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Practical observations on the performance of bare silica in hydrophilic interaction compared with C18 reversed-phase liquid chromatography (2013)
Journal Article
Heaton, J. C., Wang, X., Barber, W. E., Buckenmaier, S. M., & McCalley, D. V. (2014). Practical observations on the performance of bare silica in hydrophilic interaction compared with C18 reversed-phase liquid chromatography. Journal of Chromatography A, 1328, 7-15. https://doi.org/10.1016/j.chroma.2013.12.058

The kinetic performance of a bare silica and C18 phase prepared from the same sub-2. μm and 3.5. μm base materials were compared in the HILIC and RP mode using both charged and neutral solutes. The HILIC column was characterised using the neutral sol... Read More about Practical observations on the performance of bare silica in hydrophilic interaction compared with C18 reversed-phase liquid chromatography.

The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults (2013)
Journal Article
Jacobson, S. K., Lewis, D. A., Lewis, D., Brown, R., Williams, J., White, P., …Drake, M. J. (2013). The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults. Frontiers in Cellular and Infection Microbiology, 4(AUG), https://doi.org/10.3389/fcimb.2013.00041

The urinary microbiome of healthy individuals and the way it alters with ageing have not been characterized and may influence disease processes. Conventional microbiological methods have limited scope to capture the full spectrum of urinary bacterial... Read More about The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults.

Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy (2013)
Journal Article
Page, K., Anderson, E., Smith, A., Reid, C., Salisbury, V., Donaldson, C., & May, J. E. (2014). Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy. Mutagenesis, 29(1), 92. https://doi.org/10.1093/mutage/get060

Cytosine arabinoside (ara-C) is a key chemotherapy drug used to treat acute myeloid leukaemia (AML), however, ap- proximately 30% of patients do not respond to this therapy. 92 An evaluative assay to determine resistance/sensitivity to ara- C prior... Read More about Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy.

Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment (2013)
Journal Article
May, J. E., Morse, H. R., Page, K., Soh, M., Wexler, S., Cox, C., …Donaldson, C. (2014). Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment. Mutagenesis, 29(1), 79. https://doi.org/10.1093/mutage/get060

The bone marrow (BM) microenvironment is largely com- prised of mesenchymal stromal cells (MSCs) and is vital in supporting haematopoiesis. Limited studies have indicated that the BM microenvironment is damaged by chemotherapy; however the extent and... Read More about Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment.

Point of care monitoring of hemodialysis patients with a breath ammonia measurement device based on printed polyaniline nanoparticle sensors (2013)
Journal Article
Killard, A. J., Hibbard, T., Crowley, K., Kelly, F., Ward, F., Holian, J., …Killard, A. (2013). Point of care monitoring of hemodialysis patients with a breath ammonia measurement device based on printed polyaniline nanoparticle sensors. Analytical Chemistry, 85(24), 12158-12165. https://doi.org/10.1021/ac403472d

A device for measuring human breath ammonia was developed based on a single use, disposable, inkjet printed ammonia sensor fabricated using polyaniline nanoparticles. The device was optimized for sampling ammonia in human breath samples by addressing... Read More about Point of care monitoring of hemodialysis patients with a breath ammonia measurement device based on printed polyaniline nanoparticle sensors.

RIM1α SUMOylation is required for fast synaptic vesicle exocytosis (2013)
Journal Article
Rocca, D. L., Henley, J. M., Girach, F., Craig, T. J., Rocca, D. L., & Henley, J. M. (2013). RIM1α SUMOylation is required for fast synaptic vesicle exocytosis. Cell Reports, 5(5), 1294-1301. https://doi.org/10.1016/j.celrep.2013.10.039

The rapid, activity-dependent quantal presynaptic release of neurotransmitter is vital for brain function. The complex process of vesicle priming, fusion, and retrieval is very precisely controlled and requires thespatiotemporal coordination of multi... Read More about RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.

