Anita Mitra
The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions
Mitra, Anita; MacIntyre, David A.; Ntritsos, George; Smith, Ann; Tsilidis, Konstantinos K.; Marchesi, Julian R.; Bennett, Phillip R.; Moscicki, Anna-Barbara; Kyrgiou, Maria
Authors
David A. MacIntyre
George Ntritsos
Ann Smith
Konstantinos K. Tsilidis
Julian R. Marchesi
Phillip R. Bennett
Anna-Barbara Moscicki
Maria Kyrgiou
Abstract
Emerging evidence suggests associations between the vaginal microbiota (VMB) composition, human papillomavirus (HPV) infection, and cervical intraepithelial neoplasia (CIN); however, causal inference remains uncertain. Here, we use bacterial DNA sequencing from serially collected vaginal samples from a cohort of 87 adolescent and young women aged 16–26 years with histologically confirmed, untreated CIN2 lesions to determine whether VMB composition affects rates of regression over 24 months. We show that women with a Lactobacillus-dominant microbiome at baseline are more likely to have regressive disease at 12 months. Lactobacillus spp. depletion and presence of specific anaerobic taxa including Megasphaera, Prevotella timonensis and Gardnerella vaginalis are associated with CIN2 persistence and slower regression. These findings suggest that VMB composition may be a future useful biomarker in predicting disease outcome and tailoring surveillance, whilst it may offer rational targets for the development of new prevention and treatment strategies.
Citation
Mitra, A., MacIntyre, D. A., Ntritsos, G., Smith, A., Tsilidis, K. K., Marchesi, J. R., …Kyrgiou, M. (2020). The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions. Nature Communications, 11, Article 1999. https://doi.org/10.1038/s41467-020-15856-y
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 12, 2020 |
Online Publication Date | Apr 24, 2020 |
Publication Date | Apr 24, 2020 |
Deposit Date | Aug 4, 2020 |
Publicly Available Date | Mar 28, 2024 |
Journal | Nature Communications |
Electronic ISSN | 2041-1723 |
Publisher | Nature Research (part of Springer Nature) |
Peer Reviewed | Peer Reviewed |
Volume | 11 |
Article Number | 1999 |
DOI | https://doi.org/10.1038/s41467-020-15856-y |
Keywords | General Biochemistry; Genetics and Molecular Biology; General Physics and Astronomy; General Chemistry |
Public URL | https://uwe-repository.worktribe.com/output/6003582 |
Additional Information | Received: 19 May 2019; Accepted: 12 March 2020; First Online: 24 April 2020; : Roche Molecular Diagnostics (Pleasanton, CA) provided supplies for HPV DNA detection. There are no awarded or filed patents pertaining to the results presented in the paper. |
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The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions
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Licence
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Publisher Licence URL
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