

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This review discusses examples of alternative splicing in the Hippo pathway, how deregulation of these processes may contribute to disease and whether these processes offer new potential therapeutic targets.

Journal Article Type Review
Publication Date Mar 13, 2018
Journal Genes
Electronic ISSN 2073-4425
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 9
Issue 3
Pages 161
APA6 Citation Porazinski, S., & Ladomery, M. (2018). Alternative splicing in the hippo pathway-implications for disease and potential therapeutic targets. Genes, 9(3), 161. https://doi.org/10.3390/genes9030161
DOI https://doi.org/10.3390/genes9030161
Keywords hippo pathway, alternative splicing, yes-associated protein, splice-switching oligonucleotides, gene therapy
Publisher URL http://dx.doi.org/10.3390/genes9030161
Additional Information Additional Information : Invited review article in a special issue edited by Michael Ladomery

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