Outputs (24)

Using next-generation sequencing to develop a Shigella species threshold and profile faecal samples from suspected diarrhoea cases (2021)
Journal Article
Smith, A. (2021). Using next-generation sequencing to develop a Shigella species threshold and profile faecal samples from suspected diarrhoea cases. Folia Microbiologica, 66(3), 399-410. https://doi.org/10.1007/s12223-020-00846-w

Globally, it is estimated that there are 2 billion cases of diarrhoeal disease each year, with 525,000 children under the age of 5years, dying from diarrhoea. This also affects 1 in 5 people in the UK each year. Rapid diagnosis, appropriate treatment... Read More about Using next-generation sequencing to develop a Shigella species threshold and profile faecal samples from suspected diarrhoea cases.

Early conscious prone positioning in patients with COVID-19 receiving continuous positive airway pressure: A retrospective analysis (2020)
Journal Article
Winearls, S., Swingwood, E. L., Hardaker, C. L., Smith, A. M., Easton, F. M., Millington, K. J., …Curtis, K. J. (2020). Early conscious prone positioning in patients with COVID-19 receiving continuous positive airway pressure: A retrospective analysis. BMJ Open Respiratory Research, 7(1), e000711. https://doi.org/10.1136/bmjresp-2020-000711

The global pandemic of COVID-19 has challenged the management of hypoxaemic respiratory failure and strained intensive care unit resources. While prone positioning (PP) is an established therapy in mechanically ventilated patients with acute respirat... Read More about Early conscious prone positioning in patients with COVID-19 receiving continuous positive airway pressure: A retrospective analysis.

The effect of residual food stain on Candida albicans colonisation of denture acrylics (2020)
Journal Article
Smith, A., Williams, D., Bradshaw, D., Milward, P., Al Kutubi, S., & Rowe, W. (2020). The effect of residual food stain on Candida albicans colonisation of denture acrylics. Dental Oral Biology and Craniofacial Research, 3(2), https://doi.org/10.31487/j.DOBCR.2020.02.06

Published: NA Keywords: Candida albicans dentures food stains denture-induced stomatitis A B S T R A C T Objectives: In the UK, 19% of adults wear dentures. Failure to keep a denture clean can lead to staining from foods, along with subsequent coloni... Read More about The effect of residual food stain on Candida albicans colonisation of denture acrylics.

The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions (2020)
Journal Article
Mitra, A., MacIntyre, D. A., Ntritsos, G., Smith, A., Tsilidis, K. K., Marchesi, J. R., …Kyrgiou, M. (2020). The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions. Nature Communications, 11, Article 1999. https://doi.org/10.1038/s41467-020-15856-y

Emerging evidence suggests associations between the vaginal microbiota (VMB) composition, human papillomavirus (HPV) infection, and cervical intraepithelial neoplasia (CIN); however, causal inference remains uncertain. Here, we use bacterial DNA sequ... Read More about The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions.

The association between vaginal bacterial composition and miscarriage: a nested case-control study (2019)
Journal Article
Al-memar, M., Bobdiwala, S., Fourie, H., Mannino, R., Lee, Y., Smith, A., …MacIntyre, D. (2020). The association between vaginal bacterial composition and miscarriage: a nested case-control study. BJOG: An International Journal of Obstetrics and Gynaecology, 127(2), 264-274. https://doi.org/10.1111/1471-0528.15972

© 2019 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists Objective: To characterise vaginal bacterial composition in early pre... Read More about The association between vaginal bacterial composition and miscarriage: a nested case-control study.

Molecular community profiling of the bacterial microbiota associated with denture-related stomatitis (2019)
Journal Article
Morse, D. J., Smith, A., Wilson, M. J., Marsh, L., White, L., Posso, R., …Williams, D. W. (2019). Molecular community profiling of the bacterial microbiota associated with denture-related stomatitis. Scientific Reports, 9(1), Article 10228. https://doi.org/10.1038/s41598-019-46494-0

Denture-associated stomatitis (DS) affects over two-thirds of denture-wearers. DS presents as erythema of the palatal mucosa in areas where denture-surface associated polymicrobial biofilms containing the fungus Candida albicans exist. The contributi... Read More about Molecular community profiling of the bacterial microbiota associated with denture-related stomatitis.

Electronic longitudinal alcohol study in communities (ELAStiC) Wales - protocol for platform development (2019)
Journal Article
Trefan, L., Akbari, A., Paranjothy, S., Farewell, D. M., Gartner, A., Fone, D., …Moore, S. (2019). Electronic longitudinal alcohol study in communities (ELAStiC) Wales - protocol for platform development. International Journal of Population Data Science, 4(1), https://doi.org/10.23889/ijpds.v4i1.581

Introduction: Excessive alcohol consumption has adverse effects on health and there is a recognised need for the longitudinal analysis of population data to improve our understanding of the patterns of alcohol use, harms to consumers and those in the... Read More about Electronic longitudinal alcohol study in communities (ELAStiC) Wales - protocol for platform development.

Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis (2019)
Journal Article
Ovadia, C., Perdones‐Montero, A., Spagou, K., Smith, A., Sarafian, M. H., Gomez‐Romero, M., …Williamson, C. (2019). Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis. Hepatology, 70(1), 276-293. https://doi.org/10.1002/hep.30661

Pregnancy is associated with progressive hypercholanemia, hypercholesterolemia, and hypertriglyceridemia, which can result in metabolic disease in susceptible women. Gut signals modify hepatic homeostatic pathways, linking intestinal content to metab... Read More about Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis.

Prospective observational study of vaginal microbiota pre‐ and post‐rescue cervical cerclage (2019)
Journal Article
Brown, R. G., Chan, D., Terzidou, V., Lee, Y. S., Smith, A., Marchesi, J. R., …Bennett, P. R. (2019). Prospective observational study of vaginal microbiota pre‐ and post‐rescue cervical cerclage. BJOG: An International Journal of Obstetrics and Gynaecology, 126(7), 916-925. https://doi.org/10.1111/1471-0528.15600

Objective: To investigate the relation between vaginal microbiota composition and outcome of rescue cervical cerclage. Design: Prospective observational study. Setting: Queen Charlotte's and Chelsea Hospital, London. Population: Twenty singleton preg... Read More about Prospective observational study of vaginal microbiota pre‐ and post‐rescue cervical cerclage.

Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes (2018)
Journal Article
Lee, Y. S., Brown, R. G., Al-Memar, M., Marchesi, J. R., Smith, A., Chan, D., …MacIntyre, D. A. (2019). Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes. Translational Research, The Journal of Laboratory and Clinical Medicine, 207, 30-43. https://doi.org/10.1016/j.trsl.2018.12.005

© 2019 The Authors Vaginal bacterial community composition influences pregnancy outcome. Preterm prelabor rupture of the fetal membranes (PPROM), which precedes 30% of all spontaneous preterm births, is associated with high vaginal bacterial diversit... Read More about Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes.