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Cholesterol biosensor based on inkjet-printed Prussian blue nanoparticle-modified screen-printed electrodes

Cinti, Stefano; Arduini, Fabiana; Moscone, Danila; Palleschi, Giuseppe; Gonzalez-Macia, Laura; Killard, Anthony

Authors

Stefano Cinti Stefano.Cinti@uwe.ac.uk

Fabiana Arduini

Danila Moscone

Giuseppe Palleschi

Laura Gonzalez-Macia laura.gonzalez-macia@uwe.ac.uk

Tony Killard Tony.Killard@uwe.ac.uk
Research Professor in Biomedical Sciences



Abstract

© 2015 Elsevier B.V. Abstract Here we describe the construction and optimization of a cholesterol biosensor based on screen-printed electrodes (SPEs) modified with inkjet-printed Prussian blue nanoparticles (PBNPs). The deposition of PBNPs using inkjet printing led to the highly facile fabrication of sensors with excellent sensitivity and reproducibility for the measurement of H2O2. Further integration of the sensor with a microfabricated low volume (4 μL) sample cell allowed the measurement of cholesterol in serum with the addition of cholesterol oxidase. The biosensor exhibited a sensitivity to cholesterol of 2.1 μA/mM cm2 (r2 = 0.97, n = 5) and was linear in the range of 0-15 mM.

Journal Article Type Article
Publication Date Jul 11, 2015
Journal Sensors and Actuators, B: Chemical
Print ISSN 0925-4005
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 221
Pages 187-190
Institution Citation Killard, A. J., Cinti, S., Arduini, F., Moscone, D., Palleschi, G., Gonzalez-Macia, L., & Killard, A. (2015). Cholesterol biosensor based on inkjet-printed Prussian blue nanoparticle-modified screen-printed electrodes. Sensors and Actuators B: Chemical, 221, 187-190. https://doi.org/10.1016/j.snb.2015.06.054
DOI https://doi.org/10.1016/j.snb.2015.06.054
Keywords Prussian blue nanoparticles, screen-printed electrodes, inkjet-printing, encapsulation, biosensor, cholesterol
Publisher URL http://dx.doi.org/10.1016/j.snb.2015.06.054