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Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes

Lee, Yun S.; Brown, Richard G.; Al-Memar, Maya; Marchesi, Julian R.; Smith, Ann; Chan, Denise; Lewis, Holly; Kindinger, Lindsay; Terzidou, Vasso; Bourne, Tom; Bennett, Phillip R.; MacIntyre, David A.

Authors

Yun S. Lee

Richard G. Brown

Maya Al-Memar

Julian R. Marchesi

Ann Smith

Denise Chan

Holly Lewis

Lindsay Kindinger

Vasso Terzidou

Tom Bourne

Phillip R. Bennett

David A. MacIntyre



Abstract

© 2019 The Authors Vaginal bacterial community composition influences pregnancy outcome. Preterm prelabor rupture of the fetal membranes (PPROM), which precedes 30% of all spontaneous preterm births, is associated with high vaginal bacterial diversity prior to rupture. The point at which vaginal bacterial diversity is established before PPROM is unknown. In this study, we use metataxonomics to longitudinally characterize the vaginal bacterial composition from as early as 6 weeks of gestation in women at high (n = 38) and low (n = 22) risk of preterm birth who subsequently experience PPROM and in women delivering at term without complications (n = 36). Reduced Lactobacillus spp. abundance and high diversity was observed prior to PPROM in 20% and 26% of women at low and high risk of preterm births respectively, but in only 3% of women who delivered at term. PPROM was associated with instability of bacterial community structure during pregnancy and a shift toward higher diversity predominately occurring during the second trimester. This was characterized by increased relative abundance of potentially pathogenic species including Prevotella, Peptoniphilus, Streptococcus, and Dialister. This study identifies reduced Lactobacillus spp. abundance and increasing vaginal bacterial diversity as an early risk factor for PPROM and highlights the need for interventional studies designed to assess the impact of modifying vaginal bacterial composition for the prevention of preterm birth.

Citation

Lee, Y. S., Brown, R. G., Al-Memar, M., Marchesi, J. R., Lee, Y. S., Smith, A., …MacIntyre, D. A. (2019). Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes. Translational Research, The Journal of Laboratory and Clinical Medicine, 207, 30-43. https://doi.org/10.1016/j.trsl.2018.12.005

Journal Article Type Article
Acceptance Date Dec 21, 2018
Online Publication Date Dec 27, 2018
Publication Date May 1, 2019
Deposit Date Oct 2, 2019
Publicly Available Date Oct 4, 2019
Journal Translational Research
Print ISSN 1931-5244
Electronic ISSN 1878-1810
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 207
Pages 30-43
DOI https://doi.org/10.1016/j.trsl.2018.12.005
Keywords Public Health, Environmental and Occupational Health; Biochemistry, medical; General Medicine
Public URL https://uwe-repository.worktribe.com/output/3452687
Additional Information This article is maintained by: Elsevier; Article Title: Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes; Journal Title: Translational Research; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.trsl.2018.12.005; Content Type: article; Copyright: © 2019 The Authors. Published by Elsevier Inc.

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