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The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions

Mitra, Anita; MacIntyre, David A.; Ntritsos, George; Smith, Ann; Tsilidis, Konstantinos K.; Marchesi, Julian R.; Bennett, Phillip R.; Moscicki, Anna-Barbara; Kyrgiou, Maria

The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions Thumbnail


Authors

Anita Mitra

David A. MacIntyre

George Ntritsos

Ann Smith

Konstantinos K. Tsilidis

Julian R. Marchesi

Phillip R. Bennett

Anna-Barbara Moscicki

Maria Kyrgiou



Abstract

Emerging evidence suggests associations between the vaginal microbiota (VMB) composition, human papillomavirus (HPV) infection, and cervical intraepithelial neoplasia (CIN); however, causal inference remains uncertain. Here, we use bacterial DNA sequencing from serially collected vaginal samples from a cohort of 87 adolescent and young women aged 16–26 years with histologically confirmed, untreated CIN2 lesions to determine whether VMB composition affects rates of regression over 24 months. We show that women with a Lactobacillus-dominant microbiome at baseline are more likely to have regressive disease at 12 months. Lactobacillus spp. depletion and presence of specific anaerobic taxa including Megasphaera, Prevotella timonensis and Gardnerella vaginalis are associated with CIN2 persistence and slower regression. These findings suggest that VMB composition may be a future useful biomarker in predicting disease outcome and tailoring surveillance, whilst it may offer rational targets for the development of new prevention and treatment strategies.

Citation

Mitra, A., MacIntyre, D. A., Ntritsos, G., Smith, A., Tsilidis, K. K., Marchesi, J. R., …Kyrgiou, M. (2020). The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions. Nature Communications, 11, https://doi.org/10.1038/s41467-020-15856-y

Journal Article Type Article
Acceptance Date Mar 12, 2020
Online Publication Date Apr 24, 2020
Publication Date Apr 24, 2020
Deposit Date Aug 4, 2020
Publicly Available Date Aug 4, 2020
Journal Nature Communications
Electronic ISSN 2041-1723
Publisher Nature Research (part of Springer Nature)
Peer Reviewed Peer Reviewed
Volume 11
Article Number 1999
DOI https://doi.org/10.1038/s41467-020-15856-y
Keywords General Biochemistry; Genetics and Molecular Biology; General Physics and Astronomy; General Chemistry
Public URL https://uwe-repository.worktribe.com/output/6003582
Additional Information Received: 19 May 2019; Accepted: 12 March 2020; First Online: 24 April 2020; : Roche Molecular Diagnostics (Pleasanton, CA) provided supplies for HPV DNA detection. There are no awarded or filed patents pertaining to the results presented in the paper.

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