Prof. Tony Killard's Outputs (97)

Validation of a sensor system for the measurement of breath ammonia using selected-ion flow-tube mass spectrometry (2024)
Journal Article

The measurement of trace breath gases is of growing interest for its potential to provide non-invasive physiological information in health and disease. While instrumental techniques such as selected-ion flow-tube mass spectrometry (SIFT-MS) can achie... Read More about Validation of a sensor system for the measurement of breath ammonia using selected-ion flow-tube mass spectrometry.

Determination of the relative sensitivity of polyaniline inks and films to deprotonation by ammonia using UV–Vis spectroscopy (2023)
Journal Article

The deprotonation behavior of conducting polymers such as polyaniline (PANI) is an important functional parameter in the design of novel printed electronic devices, particularly for sensors and energy storage. PANI can be fabricated into films from p... Read More about Determination of the relative sensitivity of polyaniline inks and films to deprotonation by ammonia using UV–Vis spectroscopy.

Development of a paper-based lateral flow Prothrombin assay (2022)
Journal Article

Disorders of haemostasis result in both excessive bleeding and clotting and are a major global cause of morbidity and mortality, particularly in the developing world. A small number of simple tests can be used to screen and monitor for such dysfuncti... Read More about Development of a paper-based lateral flow Prothrombin assay.

Paper-based lateral flow device for the sustainable measurement of human plasma fibrinogen in low-resource settings (2021)
Journal Article

Fibrinogen concentration is a major determinant of both clotting and bleeding risk. Clotting and bleeding disorders cause extensive morbidity and mortality, particularly in resource-poor and emergency settings. This is exacerbated by a lack of timely... Read More about Paper-based lateral flow device for the sustainable measurement of human plasma fibrinogen in low-resource settings.

Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity (2018)
Journal Article

© 2018 Elsevier B.V. It is well-established that alterations in cell morphology are regulated by cell signalling pathways, with the qualitative and quantitative monitoring of these intrinsic processes being of potential diagnostic value. Moreover, th... Read More about Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity.

Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices (2017)
Journal Article

© The Institution of Engineering and Technology. This paper presents circuit design and simulations of a high gain organic Op-Amp, for use in quantification of real cholesterol, in the range of 1-9 mM. A 7-stage inverter chain is added onto the desig... Read More about Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices.

Disposable sensors (2017)
Journal Article

© 2017 Elsevier B.V. Device disposability is a critical feature of electrochemical sensor production, allowing complex measurements to be carried out in a low cost and efficient manner. Disposable sensors are increasing rapidly in their level of soph... Read More about Disposable sensors.

Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics (2017)
Journal Article

© 2017 American Chemical Society. Organic and printed electronics integration has the potential to revolutionize many technologies, including biomedical diagnostics. This work demonstrates the successful integration of multiple printed electronic fu... Read More about Biomedical Diagnostics Enabled by Integrated Organic and Printed Electronics.

An electrochemical sensor device for measuring blood ammonia at the point of care (2017)
Journal Article

The level of ammonia in blood is relevant in a number of medical conditions. While ammonia is a marker of dysfunction, elevated ammonia is itself a serious medical emergency and can lead to significant and permanent neurological impairment if not add... Read More about An electrochemical sensor device for measuring blood ammonia at the point of care.

A Printed and Microfabricated Sensor Device for the Sensitive Low Volume Measurement of Aqueous Ammonia (2016)
Journal Article

© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The measurement of low concentrations of ammonia in small sample volumes is required in biological, biomedical and environmental measurement applications. However, achieving this without instrumenta... Read More about A Printed and Microfabricated Sensor Device for the Sensitive Low Volume Measurement of Aqueous Ammonia.

Measurement of the viscoelastic properties of blood plasma clot formation in response to tissue factor concentration-dependent activation (2016)
Journal Article

© 2016, The Author(s). The coagulation of blood plasma in response to activation with a range of tissue factor (TF) concentrations was studied with a quartz crystal microbalance (QCM), where frequency and half width at half maximum (bandwidth) values... Read More about Measurement of the viscoelastic properties of blood plasma clot formation in response to tissue factor concentration-dependent activation.

