Alternative splicing in the hippo pathway-implications for disease and potential therapeutic targets

Porazinski, Sean; Ladomery, Michael

Abstract

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This review discusses examples of alternative splicing in the Hippo pathway, how deregulation of these processes may contribute to disease and whether these processes offer new potential therapeutic targets.

• Journal Article Type: Review
• Acceptance Date: Mar 13, 2018
• Publication Date: Mar 13, 2018
• Deposit Date: Mar 15, 2018
• Publicly Available Date: Mar 15, 2018
• Journal: Genes
• Electronic ISSN: 2073-4425
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 3
• Pages: 161
• DOI: https://doi.org/10.3390/genes9030161
• Keywords: hippo pathway, alternative splicing, yes-associated protein, splice-switching oligonucleotides, gene therapy
• Public URL: https://uwe-repository.worktribe.com/output/875606
• Publisher URL: http://dx.doi.org/10.3390/genes9030161
• Additional Information: Additional Information : Invited review article in a special issue edited by Michael Ladomery
• Contract Date: Mar 15, 2018