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All Outputs (169)

Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: A model for neuronal and synaptic differentiation in neurodegeneration (2024)
Journal Article
Targett, I. L., Crompton, L. A., Conway, M. E., & Craig, T. J. (in press). Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: A model for neuronal and synaptic differentiation in neurodegeneration. In Vitro Cellular and Developmental Biology - Animal,

There has been much interest in the use of cell culture models of neurones, to avoid the animal welfare and cost issues of using primary and human-induced pluripotent stem cell (hiPSC)-derived neurones respectively. The human neuroblastoma cell line,... Read More about Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: A model for neuronal and synaptic differentiation in neurodegeneration.

The peer review process: Past, present, and future (2024)
Journal Article
Ladomery, M. (2024). The peer review process: Past, present, and future. British Journal of Biomedical Science, 81, Article 12054. https://doi.org/10.3389/bjbs.2024.12054

The peer review process is a fundamental aspect of modern scientific paper publishing, underpinning essential quality control. First conceptualised in the 1700s, it is an iterative process that aims to elevate scientific literature to the highest sta... Read More about The peer review process: Past, present, and future.

SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression (2024)
Journal Article
Fletcher-Jones, A., Spackman, E., Craig, T. J., Nakamura, Y., Wilkinson, K. A., & Henley, J. M. (2024). SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression. Journal of Cell Science, 137(11), Article jcs261551. https://doi.org/10.1242/jcs.261551

Endocannabinoid signalling mediated by cannabinoid receptor 1 (CB1R, also known as CNR1) is critical for homeostatic neuromodulation of both excitatory and inhibitory synapses. This requires highly polarised axonal surface expression of CB1R, but how... Read More about SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression.

IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome (2024)
Journal Article
Asurappulige, H., Ladomery, M., & Morse, R. (2024). IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome. Translational Oncology, 46, Article 102030. https://doi.org/10.1016/j.tranon.2024.102030

Following infection or exposure to therapeutic agents, an aggressive immune response may result, termed cytokine storm (CS) or cytokine release syndrome. Here the innate immune system becomes uncontrolled, leading to serious consequences including po... Read More about IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome.

Coupling of cold atmospheric plasma treatment with ultrasound-assisted extraction for enhanced recovery of bioactive compounds from cornelian cherry pomace (2024)
Journal Article
Loukri, A., Kissas, T., Kyriakoudi, A., Zymvrakaki, E., Stratakos, A. C., & Mourtzinos, I. (2024). Coupling of cold atmospheric plasma treatment with ultrasound-assisted extraction for enhanced recovery of bioactive compounds from cornelian cherry pomace. Food Chemistry, 455, Article 139989. https://doi.org/10.1016/j.foodchem.2024.139989

Cornelian cherry pomace is produced during the production of juice from this traditional superfood. Due to its high nutritive value, the by-product can be utilized as a source of bioactive compounds. The present study aimed to develop a sustainable m... Read More about Coupling of cold atmospheric plasma treatment with ultrasound-assisted extraction for enhanced recovery of bioactive compounds from cornelian cherry pomace.

Admissibility of forensic evidence and expert witnesses (2024)
Book Chapter
Nsiah Amoako, E. (2024). Admissibility of forensic evidence and expert witnesses. In Forensic Evidence Processing in Gender-Based Violence Cases: Handbook for Criminal Justice Practitioners (91-96). Vienna, Austria: United Nations Office on Drugs and Crime

In GBVAW cases, where forensic evidence will likely form part of the evidence for the prosecution, an expert in the specific evidence type (such as a DNA expert) will be required to assess the evidence in the context of the case to help the court dec... Read More about Admissibility of forensic evidence and expert witnesses.

Impacts of COVID-19 on UK environmental science engagement projects (2024)
Journal Article
Hobbs, L., Stevens, C., & Fletcher-Wood, R. (in press). Impacts of COVID-19 on UK environmental science engagement projects. School Science Review,

In February-March 2020, ‘Investing in the Future of Science’ collected data on environmental science engagement with UK school-aged children. The UK then entered its first COVID-19 national lockdown. Larger or wider-reaching projects appeared more li... Read More about Impacts of COVID-19 on UK environmental science engagement projects.

Comparison of MXene and SWCNTs effectiveness for osteoblast differentiation: A preliminary study with MG-63 cells (2024)
Journal Article
Elkodous, M. A., Elkhenany, H., & Mansell, J. P. (in press). Comparison of MXene and SWCNTs effectiveness for osteoblast differentiation: A preliminary study with MG-63 cells. NANO, https://doi.org/10.1142/S179329202450036X

The exceptional chemical and physical properties of nanomaterials have attracted growing interest in the field of bone tissue engineering. Single walled carbon nanotubes (SWCNTs) and MXenes are two types of unique nanomaterials that have shown promis... Read More about Comparison of MXene and SWCNTs effectiveness for osteoblast differentiation: A preliminary study with MG-63 cells.

Investigation of novel screen-printed electrochemical sensors for measuring 17-βeta-Estradiol in an aqueous environment (2024)
Thesis
Musa, A. Investigation of novel screen-printed electrochemical sensors for measuring 17-βeta-Estradiol in an aqueous environment. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/9006674

The hormone 17β-estradiol (E2) is increasingly prevalent in environmental waters globally, posing a significant threat to human and animal health due to its adverse effects on endocrine functions. Traditional methods of analysing E2 are complex and t... Read More about Investigation of novel screen-printed electrochemical sensors for measuring 17-βeta-Estradiol in an aqueous environment.

