Regulating the regulator: nitric oxide control of post-translational modifications

Gupta, Kapuganti Jagadis; Kolbert, Zsuzsanna; Durner, Jorg; Lindermayr, Christian; Corpas, Francisco J.; Brouquisse, Renaud; Barroso, Juan B.; Umbreen, Saima; Palma, José M.; Hancock, John T.; Petrivalsky, Marek; Wendehenne, David; Loake, Gary J.

Abstract

Nitric oxide (NO) is perfectly suited for the role of a redox signalling molecule. A key route for NO bioactivity occurs via protein S-nitrosation, and involves the addition of a NO moiety to a protein cysteine (Cys) thiol (–SH) to form an S-nitrosothiol (SNO). This process is thought to underpin a myriad of cellular processes in plants that are linked to development, environmental responses and immune function. Here we collate emerging evidence showing that NO bioactivity regulates a growing number of diverse post-translational modifications including SUMOylation, phosphorylation, persulfidation and acetylation. We provide examples of how NO orchestrates these processes to mediate plant adaptation to a variety of cellular cues.

Citation

Gupta, K. J., Kolbert, Z., Durner, J., Lindermayr, C., Corpas, F. J., Brouquisse, R., …Loake, G. J. (2020). Regulating the regulator: nitric oxide control of post-translational modifications. New Phytologist, 227(5), 1319-1325. https://doi.org/10.1111/nph.16622

• Journal Article Type: Review
• Acceptance Date: Apr 7, 2020
• Online Publication Date: May 23, 2020
• Publication Date: Sep 1, 2020
• Deposit Date: Apr 7, 2020
• Publicly Available Date: May 5, 2020
• Journal: New Phytologist
• Print ISSN: 0028-646X
• Electronic ISSN: 1469-8137
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 227
• Issue: 5
• Pages: 1319-1325
• DOI: https://doi.org/10.1111/nph.16622
• Keywords: Nitric oxide, phosphorylation, post-translational modification, S-nitrosation, SUMOylation, S-nitrosylation, persulfidation, reactive nitrogen species, reactive oxygen species
• Public URL: https://uwe-repository.worktribe.com/output/5866075