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Editorial: The RNA revolution and cancer

Dlamini, Zodwa; Ladomery, Michael; Kahraman, Abdullah

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Zodwa Dlamini

Abdullah Kahraman


RNA biology has revolutionized cancer understanding and treatment, especially in endocrine-related malignancies. This editorial highlights RNA's crucial role in cancer progression, emphasizing its influence on tumor heterogeneity and behavior. Processes like alternative splicing and noncoding RNA regulation shape cancer biology, with microRNAs, long noncoding RNAs, and circular RNAs orchestrating gene expression dynamics. Aberrant RNA signatures hold promise as diagnostic and prognostic biomarkers in endocrine-related cancers. Recent findings, such as aberrant PI3Kδ splice isoforms and epithelial-mesenchymal transition-related lncRNA signatures, unveil potential therapeutic targets for personalized treatments. Insights into m6A-associated lncRNA prognostic models and the function of lncRNA LINC00659 in gastric cancer represents ongoing research in this field. As understanding of RNA's role in cancer expands, personalized therapies offer transformative potential in managing endocrine-related malignancies. This signifies a significant stride towards precision oncology, fostering innovation for more effective cancer care.

Journal Article Type Editorial
Acceptance Date May 1, 2024
Online Publication Date May 20, 2024
Publication Date May 20, 2024
Deposit Date May 20, 2024
Publicly Available Date May 21, 2024
Journal Frontiers in Endocrinology
Electronic ISSN 1664-2392
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 15
Article Number 1422599
Keywords cancer, microRNAs, alternative splicing, long noncoding RNAs, endocrine-related cancers, RNA biology, circular RNAs, noncoding RNAs
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