Attenuated-total-reflection Fourier-transformed spectroscopy as a rapid tool to reveal the molecular structure of insect powders as ingredients for animal feeds (2024)
Journal Article
Ortuño, J., Robertson, K., Stratakos, A., Stergiadis, S., & Theodoridou, K. (in press). Attenuated-total-reflection Fourier-transformed spectroscopy as a rapid tool to reveal the molecular structure of insect powders as ingredients for animal feeds. Journal of Insects as Food and Feed,

Unsustainable agriculture contributes to disastrous global effects—insect-based feed shows potential due to their sustainable, nutritional, and waste upcycling properties. Current EU legislation restricts insect-based meals to fish, pork, and poultry... Read More about Attenuated-total-reflection Fourier-transformed spectroscopy as a rapid tool to reveal the molecular structure of insect powders as ingredients for animal feeds.

Editorial: The RNA revolution and cancer (2024)
Journal Article
Dlamini, Z., Ladomery, M., & Kahraman, A. (2024). Editorial: The RNA revolution and cancer. Frontiers in Endocrinology, 15, Article 1422599. https://doi.org/10.3389/fendo.2024.1422599

RNA biology has revolutionized cancer understanding and treatment, especially in endocrine-related malignancies. This editorial highlights RNA's crucial role in cancer progression, emphasizing its influence on tumor heterogeneity and behavior. Proces... Read More about Editorial: The RNA revolution and cancer.

Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3 (2024)
Journal Article
Williams, A., Cooper, E., Clark, B., Perry, L., Ponassi, M., Iervasi, E., …Ladomery, M. (2024). Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3. International Journal of Molecular Sciences, 25(10), Article 5380. https://doi.org/10.3390/ijms25105380

In a screen of over 200 novel pyrazole compounds, ethyl 1-(2-hydroxypentyl)-5-(3-(3-(trifluoromethyl) phenyl)ureido)-1H-pyrazole-4-carboxylate (named GeGe-3) has emerged as a potential anticancer compound. GeGe-3 displays potent anti-angiogenic prope... Read More about Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3.

Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii (2024)
Journal Article
Manley, R., Fitch, C., Francis, V., Temperton, I., Turner, D., Fletcher, J., …Temperton, B. (2024). Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii. Journal of Medical Microbiology, 73(5), Article 001829. https://doi.org/10.1099/jmm.0.001829

Introduction . Acinetobacter baumannii is a critical priority pathogen for novel antimicrobials (World Health Organization) because of the rise in nosocomial infections and its ability to evolve resistance to last resort antibiotics. A. baumannii is... Read More about Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii.

The effect of 3D printing speed and temperature on transferability of Staphylococcus aureus and Escherichia coli during 3D food printing (2024)
Journal Article
Εkonomou, S. Ι., Kageler, S., & Ch Stratakos, A. (2024). The effect of 3D printing speed and temperature on transferability of Staphylococcus aureus and Escherichia coli during 3D food printing. Food Microbiology, 122, Article 104561. https://doi.org/10.1016/j.fm.2024.104561

The current study aimed to determine if the 3D-printing speed and temperature would impact the transferability of foodborne pathogens from the stainless-steel (SS) food cartridge to the 3D-printed food ink. Staphylococcus aureus and Escherichia coli... Read More about The effect of 3D printing speed and temperature on transferability of Staphylococcus aureus and Escherichia coli during 3D food printing.

Two novel Raoultella species associated with bleeding cankers of broadleaf hosts, Raoultella scottia sp. nov. and Raoultella lignicola sp. nov. (2024)
Journal Article
Brady, C., Cramptom, B., Kaur, S., Maddock, D., Kile, H., Arnold, D., & Denman, S. (2024). Two novel Raoultella species associated with bleeding cankers of broadleaf hosts, Raoultella scottia sp. nov. and Raoultella lignicola sp. nov. Frontiers in Microbiology, 15, Article 1386923. https://doi.org/10.3389/fmicb.2024.1386923

Seventeen Gram-negative, facultatively anaerobic bacterial strains were isolated from bleeding cankers of various broadleaf hosts and oak rhizosphere soil in Great Britain. The strains were tentatively identified as belonging to the genus Raoultella... Read More about Two novel Raoultella species associated with bleeding cankers of broadleaf hosts, Raoultella scottia sp. nov. and Raoultella lignicola sp. nov..

Using Minecraft Clubs to support neurodivergent children with STEM (2024)
Presentation / Conference
Behenna, S., & Hobbs, L. (2024, April). Using Minecraft Clubs to support neurodivergent children with STEM. Presented at Association for Child and Adolescent Mental Health Conference, Online

An invited presentation at the Association for Child and Adolescent Mental Health Conference, on using Minecraft clubs to support neurodivergent children with STEM.

Animal Welfare in a Pandemic: What Does COVID-19 Tell us for the Future? (2024)
Book
Hancock, J. T., Rouse, R. C., & Craig, T. J. (2024). Animal Welfare in a Pandemic: What Does COVID-19 Tell us for the Future?. England: Taylor & Francis

Animal Welfare in a Pandemic explores the impact of COVID-19 on a wide array of animals, from those in the wild to companion and captive animals. During the height of the pandemic, a range of animals were infected, and many died, but this was hard to... Read More about Animal Welfare in a Pandemic: What Does COVID-19 Tell us for the Future?.

Studies on the pathogenesis of cacao swollen shoot virus to enhance the theobroma cacao l. Quarantine procedures with appendicies (2024)
Thesis
Richardson, M. Studies on the pathogenesis of cacao swollen shoot virus to enhance the theobroma cacao l. Quarantine procedures with appendicies. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/11404419

Theobroma cacao (cocoa) is an economically important crop and the source of one of the world’s most consumed products, chocolate; an industry valued at USD 103 billion per annum. Pests and diseases pose a major threat to cocoa production, affecting y... Read More about Studies on the pathogenesis of cacao swollen shoot virus to enhance the theobroma cacao l. Quarantine procedures with appendicies.