Connecting spiking neurons to a spiking memristor network changes the memristor dynamics (2013)
Presentation / Conference
Gater, D., Iqbal, A., Davey, J. S., & Gale, E. (2013, December). Connecting spiking neurons to a spiking memristor network changes the memristor dynamics. Paper presented at Proceedings of the International Conference on Electronics, Circuits and Systems (ICECS) 2013, Abu Dhabi, UAE

Memristors have been suggested as neuromorphic computing elements. Spike-time dependent plasticity and the Hodgkin-Huxley model of the neuron have both been modelled effectively by memristor theory. The d.c. response of the memristor is a current... Read More about Connecting spiking neurons to a spiking memristor network changes the memristor dynamics.

Voltammetric behaviour of hydrogen peroxide at a silver electrode fabricated from a rewritable digital versatile disc (DVD) and its determination in water samples (2013)
Journal Article
Shafei, M., & Honeychurch, K. C. (2013). Voltammetric behaviour of hydrogen peroxide at a silver electrode fabricated from a rewritable digital versatile disc (DVD) and its determination in water samples. Analytical Methods, 5(23), 6631-6636. https://doi.org/10.1039/c3ay41557k

In this study we investigated the possibility of applying Ag electrodes manufactured from recordable rewritable digital versatile discs (DVD-RW) for the voltammetric determination of hydrogen peroxide. The calibration plot was linear from 0.087 mM to... Read More about Voltammetric behaviour of hydrogen peroxide at a silver electrode fabricated from a rewritable digital versatile disc (DVD) and its determination in water samples.

Different Wording of the Patient Global Visual Analogue Scale (PG-VAS) Affects Rheumatoid Arthritis Patients' Scoring and the Overall Disease Activity Score (DAS28): A Cross-Sectional Study (2013)
Journal Article
French, T., Hewlett, S., Kirwan, J., & Sanderson, T. (2013). Different Wording of the Patient Global Visual Analogue Scale (PG-VAS) Affects Rheumatoid Arthritis Patients' Scoring and the Overall Disease Activity Score (DAS28): A Cross-Sectional Study. Musculoskeletal Care, 11(4), 229-237. https://doi.org/10.1002/msc.1046

Objective: The Disease Activity Score in 28 joints (DAS28) is a key measure in clinical practice and clinical trials. There are at least five different versions of the 'Patient Global' Visual Analogue Scale (PG-VAS) being used in the DAS28. The devel... Read More about Different Wording of the Patient Global Visual Analogue Scale (PG-VAS) Affects Rheumatoid Arthritis Patients' Scoring and the Overall Disease Activity Score (DAS28): A Cross-Sectional Study.

Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice (2013)
Journal Article
Becker, K., Thomas, A. D., & Kaina, B. (2014). Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice. Environmental and Molecular Mutagenesis, 55(2), 145-150. https://doi.org/10.1002/em.21834

Several genotoxicity endpoints have been evaluated to define nonlinear dose-responses for S N 1 and S N 2 alkylating genotoxicants. Dose-response studies acknowledging the process of multistage tumorigenesis are important; however, data pertaining no... Read More about Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice.

The rulB gene of plasmid pWW0 is a hotspot for the site-specific insertion of integron-like elements found in the chromosomes of environmental Pseudomonas fluorescens group bacteria (2013)
Journal Article
Pickup, R. W., Jackson, R. W., Rhodes, G., Bosma, H., Studholme, D., & Arnold, D. L. (2014). The rulB gene of plasmid pWW0 is a hotspot for the site-specific insertion of integron-like elements found in the chromosomes of environmental Pseudomonas fluorescens group bacteria. Environmental Microbiology, 16(8), 2374-2388. https://doi.org/10.1111/1462-2920.12345

Summary: The rulAB operon of Pseudomonas spp. confers fitness traits on the host and has been suggested to be a hotspot for insertion of mobile elements that carry avirulence genes. Here, for the first time, we show that rulB on plasmid pWW0 is a hot... Read More about The rulB gene of plasmid pWW0 is a hotspot for the site-specific insertion of integron-like elements found in the chromosomes of environmental Pseudomonas fluorescens group bacteria.