A fully integrated microfluidic device for point of care monitoring of antithrombotics (2016)
Journal Article

© 2016 The Royal Society of Chemistry. The simplicity and efficiency of point of care diagnostics have revolutionised patient care. Current methods for measuring hypercoagulability often require trained technicians, large blood volumes, and result in... Read More about A fully integrated microfluidic device for point of care monitoring of antithrombotics.

Measurement of total cholesterol using an enzyme sensor based on a printed hydrogen peroxide electrocatalyst (2016)
Journal Article

© 2016 The Royal Society of Chemistry. Cholesterol is a major modifiable risk factor in cardiovascular disease and can be effectively managed by a combination of medication and monitoring. There continues to be a need for new point-of-care diagnostic... Read More about Measurement of total cholesterol using an enzyme sensor based on a printed hydrogen peroxide electrocatalyst.

Cholesterol biosensor based on inkjet-printed Prussian blue nanoparticle-modified screen-printed electrodes (2015)
Journal Article

© 2015 Elsevier B.V. Abstract Here we describe the construction and optimization of a cholesterol biosensor based on screen-printed electrodes (SPEs) modified with inkjet-printed Prussian blue nanoparticles (PBNPs). The deposition of PBNPs using inkj... Read More about Cholesterol biosensor based on inkjet-printed Prussian blue nanoparticle-modified screen-printed electrodes.

Development of a hydrogen peroxide sensor based on screen-printed electrodes modified with inkjet-printed prussian blue nanoparticles (2014)
Journal Article

A sensor for the simple and sensitive measurement of hydrogen peroxide has been developed which is based on screen printed electrodes (SPEs) modified with Prussian blue nanoparticles (PBNPs) deposited using piezoelectric inkjet printing. PBNP-modifie... Read More about Development of a hydrogen peroxide sensor based on screen-printed electrodes modified with inkjet-printed prussian blue nanoparticles.

A biosensor for the determination of high density lipoprotein cholesterol employing combined surfactant-derived selectivity and sensitivity enhancements (2014)
Journal Article

High density lipoprotein cholesterol (HDL-C) is a modifiable risk factor in cardiovascular disease and devices suitable for its determination at the point of care are critical to the future management of hypercholesterolaemia. An electrochemical bios... Read More about A biosensor for the determination of high density lipoprotein cholesterol employing combined surfactant-derived selectivity and sensitivity enhancements.

Modelling of blood component flexibility using quartz crystal microbalance (2014)
Journal Article

Quartz crystal microbalance (QCM) is a sensitive technique for real-time monitoring of cell adsorption, aggregation and cell-to-surface interaction processes. However, cell adhesion time courses are usually considered as merely qualitative, being pre... Read More about Modelling of blood component flexibility using quartz crystal microbalance.

Electrochemical impedance characterisation of tungsten trioxide-polyaniline nanocomposites for room temperature acetone sensing (2014)
Journal Article

Composites of WO3 nanoparticles and water-soluble polyaniline (PANI) particles doped with dodecyl benzenesulphonic acid at different mass ratios were deposited onto interdigitated electrodes and characterised using electrochemical impedance spectrosc... Read More about Electrochemical impedance characterisation of tungsten trioxide-polyaniline nanocomposites for room temperature acetone sensing.

Wholly printed polypyrrole nanoparticle-based biosensors on flexible substrate (2014)
Journal Article

Printing has been widely used in the sensor industry for its speed, low cost and production scalability. In this work we present a wholly-printed polypyrrole (PPy) based biosensor produced by inkjet printing bioinks composed of dispersions of PPy nan... Read More about Wholly printed polypyrrole nanoparticle-based biosensors on flexible substrate.

Tailored printed primary battery system for powering a diagnostic sensor device (2014)
Journal Article