A smart integrated biosensor system (2013)
Presentation / Conference
Killard, A. (2013, November). A smart integrated biosensor system. Paper presented at Printed Electronics USA, Santa Clara, USA

Drop-coated titanium dioxide memristors (2013)
Journal Article
Gale, E., Mayne, R., Adamatzky, A., & De Lacy Costello, B. (2014). Drop-coated titanium dioxide memristors. Materials Chemistry and Physics, 143(2), 524-529. https://doi.org/10.1016/j.matchemphys.2013.09.013

The fabrication of memristors by drop-coating sol-gel Ti(OH)4 solution onto either aluminium foil or sputter-coated aluminium on plastic is presented. The gel layer is thick, 37 μm, but both devices exhibit good memristance I-V profiles. The drop coa... Read More about Drop-coated titanium dioxide memristors.

Inkjet printing at the heart of sensors and diagnostics (2013)
Presentation / Conference
Gonzalez-Macia, L., & Killard, A. (2013, November). Inkjet printing at the heart of sensors and diagnostics. Paper presented at Science of inkjet and printed drops, Institute of Physics, London

A Pseudomonas syringae diversity survey reveals a differentiated phylotype of the pathovar syringae associated with the mango host and mangotoxin production (2013)
Journal Article
De Vicente, A., Cazorla, F. M., Arrebola, E., Murillo, J., Carrión, V. J., Gutiérrez-Barranquero, J. A., …Arnold, D. L. (2013). A Pseudomonas syringae diversity survey reveals a differentiated phylotype of the pathovar syringae associated with the mango host and mangotoxin production. Phytopathology, 103(11), 1115-1129. https://doi.org/10.1094/PHYTO-04-13-0093-R

Pseudomonas syringae pv. syringae, the causal agent of bacterial apical necrosis (BAN) in mango crops, has been isolated in different mango-producing areas worldwide. An extensive collection of 87 P. syringae pv. syringae strains isolated from mango... Read More about A Pseudomonas syringae diversity survey reveals a differentiated phylotype of the pathovar syringae associated with the mango host and mangotoxin production.

Validation study to compare effects of processing protocols on measured Nε-(carboxymethyl)lysine and Nε-(carboxyethyl) lysine in blood (2013)
Journal Article
Ames, J. M., Hull, G. L., Woodside, J. V., Ames, J., & Cuskelly, G. J. (2013). Validation study to compare effects of processing protocols on measured Nε-(carboxymethyl)lysine and Nε-(carboxyethyl) lysine in blood. Journal of Clinical Biochemistry and Nutrition, 53(3), 129-133. https://doi.org/10.3164/jcbn.13-5

Epidemiological studies show that elevated plasma levels of advanced glycation end products (AGEs) are associated with diabetes, kidney disease, and heart disease. Thus AGEs have been used as disease progression markers. However, the effects of varia... Read More about Validation study to compare effects of processing protocols on measured Nε-(carboxymethyl)lysine and Nε-(carboxyethyl) lysine in blood.

In planta induced changes in the native plasmid profile of Pseudomonas syringae pathover phaseolicola strain 1302A (2013)
Journal Article
Slater, R. T., Neale, H. C., Neale, H., Slater, R., Mayne, L. M., Manoharan, B., & Arnold, D. L. (2013). In planta induced changes in the native plasmid profile of Pseudomonas syringae pathover phaseolicola strain 1302A. Plasmid, 70(3), 420-424. https://doi.org/10.1016/j.plasmid.2013.07.002

Pseudomonas syringae pv. phaseolicola (Pph) strain 1302A, a causative agent of halo blight in the common bean Phaseolus vulgaris, contains four native plasmids designated pAV505 (150. kb), pAV506 (50. kb), pAV507 (47. kb) and pAV508 (42. kb). Pph 130... Read More about In planta induced changes in the native plasmid profile of Pseudomonas syringae pathover phaseolicola strain 1302A.